KEGG   Homo sapiens (human): 1139
Entry
1139              CDS       T01001                                 
Symbol
CHRNA7, CHRNA7-2, NACHRA7, nAChR7
Name
(RefSeq) cholinergic receptor nicotinic alpha 7 subunit
  KO
K04809  nicotinic acetylcholine receptor alpha-7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04725  Cholinergic synapse
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05033  Nicotine addiction
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06219  JAK-STAT signaling (cancer)
nt06230  Cell cycle (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01336  CHRNA7-E2F signaling pathway
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01340  ACH-CHRN-JAK-STAT signaling pathway
N01341  NNK/NNN to Jak-STAT signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01895  Transport of natrium/calcium, CHRN
Disease
H01877  Chromosome 15q13.3 microdeletion syndrome
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Atracurium (DG00771): D00758<US>
Bradanicline (DG01849): D10613 D10693
Cisatracurium: D00759<US>
Cytisinicline: D07770
Dimethyltubocurarine: D07272
Doxacurium chloride: D00760
Encenicline (DG01852): D10626 D10702 D10789
Fazadinium bromide: D07273
Hexamethonium bromide: D02204
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Mivacurium chloride: D00763
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Pancuronium (DG00769): D00492
Pipecuronium bromide: D00764
Rocuronium bromide: D00765<JP/US>
Tubocurarine (DG00767): D02207 D08655
Vecuronium (DG00770): D00767<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1139 (CHRNA7)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1139 (CHRNA7)
   04082 Neuroactive ligand signaling
    1139 (CHRNA7)
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1139 (CHRNA7)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1139 (CHRNA7)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1139 (CHRNA7)
   05022 Pathways of neurodegeneration - multiple diseases
    1139 (CHRNA7)
  09165 Substance dependence
   05033 Nicotine addiction
    1139 (CHRNA7)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1139 (CHRNA7)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   1139 (CHRNA7)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb SUR7
Other DBs
NCBI-GeneID: 1139
NCBI-ProteinID: NP_000737
OMIM: 118511
HGNC: 1960
Ensembl: ENSG00000175344
UniProt: P36544
Structure
LinkDB
Position
15:32030483..32173018
AA seq 502 aa
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
NT seq 1509 nt   +upstreamnt  +downstreamnt
atgcgctgctcgccgggaggcgtctggctggcgctggccgcgtcgctcctgcacgtgtcc
ctgcaaggcgagttccagaggaagctttacaaggagctggtcaagaactacaatcccttg
gagaggcccgtggccaatgactcgcaaccactcaccgtctacttctccctgagcctcctg
cagatcatggacgtggatgagaagaaccaagttttaaccaccaacatttggctgcaaatg
tcttggacagatcactatttacagtggaatgtgtcagaatatccaggggtgaagactgtt
cgtttcccagatggccagatttggaaaccagacattcttctctataacagtgctgatgag
cgctttgacgccacattccacactaacgtgttggtgaattcttctgggcattgccagtac
ctgcctccaggcatattcaagagttcctgctacatcgatgtacgctggtttccctttgat
gtgcagcactgcaaactgaagtttgggtcctggtcttacggaggctggtccttggatctg
cagatgcaggaggcagatatcagtggctatatccccaatggagaatgggacctagtggga
atccccggcaagaggagtgaaaggttctatgagtgctgcaaagagccctaccccgatgtc
accttcacagtgaccatgcgccgcaggacgctctactatggcctcaacctgctgatcccc
tgtgtgctcatctccgccctcgccctgctggtgttcctgcttcctgcagattccggggag
aagatttccctggggataacagtcttactctctcttaccgtcttcatgctgctcgtggct
gagatcatgcccgcaacatccgattcggtaccattgatagcccagtacttcgccagcacc
atgatcatcgtgggcctctcggtggtggtgacagtgatcgtgctgcagtaccaccaccac
gaccccgacgggggcaagatgcccaagtggaccagagtcatccttctgaactggtgcgcg
tggttcctgcgaatgaagaggcccggggaggacaaggtgcgcccggcctgccagcacaag
cagcggcgctgcagcctggccagtgtggagatgagcgccgtggcgccgccgcccgccagc
aacgggaacctgctgtacatcggcttccgcggcctggacggcgtgcactgtgtcccgacc
cccgactctggggtagtgtgtggccgcatggcctgctcccccacgcacgatgagcacctc
ctgcacggcgggcaaccccccgagggggacccggacttggccaagatcctggaggaggtc
cgctacattgccaaccgcttccgctgccaggacgaaagcgaggcggtctgcagcgagtgg
aagttcgccgcctgtgtggtggaccgcctgtgcctcatggccttctcggtcttcaccatc
atctgcaccatcggcatcctgatgtcggctcccaacttcgtggaggccgtgtccaaagac
tttgcgtaa

KEGG   Homo sapiens (human): 2902
Entry
2902              CDS       T01001                                 
Symbol
GRIN1, DEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1, hNR1
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 1
  KO
K05208  glutamate receptor ionotropic, NMDA 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01880  GRM1/5-interacting scaffold proteins
Disease
H00606  Early infantile epileptic encephalopathy
H00773  Autosomal dominant intellectual developmental disorder
H02705  Neurodevelopmental disorder with glutamatergic synapse dysfunction
H02865  Neurodevelopmental disorder with or without hyperkinetic movements and seizures
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2902 (GRIN1)
   04015 Rap1 signaling pathway
    2902 (GRIN1)
   04020 Calcium signaling pathway
    2902 (GRIN1)
   04024 cAMP signaling pathway
    2902 (GRIN1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2902 (GRIN1)
   04082 Neuroactive ligand signaling
    2902 (GRIN1)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2902 (GRIN1)
   04720 Long-term potentiation
    2902 (GRIN1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2902 (GRIN1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2902 (GRIN1)
   05014 Amyotrophic lateral sclerosis
    2902 (GRIN1)
   05016 Huntington disease
    2902 (GRIN1)
   05017 Spinocerebellar ataxia
    2902 (GRIN1)
   05020 Prion disease
    2902 (GRIN1)
   05022 Pathways of neurodegeneration - multiple diseases
    2902 (GRIN1)
  09165 Substance dependence
   05030 Cocaine addiction
    2902 (GRIN1)
   05031 Amphetamine addiction
    2902 (GRIN1)
   05033 Nicotine addiction
    2902 (GRIN1)
   05034 Alcoholism
    2902 (GRIN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2902 (GRIN1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2902 (GRIN1)
SSDB
Motif
Pfam: Lig_chan ANF_receptor Lig_chan-Glu_bd SBP_bac_3 Ion_trans_2 Peripla_BP_6 DUF6724
Other DBs
NCBI-GeneID: 2902
NCBI-ProteinID: NP_015566
OMIM: 138249
HGNC: 4584
Ensembl: ENSG00000176884
UniProt: Q05586
Structure
LinkDB
Position
9:137139154..137168756
AA seq 938 aa
MSTMRLLTLALLFSCSVARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
NT seq 2817 nt   +upstreamnt  +downstreamnt
atgagcaccatgcgcctgctgacgctcgccctgctgttctcctgctccgtcgcccgtgcc
gcgtgcgaccccaagatcgtcaacattggcgcggtgctgagcacgcggaagcacgagcag
atgttccgcgaggccgtgaaccaggccaacaagcggcacggctcctggaagattcagctc
aatgccacctccgtcacgcacaagcccaacgccatccagatggctctgtcggtgtgcgag
gacctcatctccagccaggtctacgccatcctagttagccatccacctacccccaacgac
cacttcactcccacccctgtctcctacacagccggcttctaccgcatacccgtgctgggg
ctgaccacccgcatgtccatctactcggacaagagcatccacctgagcttcctgcgcacc
gtgccgccctactcccaccagtccagcgtgtggtttgagatgatgcgtgtctacagctgg
aaccacatcatcctgctggtcagcgacgaccacgagggccgggcggctcagaaacgcctg
gagacgctgctggaggagcgtgagtccaaggcagagaaggtgctgcagtttgacccaggg
accaagaacgtgacggccctgctgatggaggcgaaagagctggaggcccgggtcatcatc
ctttctgccagcgaggacgatgctgccactgtataccgcgcagccgcgatgctgaacatg
acgggctccgggtacgtgtggctggtcggcgagcgcgagatctcggggaacgccctgcgc
tacgccccagacggcatcctcgggctgcagctcatcaacggcaagaacgagtcggcccac
atcagcgacgccgtgggcgtggtggcccaggccgtgcacgagctcctcgagaaggagaac
atcaccgacccgccgcggggctgcgtgggcaacaccaacatctggaagaccgggccgctc
ttcaagagagtgctgatgtcttccaagtatgcggatggggtgactggtcgcgtggagttc
aatgaggatggggaccggaagttcgccaactacagcatcatgaacctgcagaaccgcaag
ctggtgcaagtgggcatctacaatggcacccacgtcatccctaatgacaggaagatcatc
tggccaggcggagagacagagaagcctcgagggtaccagatgtccaccagactgaagatt
gtgacgatccaccaggagcccttcgtgtacgtcaagcccacgctgagtgatgggacatgc
aaggaggagttcacagtcaacggcgacccagtcaagaaggtgatctgcaccgggcccaac
gacacgtcgccgggcagcccccgccacacggtgcctcagtgttgctacggcttttgcatc
gacctgctcatcaagctggcacggaccatgaacttcacctacgaggtgcacctggtggca
gatggcaagttcggcacacaggagcgggtgaacaacagcaacaagaaggagtggaatggg
atgatgggcgagctgctcagcgggcaggcagacatgatcgtggcgccgctaaccataaac
aacgagcgcgcgcagtacatcgagttttccaagcccttcaagtaccagggcctgactatt
ctggtcaagaaggagattccccggagcacgctggactcgttcatgcagccgttccagagc
acactgtggctgctggtggggctgtcggtgcacgtggtggccgtgatgctgtacctgctg
gaccgcttcagccccttcggccggttcaaggtgaacagcgaggaggaggaggaggacgca
ctgaccctgtcctcggccatgtggttctcctggggcgtcctgctcaactccggcatcggg
gaaggcgcccccagaagcttctcagcgcgcatcctgggcatggtgtgggccggctttgcc
atgatcatcgtggcctcctacaccgccaacctggcggccttcctggtgctggaccggccg
gaggagcgcatcacgggcatcaacgaccctcggctgaggaacccctcggacaagtttatc
tacgccacggtgaagcagagctccgtggatatctacttccggcgccaggtggagctgagc
accatgtaccggcatatggagaagcacaactacgagagtgcggcggaggccatccaggcc
gtgagagacaacaagctgcatgccttcatctgggactcggcggtgctggagttcgaggcc
tcgcagaagtgcgacctggtgacgactggagagctgtttttccgctcgggcttcggcata
ggcatgcgcaaagacagcccctggaagcagaacgtctccctgtccatcctcaagtcccac
gagaatggcttcatggaagacctggacaagacgtgggttcggtatcaggaatgtgactcg
cgcagcaacgcccctgcgacccttacttttgagaacatggccggggtcttcatgctggta
gctgggggcatcgtggccgggatcttcctgattttcatcgagattgcctacaagcggcac
aaggatgctcgccggaagcagatgcagctggcctttgccgccgttaacgtgtggcggaag
aacctgcaggatagaaagagtggtagagcagagcctgaccctaaaaagaaagccacattt
agggctatcacctccaccctggcttccagcttcaagaggcgtaggtcctccaaagacacg
agcaccgggggtggacgcggcgctttgcaaaaccaaaaagacacagtgctgccgcgacgc
gctattgagagggaggagggccagctgcagctgtgttcccgtcatagggagagctga

KEGG   Homo sapiens (human): 2903
Entry
2903              CDS       T01001                                 
Symbol
GRIN2A, EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2A
  KO
K05209  glutamate receptor ionotropic, NMDA 2A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
hsa05322  Systemic lupus erythematosus
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01880  GRM1/5-interacting scaffold proteins
Disease
H01514  Landau-Kleffner syndrome
H01827  Rolandic epilepsy, mental retardation, and speech dyspraxia
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    2903 (GRIN2A)
   04015 Rap1 signaling pathway
    2903 (GRIN2A)
   04020 Calcium signaling pathway
    2903 (GRIN2A)
   04024 cAMP signaling pathway
    2903 (GRIN2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2903 (GRIN2A)
   04082 Neuroactive ligand signaling
    2903 (GRIN2A)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2903 (GRIN2A)
   04728 Dopaminergic synapse
    2903 (GRIN2A)
   04720 Long-term potentiation
    2903 (GRIN2A)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2903 (GRIN2A)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2903 (GRIN2A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2903 (GRIN2A)
   05014 Amyotrophic lateral sclerosis
    2903 (GRIN2A)
   05017 Spinocerebellar ataxia
    2903 (GRIN2A)
   05020 Prion disease
    2903 (GRIN2A)
   05022 Pathways of neurodegeneration - multiple diseases
    2903 (GRIN2A)
  09165 Substance dependence
   05030 Cocaine addiction
    2903 (GRIN2A)
   05031 Amphetamine addiction
    2903 (GRIN2A)
   05033 Nicotine addiction
    2903 (GRIN2A)
   05034 Alcoholism
    2903 (GRIN2A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2903 (GRIN2A)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2903 (GRIN2A)
SSDB
Motif
Pfam: NMDAR2_C Lig_chan Lig_chan-Glu_bd ANF_receptor SBP_bac_3
Other DBs
NCBI-GeneID: 2903
NCBI-ProteinID: NP_000824
OMIM: 138253
HGNC: 4585
Ensembl: ENSG00000183454
UniProt: Q12879 Q547U9
Structure
LinkDB
Position
16:complement(9753404..10182908)
AA seq 1464 aa
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV
NT seq 4395 nt   +upstreamnt  +downstreamnt
atgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggt
ccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctg
ggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcg
gcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaag
agcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgttt
ggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacacc
ttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccg
acgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaag
atcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctac
agggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatg
cagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaag
aagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctg
agtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttg
gtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcc
tacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaacc
accgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgc
tacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaat
gttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccagg
ctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaac
catacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgag
ccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaa
gacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtc
aaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgc
attgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtg
accaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtg
gtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaa
gtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagt
aatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatg
atgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagc
cctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttaca
attggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccag
aatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcata
ttcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggac
caagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccacctttt
cgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctac
atgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctg
aaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctggg
agggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggt
tatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgctt
cagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgc
cacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgta
ttctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctc
ttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctc
ttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaag
aagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtca
gccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaaga
gctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaat
ttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatg
aacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattc
cagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtg
agcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattcc
atacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagag
aataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgac
atttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccac
aaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgag
gtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactata
gatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgacc
ctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaag
ggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaac
aacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcac
agtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaac
atgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctg
cggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacaggtaaccca
gccaccggggagcaggtctaccagcaggactgggcacagaacaatgcccttcaattacaa
aagaacaagctaaggattagccgtcagcattcctacgataacattgtcgacaaacctagg
gagctagaccttagcaggccctcccggagcataagcctcaaggacagggaacggcttctg
gagggaaatttttacggcagcctgtttagtgtcccctcaagcaaactctcggggaaaaaa
agctcccttttcccccaaggtctggaggacagcaagaggagcaagtctctcttgccagac
cacacctccgataaccctttcctccactcccacagggatgaccaacgcttggttattggg
agatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctat
cttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaat
gatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactct
acccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatc
gaatctgatgtttaa

KEGG   Homo sapiens (human): 2905
Entry
2905              CDS       T01001                                 
Symbol
GRIN2C, GluN2C, NMDAR2C, NR2C
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2C
  KO
K05211  glutamate receptor ionotropic, NMDA 2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01880  GRM1/5-interacting scaffold proteins
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2905 (GRIN2C)
   04024 cAMP signaling pathway
    2905 (GRIN2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2905 (GRIN2C)
   04082 Neuroactive ligand signaling
    2905 (GRIN2C)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2905 (GRIN2C)
   04720 Long-term potentiation
    2905 (GRIN2C)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2905 (GRIN2C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2905 (GRIN2C)
   05014 Amyotrophic lateral sclerosis
    2905 (GRIN2C)
   05017 Spinocerebellar ataxia
    2905 (GRIN2C)
   05020 Prion disease
    2905 (GRIN2C)
   05022 Pathways of neurodegeneration - multiple diseases
    2905 (GRIN2C)
  09165 Substance dependence
   05030 Cocaine addiction
    2905 (GRIN2C)
   05031 Amphetamine addiction
    2905 (GRIN2C)
   05033 Nicotine addiction
    2905 (GRIN2C)
   05034 Alcoholism
    2905 (GRIN2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2905 (GRIN2C)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2905 (GRIN2C)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd ANF_receptor SBP_bac_3 NMDAR2_C DUF63
Other DBs
NCBI-GeneID: 2905
NCBI-ProteinID: NP_000826
OMIM: 138254
HGNC: 4587
Ensembl: ENSG00000161509
UniProt: Q14957 A0A8D9PH81 O15398
Structure
LinkDB
Position
17:complement(74842023..74861532)
AA seq 1233 aa
MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
NT seq 3702 nt   +upstreamnt  +downstreamnt
atgggtggggccctggggccggccctgttgctcacctcgctcttcggtgcctgggcaggg
ctgggtccggggcagggcgagcagggcatgacggtggccgtggtgtttagcagctcaggg
ccgccccaggcccagttccgtgcccgcctcaccccccagagcttcctggacctacccctg
gagatccagccgctcacagttggggtcaacaccaccaaccccagcagcctcctcacccag
atctgcggcctcctgggtgctgcccacgtccacggcattgtctttgaggacaacgtggac
accgaggcggtggcccagatccttgacttcatctcctcccagacccatgtgcccatcctc
agcatcagcggaggctctgctgtggtcctcacccccaaggagccgggctccgccttcctg
cagctgggcgtgtccctggagcagcagctgcaggtgctgttcaaggtgctggaagagtac
gactggagcgccttcgccgtcatcaccagcctgcacccgggccacgcgctcttcctggag
ggcgtgcgcgccgtcgccgacgccagccacgtgagttggcggctgctggacgtggtcacg
ctggagctgggcccgggagggccgcgcgcgcgcacgcagcgcctgctgcgccagctcgac
gcgcccgtgtttgtggcctactgctcgcgcgaggaggccgaggtgctcttcgccgaggcg
gcgcaggccggtctggtggggcccggccacgtgtggctggtgcccaacctggcgctgggc
agcaccgatgcgccccccgccaccttccccgtgggcctcatcagcgtcgtcaccgagagc
tggcgcctcagcctgcgccagaaggtgcgcgacggcgtggccattctggccctgggcgcc
cacagctactggcgccagcatggaaccctgccagccccggccggggactgccgtgttcac
cctgggcccgtcagccctgcccgggaggccttctacaggcacctactgaatgtcacctgg
gagggccgagacttctccttcagccctggtgggtacctggtccagcccaccatggtggtg
atcgccctcaaccggcaccgcctctgggagatggtggggcgctgggagcatggcgtccta
tacatgaagtaccccgtgtggcctcgctacagtgcctctctgcagcctgtggtggacagt
cggcacctgacggtggccacgctggaagagcggccctttgtcatcgtggagagccctgac
cctggcacaggaggctgtgtccccaacaccgtgccctgccgcaggcagagcaaccacacc
ttcagcagcggggacgtggccccctacaccaagctctgctgtaagggattctgcatcgac
atcctcaagaagctggccagagtggtcaaattctcctacgacctgtacctggtgaccaac
ggcaagcatggcaagcgggtgcgcggcgtatggaacggcatgattggggaggtgtactac
aagcgggcagacatggccatcggctccctcaccatcaatgaggaacgctccgagatcgta
gacttctctgtaccctttgtggagacgggcatcagtgtgatggtggctcgcagcaatggc
accgtctccccctcggccttcttggagccatatagccctgcagtgtgggtgatgatgttt
gtcatgtgcctcactgtggtggccatcaccgtcttcatgttcgagtacttcagccctgtc
agctacaaccagaacctcaccagaggcaagaagtccgggggcccagctttcactatcggc
aagtccgtgtggctgctgtgggcgctggtcttcaacaactcagtgcccatcgagaacccg
cggggcaccaccagcaagatcatggttctggtctgggccttctttgctgtcatcttcctc
gccagctacacggccaacctggccgccttcatgatccaagagcaatacatcgacactgtg
tcgggcctcagtgacaagaagtttcagcggcctcaagatcagtacccacctttccgcttc
ggcacggtgcccaacggcagcacggagcggaacatccgcagtaactaccgtgacatgcac
acccacatggtcaagttcaaccagcgctcggtggaggacgcgctcaccagcctcaagatg
gggaagctggatgccttcatctatgatgctgctgtcctcaactacatggcaggcaaggac
gagggctgcaagctggtcaccattgggtctggcaaggtctttgctaccactggctacggc
atcgccatgcagaaggactcccactggaagcgggccatagacctggcgctcttgcagttc
ctgggggacggagagacacagaaactggagacagtgtggctctcagggatctgccagaat
gagaagaacgaggtgatgagcagcaagctggacatcgacaacatggcaggcgtcttctac
atgctgctggtggccatggggctggccctgctggtcttcgcctgggagcacctggtctac
tggaagctgcgccactcggtgcccaactcatcccagctggacttcctgctggctttcagc
aggggcatctacagctgcttcagcggggtgcagagcctcgccagcccaccgcggcaggcc
agcccggacctcacggccagctcggcccaggccagcgtgctcaagatgctgcaggcagcc
cgcgacatggtgaccacggcgggcgtaagcagctccctggaccgcgccactcgcaccatc
gagaattggggtggcggccgccgtgcgcccccaccgtccccctgcccgaccccgcggtct
ggccccagcccatgcctgcccacccccgacccgcccccagagccgagccccacgggctgg
ggaccgccagacgggggtcgcgcggcgcttgtgcgcagggctccgcagcccccgggccgc
cccccgacgccggggccgcccctgtccgacgtctcccgagtgtcgcgccgcccagcctgg
gaggcgcggtggccggtgcggaccgggcactgcgggaggcacctctcggcctccgagcgg
cccctgtcgcccgcgcgctgtcactacagctcctttcctcgagccgaccgatccggccgc
cccttcctcccgctcttcccggagctggaggacctgccgctgctcggtccggagcagctg
gcccggcgggaggccctgctgcacgcggcctgggcccggggctcgcgcccgcgtcacgct
tccctgcccagctccgtggccgaggccttcgctcggcccagctcgctgcccgctgggtgc
accggccccgcctgcgcccgccccgacggccactcggcctgcaggcgcttggcgcaggcg
cagtcgatgtgcttgccgatctaccgggaggcctgccaggagggcgagcaggcaggggcc
cccgcctggcagcacagacagcacgtctgcctgcacgcccacgcccacctgccattttgc
tggggggctgtctgtcctcaccttccaccctgtgccagccacggctcctggctctccggg
gcctgggggcctctggggcacaggggcaggactctggggctgggcacaggctacagagac
agtgggggactggacgagatcagcagggtagcccgtgggacgcaaggcttcccgggaccc
tgcacctggagacggatctccagtctggagtcagaagtgtga

KEGG   Homo sapiens (human): 2906
Entry
2906              CDS       T01001                                 
Symbol
GRIN2D, DEE46, EB11, EIEE46, GluN2D, NMDAR2D, NR2D
Name
(RefSeq) glutamate ionotropic receptor NMDA type subunit 2D
  KO
K05212  glutamate receptor ionotropic, NMDA 2D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04713  Circadian entrainment
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05033  Nicotine addiction
hsa05034  Alcoholism
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N00970  Transport of calcium
N00971  Mutation-caused aberrant PDYN to transport of calcium
N00987  Mutation-caused aberrant Htt to transport of calcium
N01003  Mutation-caused aberrant Abeta to transport of calcium
N01200  Scrapie conformation PrPSc to transport of calcium
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01880  GRM1/5-interacting scaffold proteins
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Acamprosate (DG00996): D02780<JP/US> D07058
Amantadine (DG00860): D00777<JP/US> D07441
Apimostinel: D11299
Aptiganel hydrochloride: D02973
Budipine (DG00866): D07306 D07589
Dalzanemdor: D12788
Delucemine hydrochloride: D03679
Dextromethorphan (DG01078): D00848<JP> D03742 D03744
Dextrorphan hydrochloride: D03746
Dizocilpine maleate: D03878
Esketamine (DG01829): D07283 D10627<US>
Esmethadone  
Dextromethadone (DG03176): D12214 D12215
Felbamate: D00536<US>
Gavestinel: D04308
Ketamine (DG00796): D00711<JP/US> D08098
Latrepirdine (DG01379): D09917 D09918
Levomethadone (DG01002): D08121 D08122
Licostinel: D04728
Memantine (DG00986): D04905<JP/US> D08174
Methadone (DG00999): D02102<JP/US> D08195
Nevadistinel: D12553
Orphenadrine (DG01252): D08305
Orphenadrine (chloride): D02599
Orphenadrine (citrate): D00774<US>
Perzinfotel: D05447
Phencyclidine hydrochloride: D05453
Remacemide hydrochloride: D05714
Riluzole: D00775<JP/US>
Risevistinel: D12554
Selfotel: D02410
Tenocyclidine: D12702
Tiletamine (DG01380): D06146 D08596
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    2906 (GRIN2D)
   04024 cAMP signaling pathway
    2906 (GRIN2D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2906 (GRIN2D)
   04082 Neuroactive ligand signaling
    2906 (GRIN2D)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2906 (GRIN2D)
   04720 Long-term potentiation
    2906 (GRIN2D)
  09159 Environmental adaptation
   04713 Circadian entrainment
    2906 (GRIN2D)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    2906 (GRIN2D)
   05014 Amyotrophic lateral sclerosis
    2906 (GRIN2D)
   05017 Spinocerebellar ataxia
    2906 (GRIN2D)
   05020 Prion disease
    2906 (GRIN2D)
   05022 Pathways of neurodegeneration - multiple diseases
    2906 (GRIN2D)
  09165 Substance dependence
   05030 Cocaine addiction
    2906 (GRIN2D)
   05031 Amphetamine addiction
    2906 (GRIN2D)
   05033 Nicotine addiction
    2906 (GRIN2D)
   05034 Alcoholism
    2906 (GRIN2D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2906 (GRIN2D)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2906 (GRIN2D)
SSDB
Motif
Pfam: Lig_chan Lig_chan-Glu_bd ANF_receptor SBP_bac_3 SH3_YKFC_2nd NMDAR2_C
Other DBs
NCBI-GeneID: 2906
NCBI-ProteinID: NP_000827
OMIM: 602717
HGNC: 4588
Ensembl: ENSG00000105464
UniProt: O15399 Q59G17
Structure
LinkDB
Position
19:48393668..48444931
AA seq 1336 aa
MRGAGGPRGPRGPAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGP
AYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDD
SRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLE
EYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVS
AQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPL
PAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESL
HRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG
RFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPE
KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSL
TINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVT
VFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVL
VWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK
NIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGS
GKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKL
DIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAE
AAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADG
FHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPP
AGAFPGFPSPPAPPAAAATAVGPPLCRLAFEDESPPAPARWPRSDPESQPLLGPGAGGAG
GTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYP
YAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHD
GLDGGWWAPPPPPWAAGPLPRRRARCGCPRSHPHRPRASHRTPAAAAPHHHRHRRAAGGW
DLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDL
GTRRGSAHFSSLESEV
NT seq 4011 nt   +upstreamnt  +downstreamnt
atgcgcggcgccggtggcccccgcggccctcggggccccgctaagatgctgctgctgctg
gcgctggcctgcgccagcccgttcccggaggaggcgccggggccgggcggggccggtggg
cccggcggcggcctcggcggggcgcggccgctcaacgtggcgctcgtgttctcggggccc
gcgtacgcggccgaggcggcacgcctgggcccggccgtggcggcggcggtgcgcagcccg
ggcctagacgtgcggcccgtggcgctggtgctcaacggctcggacccgcgcagcctcgtg
ctgcagctctgcgacctgctgtcggggttgcgcgtgcacggcgtggtcttcgaagacgac
tcgcgcgcgcccgccgtcgcgcccatcctcgacttcctgtcggcgcagacctcgctgccc
atcgtggccgtgcacggcggcgccgcgctcgtgctcacgcccaaggagaagggctccacc
ttcctgcagctgggctcttccaccgagcaacagcttcaggtcatctttgaggtgctggag
gagtatgactggacgtcctttgtagccgtgaccactcgtgcccctggccaccgggccttc
ctgtcctacattgaggtgctgactgacggtagtctggtgggctgggagcaccgcggagcg
ctgacgctggaccctggggcgggcgaggccgtgctcagtgcccagctccgcagtgtcagc
gcgcagatccgcctgctcttctgcgcccgagaggaggccgagcccgtgttccgcgcagct
gaggaggctggcctcactggatctggctacgtctggttcatggtggggccccagctggct
ggaggcgggggctctggggcccctggtgagccccctcttctgccaggaggcgcccccctg
cctgccgggctgtttgcagtgcgctcggctggctggcgggatgacctggctcggcgagtg
gcagctggcgtggccgtagtggccagaggtgcccaggccctgctgcgtgattatggtttc
cttcctgagctcggccacgactgtcgcgcccagaaccgcacccaccgcggcgagagtctg
cataggtacttcatgaacatcacgtgggataaccgggattactccttcaatgaggacggc
ttcctagtgaacccctccctggtggtcatctccctcaccagagacaggacgtgggaggtg
gtgggcagctgggagcagcagacgctccgcctcaagtacccgctgtggtcccgctatggt
cgcttcctgcagccagtggacgacacgcagcacctcacggtggccacgctggaggaaagg
ccgtttgtcatcgtggagcctgcagaccctatcagcggcacctgcatccgagactccgtc
ccctgccggagccagctcaaccgaacccacagccctccaccggatgccccccgcccggaa
aagcgctgctgcaagggtttctgcatcgacattctgaagcggctggcgcataccatcggc
ttcagctacgacctctacctggtcaccaatggcaagcacggaaagaagatcgatggcgtc
tggaacggcatgatcggggaggtgttctaccagcgcgcagacatggccatcggctccctc
accatcaacgaggagcgctccgagatcgtggacttctccgtccccttcgtggagaccggc
atcagcgtcatggtggcgcgcagcaatggcacggtgtccccctcggccttcctcgagccc
tacagccccgccgtgtgggtgatgatgttcgtcatgtgcctcactgtggtcgccgtcact
gttttcatcttcgagtacctcagtcctgttggttacaaccgcagcctggccacgggcaag
cgccctggcggttcaaccttcaccattgggaaatccatctggctgctctgggccctggtg
ttcaataattcggtgcccgtggagaacccccggggaaccaccagcaaaatcatggtgctg
gtgtgggccttcttcgccgtcatcttcctcgccagctacacagccaacctggccgccttc
atgatccaggaggagtacgtggatactgtgtctgggctcagtgaccgcaagttccagagg
ccccaggagcagtacccgcccctgaagtttgggaccgtgcccaacggctccacggagaag
aacatccgcagcaactatcccgacatgcacagctacatggtgcgctacaaccagccccgc
gtagaggaagcgctcactcagctcaaggcagggaagctggacgccttcatctacgatgct
gcagtgctcaattacatggcccgcaaggacgagggctgcaagcttgtcaccatcggctcc
ggcaaggtcttcgccacgacaggctatggcatcgccctgcacaagggctcccgctggaag
cggcccatcgacctggcgttgctgcagttcctgggggatgatgagatcgagatgctggag
cggctgtggctctctgggatctgccacaatgacaaaatcgaggtgatgagcagcaagctg
gacatcgacaacatggcgggcgtcttctacatgctcctggtggccatgggcctgtccctg
ctggtcttcgcctgggagcacctggtgtactggcgcctgcggcactgcctggggcccacc
caccgcatggacttcctgctggccttctccaggggcatgtacagctgctgcagcgctgag
gccgccccaccgcccgccaagcccccgccgccgccacagcccctgcccagccccgcgtac
cccgcgccgcggccggctcccgggcccgcacctttcgtgccccgcgagcgcgcctcagtg
gaccgctggcgccggaccaagggcgcggggccgccggggggcgcgggcctggccgacggc
ttccaccgctactacggccccatcgagccgcagggcctaggcctcggcctgggcgaagcg
cgcgcggcaccgcggggcgcagccgggcgcccgctgtccccgccggccgctcagcccccg
cagaagccgccgccctcctatttcgccatcgtacgcgacaaggagccagccgagcccccc
gccggcgccttccccggcttcccgtcgccgcccgcgccccccgccgccgcggccaccgcc
gtcgggccgccactctgccgcttggccttcgaggacgagagcccgccggcgcccgcgcgg
tggccgcgctcggaccccgagagccaacccctgctggggccaggcgcgggcggcgcgggg
ggcacggggggcgcaggcggaggagccccggccgctccgcccccgtgccgcgccgcgccg
cccccgtgcccttacctcgatctcgagccgtcgccgtcggactcggaggactcggagagc
ctgggcggcgcgtcgctgggcggcctggagccctggtggttcgccgacttcccttacccg
tatgccgagcgcctcgggccgccgcccggccgctactggtcggtcgacaagctcgggggc
tggcgcgccgggagctgggactacctgcccccgcgcagcggtccggccgcctggcactgt
cggcactgcgccagcctggagctgctgccgccgccgcgccatctcagctgctcgcacgat
ggcctggacggcggctggtgggcgccaccgcctccaccctgggccgccgggcccctgccc
cgacgccgggcccgctgcgggtgcccgcggtcgcacccgcaccgcccgcgggcctcgcac
cgcacgcccgccgccgccgcgccccaccaccacaggcaccggcgcgccgctgggggctgg
gacctcccgccgcccgcgcccacctcgcgctcgctcgaggacctcagctcgtgccctcgc
gccgcccctgcgcgcaggcttaccgggccctcccgccacgctcgcaggtgtccgcacgcc
gcgcactgggggccgccgctgcccacagcttcccaccggagacaccggggcggggacctg
ggcacccgcaggggctcggcgcacttctctagcctcgagtccgaggtatga

KEGG   Homo sapiens (human): 5023
Entry
5023              CDS       T01001                                 
Symbol
P2RX1, P2X1
Name
(RefSeq) purinergic receptor P2X 1
  KO
K05215  P2X purinoceptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04611  Platelet activation
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5023 (P2RX1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5023 (P2RX1)
   04082 Neuroactive ligand signaling
    5023 (P2RX1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5023 (P2RX1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5023 (P2RX1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5023 (P2RX1)
SSDB
Motif
Pfam: P2X_receptor MASE11
Other DBs
NCBI-GeneID: 5023
NCBI-ProteinID: NP_002549
OMIM: 600845
HGNC: 8533
Ensembl: ENSG00000108405
UniProt: P51575
Structure
LinkDB
Position
17:complement(3896592..3916465)
AA seq 399 aa
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
NT seq 1200 nt   +upstreamnt  +downstreamnt
atggcacggcggttccaggaggagctggccgccttcctcttcgagtatgacaccccccgc
atggtgctggtgcgtaataagaaggtgggcgttatcttccgactgatccagctggtggtc
ctggtctacgtcatcgggtgggtgtttctctatgagaagggctaccagacctcgagcggc
ctcatcagcagtgtctctgtgaaactcaagggcctggccgtgacccagctccctggcctc
ggcccccaggtctgggatgtggctgactacgtcttcccagcccagggggacaactccttc
gtggtcatgaccaatttcatcgtgaccccgaagcagactcaaggctactgcgcagagcac
ccagaagggggcatatgcaaggaagacagtggctgtacccctgggaaggccaagaggaag
gcccaaggcatccgcacgggcaagtgtgtggccttcaacgacactgtgaagacgtgtgag
atctttggctggtgccccgtggaggtggatgacgacatcccgcgccctgcccttctccga
gaggccgagaacttcactcttttcatcaagaacagcatcagctttccacgcttcaaggtc
aacaggcgcaacctggtggaggaggtgaatgctgcccacatgaagacctgcctctttcac
aagaccctgcaccccctgtgcccagtcttccagcttggctacgtggtgcaagagtcaggc
cagaacttcagcaccctggctgagaagggtggagtggttggcatcaccatcgactggcac
tgtgacctggactggcacgtacggcactgcagacccatctatgagttccatgggctgtac
gaagagaaaaatctctccccaggcttcaacttcaggtttgccaggcactttgtggagaac
gggaccaactaccgtcacctcttcaaggtgtttgggattcgctttgacatcctggtggac
ggcaaggccgggaagtttgacatcatccctacaatgaccaccatcggctctggaattggc
atctttggggtggccacagttctctgtgacctgctgctgcttcacatcctgcctaagagg
cactactacaagcagaagaagttcaaatacgctgaggacatggggccaggggcggctgag
cgtgacctcgcagctaccagctccaccctgggcctgcaggagaacatgaggacatcctga

KEGG   Homo sapiens (human): 22953
Entry
22953             CDS       T01001                                 
Symbol
P2RX2, DFNA41, P2X2
Name
(RefSeq) purinergic receptor P2X 2
  KO
K05216  P2X purinoceptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04742  Taste transduction
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    22953 (P2RX2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    22953 (P2RX2)
   04082 Neuroactive ligand signaling
    22953 (P2RX2)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    22953 (P2RX2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    22953 (P2RX2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   22953 (P2RX2)
SSDB
Motif
Pfam: P2X_receptor WAP
Other DBs
NCBI-GeneID: 22953
NCBI-ProteinID: NP_733782
OMIM: 600844
HGNC: 15459
Ensembl: ENSG00000187848
UniProt: Q9UBL9 Q32MC3
LinkDB
Position
12:132618776..132622388
AA seq 471 aa
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV
FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ
TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED
GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK
LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN
FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD
WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG
QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
NT seq 1416 nt   +upstreamnt  +downstreamnt
atggccgccgcccagcccaagtaccccgccggggcgaccgcccggcgcctggcccggggc
tgctggtccgccctctgggactacgagacgcccaaggtgatcgtggtgaggaaccggcgc
ctgggggtcctgtaccgcgccgtgcagctgctcatcctgctctacttcgtgtggtacgta
ttcatcgtgcagaaaagctaccaggagagcgagacgggccccgagagctccatcatcacc
aaggtcaaggggatcaccacgtccgagcacaaagtgtgggacgtggaggagtacgtgaag
ccccccgaggggggcagcgtgttcagcatcatcaccagggtcgaggccacccactcccag
acccagggaacctgccccgagagcataagggtccacaacgccacctgcctctccgacgcc
gactgcgtggctggggagctggacatgctgggaaacggcctgaggactgggcgctgtgtg
ccctattaccaggggccctccaagacctgcgaggtgttcggctggtgcccggtggaagat
ggggcctctgtcagccaatttctgggtacgatggccccaaatttcaccatcctcatcaag
aacagcatccactaccccaaattccacttctccaagggcaacatcgccgaccgcacagac
gggtacctgaagcgctgcacgttccacgaggcctccgacctctactgccccatcttcaag
ctgggctttatcgtggagaaggctggggagagcttcacagagctcgcacacaagggtggt
gtcatcggggtcattatcaactgggactgtgacctggacctgcctgcatcggagtgcaac
cccaagtactccttccggaggcttgaccccaagcacgtgcctgcctcgtcaggctacaac
ttcaggtttgccaaatactacaagatcaatggcaccaccacccgcacgctcatcaaggcc
tacgggatccgcattgacgtcattgtgcatggacaggccgggaagttcagcctgattccc
accattattaatctggccacagctctgacttccgtcggggtgggctccttcctgtgcgac
tggatcttgctaacattcatgaacaaaaacaaggtctacagccataagaaatttgacaag
gtgtgtacgccgagccacccctcaggtagctggcctgtgacccttgcccgtgtattgggc
caggcccctcccgaacccggccaccgctccgaggaccagcaccccagccctccatcaggc
caggagggccaacaaggggcagagtgtggcccagccttcccgcccctgcggccttgcccc
atctctgccccttctgagcagatggtggacactcctgcctccgagcctgcccaagcctcc
acacccacagaccccaaaggtttggctcaactctga

KEGG   Homo sapiens (human): 5024
Entry
5024              CDS       T01001                                 
Symbol
P2RX3, P2X3
Name
(RefSeq) purinergic receptor P2X 3
  KO
K05217  P2X purinoceptor 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04742  Taste transduction
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Drug target
Camlipixant: D12785
Eliapixant: D12323
Gefapixant (DG03083): D11349 D11693<JP>
Sivopixant: D12355
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5024 (P2RX3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5024 (P2RX3)
   04082 Neuroactive ligand signaling
    5024 (P2RX3)
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    5024 (P2RX3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5024 (P2RX3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5024 (P2RX3)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5024
NCBI-ProteinID: NP_002550
OMIM: 600843
HGNC: 8534
Ensembl: ENSG00000109991
UniProt: P56373
Structure
LinkDB
Position
11:57335950..57372396
AA seq 397 aa
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
NT seq 1194 nt   +upstreamnt  +downstreamnt
atgaactgcatatccgacttcttcacctatgagaccaccaagtcggtggttgtgaagagc
tggaccatcgggatcatcaaccgagtagttcagcttctgatcatctcctactttgtaggg
tgggttttcttgcacgagaaggcttaccaggtacgggacacagccattgagtcctcggtg
gtaaccaaggtgaagggctccggactctacgccaacagagtcatggatgtgtctgattac
gtgacgccacctcagggcacctcggtctttgtcatcatcaccaagatgattgttactgaa
aatcagatgcaaggattctgcccagagagtgaggagaaataccgctgtgtatcagacagc
cagtgcgggcctgagcgcttgccaggtggggggatcctcactggccgctgcgtgaactac
agctctgtgctccggacctgtgagatccagggctggtgccccacggaggtggacacagtg
gaaacgcccatcatgatggaagctgagaacttcactattttcatcaagaacagcatccgt
ttccccctcttcaactttgagaagggaaacctccttcccaacctgacagccagggacatg
aagacctgccgcttccacccggacaaggaccctttctgccccatcttgcgggtaggggac
gtggtcaagtttgcggggcaggattttgccaaactggcgcgcacggggggagttctgggc
attaagatcggctgggtgtgcgacttggacaaggcctgggaccagtgcatccccaaatac
tccttcacccggctcgacagcgtttctgagaaaagcagcgtgtccccaggctacaacttc
aggtttgccaagtactacaaaatggaaaatggcagtgagtaccgcaccctcctgaaggct
tttggcatccgcttcgacgtgctggtatacgggaatgctggcaagttcaacatcatcccc
accatcatcagctctgtggcggcctttacttctgtgggagtgggaactgttctctgtgac
atcatcctgctcaacttcctcaagggggccgaccagtacaaagccaagaagtttgaggag
gtgaatgagactacgctgaaaatcgcggctttgaccaacccagtgtaccccagcgaccag
accacagcggagaagcagtccaccgattcgggggccttctccataggccactag

KEGG   Homo sapiens (human): 5025
Entry
5025              CDS       T01001                                 
Symbol
P2RX4, P2X4, P2X4R
Name
(RefSeq) purinergic receptor P2X 4
  KO
K05218  P2X purinoceptor 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5025 (P2RX4)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5025 (P2RX4)
   04082 Neuroactive ligand signaling
    5025 (P2RX4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5025 (P2RX4)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5025 (P2RX4)
SSDB
Motif
Pfam: P2X_receptor DUF3624
Other DBs
NCBI-GeneID: 5025
NCBI-ProteinID: NP_002551
OMIM: 600846
HGNC: 8535
Ensembl: ENSG00000135124
UniProt: Q99571
Structure
LinkDB
Position
12:121210129..121234106
AA seq 388 aa
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
NT seq 1167 nt   +upstreamnt  +downstreamnt
atggcgggctgctgcgccgcgctggcggccttcctgttcgagtacgacacgccgcgcatc
gtgctcatccgcagccgcaaagtggggctcatgaaccgcgccgtgcaactgctcatcctg
gcctacgtcatcgggtgggtgtttgtgtgggaaaagggctaccaggaaactgactccgtg
gtcagctccgttacgaccaaggtcaagggcgtggctgtgaccaacacttctaaacttgga
ttccggatctgggatgtggcggattatgtgataccagctcaggaggaaaactccctcttc
gtcatgaccaacgtgatcctcaccatgaaccagacacagggcctgtgccccgagattcca
gatgcgaccactgtgtgtaaatcagatgccagctgtactgccggctctgccggcacccac
agcaacggagtctcaacaggcaggtgcgtagctttcaacgggtctgtcaagacgtgtgag
gtggcggcctggtgcccggtggaggatgacacacacgtgccacaacctgcttttttaaag
gctgcagaaaacttcactcttttggttaagaacaacatctggtatcccaaatttaatttc
agcaagaggaatatccttcccaacatcaccactacttacctcaagtcgtgcatttatgat
gctaaaacagatcccttctgccccatattccgtcttggcaaaatagtggagaacgcagga
cacagtttccaggacatggccgtggagggaggcatcatgggcatccaggtcaactgggac
tgcaacctggacagagccgcctccctctgcttgcccaggtactccttccgccgcctcgat
acacgggacgttgagcacaacgtatctcctggctacaatttcaggtttgccaagtactac
agagacctggctggcaacgagcagcgcacgctcatcaaggcctatggcatccgcttcgac
atcattgtgtttgggaaggcagggaaatttgacatcatccccactatgatcaacatcggc
tctggcctggcactgctaggcatggcgaccgtgctgtgtgacatcatagtcctctactgc
atgaagaaaagactctactatcgggagaagaaatataaatatgtggaagattacgagcag
ggtcttgctagtgagctggaccagtga

KEGG   Homo sapiens (human): 5026
Entry
5026              CDS       T01001                                 
Symbol
P2RX5, LRH-1, P2X5, P2X5R
Name
(RefSeq) purinergic receptor P2X 5
  KO
K05219  P2X purinoceptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
Network
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01642  Ca2+ entry, Ligand-gated Ca2+ channel
N01909  Transport of calcium, P2RX
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5026 (P2RX5)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5026 (P2RX5)
   04082 Neuroactive ligand signaling
    5026 (P2RX5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    5026 (P2RX5)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  ATP-gated cation channel (P2X)
   5026 (P2RX5)
SSDB
Motif
Pfam: P2X_receptor
Other DBs
NCBI-GeneID: 5026
NCBI-ProteinID: NP_002552
OMIM: 602836
HGNC: 8536
Ensembl: ENSG00000083454
UniProt: Q93086
LinkDB
Position
17:complement(3673227..3723835)
AA seq 422 aa
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDT
SLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAE
NEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEP
FLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRW
AGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARY
YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDS
SQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR
ST
NT seq 1269 nt   +upstreamnt  +downstreamnt
atggggcaggcgggctgcaaggggctctgcctgtcgctgttcgactacaagaccgagaag
tatgtcatcgccaagaacaagaaggtgggcctgctgtaccggctgctgcaggcctccatc
ctggcgtacctggtcgtatgggtgttcctgataaagaagggttaccaagacgtcgacacc
tccctgcagagtgctgtcatcaccaaagtcaagggcgtggccttcaccaacacctcggat
cttgggcagcggatctgggatgtcgccgactacgtcattccagcccagggagagaacgtc
ttttttgtggtcaccaacctgattgtgacccccaaccagcggcagaacgtctgtgctgag
aatgaaggcattcctgatggcgcgtgctccaaggacagcgactgccacgctggggaagcg
gttacagctggaaacggagtgaagaccggccgctgcctgcggagagagaacttggccagg
ggcacctgtgagatctttgcctggtgcccgttggagacaagctccaggccggaggagcca
ttcctgaaggaggccgaagacttcaccattttcataaagaaccacatccgtttccccaaa
ttcaacttctccaaaagcaatgtgatggacgtcaaggacagatctttcctgaaatcatgc
cactttggccccaagaaccactactgccccatcttccgactgggctccgtgatccgctgg
gccgggagcgacttccaggatatagccctggagggtggcgtgataggaattaatattgaa
tggaactgtgatcttgataaagctgcctctgagtgccaccctcactattcttttagccgt
ctggacaataaactttcaaagtctgtctcctccgggtacaacttcagatttgccagatat
taccgagacgcagccggggtggagttccgcaccctgatgaaagcctacgggatccgcttt
gacgtgatggtgaacggcaagggtgctttcttctgcgacctggtactcatctacctcatc
aaaaagagagagttttaccgtgacaagaagtacgaggaagtgaggggcctagaagacagt
tcccaggaggccgaggacgaggcatcggggctggggctatctgagcagctcacatctggg
ccagggctgctggggatgccggagcagcaggagctgcaggagccacccgaggcgaagcgt
ggaagcagcagtcagaaggggaacggatctgtgtgcccacagctcctggagccccacagg
agcacgtga

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