KEGG   PATHWAY: lcat05146
Entry
lcat05146                   Pathway                                
Name
Amoebiasis - Lemur catta (Ring-tailed lemur)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
lcat05146  Amoebiasis
lcat05146

Disease
H00360  Amoebiasis
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620296  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123620722  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123620954  RAB5C; ras-related protein Rab-5C [KO:K07889]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123621523  SERPINB10; serpin B10 [KO:K13963]
123621578  SERPINB13; serpin B13 isoform X1 [KO:K13963]
123621656  [KO:K06240]
123621682  SERPINB3; serpin B3 [KO:K13963]
123621697  LAMA1; laminin subunit alpha-1 [KO:K05637]
123621827  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
123622057  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622065  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123622308  [KO:K04632]
123622310  [KO:K04632]
123622511  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
123623287  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
123624079  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123624110  [KO:K05505]
123624366  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123624368  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123624520  CXCL8; interleukin-8 [KO:K10030]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123624714  [KO:K05505]
123624715  [KO:K05505]
123625652  RAB7A; LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897]
123626839  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123626869  LAMC2; laminin subunit gamma-2 [KO:K06246]
123626918  LAMB3; laminin subunit beta-3 [KO:K06244]
123627028  LAMC1; laminin subunit gamma-1 [KO:K05635]
123627121  RAB7B; ras-related protein Rab-7b [KO:K07898]
123627137  IL10; interleukin-10 isoform X1 [KO:K05443]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123628143  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
123628302  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630775  [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123631724  TNF; tumor necrosis factor [KO:K03156]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632591  HSPB1; heat shock protein beta-1 [KO:K04455]
123632686  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123633180  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123633252  LAMA2; laminin subunit alpha-2 [KO:K05637]
123633263  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
123633362  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
123633418  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
123634187  [KO:K02649]
123634203  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123635146  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
123635148  [KO:K06448]
123635150  [KO:K06448]
123635152  [KO:K06448]
123635153  [KO:K06448]
123635154  [KO:K06448]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635595  C8B; complement component C8 beta chain [KO:K03998]
123635596  C8A; complement component C8 alpha chain [KO:K03997]
123637166  IL1B; interleukin-1 beta [KO:K04519]
123637265  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
123637267  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
123637744  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637863  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123638007  IL12B; interleukin-12 subunit beta [KO:K05425]
123638172  SERPINB9; serpin B9 [KO:K13963]
123638174  SERPINB6; serpin B6 [KO:K13963]
123638501  TLR2; toll-like receptor 2 [KO:K10159]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123639672  RAB5B; ras-related protein Rab-5B [KO:K07888]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123640661  IFNG; interferon gamma [KO:K04687]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641430  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
123642184  MUC2; mucin-2 [KO:K10955]
123643379  [KO:K06856]
123643441  [KO:K06856]
123643449  [KO:K06856]
123643456  [KO:K06856]
123643464  [KO:K06856]
123643683  COL3A1; collagen alpha-1(III) chain [KO:K19720]
123644039  FN1; fibronectin isoform X1 [KO:K05717]
123644098  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123644099  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123646016  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
123646094  TLR4; toll-like receptor 4 [KO:K10160]
123646097  IL12A; interleukin-12 subunit alpha [KO:K05406]
123646308  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
123646462  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
123646589  LAMC3; laminin subunit gamma-3 [KO:K06247]
123646908  IL6; interleukin-6 [KO:K05405]
123647251  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123647516  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123647643  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
123647710  LAMB4; laminin subunit beta-4 [KO:K06245]
123647712  LAMB1; laminin subunit beta-1 [KO:K05636]
123648483  C9; LOW QUALITY PROTEIN: complement component C9 [KO:K04000]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123649315  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123649345  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123650282  VCL; vinculin isoform X1 [KO:K05700]
123650612  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
lcat00330  Arginine and proline metabolism
lcat00590  Arachidonic acid metabolism
lcat04144  Endocytosis
lcat04210  Apoptosis
lcat04510  Focal adhesion
lcat04610  Complement and coagulation cascades
lcat04612  Antigen processing and presentation
lcat04620  Toll-like receptor signaling pathway
lcat04672  Intestinal immune network for IgA production
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

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