Entry
Name
Cytosolic DNA-sensing pathway - Macaca mulatta (rhesus monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene
100423709 POLR3K; DNA-directed RNA polymerase III subunit RPC10 [KO:K03019 ]
100426798 DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009 ]
100429040 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016 ]
114671810 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009 ]
114677647 DNA-directed RNA polymerases I, II, and III subunit RPABC5-like [KO:K03007 ]
574243 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
694353 TMEM173; stimulator of interferon genes protein [KO:K12654 ]
695330 POLR3G; DNA-directed RNA polymerase III subunit RPC7 isoform X1 [KO:K03024 ]
696943 POLR3C; DNA-directed RNA polymerase III subunit RPC3 isoform X1 [KO:K03023 ]
697901 POLR3E; DNA-directed RNA polymerase III subunit RPC5 isoform X1 [KO:K14721 ]
697927 POLR3F; DNA-directed RNA polymerase III subunit RPC6 [KO:K03025 ]
698563 POLR3GL; DNA-directed RNA polymerase III subunit RPC7-like [KO:K03024 ]
699566 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014 ]
700727 POLR1C; DNA-directed RNA polymerases I and III subunit RPAC1 [KO:K03027 ]
701181 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
701237 IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210 ]
701278 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
707546 POLR3H; DNA-directed RNA polymerase III subunit RPC8 [KO:K03022 ]
707923 POLR3D; DNA-directed RNA polymerase III subunit RPC4 [KO:K03026 ]
708013 RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861 ] [EC:2.7.11.1 ]
708464 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1 [KO:K03009 ]
708606 FADD; FAS-associated death domain protein [KO:K02373 ]
709060 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544 ] [EC:3.1.5.-]
709511 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467 ] [EC:2.7.11.10 ]
710324 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
713563 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
714477 ZCCHC3; zinc finger CCHC domain-containing protein 3 [KO:K27162 ]
715919 RELA; transcription factor p65 isoform X1 [KO:K04735 ]
717616 MAVS; mitochondrial antiviral-signaling protein [KO:K12648 ]
718341 POLR1D; DNA-directed RNA polymerases I and III subunit RPAC2 [KO:K03020 ]
719253 IFI16; gamma-interferon-inducible protein 16 [KO:K20914 ]
719260 AIM2; interferon-inducible protein AIM2 isoform X1 [KO:K12966 ]
721178 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X2 [KO:K03013 ]
Compound
Reference
Authors
Yanai H, Savitsky D, Tamura T, Taniguchi T
Title
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.
Journal
Reference
Authors
Vilaysane A, Muruve DA
Title
The innate immune response to DNA.
Journal
Reference
Authors
Takeshita F, Ishii KJ
Title
Intracellular DNA sensors in immunity.
Journal
Reference
Authors
Takaoka A, Shinohara S
Title
DNA sensors in innate immune system.
Journal
Reference
Authors
Takaoka A, Taniguchi T
Title
Cytosolic DNA recognition for triggering innate immune responses.
Journal
Reference
Authors
Kaiser WJ, Upton JW, Mocarski ES
Title
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.
Journal
Reference
Authors
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J
Title
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Journal
Reference
Authors
Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T
Title
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
Journal
Reference
Authors
Stetson DB, Ko JS, Heidmann T, Medzhitov R
Title
Trex1 prevents cell-intrinsic initiation of autoimmunity.
Journal
Reference
Authors
Schroder K, Muruve DA, Tschopp J
Title
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Journal
Reference
Authors
Krieg AM
Title
AIMing 2 detect foreign DNA.
Journal
Reference
Authors
O'Neill LA
Title
DNA makes RNA makes innate immunity.
Journal
Reference
Authors
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S
Title
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Journal
Reference
Authors
Cao X
Title
New DNA-sensing pathway feeds RIG-I with RNA.
Journal
Reference
Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Journal
Reference
Authors
Gao M, He Y, Tang H, Chen X, Liu S, Tao Y
Title
cGAS/STING: novel perspectives of the classic pathway.
Journal
Reference
Authors
Benjamin P, Sudhakar S, D'Arco F, Lobel U, Carney O, Roux CJ, Boddaert N, Hemingway C, Eleftheriou D, Mankad K
Title
Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies.
Journal
Reference
Authors
Place DE, Lee S, Kanneganti TD
Title
PANoptosis in microbial infection.
Journal
Reference
Authors
Jiang W, Deng Z, Dai X, Zhao W
Title
PANoptosis: A New Insight Into Oral Infectious Diseases.
Journal
Reference
Authors
Wang Y, Kanneganti TD
Title
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.
Journal
Related pathway
mcc04621 NOD-like receptor signaling pathway
mcc04622 RIG-I-like receptor signaling pathway
KO pathway
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