KEGG   PATHWAY: mcc04621
Entry
mcc04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Macaca mulatta (rhesus monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
mcc04621  NOD-like receptor signaling pathway
mcc04621

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100169969  DEFB4; beta-defensin 4A precursor [KO:K21100]
100424064  [KO:K05505]
100424758  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
100425392  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
100425664  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
100426067  PYDC1; LOW QUALITY PROTEIN: pyrin domain-containing protein 1 [KO:K12802]
100426388  [KO:K01370] [EC:3.4.22.36]
100427191  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
106992322  [KO:K05414]
106993454  CARD16; caspase recruitment domain-containing protein 16 isoform X1 [KO:K12806]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
106997578  TRIP6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
114670292  PYDC5; LOW QUALITY PROTEIN: pyrin domain-containing protein 5 [KO:K20916]
114672663  [KO:K05414]
114672664  [KO:K05414]
114675435  [KO:K21100]
114675439  [KO:K21100]
114676064  [KO:K21100]
114680386  [KO:K05230]
114680396  [KO:K21100]
574121  RTD1C; demidefensin-3 precursor [KO:K05230]
574122  RTD1A; rhesus theta defensin-1/3 subunit A precursor [KO:K05230]
574123  RTD1B; rhesus theta defensin-1/2 subunit B precursor [KO:K05230]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
574138  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
574151  IL18; interleukin-18 [KO:K05482]
574178  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
574196  MNP1A; neutrophil defensin 8 precursor [KO:K05230]
574197  MNP2; neutrophil defensin 6 precursor [KO:K05230]
574222  CXCL1; growth-regulated alpha protein precursor [KO:K05505]
574223  CXCL3; C-X-C motif chemokine 3 precursor [KO:K05505]
574294  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
574309  [KO:K05230]
574310  [KO:K05230]
574311  DEFA4; neutrophil defensin 4 precursor [KO:K05230]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
619186  CAMP; cathelicidin antimicrobial peptide precursor [KO:K13916]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
693505  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
694046  SUGT1; protein SGT1 homolog [KO:K12795]
694235  [KO:K23126]
694283  GBP3; guanylate-binding protein 3 [KO:K20899]
694353  TMEM173; stimulator of interferon genes protein [KO:K12654]
694538  [KO:K20899]
694631  [KO:K05414]
694656  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
694684  [KO:K20897]
694801  GBP7; guanylate-binding protein 7 [KO:K20899]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
695388  DNM1L; dynamin-1-like protein isoform X6 [KO:K17065] [EC:3.6.5.5]
695419  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
695542  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
695567  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
695655  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
695781  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
695986  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
696176  PYDC2; pyrin domain-containing protein 2 [KO:K20911]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
696513  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
696542  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
696748  [KO:K08009]
696765  ATG12; LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
696874  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
696875  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
697137  GSDMD; gasdermin-D isoform X1 [KO:K20917]
697204  PANX1; pannexin-1 [KO:K03443]
697398  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform 1 [KO:K20864]
697790  [KO:K10435]
698057  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698609  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
698683  TXNIP; thioredoxin-interacting protein [KO:K20910]
699455  P2RX7; P2X purinoceptor 7 [KO:K05220]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
700429  ERBIN; erbin isoform X1 [KO:K12796]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
700942  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701278  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
701927  MEFV; pyrin [KO:K12803]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
702067  [KO:K05505]
702293  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
702468  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
702592  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
702827  [KO:K08341]
702888  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
703390  [KO:K05505]
703409  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
703669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
703981  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
704130  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
704257  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
704864  CASP4; caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
704964  CASP5; caspase-5 isoform X1 [KO:K04395] [EC:3.4.22.58]
705116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
705157  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
705678  CARD18; caspase recruitment domain-containing protein 18 [KO:K12806]
705819  IL6; interleukin-6 precursor [KO:K05405]
706378  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
706455  RHOA; transforming protein RhoA [KO:K04513]
706487  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
706568  [KO:K01370] [EC:3.4.22.36]
706971  [KO:K12806]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
707439  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
707630  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
708013  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
708327  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
708334  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
708391  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
708431  HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 [KO:K04079]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708714  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709570  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
710045  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
710237  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710464  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
710485  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
710487  [KO:K05414]
710528  [KO:K05414]
710568  [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710751  [KO:K05414]
710848  [KO:K05414]
711088  [KO:K05414]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711414  IFNB1; interferon beta precursor [KO:K05415]
711879  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
711977  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
712265  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
712342  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
712401  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
712587  TXN; thioredoxin [KO:K03671]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
713534  SHARPIN; sharpin isoform X1 [KO:K20894]
713563  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
714092  ATG16L1; autophagy-related protein 16-1 [KO:K17890]
714413  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
714441  CASR; extracellular calcium-sensing receptor [KO:K04612]
714597  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
714692  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
715239  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
715467  TNF; tumor necrosis factor [KO:K03156]
715520  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
715647  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
715745  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715794  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716138  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
716452  JUN; transcription factor AP-1 [KO:K04448]
716755  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
717000  DEFA6; defensin-6 [KO:K05230]
717356  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
717640  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
718040  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718576  [KO:K12801]
718594  [KO:K12801]
718834  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
718976  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
719085  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
719253  IFI16; gamma-interferon-inducible protein 16 [KO:K20914]
719260  AIM2; interferon-inducible protein AIM2 isoform X1 [KO:K12966]
720156  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
720741  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
721648  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
722161  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
722733  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
724039  CASP12; caspase-12 [KO:K04741] [EC:3.4.22.-]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
mcc04010  MAPK signaling pathway
mcc04064  NF-kappa B signaling pathway
mcc04140  Autophagy - animal
mcc04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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