KEGG   PATHWAY: mcoc04217
Entry
mcoc04217                   Pathway                                
Name
Necroptosis - Mastomys coucha (southern multimammate mouse)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
mcoc04217  Necroptosis
mcoc04217

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116074547  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
116099614  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116070032  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116089826  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116069008  Traf5; TNF receptor-associated factor 5 [KO:K09849]
116082569  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
116072766  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
116072810  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
116079101  Xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116091162  Rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
116084366  Rnf31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
116074589  sharpin [KO:K20894]
116070355  Spata2l; spermatogenesis-associated protein 2-like protein [KO:K17595]
116091425  Spata2; spermatogenesis-associated protein 2 [KO:K17595]
116069824  Cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
116103283  Fadd; FAS-associated death domain protein [KO:K02373]
116088467  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
116088466  Cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
116084409  Ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
116069354  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116094815  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
116068035  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
116068749  ADP/ATP translocase 2-like isoform X1 [KO:K05863]
116069234  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
116091233  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
116093017  Ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
116099029  voltage-dependent anion-selective channel protein 1 [KO:K05862]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116084380  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116069012  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116085354  Glud1; glutamate dehydrogenase 1, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
116101519  Glul; LOW QUALITY PROTEIN: glutamine synthetase [KO:K01915] [EC:6.3.1.2]
116103451  Pygm; glycogen phosphorylase, muscle form isoform X1 [KO:K00688] [EC:2.4.1.1]
116079987  Pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
116091133  Pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116103541  Fth1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
116101450  LOW QUALITY PROTEIN: ferritin, mitochondrial-like [KO:K00522] [EC:1.16.3.1]
116091577  Fthl18; ferritin, heavy polypeptide-like 18 [KO:K00522] [EC:1.16.3.1]
116102202  Ftl; ferritin light chain [KO:K13625]
116071943  ferritin light chain 1-like isoform X1 [KO:K13625]
116100272  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
116100719  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116090743  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090754  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
116090758  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090760  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116103425  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
116068107  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116102729  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
116070196  Mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
116068121  Pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
116085631  Dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
116078316  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
116103048  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
116072579  caspase-1 [KO:K01370] [EC:3.4.22.36]
116090916  Il1b; interleukin-1 beta [KO:K04519]
116101657  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
116086049  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
116091221  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
116094942  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
116078417  Chmp6; charged multivesicular body protein 6 [KO:K12195]
116097347  Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
116070112  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
116094079  charged multivesicular body protein 1b-2-like [KO:K12197]
116087295  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
116070357  Chmp1a; charged multivesicular body protein 1a [KO:K12197]
116095827  Chmp5; charged multivesicular body protein 5 [KO:K12198]
116085426  Chmp7; charged multivesicular body protein 7 [KO:K15053]
116090864  Trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
116090915  Il1a; interleukin-1 alpha [KO:K04383]
116103724  Il33; interleukin-33 isoform X1 [KO:K12967]
116104720  Hmgb1; high mobility group protein B1 [KO:K10802]
116095017  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
116084931  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116103761  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116095401  interferon alpha-7-like [KO:K05414]
116095403  interferon alpha-1-like [KO:K05414]
116095406  interferon alpha-9-like [KO:K05414]
116095408  interferon alpha-12-like [KO:K05414]
116095410  interferon alpha-1 [KO:K05414]
116095416  interferon alpha-1-like [KO:K05414]
116095417  interferon alpha-4-like [KO:K05414]
116095418  interferon alpha-12 [KO:K05414]
116095419  interferon alpha-7-like [KO:K05414]
116095420  interferon alpha-12-like [KO:K05414]
116095421  interferon alpha-7-like [KO:K05414]
116096218  interferon alpha-11 [KO:K05414]
116095400  Ifnb1; interferon beta [KO:K05415]
116076208  Ifng; interferon gamma [KO:K04687]
116086128  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
116086124  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116097807  Ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
116086134  Ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05133]
116096295  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
116103711  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116069528  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
116073782  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
116088407  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116076236  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
116076801  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
116088411  Stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
116078736  signal transducer and activator of transcription 5A [KO:K11223]
116078734  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
116076456  Stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
116084367  Irf9; interferon regulatory factor 9 [KO:K04693]
116080069  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
116096145  Tlr4; toll-like receptor 4 [KO:K10160]
116087132  Ticam2; TIR domain-containing adapter molecule 2 [KO:K05409]
116075485  Ticam1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
116069217  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
116091483  Zbp1; Z-DNA-binding protein 1 isoform X1 [KO:K12965]
116103374  Usp21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
116077040  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
116074367  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
116081114  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
116097806  Tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
116104693  Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
116099518  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
116102201  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
116080318  Aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
116099722  histone H2A.J [KO:K11251]
116082010  histone H2A type 1-B/E [KO:K11251]
116082014  histone H2A type 1-B/E [KO:K11251]
116082015  histone H2A type 1-F [KO:K11251]
116082016  histone H2A type 1-B/E [KO:K11251]
116082018  histone H2A type 1-B/E-like [KO:K11251]
116082019  histone H2A type 1-B/E [KO:K11251]
116082075  histone H2A type 4 [KO:K11251]
116082533  histone H2A type 1-B/E [KO:K11251]
116082537  histone H2A type 1-B/E [KO:K11251]
116082538  histone H2A type 1-B/E [KO:K11251]
116082539  histone H2A type 1-H [KO:K11251]
116092327  histone H2A-Bbd type 2/3-like [KO:K11251]
116074310  core histone macro-H2A.2 [KO:K11251]
116082764  core histone macro-H2A.1 isoform X1 [KO:K11251]
116093837  histone H2A.Z [KO:K11251]
116093445  histone H2A type 2-B [KO:K11251]
116093446  histone H2A type 2-C [KO:K11251]
116069286  histone H2A-Bbd type 1-like [KO:K11251]
116069537  histone H2A-Bbd type 1-like [KO:K11251]
116069580  histone H2A.V isoform X1 [KO:K11251]
116078893  histone H2A type 3 [KO:K11251]
116089502  histone H2A.V-like [KO:K11251]
116072657  histone H2AX [KO:K11251]
116069535  Ppia; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
116091610  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
116091806  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
116097315  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
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Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
mcoc00250  Alanine, aspartate and glutamate metabolism
mcoc04210  Apoptosis
mcoc04668  TNF signaling pathway
mcoc04922  Glucagon signaling pathway
KO pathway
ko04217   
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