KEGG   PATHWAY: nfu04140
Entry
nfu04140                    Pathway                                
Name
Autophagy - animal - Nothobranchius furzeri (turquoise killifish)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
nfu04140  Autophagy - animal
nfu04140

Other DBs
GO: 0006914
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107372394  [KO:K00922] [EC:2.7.1.153]
107372603  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
107373027  [KO:K20180]
107373219  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
107373442  [KO:K04382] [EC:3.1.3.16]
107373474  [KO:K21348]
107373867  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
107373885  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
107374040  [KO:K02649]
107374177  [KO:K21357] [EC:2.7.11.1]
107374242  [KO:K17603]
107374311  [KO:K21247]
107374715  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107374744  [KO:K15464]
107374810  [KO:K08512]
107374839  wdr41; WD repeat-containing protein 41 [KO:K23610]
107374862  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107374929  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
107375136  [KO:K07206]
107375330  [KO:K07920]
107375479  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
107375502  [KO:K07874]
107375638  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107375824  [KO:K04456] [EC:2.7.11.1]
107375912  [KO:K04440] [EC:2.7.11.24]
107376003  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
107376033  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107376227  atg4d; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
107376335  smcr8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
107376348  wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
107376365  [KO:K01379] [EC:3.4.23.5]
107376527  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107376655  [KO:K07827]
107376681  [KO:K04371] [EC:2.7.11.24]
107377017  [KO:K07187]
107377126  bad; bcl2-associated agonist of cell death [KO:K02158]
107377258  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
107377348  [KO:K16172]
107377360  [KO:K10435]
107377387  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
107377536  atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
107377587  ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
107377711  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107377983  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
107377985  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
107377987  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
107377991  [KO:K08488]
107378291  [KO:K04345] [EC:2.7.11.11]
107378483  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
107379028  pik3r4; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
107379245  atg5; autophagy protein 5 [KO:K08339]
107379336  rragc; ras-related GTP-binding protein C [KO:K16186]
107379424  [KO:K08341]
107379688  atg12; ubiquitin-like protein ATG12 [KO:K08336]
107379747  stx17; syntaxin-17 [KO:K08491]
107379773  [KO:K08268]
107379902  [KO:K20868]
107379938  atg16l1; autophagy-related protein 16-1 [KO:K17890]
107380026  [KO:K10802]
107380537  rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
107380539  vmp1; vacuole membrane protein 1 [KO:K21248]
107380736  [KO:K08269] [EC:2.7.11.1]
107380843  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
107380884  [KO:K07187]
107380912  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
107381024  [KO:K07187]
107381143  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
107381178  [KO:K01363] [EC:3.4.22.1]
107381433  rras2; ras-related protein R-Ras2 [KO:K07830]
107381527  [KO:K08341]
107381541  [KO:K08803] [EC:2.7.11.1]
107381631  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107382005  [KO:K05087] [EC:2.7.10.1]
107382058  [KO:K01379] [EC:3.4.23.5]
107382303  [KO:K08342] [EC:3.4.22.-]
107382533  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
107382561  optn; optineurin [KO:K19946]
107382675  [KO:K11248]
107382812  [KO:K26797]
107383256  [KO:K08803] [EC:2.7.11.1]
107383378  [KO:K21347]
107383555  rheb; GTP-binding protein Rheb [KO:K07208]
107383584  [KO:K07901]
107383589  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107383608  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
107383861  [KO:K17907]
107383870  rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
107383895  [KO:K04345] [EC:2.7.11.11]
107383905  [KO:K04526]
107383942  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
107384050  [KO:K04958]
107384096  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
107384270  [KO:K26797]
107384302  [KO:K26797]
107384355  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
107384414  [KO:K02649]
107384477  [KO:K00922] [EC:2.7.1.153]
107384530  atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
107384823  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
107385288  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
107385419  [KO:K07897]
107385689  rhebl1; GTPase RhebL1 [KO:K07208]
107385705  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
107385713  [KO:K07897]
107385796  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107385862  [KO:K07897]
107385866  [KO:K04570]
107386006  atg101; autophagy-related protein 101 [KO:K19730]
107386012  uvrag; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
107386038  [KO:K04371] [EC:2.7.11.24]
107386065  wdfy3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
107386108  [KO:K01365] [EC:3.4.22.15]
107386109  [KO:K01365] [EC:3.4.22.15]
107386110  dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
107386134  [KO:K02649]
107386136  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107386302  [KO:K07206]
107386351  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
107386495  [KO:K16172]
107386560  [KO:K16185]
107386784  [KO:K04526]
107386839  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107386925  hmgb1; high mobility group protein B1 [KO:K10802]
107387044  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107387306  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
107387356  [KO:K07920]
107387458  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
107387492  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107387632  nbr1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
107387647  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
107387745  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
107387823  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
107387871  becn1; beclin-1 isoform X1 [KO:K08334]
107388035  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107388064  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
107388136  mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
107388192  wipi1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
107388204  [KO:K04440] [EC:2.7.11.24]
107388566  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
107388720  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107388750  dapk2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
107388775  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107388825  [KO:K05087] [EC:2.7.10.1]
107388958  [KO:K23611]
107388963  kras; GTPase KRas isoform X1 [KO:K07827]
107389003  hras; GTPase HRas [KO:K02833]
107389120  ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
107389191  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
107389278  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
107389745  [KO:K07920]
107389812  [KO:K06528]
107389850  irs2; insulin receptor substrate 2 [KO:K07187]
107390030  gorasp2; Golgi reassembly-stacking protein 2 isoform X1 [KO:K26797]
107390074  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
107390131  cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
107390181  mras; ras-related protein M-Ras [KO:K07831]
107390202  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
107390291  tsc2; tuberin isoform X1 [KO:K07207]
107390759  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107391027  [KO:K21247]
107391028  [KO:K21247]
107391092  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
107391189  supt20h; transcription factor SPT20 homolog isoform X1 [KO:K21245]
107391286  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
107391440  [KO:K04570]
107391561  [KO:K17908]
107391810  rras; ras-related protein R-Ras [KO:K07830]
107391862  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
107391904  atg14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
107392036  [KO:K01365] [EC:3.4.22.15]
107392104  atg9a; autophagy-related protein 9A isoform X1 [KO:K17907]
107392206  [KO:K01365] [EC:3.4.22.15]
107392302  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
107392381  atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
107392429  [KO:K17603]
107392455  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
107392461  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107392609  csgr16h9orf72; protein C9orf72 homolog isoform X1 [KO:K23609]
107392711  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107392741  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330]
107392821  [KO:K02649]
107392835  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
107392924  atg4c; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
107392966  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107393169  rab8a; ras-related protein Rab-8A [KO:K07901]
107393294  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107393378  [KO:K01365] [EC:3.4.22.15]
107393439  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
107393503  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
107393703  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
107393923  epg5; ectopic P granules protein 5 homolog [KO:K23883]
107394101  rab1a; ras-related protein Rab-1A [KO:K07874]
107394251  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
107394268  snap29; synaptosomal-associated protein 29 isoform X1 [KO:K08509]
107394277  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
107394765  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
107394818  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
107395059  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
107395214  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107395449  [KO:K04456] [EC:2.7.11.1]
107395469  rab39b; ras-related protein Rab-39B [KO:K07925]
107395495  nrbf2; nuclear receptor-binding factor 2 [KO:K21246]
107395568  tax1bp1; tax1-binding protein 1 isoform X1 [KO:K21347]
107395782  [KO:K17603]
107395980  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107396298  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
107396324  [KO:K08270]
107396624  atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
107396767  [KO:K04688] [EC:2.7.11.1]
107397066  ulk1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
107397194  [KO:K04456] [EC:2.7.11.1]
107397234  camkk2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
nfu04010  MAPK signaling pathway
nfu04141  Protein processing in endoplasmic reticulum
nfu04142  Lysosome
nfu04150  mTOR signaling pathway
nfu04910  Insulin signaling pathway
KO pathway
ko04140   

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