KEGG   PATHWAY: oaa00230
Entry
oaa00230                    Pathway                                
Name
Purine metabolism - Ornithorhynchus anatinus (platypus)
Class
Metabolism; Nucleotide metabolism
Pathway map
oaa00230  Purine metabolism
oaa00230

Module
oaa_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:oaa00230]
oaa_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:oaa00230]
oaa_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:oaa00230]
oaa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:oaa00230]
oaa_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:oaa00230]
oaa_M00546  Purine degradation, xanthine => urea [PATH:oaa00230]
oaa_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:oaa00230]
oaa_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:oaa00230]
Other DBs
GO: 0006163 0042278
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073391  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
100073529  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100073575  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
100073646  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
100073679  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100074075  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
100074233  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
100074241  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
100074336  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100074382  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100074457  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100074490  [KO:K12321] [EC:4.6.1.2]
100074493  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
100074500  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100074630  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
100074634  [KO:K01081] [EC:3.1.3.5]
100075073  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
100075186  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
100075558  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
100075755  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
100076221  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100076489  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
100077124  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
100077360  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
100077418  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
100077459  ALLC; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
100077581  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
100077908  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100077965  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100078016  [KO:K12324] [EC:4.6.1.2]
100078080  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
100078128  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
100078272  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100078307  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100078335  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100078370  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100078818  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
100078824  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
100078866  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
100078972  [KO:K00365] [EC:1.7.3.3]
100079289  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3 [KO:K18436] [EC:3.1.4.53]
100079688  [KO:K13484] [EC:3.5.2.17 4.1.1.97]
100079900  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100079941  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
100080000  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
100080033  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
100080569  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100080582  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
100080631  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
100080765  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
100080804  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100080806  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
100080901  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
100081071  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
100081118  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100081520  GMPS; LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
100081553  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100081603  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
100081730  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
100081836  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2 [KO:K13762] [EC:3.1.4.35]
100082418  NT5E; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
100082463  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100082549  [KO:K22600] [EC:4.6.1.2]
100082873  [KO:K01466] [EC:3.5.2.5]
100082922  [KO:K12319] [EC:4.6.1.2]
100083096  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
100083210  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100083258  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
100083317  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100083336  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100083363  DGUOK; deoxyguanosine kinase, mitochondrial isoform X3 [KO:K00904] [EC:2.7.1.113]
100083444  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
100083682  NME7; nucleoside diphosphate kinase 7 isoform X2 [KO:K00940] [EC:2.7.4.6]
100083769  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
100084158  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
100084375  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
100084587  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
100084590  [KO:K03783] [EC:2.4.2.1]
100084944  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
100084986  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
100085441  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
100085552  [KO:K18283] [EC:3.1.4.17]
100085630  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100085901  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100086209  PFAS; LOW QUALITY PROTEIN: phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100086365  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
100086657  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100086706  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
100086862  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
100087666  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
100088014  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
100088234  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
100088379  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
100088412  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
100088736  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
100088796  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
100088930  [KO:K01081] [EC:3.1.3.5]
100088979  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
100089045  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
100089232  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
100089526  ADPRM; LOW QUALITY PROTEIN: manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100089708  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100089876  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
100090263  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
100090398  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
100090458  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
100091143  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
100091310  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
100091748  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
100092015  [KO:K00939] [EC:2.7.4.3]
100092292  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
100092533  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
100093091  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
100533973  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
100533974  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100680928  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
100681543  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103165599  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
103165694  [KO:K11265] [EC:4.6.1.1]
103166085  [KO:K13760]
103166385  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103166579  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
103166740  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
103168601  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103168714  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103168734  [KO:K01510] [EC:3.6.1.5]
103170817  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
107548067  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
114805627  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
114805687  [KO:K13760]
114806085  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
114806110  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
114806339  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
114806406  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
114807825  [KO:K01510] [EC:3.6.1.5]
114810216  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
114811232  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
114812804  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
114817020  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
791108  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
oaa00030  Pentose phosphate pathway
oaa00220  Arginine biosynthesis
oaa00250  Alanine, aspartate and glutamate metabolism
oaa00260  Glycine, serine and threonine metabolism
oaa00340  Histidine metabolism
oaa00630  Glyoxylate and dicarboxylate metabolism
oaa00730  Thiamine metabolism
oaa00740  Riboflavin metabolism
oaa00790  Folate biosynthesis
KO pathway
ko00230   

DBGET integrated database retrieval system