KEGG   PATHWAY: osa03430
Entry
osa03430                    Pathway                                
Name
Mismatch repair - Oryza sativa japonica (Japanese rice) (RefSeq)
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
osa03430  Mismatch repair
osa03430

Other DBs
GO: 0006298
Organism
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
Gene
4337429  endonuclease MutS2 [KO:K07456]
4326564  single-stranded DNA-binding protein, mitochondrial [KO:K03111]
4329835  DNA mismatch repair protein PMS1 isoform X1 [KO:K10858]
4325393  DNA mismatch repair protein MLH1 isoform X1 [KO:K08734]
4347016  DNA mismatch repair protein MSH6 [KO:K08737]
4325353  DNA mismatch repair protein MSH7 [KO:K08737]
4338271  DNA mismatch repair protein MSH2 [KO:K08735]
4337442  DNA mismatch repair protein MSH3 isoform X1 [KO:K08736]
4350754  replication factor C subunit 1 [KO:K10754]
4351654  replication factor C subunit 2 [KO:K10755]
4336704  replication factor C subunit 4 [KO:K10755]
4330895  replication factor C subunit 3 [KO:K10756]
4334389  replication factor C subunit 5 [KO:K10756]
4349480  replication factor C subunit 3 [KO:K10756]
4331062  proliferating cell nuclear antigen [KO:K04802]
4327899  exonuclease 1 isoform X1 [KO:K10746] [EC:3.1.-.-]
4330902  replication protein A 70 kDa DNA-binding subunit A [KO:K07466]
4338202  uncharacterized protein At4g28440 [KO:K07466]
4326359  uncharacterized protein At4g28440 [KO:K07466]
4337594  replication protein A 70 kDa DNA-binding subunit C [KO:K07466]
4325130  uncharacterized protein At4g28440 [KO:K07466]
4332052  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
9267714  uncharacterized protein At4g28440 [KO:K07466]
4327373  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
4334834  replication protein A 70 kDa DNA-binding subunit B isoform X1 [KO:K07466]
4348221  replication protein A 70 kDa DNA-binding subunit B [KO:K07466]
9266301  uncharacterized protein LOC9266301 [KO:K07466]
4342616  replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
107280671  replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
9272338  replication protein A 70 kDa DNA-binding subunit [KO:K07466]
107279348  replication protein A 70 kDa DNA-binding subunit D-like isoform X1 [KO:K07466]
4345008  uncharacterized protein LOC4345008 isoform X1 [KO:K07466]
4351558  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
9266862  replication protein A 70 kDa DNA-binding subunit D isoform X1 [KO:K07466]
4331236  replication protein A 32 kDa subunit A [KO:K10739]
4330068  replication protein A 32 kDa subunit B isoform X2 [KO:K10739]
4327706  replication protein A 14 kDa subunit [KO:K10740]
4349968  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
4331489  DNA polymerase delta small subunit [KO:K02328]
4327080  protein IWS1 homolog A [KO:K03504]
4347604  uncharacterized protein LOC4347604 [KO:K03505]
4344737  DNA polymerase delta subunit 4 [KO:K03505]
4348965  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
4324149  DNA ligase 3 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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