KEGG   PATHWAY: arut04137
Entry
arut04137                   Pathway                                
Name
Mitophagy - animal - Acipenser ruthenus (sterlet)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
arut04137  Mitophagy - animal
arut04137

Other DBs
GO: 0000422
Organism
Acipenser ruthenus (sterlet) [GN:arut]
Gene
117435053  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
117432245  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
117426073  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
117399846  tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
117970139  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
117434082  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
117397371  mitochondrial import receptor subunit TOM40B-like isoform X1 [KO:K11518]
117397173  mitochondrial import receptor subunit TOM40B-like isoform X2 [KO:K11518]
117402249  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
117410520  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
117407477  mitochondrial import receptor subunit TOM70-like isoform X1 [KO:K17768]
117405121  mitochondrial import receptor subunit TOM70-like isoform X1 [KO:K17768]
117403298  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
117962427  E3 ubiquitin-protein ligase MARCHF5-like [KO:K10660] [EC:2.3.2.27]
117397723  E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
117416015  E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
117418451  E3 ubiquitin-protein ligase MARCHF5 [KO:K10660] [EC:2.3.2.27]
117962289  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117962309  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117396690  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117396934  TNF receptor-associated factor 2-like isoform X2 [KO:K03173] [EC:2.3.2.27]
117424634  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117417617  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
117431517  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117423487  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
117424704  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
117425755  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
117425361  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1 [KO:K15688] [EC:2.3.2.27]
117416698  mitochondrial ubiquitin ligase activator of nfkb 1-A [KO:K15688] [EC:2.3.2.27]
117417178  mul1a; mitochondrial ubiquitin ligase activator of nfkb 1-A [KO:K15688] [EC:2.3.2.27]
117423133  mitochondrial ubiquitin ligase activator of nfkb 1-A-like isoform X1 [KO:K15688] [EC:2.3.2.27]
117404270  E3 ubiquitin-protein ligase HUWE1-like [KO:K10592] [EC:2.3.2.26]
117424847  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117425774  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
117428296  E3 ubiquitin-protein ligase arih1 isoform X1 [KO:K11968] [EC:2.3.2.31]
117429618  E3 ubiquitin-protein ligase arih1-like isoform X1 [KO:K11968] [EC:2.3.2.31]
117417144  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
117423563  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
117963670  mitofusin-2-like [KO:K06030] [EC:3.6.5.-]
117425849  mitofusin-2 [KO:K06030] [EC:3.6.5.-]
117424515  mitochondrial Rho GTPase 1-like isoform X1 [KO:K07870] [EC:3.6.5.-]
117423529  mitochondrial Rho GTPase 1 isoform X1 [KO:K07870] [EC:3.6.5.-]
117973830  mitochondrial Rho GTPase 2-like [KO:K07871] [EC:3.6.5.-]
117418585  mitochondrial Rho GTPase 2 isoform X1 [KO:K07871] [EC:3.6.5.-]
117428916  ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
117401241  ubiquitin-60S ribosomal protein L40 [KO:K02927]
117410763  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
117402620  ubiquitin-40S ribosomal protein S27a [KO:K02977]
117430252  polyubiquitin-B isoform X1 [KO:K04551]
117962256  polyubiquitin-B [KO:K04551]
117428188  LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
117426929  polyubiquitin-C isoform X1 [KO:K08770]
117962933  polyubiquitin-C [KO:K08770]
117429187  polyubiquitin-C [KO:K08770]
117435427  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
117399635  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
117964626  sequestosome-1-like isoform X1 [KO:K14381]
117431815  sequestosome-1-like isoform X1 [KO:K14381]
117435137  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
117433532  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
117419464  optineurin-like isoform X1 [KO:K19946]
117415981  optineurin-like isoform X1 [KO:K19946]
117433407  nbr1b; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
117419798  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
117970980  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
117424537  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
117424538  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
117424803  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117425284  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
117425285  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
117425659  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117404452  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
117970136  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
117424378  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
117398643  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
117425750  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
117411227  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
117421517  microtubule-associated proteins 1A/1B light chain 3A-like [KO:K10435]
117403131  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
117432654  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
117435012  beclin-1-like isoform X1 [KO:K08334]
117433215  beclin-1 isoform X1 [KO:K08334]
117428240  ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [KO:K11839] [EC:3.4.19.12]
117429826  ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [KO:K11839] [EC:3.4.19.12]
117415918  ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
117419470  ubiquitin carboxyl-terminal hydrolase 15-like isoform X1 [KO:K21343] [EC:3.4.19.12]
117426314  LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 30-like [KO:K11851] [EC:3.4.19.12]
117427818  LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 30-like [KO:K11851] [EC:3.4.19.12]
117420711  bcl-2-like protein 1 [KO:K04570]
117434069  bcl-2-like protein 1 [KO:K04570]
117426558  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
117428222  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
117431472  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117968459  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117970024  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
117425150  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
117400491  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117394445  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
117424124  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
117971090  casein kinase II subunit beta [KO:K03115]
117433984  casein kinase II subunit beta [KO:K03115]
117419815  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117431239  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117427648  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
117426103  LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
117406490  fundc1; LOW QUALITY PROTEIN: FUN14 domain-containing protein 1 [KO:K17986]
117405199  FUN14 domain-containing protein 1-like isoform X1 [KO:K17986]
117973522  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
117404037  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
117414835  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
117962651  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2 [KO:K15465]
117397829  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15465]
117419500  bcl-2-like protein 13 [KO:K15485]
117415130  bcl-2-like protein 13 [KO:K15485]
117428347  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
117429056  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
117401499  peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
117966266  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
117415881  samm50; sorting and assembly machinery component 50 homolog A [KO:K07277]
117419889  sorting and assembly machinery component 50 homolog isoform X1 [KO:K07277]
117417321  prohibitin-2-like [KO:K17081]
117423665  prohibitin-2-like [KO:K17081]
117397214  NLR family member X1 [KO:K12653]
117966541  LOW QUALITY PROTEIN: NLR family member X1-like [KO:K12653]
117403750  metaxin-3-like isoform X1 [KO:K17776]
117404087  metaxin-3 isoform X1 [KO:K17776]
117970759  metaxin-1-like [KO:K17776]
117426931  metaxin-2-like [KO:K17776]
117402818  metaxin-2 [KO:K17776]
117395125  metaxin-1 [KO:K17776]
117408518  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
117421266  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
117421495  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117422066  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117409061  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117415548  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117962527  mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
117418084  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117431535  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
117413208  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117963780  transcription factor AP-1-like [KO:K04448]
117421449  transcription factor AP-1-like [KO:K04448]
117416589  transcription factor AP-1-like [KO:K04448]
117401403  transcription factor AP-1 [KO:K04448]
117962714  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117967842  putative transcription factor p65 homolog [KO:K04735]
117398684  putative transcription factor p65 homolog isoform X1 [KO:K04735]
117431924  GTPase HRas [KO:K02833]
117434435  GTPase HRas [KO:K02833]
117419957  GTPase KRas isoform X1 [KO:K07827]
117962512  GTPase HRas-like [KO:K07827]
117415640  GTPase KRas isoform X1 [KO:K07827]
117407743  GTPase HRas-like [KO:K07827]
117428047  GTPase NRas [KO:K07828]
117962404  GTPase NRas [KO:K07828]
117968182  ras-related protein M-Ras-like [KO:K07831]
117427088  ras-related protein M-Ras-like [KO:K07831]
117412466  ras-related protein M-Ras [KO:K07831]
117435061  ras-related protein R-Ras2 [KO:K07830]
117431956  ras-related protein R-Ras2 [KO:K07830]
117963853  transcription factor E2F1-like [KO:K17454]
117406596  transcription factor E2F1-like [KO:K17454]
117422192  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
117418428  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
117396830  hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268]
117966968  transcription factor Sp1-like isoform X1 [KO:K04684]
117401144  transcription factor Sp1 isoform X1 [KO:K04684]
117970978  cellular tumor antigen p53-like isoform X1 [KO:K04451]
117404615  cellular tumor antigen p53 [KO:K04451]
117411026  foxo3a; forkhead box protein O3a [KO:K09408]
117402974  forkhead box protein O3 [KO:K09408]
117410847  cbp/p300-interacting transactivator 2-like [KO:K21361]
117402712  cbp/p300-interacting transactivator 2-like [KO:K21361]
117414056  microphthalmia-associated transcription factor isoform X1 [KO:K09455]
117412385  mitfb; melanocyte inducing transcription factor b isoform X1 [KO:K09455]
117427154  LOW QUALITY PROTEIN: transcription factor EB-like [KO:K15590]
117397076  LOW QUALITY PROTEIN: transcription factor EB-like [KO:K15590]
117401593  transcription factor E3-like isoform X1 [KO:K09105]
117972119  transcription factor E3-like isoform X1 [KO:K09105]
117426238  rab5 GDP/GTP exchange factor-like [KO:K20131]
117427842  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
117964264  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
117429538  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
117430287  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
117400548  ras-related protein Rab-5A-like [KO:K07887]
117394839  ras-related protein Rab-5A [KO:K07887]
117400953  ras-related protein Rab-5B [KO:K07888]
117967041  ras-related protein Rab-5B-like [KO:K07888]
117403034  ras-related protein Rab-5B-like [KO:K07888]
117435086  ras-related protein Rab-5C [KO:K07889]
117433222  ras-related protein Rab-5C-like [KO:K07889]
117404246  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
117411916  LOW QUALITY PROTEIN: protein SAND-like [KO:K20195]
117413753  LOW QUALITY PROTEIN: protein SAND-like [KO:K20195]
117418109  vacuolar fusion protein CCZ1 homolog isoform X1 [KO:K27045]
117962425  ras-related protein rab7 [KO:K07897]
117401619  ras-related protein Rab-7a-like [KO:K07897]
117401736  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
117412364  ras-related protein rab7 [KO:K07897]
117395570  ras-related protein Rab-7b-like [KO:K07898]
117419375  TBC1 domain family member 15-like [KO:K20168]
117414460  TBC1 domain family member 15-like [KO:K20168]
117421659  TBC1 domain family member 17 [KO:K19945]
117966752  TBC1 domain family member 17-like [KO:K19945]
117404576  fis1; mitochondrial fission 1 protein [KO:K17969]
117435461  autophagy-related protein 9A [KO:K17907]
117400696  autophagy-related protein 9A-like [KO:K17907]
117427164  autophagy-related protein 9A-like isoform X1 [KO:K17907]
117402849  autophagy-related protein 9A-like [KO:K17907]
117417265  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
117423478  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
117403761  transitional endoplasmic reticulum ATPase [KO:K13525]
117404101  transitional endoplasmic reticulum ATPase [KO:K13525]
117402165  transitional endoplasmic reticulum ATPase-like [KO:K13525]
117965612  transitional endoplasmic reticulum ATPase-like [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
arut04140  Autophagy - animal
arut04210  Apoptosis
KO pathway
ko04137   
LinkDB

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