KEGG   PATHWAY: cgib04110
Entry
cgib04110                   Pathway                                
Name
Cell cycle - Carassius gibelio (silver crucian carp)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
cgib04110  Cell cycle
cgib04110

Other DBs
GO: 0000278
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127962195  G1/S-specific cyclin-D1 [KO:K04503]
128016536  G1/S-specific cyclin-D1-like [KO:K04503]
127956853  G1/S-specific cyclin-D2b [KO:K10151]
127947336  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
127978113  G1/S-specific cyclin-D2-like [KO:K10151]
128014237  G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
127987601  G1/S-specific cyclin-D3 [KO:K10152]
127968260  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128022703  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
127951658  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127979376  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127953547  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127935432  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
128015620  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127941810  retinoblastoma-associated protein-like isoform X1 [KO:K06618]
127986424  retinoblastoma-associated protein [KO:K06618]
127960039  retinoblastoma-like protein 1 [KO:K04681]
127947118  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
127957706  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
127992700  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
127978962  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
127935505  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
127944596  transcription factor E2F1-like [KO:K17454]
128011973  transcription factor E2F1-like [KO:K17454]
127976738  transcription factor E2F2 isoform X1 [KO:K09389]
128031347  transcription factor E2F2-like [KO:K09389]
127979480  transcription factor E2F3-like [KO:K06620]
127935271  transcription factor E2F3-like isoform X1 [KO:K06620]
127951472  transcription factor E2F5 [KO:K04682]
127947382  transcription factor E2F4-like [KO:K04682]
128014480  transcription factor E2F4 [KO:K04682]
128030241  transcription factor E2F5-like [KO:K04682]
127965288  transcription factor Dp-1-like [KO:K04683]
127966532  transcription factor Dp-1b isoform X1 [KO:K04683]
127948904  transcription factor Dp-1-like [KO:K04683]
128019983  transcription factor Dp-1a isoform X1 [KO:K04683]
127972423  transcription factor Dp-2-like isoform X1 [KO:K09392]
128028712  transcription factor Dp-2-like isoform X1 [KO:K09392]
127964368  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127949092  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
128017481  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
128017692  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
128019474  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
127942123  transforming growth factor beta-1 proprotein-like [KO:K13375]
127973105  transforming growth factor beta-1 proprotein-like [KO:K13375]
127985940  transforming growth factor beta-1 proprotein [KO:K13375]
128028714  transforming growth factor beta-1 proprotein-like [KO:K13375]
127970925  transforming growth factor beta-2 proprotein [KO:K13376]
127974945  transforming growth factor beta-2 proprotein-like [KO:K13376]
128030893  transforming growth factor beta-2 proprotein-like [KO:K13376]
128026998  transforming growth factor beta-2 proprotein-like [KO:K13376]
127975812  transforming growth factor beta-3 proprotein-like [KO:K13377]
128031399  transforming growth factor beta-3 proprotein-like [KO:K13377]
127966259  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
128021490  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
127961960  mothers against decapentaplegic homolog 3a [KO:K23605]
127934301  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
127977271  mothers against decapentaplegic homolog 3b [KO:K23605]
128016895  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
127979320  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
127966326  mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
127975090  mothers against decapentaplegic homolog 4-like [KO:K04501]
127935660  mothers against decapentaplegic homolog 4 [KO:K04501]
128020899  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
128014843  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
128029996  mothers against decapentaplegic homolog 4-like [KO:K04501]
127951108  transcriptional regulator Myc-B [KO:K04377]
127945911  transcriptional regulator Myc-1-like [KO:K04377]
128013593  transcriptional regulator Myc-A [KO:K04377]
128030400  transcriptional regulator Myc-B [KO:K04377]
127944997  zinc finger and BTB domain-containing protein 17-like isoform X1 [KO:K10500]
128011934  zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
127951239  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
127962835  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
128018839  cyclin-dependent kinase 4 inhibitor C-like [KO:K06622]
127959647  cyclin-dependent kinase 4 inhibitor D [KO:K06623]
127956965  cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
127974495  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
127947230  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
128014511  cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
127961866  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
127961867  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
127946687  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
128014612  LOW QUALITY PROTEIN: uncharacterized protein LOC128014612 [KO:K09993]
128016300  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
127943101  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
127987607  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
127956439  cyclin-dependent kinase inhibitor 1D [KO:K06625]
127961935  G1/S-specific cyclin-E1 [KO:K06626]
127979210  G1/S-specific cyclin-E2-like [KO:K06626]
127974335  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
127935806  G1/S-specific cyclin-E2-like [KO:K06626]
128016682  G1/S-specific cyclin-E1-like [KO:K06626]
128030026  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
127967894  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
127941481  S-phase kinase-associated protein 1 [KO:K03094]
127985703  S-phase kinase-associated protein 1 [KO:K03094]
127951171  cullin-1-like [KO:K03347]
127946209  cullin-1-like [KO:K03347]
127936157  cullin-1 [KO:K03347]
128013172  cullin-1b [KO:K03347]
127953577  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
127945830  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
127941621  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
127986261  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
127971157  cyclin-A2-like [KO:K06627]
127966475  cyclin-A1 [KO:K06627]
128027547  cyclin-A2 [KO:K06627]
127968039  cell division control protein 6 homolog [KO:K02213]
128022472  cell division control protein 6 homolog [KO:K02213]
127962201  DNA replication factor Cdt1 [KO:K10727]
128016588  DNA replication factor Cdt1-like isoform X1 [KO:K10727]
127959385  origin recognition complex subunit 1-like [KO:K02603]
128015652  origin recognition complex subunit 1-like isoform X1 [KO:K02603]
127968587  origin recognition complex subunit 2 [KO:K02604]
127975845  origin recognition complex subunit 3 [KO:K02605]
127959104  origin recognition complex subunit 4 [KO:K02606]
127973173  origin recognition complex subunit 5 isoform X1 [KO:K02607]
127961658  origin recognition complex subunit 6-like [KO:K02608]
128016739  origin recognition complex subunit 6-like [KO:K02608]
127942843  DNA replication licensing factor mcm2-like [KO:K02540] [EC:5.6.2.3]
127988138  DNA replication licensing factor mcm2 [KO:K02540] [EC:5.6.2.3]
127938450  MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [KO:K02541] [EC:5.6.2.3]
127938761  DNA replication licensing factor MCM3-like [KO:K02541] [EC:5.6.2.3]
127984533  DNA replication licensing factor MCM3-like [KO:K02541] [EC:5.6.2.3]
127946240  DNA replication licensing factor mcm4-A [KO:K02212] [EC:5.6.2.3]
128012878  DNA replication licensing factor mcm4-A-like [KO:K02212] [EC:5.6.2.3]
127951828  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
127945122  DNA replication licensing factor mcm5 [KO:K02209] [EC:5.6.2.3]
127950484  MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
127960233  DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
128015382  DNA replication licensing factor MCM6-like [KO:K02542] [EC:5.6.2.3]
127971660  DNA replication licensing factor mcm7-B-like [KO:K02210] [EC:5.6.2.3]
128027427  DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
127964126  LOW QUALITY PROTEIN: cell division control protein 45 homolog [KO:K06628]
128018987  cell division control protein 45 homolog [KO:K06628]
127946977  treslin-like [KO:K26117]
128014460  treslin-like isoform X1 [KO:K26117]
127974272  mdm2-binding protein isoform X1 [KO:K26116]
128030215  LOW QUALITY PROTEIN: mdm2-binding protein-like [KO:K26116]
127950845  cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
127975474  protein DBF4 homolog A [KO:K06629]
127968707  uncharacterized protein LOC127968707 isoform X1 [KO:K06629]
128025673  uncharacterized protein LOC128025673 isoform X1 [KO:K06629]
128030406  protein DBF4 homolog A-like isoform X1 [KO:K06629]
127975793  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
128031669  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
127958878  G2/mitotic-specific cyclin-B1-like [KO:K05868]
127977012  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
127993383  G2/mitotic-specific cyclin-B1 [KO:K05868]
127961597  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
128016970  G2/mitotic-specific cyclin-B2-like [KO:K21770]
128017157  G2/mitotic-specific cyclin-B3-like [KO:K21771]
127962078  G2/mitotic-specific cyclin-B3-like isoform X1 [KO:K21771]
127970606  M-phase inducer phosphatase 1-like isoform X1 [KO:K05866] [EC:3.1.3.48]
128026373  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
127978952  14-3-3 protein zeta/delta [KO:K16197]
127983612  14-3-3 protein zeta-like [KO:K16197]
127963284  14-3-3 protein beta/alpha-B-like [KO:K16197]
127975083  14-3-3 protein zeta-like [KO:K16197]
127975914  14-3-3 protein zeta-like [KO:K16197]
127935427  14-3-3 protein beta/alpha-A-like [KO:K16197]
127959464  14-3-3 protein beta/alpha-A [KO:K16197]
127938252  14-3-3 protein beta/alpha-1-like [KO:K16197]
128031762  14-3-3 protein zeta/delta-like [KO:K16197]
128015970  14-3-3 protein beta/alpha-A-like [KO:K16197]
128018328  14-3-3 protein beta/alpha-B [KO:K16197]
128030695  14-3-3 protein beta/alpha-A-like [KO:K16197]
127962037  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2 isoform X1 [KO:K06630]
127972666  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
128016433  14-3-3 protein epsilon-like [KO:K06630]
128029202  14-3-3 protein epsilon-like [KO:K06630]
127972515  14-3-3 protein gamma-B [KO:K16198]
127966170  14-3-3 protein eta [KO:K16198]
127957813  14-3-3 protein gamma-1 [KO:K16198]
128021356  14-3-3 protein gamma-like [KO:K16198]
128014873  14-3-3 protein gamma-1-like [KO:K16198]
128029363  14-3-3 protein gamma-1 [KO:K16198]
127948908  serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
127985097  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
127934382  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
127977150  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
127977323  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
128025681  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
127957783  cyclin-H-like [KO:K06634]
127999398  cyclin-H-like [KO:K06634]
127957796  cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
127998537  cyclin-dependent kinase 7-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
127970106  anaphase-promoting complex subunit 1-like isoform X1 [KO:K03348]
128026539  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1 [KO:K03348]
127957625  anaphase-promoting complex subunit 2-like [KO:K03349]
127958694  anaphase-promoting complex subunit 2-like [KO:K03349]
127958868  anaphase-promoting complex subunit 2-like [KO:K03349]
128030942  anaphase-promoting complex subunit 2-like [KO:K03349]
127993351  anaphase-promoting complex subunit 2-like [KO:K03349]
127952685  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
127946843  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
127939016  anaphase-promoting complex subunit 4 [KO:K03351]
128018428  anaphase-promoting complex subunit 5 [KO:K03352]
127965158  cell division cycle protein 16 homolog [KO:K03353]
128019980  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
127963603  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
128018910  anaphase-promoting complex subunit 7 [KO:K03354]
127985634  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
127944437  anaphase-promoting complex subunit 10 [KO:K03357]
128011395  anaphase-promoting complex subunit 10-like [KO:K03357]
127958596  anaphase-promoting complex subunit CDC26-like [KO:K03359]
127994437  anaphase-promoting complex subunit CDC26 [KO:K03359]
127942368  anaphase-promoting complex subunit 13-like [KO:K12456]
127985743  anaphase-promoting complex subunit 13 [KO:K12456]
127972308  anaphase-promoting complex subunit 15 [KO:K25228]
127968759  anaphase-promoting complex subunit 16 [KO:K25229]
128025573  anaphase-promoting complex subunit 16 [KO:K25229]
127951585  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
128026836  cell division cycle protein 20 homolog [KO:K03363]
127971866  securin [KO:K06635]
128027187  securin-like [KO:K06635]
127959757  separin [KO:K02365] [EC:3.4.22.49]
127944688  structural maintenance of chromosomes protein 1A-like [KO:K06636]
127944998  structural maintenance of chromosomes protein 1A [KO:K06636]
128013942  structural maintenance of chromosomes protein 1B [KO:K06636]
128012120  structural maintenance of chromosomes 1A, like [KO:K06636]
127943099  structural maintenance of chromosomes protein 3-like [KO:K06669]
127988241  structural maintenance of chromosomes protein 3 [KO:K06669]
127974683  double-strand-break repair protein rad21 homolog A [KO:K06670]
127934944  double-strand-break repair protein rad21 homolog A-like isoform X1 [KO:K06670]
127978752  RAD21 cohesin complex component b [KO:K06670]
128031069  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
128018230  double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
127971378  cohesin subunit SA-2 isoform X1 [KO:K06671]
127965009  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
127946522  cohesin subunit SA-1-like [KO:K06671]
127957534  cohesin subunit SA-2a [KO:K06671]
127950562  cohesin subunit SA-1a [KO:K06671]
128027300  cohesin subunit SA-2 isoform X1 [KO:K06671]
128011480  cohesin subunit SA-2-like isoform X1 [KO:K06671]
128028918  cohesin subunit SA-1 isoform X1 [KO:K06671]
128012910  cohesin subunit SA-1-like [KO:K06671]
127970976  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
127957549  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
128026856  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
127934569  ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
127966516  nipped-B-like protein B isoform X1 [KO:K06672]
127957744  nipped-B-like protein A [KO:K06672]
128021002  nipped-B-like protein B isoform X1 [KO:K06672]
128014836  nipped-B-like protein A [KO:K06672]
127951643  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
127938717  MAU2 chromatid cohesion factor homolog [KO:K11266]
127962561  histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
128017738  histone deacetylase 8-like isoform X1 [KO:K11405] [EC:3.5.1.98]
127984144  N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
127945921  N-acetyltransferase ESCO1-like [KO:K11268] [EC:2.3.1.-]
127938005  N-acetyltransferase ESCO2-like [KO:K11268] [EC:2.3.1.-]
128013245  N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
127972475  sister chromatid cohesion protein PDS5 homolog B-like [KO:K11267]
127956456  sister chromatid cohesion protein PDS5 homolog A-like isoform X1 [KO:K11267]
127933885  sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
127941364  sister chromatid cohesion protein PDS5 homolog A-like [KO:K11267]
128028948  sister chromatid cohesion protein PDS5 homolog B-like [KO:K11267]
127933363  wings apart-like protein homolog isoform X1 [KO:K25163]
127976066  wings apart-like protein homolog [KO:K25163]
127968888  LOW QUALITY PROTEIN: wings apart-like protein homolog [KO:K25163]
128024922  wings apart-like protein homolog [KO:K25163]
127958858  sororin [KO:K17390]
127991041  sororin-B-like isoform X1 [KO:K17390]
127971424  aurora kinase B [KO:K11479] [EC:2.7.11.1]
128027415  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
127979046  shugoshin 1 isoform X1 [KO:K11580]
127935649  shugoshin 1-like [KO:K11580]
127941767  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127971951  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
127965984  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
128021558  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127986230  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128027577  protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
127958614  protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
127994569  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
127983606  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
127983919  protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
127984003  protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
127933169  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
127938421  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
127938541  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
127938897  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
127961158  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
127969894  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
127970284  protein phosphatase 2, regulatory subunit B', epsilon [KO:K11584]
128026000  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
128017098  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
128026494  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
128024961  kinetochore protein NDC80 homolog [KO:K11547]
127978340  uncharacterized protein LOC127978340 isoform X1 [KO:K11542]
127974898  dual specificity protein kinase Ttk-like isoform X1 [KO:K08866] [EC:2.7.12.1]
128031198  dual specificity protein kinase Ttk-like isoform X1 [KO:K08866] [EC:2.7.12.1]
127982783  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
127948837  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
127961207  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
128016598  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
127963558  mitotic spindle assembly checkpoint protein MAD2B-like isoform X1 [KO:K13728]
127976532  mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
128025599  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
127938567  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
127975104  pachytene checkpoint protein 2 homolog [KO:K22399]
127969833  MAD2L1-binding protein [KO:K26093]
128026063  MAD2L1-binding protein-like [KO:K26093]
127951173  fizzy-related protein homolog [KO:K03364]
127963812  fizzy/cell division cycle 20 related 1a [KO:K03364]
128025494  fizzy-related protein homolog [KO:K03364]
128018750  fizzy-related protein homolog [KO:K03364]
127969800  F-box only protein 5-like [KO:K10292]
128025812  F-box only protein 5-like [KO:K10292]
128026371  F-box only protein 5 [KO:K10292]
127942737  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127963866  dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127950919  cell division cycle 14Aa isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127986928  dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
128019089  dual specificity protein phosphatase CDC14A-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
127951774  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
127951841  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127943076  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127955109  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127955185  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127945592  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127968871  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
128025190  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
127988422  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
127962738  DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
128027031  serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
127972527  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
127956464  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
127972941  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
127972656  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127957502  cellular tumor antigen p53 isoform X1 [KO:K04451]
128017696  cellular tumor antigen p53-like [KO:K04451]
128011372  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127941463  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127951292  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
127962959  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127967754  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
127959768  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
127950341  growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
128031482  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
128022541  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
128015515  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
127986689  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
128026543  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
128018513  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127966820  proliferating cell nuclear antigen-like [KO:K04802]
128020938  proliferating cell nuclear antigen [KO:K04802]
127941762  serine/threonine-protein kinase Chk1-like [KO:K02216] [EC:2.7.11.1]
127985384  serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
127957325  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
128014228  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
Reference
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Nat Rev Cancer 7:495-507 (2007)
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J Cell Sci 121:3853-7 (2008)
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
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Harris SL, Levine AJ.
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The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
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Reference
PMID:11099028
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Vogelstein B, Lane D, Levine AJ
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Surfing the p53 network.
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Nature 408:307-10 (2000)
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PMID:7973727
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Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
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EMBO J 18:396-410 (1999)
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Reference
PMID:9029154
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Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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Musacchio A, Salmon ED
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The spindle-assembly checkpoint in space and time.
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Nat Rev Mol Cell Biol 8:379-93 (2007)
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Chromosome cohesion and separation: from men and molecules.
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Stegmeier F, Amon A
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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PMID:9618481
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Moustakas A, Kardassis D
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
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PMID:20935501
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APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
cgib03030  DNA replication
cgib04010  MAPK signaling pathway
cgib04120  Ubiquitin mediated proteolysis
cgib04210  Apoptosis
KO pathway
ko04110   
LinkDB

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