KEGG   PATHWAY: crg04148
Entry
crg04148                    Pathway                                
Name
Efferocytosis - Magallana gigas (Pacific oyster)
Class
Cellular Processes; Transport and catabolism
Pathway map
crg04148  Efferocytosis
crg04148

Organism
Magallana gigas (Pacific oyster) [GN:crg]
Gene
105343829  caspase-3 [KO:K02187] [EC:3.4.22.56]
117684706  uncharacterized protein LOC117684706 [KO:K02187] [EC:3.4.22.56]
105325616  uncharacterized protein LOC105325616 isoform X1 [KO:K02187] [EC:3.4.22.56]
105342048  caspase-7-like [KO:K04397] [EC:3.4.22.60]
105322178  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105322179  caspase-7-like isoform X1 [KO:K04397] [EC:3.4.22.60]
105336650  uncharacterized protein LOC105336650 [KO:K04397] [EC:3.4.22.60]
105340742  caspase-3 isoform X1 [KO:K04397] [EC:3.4.22.60]
105328899  caspase-7 [KO:K04397] [EC:3.4.22.60]
105342049  caspase-7 [KO:K04397] [EC:3.4.22.60]
105346972  caspase-3-like isoform X2 [KO:K04397] [EC:3.4.22.60]
109617112  caspase-7 isoform X3 [KO:K04397] [EC:3.4.22.60]
105322180  caspase-7-like isoform X1 [KO:K04397] [EC:3.4.22.60]
105325186  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105328531  caspase-14-like [KO:K04397] [EC:3.4.22.60]
105348272  caspase-7 [KO:K04397] [EC:3.4.22.60]
105343802  sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105325995  85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
117692099  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
105322394  ATP-binding cassette sub-family A member 7 [KO:K05641]
105334096  phospholipid-transporting ATPase ABCA1 [KO:K05641]
105338334  ADAM 17-like protease isoform X2 [KO:K06059] [EC:3.4.24.86]
105338464  ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]
105330896  ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]
105322445  ADAM 17-like protease isoform X1 [KO:K06059] [EC:3.4.24.86]
105348437  ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]
117687376  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
105317458  disintegrin and metalloproteinase domain-containing protein 10-like isoform X1 [KO:K06704] [EC:3.4.24.81]
105347325  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
105346452  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
117687384  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
105323098  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
109620949  disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
105343010  endothelial PAS domain-containing protein 1 isoform X1 [KO:K08268]
105322432  aryl hydrocarbon receptor nuclear translocator homolog isoform X1 [KO:K09097]
105333485  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
117684230  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
105334418  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105345813  CCAAT/enhancer-binding protein gamma [KO:K10048]
105317849  peroxisome proliferator-activated receptor alpha [KO:K08530]
105322741  ecdysone-induced protein 78C-like [KO:K08530]
105333288  retinoic acid receptor RXR isoform X1 [KO:K08524]
105334365  retinoic acid receptor RXR-alpha-B [KO:K08524]
105320144  coagulation factor V isoform X1 [KO:K17253]
105330202  uncharacterized protein LOC105330202 [KO:K17253]
117685400  neuropilin-1-like isoform X1 [KO:K17253]
105339781  lactadherin isoform X1 [KO:K17253]
105339480  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105344258  prostaglandin G/H synthase 2-like precursor [KO:K11987] [EC:1.14.99.1]
105337232  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105343936  prostaglandin F2-alpha receptor [KO:K04259]
105317370  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105320130  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105320131  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105321048  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105321049  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105324426  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105323519  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105327545  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105336330  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105338783  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105339657  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
105340910  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105342767  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105343930  prostaglandin E2 receptor EP2 subtype-like [KO:K04261]
109617611  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
105320228  prostaglandin E2 receptor EP4 subtype [KO:K04261]
117684360  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
105344807  prostaglandin E2 receptor EP3 subtype [KO:K04261]
105345486  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105345487  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105345490  prostaglandin E2 receptor EP4 subtype isoform X2 [KO:K04261]
105345968  prostaglandin E2 receptor EP4 subtype [KO:K04261]
105320129  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
105323502  prostaglandin E2 receptor EP4 subtype [KO:K04261]
109619351  prostaglandin E2 receptor EP4 subtype [KO:K04261]
109619502  prostaglandin E2 receptor EP4 subtype [KO:K04261]
109620337  prostaglandin E2 receptor EP3 subtype [KO:K04261]
109620519  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
117680732  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
117680736  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
117680737  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
105342835  cAMP-responsive element modulator isoform X1 [KO:K05870]
105327139  calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [KO:K05853] [EC:7.2.2.10]
105341112  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
105347124  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
105320307  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105327296  allene oxide synthase-lipoxygenase protein isoform X1 [KO:K00461] [EC:1.13.11.34]
105333405  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
105333406  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
105336201  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
117683956  allene oxide synthase-lipoxygenase protein-like isoform X1 [KO:K00461] [EC:1.13.11.34]
105327236  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
105327652  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
105319481  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
105324873  arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
105327235  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
105328965  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105344195  uncharacterized protein LOC105344195 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105347192  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105320314  anoctamin-4 isoform X1 [KO:K19480]
117691484  anoctamin-4-like isoform X1 [KO:K19480]
105345893  anoctamin-7 isoform X1 [KO:K19501]
105344205  neuroplastin isoform X1 [KO:K06535]
117680467  basigin-like [KO:K06535]
105319805  XK-related protein 6 [KO:K26811]
105347295  uncharacterized protein LOC105347295 [KO:K26811]
105348731  probable phospholipid-transporting ATPase IA isoform X4 [KO:K14802] [EC:7.6.2.1]
105330584  probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
105318436  cell cycle control protein 50A isoform X1 [KO:K26935]
105332751  integrin beta pat-3 isoform X1 [KO:K06493]
105342576  integrin beta-3-like isoform X1 [KO:K06493]
105328932  integrin beta-3 [KO:K06493]
117683865  integrin beta-3-like [KO:K06493]
105342575  integrin beta-3-like isoform X1 [KO:K06493]
117684088  integrin beta-3-like [KO:K06493]
117684089  integrin beta-1-like [KO:K06493]
105346726  integrin beta-6 [KO:K06493]
117683864  integrin beta-6-like isoform X1 [KO:K06588]
105334284  integrin beta-3 [KO:K06588]
105334283  integrin beta-3 isoform X1 [KO:K06588]
117684087  integrin beta pat-3-like [KO:K06588]
105340170  stabilin-2 [KO:K19013]
105318395  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
105329588  enhancer of filamentation 1 isoform X1 [KO:K05726]
105330355  adapter molecule Crk [KO:K04438]
105325386  engulfment and cell motility protein 2 isoform X1 [KO:K12366]
105338650  dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
105317565  rho-related protein racD [KO:K04392]
105321031  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105322710  rac-like GTP-binding protein ARAC7 [KO:K04392]
105328475  cdc42 homolog [KO:K04392]
105328476  rac-like GTP-binding protein 2 [KO:K04392]
105328483  cdc42 homolog [KO:K04392]
105333108  cdc42 homolog [KO:K04392]
117684397  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
105344224  ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K04392]
105317564  rho-related protein racD [KO:K04392]
117689129  rho-related protein racD-like [KO:K04392]
117689131  rho-related protein racD-like [KO:K04392]
105336966  Crt; calreticulin precursor [KO:K08057]
105320711  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 1 [KO:K04550]
105325378  protein draper isoform X1 [KO:K24068]
105331846  protein draper isoform X1 [KO:K24068]
105337223  multiple epidermal growth factor-like domains protein 10 [KO:K24068]
105323097  LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 10 [KO:K24068]
105346814  multiple epidermal growth factor-like domains protein 10 [KO:K24068]
105332872  uncharacterized protein LOC105332872 isoform X1 [KO:K24068]
105334720  uncharacterized protein LOC105334720 isoform X1 [KO:K24068]
105325729  multiple epidermal growth factor-like domains protein 10 [KO:K24068]
117688472  multiple epidermal growth factor-like domains protein 10 [KO:K24068]
117685504  uncharacterized protein LOC117685504 [KO:K24318]
105343501  multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24318]
105317315  laminin subunit alpha-4 [KO:K24318]
105345149  protein crumbs isoform X1 [KO:K24318]
105322573  multiple epidermal growth factor-like domains protein 10 [KO:K24318]
105322767  PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
105327336  ras-related protein Rab-5C [KO:K07888]
105348232  ras-related protein RABF2b [KO:K07888]
105325016  ras-related protein RABF1-like isoform X2 [KO:K07889]
105322207  transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
105317892  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
105338358  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
105323089  vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
105348706  vacuolar protein sorting-associated protein 18 homolog isoform X2 [KO:K20181]
105319309  vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
105339646  ras-related protein Rab-14 [KO:K07881]
105340613  vam6/Vps39-like protein [KO:K20183]
105336073  vacuolar protein sorting-associated protein 41 homolog isoform X8 [KO:K20184]
105347620  ras-related protein rab7 [KO:K07897]
105345877  lysosomal amino acid transporter 1 homolog [KO:K23678]
105339545  arginase, hepatic isoform X1 [KO:K01476] [EC:3.5.3.1]
105318614  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
105321530  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
105336654  cholesterol 25-hydroxylase-like [KO:K10223] [EC:1.14.99.38]
105320474  ecdysone receptor isoform X1 [KO:K08536]
105328226  carnitine O-palmitoyltransferase 1, liver isoform isoform X2 [KO:K08765] [EC:2.3.1.21]
105328130  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
117687545  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
105319102  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
105345808  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
105339186  LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
105345687  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
105346717  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
105329404  phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
105323212  peroxisome proliferator-activated receptor delta [KO:K04504]
105320187  solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
105330675  solute carrier family 2, facilitated glucose transporter member 3 isoform X3 [KO:K07299]
105334485  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
105336445  glucose transporter type 1 isoform X2 [KO:K07299]
105321845  tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
105347587  tyrosine-protein phosphatase non-receptor type ptp-2-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
crg00010  Glycolysis / Gluconeogenesis
crg04140  Autophagy - animal
crg04145  Phagosome
KO pathway
ko04148   
LinkDB

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