KEGG   PATHWAY: eju00230
Entry
eju00230                    Pathway                                
Name
Purine metabolism - Eumetopias jubatus (Steller sea lion)
Class
Metabolism; Nucleotide metabolism
Pathway map
eju00230  Purine metabolism
eju00230

Module
eju_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:eju00230]
eju_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:eju00230]
eju_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:eju00230]
eju_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:eju00230]
eju_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:eju00230]
eju_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:eju00230]
eju_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:eju00230]
Other DBs
GO: 0006163 0042278
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114220101  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
114225347  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
114217686  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
114212096  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
114197194  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
114218070  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
114221462  PRPS1L1; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
114198335  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
114206810  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
114218318  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
114225371  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
114206674  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
114206809  trihelix transcription factor GT-2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
114218546  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
114215981  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
114199277  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
114224301  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
114205216  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
114198164  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
114205955  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
114216057  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
114223442  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
114213027  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
114209701  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
114221354  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
114211572  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
114201650  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
114224962  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
114210623  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
114225015  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
114215488  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
114199465  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
114199466  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
114215740  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
114223983  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
114209933  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
114201758  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
114212359  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
114205283  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
114216321  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
114217473  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
114224517  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
114205733  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
114220692  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
114219619  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
114218271  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
114209083  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
114217890  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
114212522  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
114197893  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
114202643  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
114218713  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
114205923  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
114214816  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
114219549  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
114218925  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
114206841  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
114223288  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
114197362  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
114213699  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114223681  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
114205853  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
114217911  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114199416  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
114225777  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
114202960  adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
114202963  adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
114211178  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
114219898  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114204463  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
114215584  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
114210207  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
114211229  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
114210206  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
114210498  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
114221649  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
114225449  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
114218609  LOW QUALITY PROTEIN: olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
114198355  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
114200048  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
114198680  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
114218250  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
114202844  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
114224741  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
114225818  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
114202970  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
114202971  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
114218702  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
114200912  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
114219342  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
114196664  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
114211995  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
114203397  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
114203399  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
114205393  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
114210870  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
114216041  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
114221609  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
114226425  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
114209325  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
114224270  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
114204669  ADSSL1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
114215515  ADSS; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
114208003  AMPD1; LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
114219347  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
114207926  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
114214191  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
114223222  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
114222537  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
114208429  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
114208477  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
114217020  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
114226106  LOW QUALITY PROTEIN: adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
114212864  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
114198878  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
114207122  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
114208865  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
114204535  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
114198253  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
114224871  LOW QUALITY PROTEIN: GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
114219739  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
114201771  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
114210291  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
114225624  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
114225633  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
114208335  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
114196478  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
114220973  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
114197756  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
114214458  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
114222746  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
114217652  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
114198137  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
114214644  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
114204562  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
114210364  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
114222661  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
114208481  uricase [KO:K00365] [EC:1.7.3.3]
114202734  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
eju00030  Pentose phosphate pathway
eju00220  Arginine biosynthesis
eju00250  Alanine, aspartate and glutamate metabolism
eju00260  Glycine, serine and threonine metabolism
eju00340  Histidine metabolism
eju00630  Glyoxylate and dicarboxylate metabolism
eju00730  Thiamine metabolism
eju00740  Riboflavin metabolism
eju00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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