KEGG   PATHWAY: etf05415
Entry
etf05415                    Pathway                                
Name
Diabetic cardiomyopathy - Echinops telfairi (small Madagascar hedgehog)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
etf05415  Diabetic cardiomyopathy
etf05415

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101659113  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101659665  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
101659644  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
101653282  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101648930  TNNI3; troponin I, cardiac muscle [KO:K12044]
101639879  RYR2; ryanodine receptor 2 [KO:K04962]
101644023  PLN; cardiac phospholamban [KO:K05852]
101661059  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101639123  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101651580  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101656971  SP1; transcription factor Sp1 [KO:K04684]
101653271  AGT; angiotensinogen [KO:K09821]
101642532  REN; renin [KO:K01380] [EC:3.4.23.15]
101640954  CMA1; chymase isoform X2 [KO:K01329] [EC:3.4.21.39]
101657103  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
101646399  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101640739  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101654504  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
101658151  cytochrome b-245 light chain [KO:K08009]
101649411  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101657587  NCF4; LOW QUALITY PROTEIN: neutrophil cytosol factor 4 [KO:K08012]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101656762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101646805  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101663870  RELA; transcription factor p65 [KO:K04735]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101655753  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101662935  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101647520  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101647433  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101645714  COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101642513  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101659291  CD36; platelet glycoprotein 4 [KO:K06259]
101655834  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
101651337  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
101650430  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
101642479  PDK3; pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
101648057  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101650810  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101662700  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
101653184  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101663948  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101656573  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
101638709  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101654577  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101661315  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101656559  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
101641705  INS; insulin [KO:K04526]
101657077  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101650216  IRS1; insulin receptor substrate 1 [KO:K16172]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101651083  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101650073  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101655785  TBC1D4; TBC1 domain family member 4 [KO:K17902]
101645415  mitochondrial pyruvate carrier-like protein [KO:K22138]
101663910  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
101654038  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
101656380  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
101650368  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X2 [KO:K00161] [EC:1.2.4.1]
101662434  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
101659257  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
101650016  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
802330  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
802331  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
802332  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
802333  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
802334  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
802335  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
802336  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101654446  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101648307  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101649115  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
115871646  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101652658  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105979080  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
101642634  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
115871468  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115871615  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
115871629  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101654708  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
115873240  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
101654892  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101660982  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101639113  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
101655451  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101653317  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101653949  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101641344  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101657923  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101654342  acyl carrier protein, mitochondrial-like [KO:K03955]
101642903  acyl carrier protein, mitochondrial [KO:K03955]
101658197  acyl carrier protein, mitochondrial-like [KO:K03955]
101658798  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101644308  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
115869492  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
101660948  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
101657908  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101644575  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
115868737  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
115873199  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
115869395  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
101656638  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
115872092  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
115872006  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101654519  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101643828  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101640401  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101643885  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101647046  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
101664420  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101654859  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101658030  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101649968  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101644338  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101658539  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101651179  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
101651054  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101643499  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101660829  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101640767  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
101655488  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101657196  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101649217  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101647009  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101640009  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101653242  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101660670  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101660430  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101640820  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101644773  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
802338  CYTB; cytochrome b [KO:K00412]
101641779  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101639006  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101658800  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101641378  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
101660663  cytochrome b-c1 complex subunit 7-like [KO:K00417]
101655377  cytochrome b-c1 complex subunit 7 [KO:K00417]
115870168  cytochrome b-c1 complex subunit 7-like [KO:K00417]
101655167  cytochrome b-c1 complex subunit 8 [KO:K00418]
101649136  cytochrome b-c1 complex subunit 9 [KO:K00419]
101647848  cytochrome b-c1 complex subunit 10-like [KO:K00420]
101646763  cytochrome b-c1 complex subunit 10 [KO:K00420]
101641433  cytochrome b-c1 complex subunit 10-like [KO:K00420]
802329  COX3; cytochrome c oxidase subunit III [KO:K02262]
802327  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
802328  COX2; cytochrome c oxidase subunit II [KO:K02261]
101662244  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101644516  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101663125  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105979674  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101645126  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
101657136  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
101641935  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105979995  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101656692  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101660222  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101640324  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101654913  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101649535  cytochrome c oxidase subunit 6B1-like [KO:K02267]
115868703  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101655402  cytochrome c oxidase subunit 6B2 [KO:K02267]
101657672  cytochrome c oxidase subunit 6B1 [KO:K02267]
115869234  cytochrome c oxidase subunit 6B1-like [KO:K02267]
115868698  cytochrome c oxidase subunit 6C isoform X2 [KO:K02268]
115871260  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
101652550  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
115871755  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101663987  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101651542  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
115868983  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
101655666  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101650318  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
115871644  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115872385  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123522755  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115873769  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
115868264  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115868682  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115869232  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
115872049  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
115872554  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
115872007  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101647414  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101659808  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101648654  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
101640525  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
101641389  ATP synthase subunit delta, mitochondrial [KO:K02134]
101650207  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
115871972  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
115868774  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
802337  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101649586  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
101662086  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101642029  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
101638576  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
105979491  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101657495  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105979765  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101651440  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101654301  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101660847  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105979066  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
101658560  ATP synthase subunit d, mitochondrial-like [KO:K02138]
101663222  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101648762  ATP synthase subunit d, mitochondrial-like [KO:K02138]
101643680  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
101640972  ATP synthase subunit O, mitochondrial-like [KO:K02137]
101661561  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101653269  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
101655801  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
101638485  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
802326  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101656727  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101653907  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101649902  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101642569  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101638395  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101643848  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101648707  ADP/ATP translocase 2 [KO:K05863]
101655091  ADP/ATP translocase 3 [KO:K05863]
101646088  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101653289  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101649341  ADP/ATP translocase 2-like [KO:K05863]
101642037  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial-like [KO:K09565] [EC:5.2.1.8]
101638230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101651846  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101644765  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101659943  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105978642  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101645056  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101659821  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101652698  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
101644672  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101652412  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101640691  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
105979225  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
115871329  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
101654058  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
101645792  glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101650765  glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101648646  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101662378  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
101652427  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101660774  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101642964  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105979476  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
101651304  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101650582  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101647679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101656854  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101656494  angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
101656382  angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
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Of mice and men: models and mechanisms of diabetic cardiomyopathy.
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Basic Res Cardiol 114:2 (2018)
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Reference
PMID:24462787
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Reference
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Reference
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Front Endocrinol (Lausanne) 8:72 (2017)
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Related
pathway
etf00010  Glycolysis / Gluconeogenesis
etf00020  Citrate cycle (TCA cycle)
etf00190  Oxidative phosphorylation
etf00520  Amino sugar and nucleotide sugar metabolism
etf03320  PPAR signaling pathway
etf04071  Sphingolipid signaling pathway
etf04150  mTOR signaling pathway
etf04210  Apoptosis
etf04260  Cardiac muscle contraction
etf04350  TGF-beta signaling pathway
etf04614  Renin-angiotensin system
etf04910  Insulin signaling pathway
etf04930  Type II diabetes mellitus
etf04931  Insulin resistance
etf04933  AGE-RAGE signaling pathway in diabetic complications
etf04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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