KEGG   PATHWAY: hald04810
Entry
hald04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Haliaeetus albicilla (white-tailed eagle)
Class
Cellular Processes; Cell motility
Pathway map
hald04810  Regulation of actin cytoskeleton
hald04810

Other DBs
GO: 0030036
Organism
Haliaeetus albicilla (white-tailed eagle) [GN:hald]
Gene
104324820  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104315273  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104317523  LPAR4; lysophosphatidic acid receptor 4 isoform X1 [KO:K04275]
104318871  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104325315  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104317924  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104323769  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
104317992  F2R; proteinase-activated receptor 1 [KO:K03914]
104319005  INS; insulin [KO:K04526]
104321638  EGF; pro-epidermal growth factor [KO:K04357]
104311887  FGF2; fibroblast growth factor 2 [KO:K18497]
104313730  fibroblast growth factor 10-like [KO:K04358]
104313915  fibroblast growth factor 20 [KO:K04358]
104311650  FGF3; fibroblast growth factor 3 [KO:K04358]
104315221  FGF7; fibroblast growth factor 7 [KO:K04358]
104322486  FGF18; fibroblast growth factor 18 [KO:K04358]
104322492  FGF6; fibroblast growth factor 6 [KO:K04358]
104312026  fibroblast growth factor 9 [KO:K04358]
104322496  FGF23; fibroblast growth factor 23 [KO:K22428]
104311822  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104321158  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104324649  PDGFD; platelet-derived growth factor D [KO:K05450]
104325380  PDGFC; platelet-derived growth factor C [KO:K05450]
104314842  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104319974  LOW QUALITY PROTEIN: fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
104321767  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104323103  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104324083  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104323572  FN1; fibronectin [KO:K05717]
104323349  ITGA1; integrin alpha-1 [KO:K06480]
104315505  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
104323280  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
104314869  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
104324091  ITGA8; integrin alpha-8 [KO:K06584]
104322949  LOW QUALITY PROTEIN: integrin alpha-11-like [KO:K06587]
104315023  ITGAV; integrin alpha-V [KO:K06487]
104325758  integrin alpha-E-like [KO:K06524]
104318188  ITGB1; integrin beta-1 [KO:K05719]
104315832  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
104314489  ITGB3; integrin beta-3 [KO:K06493]
104324455  ITGB4; integrin beta-4 [KO:K06525]
104319789  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104311746  ITGB8; integrin beta-8 [KO:K06591]
104320734  kininogen-1-like [KO:K03898]
104313434  B2 bradykinin receptor-like [KO:K03916]
104315154  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104318401  CHRM3; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M3 [KO:K04131]
104316121  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M4-like [KO:K04132]
104317448  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104314278  C5; complement C5 [KO:K03994]
104322074  C6; complement component C6 [KO:K03995]
104320442  C7; complement component C7 [KO:K03996]
104319248  C8A; complement component C8 alpha chain [KO:K03997]
104319324  C8B; complement component C8 beta chain [KO:K03998]
104322604  C9; complement component C9 [KO:K04000]
104321090  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104314263  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
104323012  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104320196  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
104315085  CRKL; crk-like protein [KO:K04438]
104318277  CRK; adapter molecule crk [KO:K04438]
104323464  dedicator of cytokinesis protein 1-like [KO:K13708]
104325774  SOS2; son of sevenless homolog 2 [KO:K03099]
104316833  SOS1; son of sevenless homolog 1 [KO:K03099]
104317684  HRAS; GTPase HRas [KO:K02833]
104323482  KRAS; GTPase KRas [KO:K07827]
104318405  GTPase NRas [KO:K07828]
104320519  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104320362  MRAS; ras-related protein M-Ras [KO:K07831]
104314561  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
104314241  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104316099  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104316120  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104319651  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104315723  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104323052  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
104320636  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104321222  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104323092  proto-oncogene vav-like [KO:K05730]
104325106  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104321152  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104323051  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104322861  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104318307  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104319172  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
104310858  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104317107  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104323731  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
104315814  regulator of cell cycle RGCC-like [KO:K26108]
104310417  regulator of cell cycle RGCC-like [KO:K26108]
104324633  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104314025  ARHGAP35; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
104317542  RHOA; transforming protein RhoA [KO:K04513]
104315993  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104322691  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104312409  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
104316583  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104322946  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104323184  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104320719  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104315654  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104317812  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104314112  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
104310626  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
104315556  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104319310  calcium-dependent protein kinase 20-like [KO:K00907] [EC:2.7.11.18]
104319374  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104317041  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
104317959  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104311435  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104317487  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
104315090  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
104316991  myosin regulatory light chain 2A, cardiac muscle isoform [KO:K10351]
104313563  myosin regulatory light polypeptide 9 [KO:K12755]
104322292  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104312675  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
104310657  myosin regulatory light polypeptide 9-like [KO:K12757]
104324299  MYH9; myosin-9 [KO:K10352]
104325103  MYH10; myosin-10 isoform X1 [KO:K10352]
104325537  MYH11; myosin-11 [KO:K10352]
104324506  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
104313135  SLC9A1; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 1 [KO:K05742]
104320459  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
104322330  PIP5K1A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104312297  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
104325505  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
104321732  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
104315834  LIMK2; LOW QUALITY PROTEIN: LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
104311246  ENAH; protein enabled homolog [KO:K05746]
104319219  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
104322972  cytoplasmic FMR1-interacting protein 2 [KO:K05749]
104320127  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
104323875  ABI2; abl interactor 2 isoform X1 [KO:K05751]
104325990  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
104311179  ACTR2; actin-related protein 2 [KO:K17260]
104314118  actin-related protein 3 [KO:K18584]
104314779  actin-related protein 3B [KO:K18584]
104324415  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
104324000  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104313054  ARPC2; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2 [KO:K05758]
104311617  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104325892  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104312470  actin, cytoplasmic type 5 [KO:K05692]
104324128  actin, cytoplasmic 2-like [KO:K05692]
104324189  LOW QUALITY PROTEIN: actin, muscle-like [KO:K05692]
104324449  PFN4; profilin-4 [KO:K05759]
104318655  PFN2; profilin-2 [KO:K05759]
104316745  paxillin-like [KO:K05760]
104310838  EZR; ezrin isoform X1 [KO:K08007]
104318442  radixin [KO:K05762]
104323935  MSN; moesin [KO:K05763]
104312823  TMSB4X; thymosin beta-4 [KO:K05764]
104312229  CFL2; cofilin-2 [KO:K05765]
104315624  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104316495  LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104321171  VCL; vinculin [KO:K05700]
104318295  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104319784  LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP3 [KO:K05767]
104321619  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
104324932  GSN; gelsolin [KO:K05768]
104310736  SCIN; adseverin [KO:K05768]
104311398  alpha-actinin-1 [KO:K05699]
104318682  LOW QUALITY PROTEIN: alpha-actinin-4-like [KO:K05699]
104310686  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
104312590  uncharacterized protein LOC104312590 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hald04010  MAPK signaling pathway
hald04510  Focal adhesion
hald04520  Adherens junction
KO pathway
ko04810   
LinkDB

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