KEGG   PATHWAY: hsp00310
Entry
hsp00310                    Pathway                                
Name
Lysine degradation - Hippoglossus stenolepis (Pacific halibut)
Class
Metabolism; Amino acid metabolism
Pathway map
hsp00310  Lysine degradation
hsp00310

Module
hsp_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:hsp00310]
Other DBs
GO: 0006554
Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118109577  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
118120794  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118102456  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
118109529  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
118099223  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
118116580  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
118109657  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
118097977  gcdha; glutaryl-CoA dehydrogenase a [KO:K00252] [EC:1.3.8.6]
118123934  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
118116643  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
118120384  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
118119153  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
118123693  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
118099212  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
118121996  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
118120671  hydroxylysine kinase isoform X1 [KO:K18201] [EC:2.7.1.81]
118121119  hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
118121121  hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
118112487  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
118106474  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
118119051  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
118105801  kmt2a; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
118110520  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
118118312  kmt2cb; histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
118098932  histone-lysine N-methyltransferase 2C-like [KO:K09188] [EC:2.1.1.354]
118113601  kmt2bb; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
118124314  kmt2ba; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
118101325  kmt2e; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
118123874  setd1a; histone-lysine N-methyltransferase SETD1A [KO:K11422] [EC:2.1.1.354]
118125992  setd1ba; histone-lysine N-methyltransferase SETD1B-A isoform X1 [KO:K11422] [EC:2.1.1.354]
118111964  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
118100705  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
118113702  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
118125034  ash1l; histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
118115053  smyd1b; histone-lysine N-methyltransferase SMYD1b isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118099688  smyd2b; N-lysine methyltransferase SMYD2-B [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118112808  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118098070  smyd1a; histone-lysine N-methyltransferase SMYD1a [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118105736  smyd2a; N-lysine methyltransferase SMYD2-A [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118111057  histone-lysine N-methyltransferase SUV39H1 [KO:K11419] [EC:2.1.1.355]
118124531  ehmt2; histone-lysine N-methyltransferase EHMT2 isoform X1 [KO:K11420] [EC:2.1.1.355]
118125578  ehmt1b; histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
118115404  ehmt1a; histone-lysine N-methyltransferase EHMT1a isoform X1 [KO:K11420] [EC:2.1.1.355]
118113532  setdb1b; histone-lysine N-methyltransferase SETDB1-B isoform X1 [KO:K11421] [EC:2.1.1.366]
118103405  setdb2; histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
118110933  prdm2a; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
118104898  prdm2b; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
118123196  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
118098326  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
118105497  setmar; histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
118122475  nsd1b; histone-lysine N-methyltransferase, H3 lysine-36 specific [KO:K15588] [EC:2.1.1.357]
118112241  nsd1a; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
118115964  nsd2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
118115062  nsd3; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
118113301  setd2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
124854783  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
118115071  kmt5ab; lysine methyltransferase 5Ab [KO:K11428] [EC:2.1.1.361]
118098042  kmt5aa; N-lysine methyltransferase KMT5A-A [KO:K11428] [EC:2.1.1.361]
118114691  prdm6; putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
118106138  kmt5b; histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
118109361  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase KMT5C [KO:K11429] [EC:2.1.1.362]
118123194  kmt5c; histone-lysine N-methyltransferase KMT5C isoform X1 [KO:K11429] [EC:2.1.1.362]
118106548  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118111321  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
118121692  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
118122599  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
118105798  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00128] [EC:1.2.1.3]
118105799  aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
118114239  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
118123683  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
118117824  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118121327  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118108668  bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
124852240  gamma-butyrobetaine dioxygenase-like [KO:K00471] [EC:1.14.11.1]
118110588  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X1 [KO:K00473] [EC:1.14.11.4]
118098415  plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
118102891  plod3; LOW QUALITY PROTEIN: multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
118122921  colgalt1a; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
118118133  procollagen galactosyltransferase 2-like [KO:K11703] [EC:2.4.1.50]
118120340  colgalt1b; procollagen galactosyltransferase 1 isoform X1 [KO:K11703] [EC:2.4.1.50]
118125405  cercam; procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
124854813  colgalt2b; procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
hsp00020  Citrate cycle (TCA cycle)
hsp00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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