KEGG   PATHWAY: hsyr03013
Entry
hsyr03013                   Pathway                                
Name
Nucleocytoplasmic transport - Hibiscus syriacus (Rose-of-Sharon)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
hsyr03013  Nucleocytoplasmic transport
hsyr03013

Other DBs
GO: 0050658
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:hsyr]
Gene
120183990  aladin-like [KO:K14320]
120202919  aladin isoform X1 [KO:K14320]
120168123  zinc finger CCCH domain-containing protein 16-like [KO:K14321]
120192602  zinc finger CCCH domain-containing protein 16-like [KO:K14321]
120150325  LOW QUALITY PROTEIN: protein GLE1-like [KO:K18723]
120183267  protein GLE1-like isoform X1 [KO:K18723]
120211708  DEAD-box ATP-dependent RNA helicase 38-like [KO:K18655] [EC:5.6.2.7]
120148573  protein RAE1-like [KO:K14298]
120148948  protein RAE1-like [KO:K14298]
120133487  protein RAE1 [KO:K14298]
120118404  protein RAE1-like isoform X1 [KO:K14298]
120194446  protein RAE1-like [KO:K14298]
120132481  nuclear pore complex protein NUP98A-like [KO:K14297]
120185014  nuclear pore complex protein NUP98A-like isoform X1 [KO:K14297]
120169667  nuclear pore complex protein NUP96-like isoform X1 [KO:K14297]
120125430  nuclear pore complex protein NUP96-like [KO:K14297]
120158529  nuclear pore complex protein NUP98A-like [KO:K14297]
120172625  nuclear pore complex protein NUP214 [KO:K14317]
120177456  nuclear pore complex protein NUP214-like [KO:K14317]
120213506  nuclear pore complex protein NUP88-like [KO:K14318]
120138665  nuclear pore complex protein NUP88-like [KO:K14318]
120136809  RAN GTPase-activating protein 1-like [KO:K14319]
120179587  SUMO-conjugating enzyme UBC9-like [KO:K10577]
120212820  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120196834  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120132411  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120168268  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120169707  SUMO-conjugating enzyme SCE1 [KO:K10577]
120137721  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120139330  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120171788  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
120156767  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120191415  SUMO-conjugating enzyme SCE1-like [KO:K10577]
120194987  SUMO-conjugating enzyme UBC9-like [KO:K10577]
120119601  nuclear pore complex protein NUP160-like isoform X1 [KO:K14303]
120203848  nuclear pore complex protein NUP160-like isoform X1 [KO:K14303]
120147962  nuclear pore complex protein NUP85-like [KO:K14304]
120119086  nuclear pore complex protein NUP85-like [KO:K14304]
120141346  LOW QUALITY PROTEIN: nuclear pore complex protein NUP85-like [KO:K14304]
120192428  nuclear pore complex protein NUP85-like [KO:K14304]
120167382  protein transport protein SEC13 homolog B-like [KO:K14004]
120140599  protein transport protein SEC13 homolog B-like [KO:K14004]
120208383  protein transport protein SEC13 homolog B-like [KO:K14004]
120178728  protein transport protein SEC13 homolog B-like [KO:K14004]
120158860  nuclear pore complex protein NUP107 [KO:K14301]
120146417  nuclear pore complex protein NUP133-like [KO:K14300]
120127072  LOW QUALITY PROTEIN: nuclear pore complex protein NUP133-like [KO:K14300]
120114474  protein SEH1-like [KO:K14299]
120193742  protein SEH1-like [KO:K14299]
120160058  nuclear pore complex protein NUP62-like [KO:K14306]
120210978  nuclear pore complex protein NUP62-like [KO:K14306]
120152183  nuclear pore complex protein NUP58-like [KO:K14307]
120126935  nuclear pore complex protein NUP58-like [KO:K14307]
120149133  nuclear pore complex protein NUP54-like isoform X1 [KO:K14308]
120124898  nuclear pore complex protein NUP54-like [KO:K14308]
120150176  LOW QUALITY PROTEIN: nuclear pore complex protein NUP205-like [KO:K14310]
120177655  nuclear pore complex protein NUP205-like isoform X1 [KO:K14310]
120190102  uncharacterized protein LOC120190102 [KO:K14311]
120149142  nuclear pore complex protein NUP155-like isoform X1 [KO:K14312]
120215357  nuclear pore complex protein NUP155-like isoform X1 [KO:K14312]
120116944  nuclear pore complex protein NUP93A-like [KO:K14309]
120158029  LOW QUALITY PROTEIN: nuclear pore complex protein NUP93A-like [KO:K14309]
120195879  nuclear pore complex protein NUP35-like [KO:K14313]
120137502  nuclear pore complex protein NUP35-like [KO:K14313]
120204252  nuclear pore complex protein NUP35-like [KO:K14313]
120125282  nuclear pore complex protein NUP35-like [KO:K14313]
120159503  nuclear pore complex protein NUP35-like [KO:K14313]
120175786  nuclear pore complex protein NUP35-like [KO:K14313]
120129656  uncharacterized protein LOC120129656 [KO:K14315]
120209047  uncharacterized protein LOC120209047 [KO:K14315]
120140186  nuclear pore complex protein GP210 isoform X1 [KO:K14314]
120182974  transmembrane protein 33 homolog [KO:K20724]
120200706  transmembrane protein 33 homolog [KO:K20724]
120209022  uncharacterized protein LOC120209022 [KO:K20724]
120161316  transmembrane protein 33 homolog [KO:K20724]
120198301  nuclear-pore anchor-like isoform X1 [KO:K09291]
120157561  LOW QUALITY PROTEIN: nuclear-pore anchor-like [KO:K09291]
120146304  uncharacterized protein LOC120146304 [KO:K14295]
120166827  uncharacterized protein DDB_G0271670-like [KO:K14295]
120114344  importin subunit alpha-1a-like [KO:K15042]
120114802  importin subunit alpha-2-like [KO:K15042]
120165242  importin subunit alpha-like [KO:K15042]
120198882  LOW QUALITY PROTEIN: importin subunit alpha-9-like [KO:K15042]
120117724  importin subunit alpha-like [KO:K15042]
120183146  importin subunit alpha-like [KO:K15042]
120152491  importin subunit alpha-2-like [KO:K15042]
120152525  importin subunit alpha-4-like [KO:K15042]
120136923  importin subunit alpha-like [KO:K15042]
120154161  importin subunit alpha-4-like [KO:K15042]
120155858  importin subunit alpha-2-like [KO:K15042]
120205542  importin subunit alpha-like [KO:K15042]
120123416  importin subunit alpha-4-like [KO:K15042]
120173778  importin subunit alpha-like [KO:K15042]
120158431  importin subunit alpha-2-like [KO:K15042]
120158902  importin subunit alpha-4-like [KO:K15042]
120159229  importin subunit alpha-2-like [KO:K15042]
120160248  importin subunit alpha-2-like isoform X1 [KO:K15042]
120161215  importin subunit alpha-like [KO:K15042]
120128717  importin subunit alpha-9-like [KO:K15042]
120199767  importin subunit beta-1-like [KO:K14293]
120151084  importin subunit beta-1-like [KO:K14293]
120135227  importin subunit beta-1-like [KO:K14293]
120202647  importin subunit beta-1-like [KO:K14293]
120137363  importin subunit beta-1-like [KO:K14293]
120155377  LOW QUALITY PROTEIN: importin subunit beta-1-like [KO:K14293]
120142837  importin subunit beta-1-like [KO:K14293]
120191673  importin subunit beta-1-like [KO:K14293]
120134552  transportin-1-like [KO:K18752]
120176985  transportin-1-like [KO:K18752]
120145546  transportin-1-like [KO:K18752]
120211407  transportin-1-like isoform X1 [KO:K18752]
120129556  transportin MOS14 [KO:K15436]
120165650  uncharacterized protein LOC120165650 isoform X1 [KO:K15436]
120166305  transportin MOS14-like [KO:K15436]
120178443  transportin MOS14-like [KO:K15436]
120184212  importin-4-like [KO:K20221]
120162180  importin-5-like [KO:K20222]
120130432  importin-5-like [KO:K20222]
120164758  importin-5-like isoform X1 [KO:K20222]
120182560  importin-5-like [KO:K20222]
120168019  importin-5-like [KO:K20222]
120202710  importin-5-like [KO:K20222]
120115136  importin beta-like SAD2 [KO:K20223]
120218161  importin beta-like SAD2 [KO:K20223]
120169944  importin beta-like SAD2 isoform X1 [KO:K20223]
120137825  importin beta-like SAD2 isoform X1 [KO:K20223]
120192053  importin beta-like SAD2 isoform X1 [KO:K20223]
120184255  importin-9-like [KO:K20224]
120151092  importin-11-like [KO:K25201]
120135490  importin-11-like [KO:K25201]
120188284  importin-11-like [KO:K25201]
120129268  importin-11-like [KO:K25201]
120215934  snurportin-1-like [KO:K13151]
120193731  snurportin-1-like [KO:K13151]
120213532  protein EXPORTIN 1A-like [KO:K14290]
120200349  protein EXPORTIN 1A-like [KO:K14290]
120170248  protein EXPORTIN 1A isoform X1 [KO:K14290]
120120198  exportin-2-like [KO:K18423]
120188763  exportin-2-like [KO:K18423]
120119333  exportin-T-like [KO:K14288]
120137619  exportin-T-like [KO:K14288]
120116159  LOW QUALITY PROTEIN: exportin-4-like [KO:K25203]
120151300  protein HASTY 1-like [KO:K14289]
120161685  protein HASTY 1-like isoform X1 [KO:K14289]
120213181  LOW QUALITY PROTEIN: exportin-7-like [KO:K18460]
120172862  exportin-7-like isoform X1 [KO:K18460]
120149608  GTP-binding nuclear protein Ran-3 [KO:K07936]
120134064  GTP-binding nuclear protein Ran-3 [KO:K07936]
120156586  GTP-binding nuclear protein Ran-3 isoform X1 [KO:K07936]
120124172  GTP-binding nuclear protein Ran-3-like [KO:K07936]
120159277  GTP-binding nuclear protein Ran-3-like [KO:K07936]
120192203  GTP-binding nuclear protein Ran1B-like [KO:K07936]
120176724  GTP-binding nuclear protein Ran1B-like [KO:K07936]
120129602  elongation factor 1-alpha [KO:K03231]
120129754  elongation factor 1-alpha-like [KO:K03231]
120146055  elongation factor 1-alpha-like [KO:K03231]
120214184  elongation factor 1-alpha-like [KO:K03231]
120214487  elongation factor 1-alpha-like [KO:K03231]
120116400  elongation factor 1-alpha-like [KO:K03231]
120217523  elongation factor 1-alpha-like [KO:K03231]
120151779  elongation factor 1-alpha-like [KO:K03231]
120187762  elongation factor 1-alpha [KO:K03231]
120156252  elongation factor 1-alpha-like [KO:K03231]
120171537  elongation factor 1-alpha-like [KO:K03231]
120123999  elongation factor 1-alpha-like [KO:K03231]
120207510  elongation factor 1-alpha-like [KO:K03231]
120174602  elongation factor 1-alpha-like [KO:K03231]
120175007  elongation factor 1-alpha-like [KO:K03231]
120126153  elongation factor 1-alpha-like [KO:K03231]
120176475  elongation factor 1-alpha-like [KO:K03231]
120209819  elongation factor 1-alpha-like [KO:K03231]
120211643  elongation factor 1-alpha-like [KO:K03231]
120211644  elongation factor 1-alpha-like [KO:K03231]
120132006  uncharacterized protein LOC120132006 [KO:K14291]
120218717  uncharacterized protein LOC120218717 isoform X1 [KO:K14291]
120157066  uncharacterized protein LOC120157066 isoform X1 [KO:K14291]
120164736  nuclear cap-binding protein subunit 1-like [KO:K12882]
120116545  nuclear cap-binding protein subunit 1-like isoform X1 [KO:K12882]
120215193  nuclear cap-binding protein subunit 2-like [KO:K12883]
120151486  nuclear cap-binding protein subunit 2-like [KO:K12883]
120171310  nuclear cap-binding protein subunit 2-like [KO:K12883]
120172428  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
120175375  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
120212908  60S ribosomal export protein NMD3-like [KO:K07562]
120147543  60S ribosomal export protein NMD3-like [KO:K07562]
120161655  60S ribosomal export protein NMD3-like [KO:K07562]
120162456  RNA-binding protein Y14-like [KO:K12876]
120164732  RNA-binding protein Y14-like [KO:K12876]
120116626  RNA-binding protein Y14-like [KO:K12876]
120117532  RNA-binding protein Y14-like [KO:K12876]
120168108  RNA-binding protein Y14-like [KO:K12876]
120155484  RNA-binding protein Y14-like isoform X1 [KO:K12876]
120142171  RNA-binding protein Y14-like [KO:K12876]
120144211  RNA-binding protein Y14-like [KO:K12876]
120211363  RNA-binding protein Y14-like [KO:K12876]
120188756  protein mago nashi homolog isoform X1 [KO:K12877]
120140682  protein mago nashi homolog [KO:K12877]
120208399  protein mago nashi homolog [KO:K12877]
120163649  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
120149292  eukaryotic initiation factor 4A-III homolog A-like [KO:K13025] [EC:5.6.2.7]
120149670  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
120134583  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
120119748  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
120186628  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
120165583  uncharacterized protein LOC120165583 [KO:K12875]
120122409  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
120195625  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
120116873  histone deacetylase complex subunit SAP18-like [KO:K14324]
120136104  histone deacetylase complex subunit SAP18-like [KO:K14324]
120123860  serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325]
120160304  serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325]
120127892  serine/arginine-rich splicing factor SR45-like isoform X1 [KO:K14325]
120121772  LOW QUALITY PROTEIN: pinin-like [KO:K13114]
120192430  pinin-like [KO:K13114]
120148173  THO complex subunit 4A-like [KO:K12881]
120197974  THO complex subunit 4D-like [KO:K12881]
120165766  THO complex subunit 4A-like [KO:K12881]
120119225  THO complex subunit 4A-like [KO:K12881]
120170466  THO complex subunit 4A-like [KO:K12881]
120174981  THO complex subunit 4A-like [KO:K12881]
120126548  THO complex subunit 4D-like [KO:K12881]
120160060  THO complex subunit 4A-like [KO:K12881]
120160299  THO complex subunit 4D-like isoform X1 [KO:K12881]
120175798  THO complex subunit 4B-like [KO:K12881]
120145450  THO complex subunit 4D-like isoform X1 [KO:K12881]
120161762  THO complex subunit 4A-like [KO:K12881]
120200005  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
120151758  regulator of nonsense transcripts UPF2-like [KO:K14327]
120204154  regulator of nonsense transcripts UPF2-like [KO:K14327]
120146691  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
120196097  regulator of nonsense transcripts UPF3-like [KO:K14328]
120214715  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
120217253  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
120151289  regulator of nonsense transcripts UPF3-like [KO:K14328]
120119700  regulator of nonsense transcripts UPF3-like [KO:K14328]
120137661  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
120204104  regulator of nonsense transcripts UPF3-like [KO:K14328]
120125479  regulator of nonsense transcripts UPF3-like [KO:K14328]
120162481  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120148004  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120132197  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
120117682  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120150809  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120135814  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120185830  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120157252  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
120159407  DEAD-box ATP-dependent RNA helicase 15-like [KO:K12812] [EC:5.6.2.7]
120192666  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
120194460  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
120161465  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
120167892  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
120189420  serine/arginine repetitive matrix protein 1-like [KO:K13171]
120124606  LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1-like [KO:K13171]
120142205  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
120201650  partner of Y14 and mago-like isoform X1 [KO:K14294]
120123151  LOW QUALITY PROTEIN: partner of Y14 and mago-like [KO:K14294]
120145395  partner of Y14 and mago-like [KO:K14294]
120120064  THO complex subunit 1-like [KO:K12878]
120204482  LOW QUALITY PROTEIN: THO complex subunit 1-like [KO:K12878]
120178932  THO complex subunit 2-like isoform X1 [KO:K12879]
120169739  THO complex subunit 2-like isoform X1 [KO:K12879]
120125146  THO complex subunit 2-like isoform X1 [KO:K12879]
120198855  LOW QUALITY PROTEIN: THO complex subunit 5B-like [KO:K13174]
120216648  THO complex subunit 5B-like [KO:K13174]
120192326  THO complex subunit 6-like [KO:K13175]
120133581  THO complex subunit 7B-like [KO:K13176]
120189421  THO complex subunit 7A-like [KO:K13176]
120146208  THO complex subunit 3-like [KO:K12880]
120200437  THO complex subunit 3 [KO:K12880]
120202138  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
hsyr03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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