KEGG   PATHWAY: masi04910
Entry
masi04910                   Pathway                                
Name
Insulin signaling pathway - Myxocyprinus asiaticus (Chinese sucker)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
masi04910  Insulin signaling pathway
masi04910

Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127413002  preproinsulin b isoform X1 [KO:K04526]
127451533  insulin-1 [KO:K04526]
127427992  insulin-like isoform X1 [KO:K04526]
127428010  insulin [KO:K04526]
127435195  insulin-like [KO:K04526]
127435203  insulin-like [KO:K04526]
127438114  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
127439259  insulin receptor b [KO:K04527] [EC:2.7.10.1]
127441273  insulin receptor a [KO:K04527] [EC:2.7.10.1]
127442204  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
127422333  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
127430169  insulin receptor substrate 1-B-like [KO:K16172]
127430408  insulin receptor substrate 2-A-like [KO:K07187]
127443685  insulin receptor substrate 2a [KO:K07187]
127432027  insulin receptor substrate 2-B [KO:K07187]
127451354  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
127447519  LOW QUALITY PROTEIN: insulin receptor substrate 2-like [KO:K07187]
127429335  insulin receptor substrate 2-A-like isoform X1 [KO:K07187]
127448591  insulin receptor substrate 2-like [KO:K07187]
127419178  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127446660  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
127433853  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
127440526  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127448746  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127442587  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127419506  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127419549  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127419818  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
127425899  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127420056  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127422253  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127428087  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
127429484  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127431563  3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
127451546  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
127434374  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
127455191  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127444251  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127444559  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127456456  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127456734  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127413674  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127433087  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127433824  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127415836  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127410715  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127416893  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127411771  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127444093  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127445310  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127447073  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127448192  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
127450493  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
127451773  glycogen [starch] synthase, muscle-like [KO:K00693] [EC:2.4.1.11]
127435369  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
127450747  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
127451221  protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
127433369  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A-like [KO:K06269] [EC:3.1.3.16]
127415860  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127410281  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127410653  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127423013  protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
127442105  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
127423544  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
127455060  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
127418725  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
127455556  protein phosphatase 1 regulatory subunit 3C-B-like isoform X1 [KO:K07189]
127431309  protein phosphatase 1 regulatory subunit 3B-like [KO:K07189]
127456319  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
127414500  si:ch211-167b20.8; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
127427252  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
127415484  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
127428304  protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
127428887  protein phosphatase 1 regulatory subunit 3B-like isoform X1 [KO:K07189]
127423297  protein phosphatase 1 regulatory subunit 3C-B isoform X1 [KO:K07189]
127411169  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
127417337  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
127423829  uncharacterized protein LOC127423829 isoform X1 [KO:K07189]
127435937  uncharacterized protein LOC127435937 [KO:K07189]
127423979  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
127422280  phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
127428847  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like isoform X1 [KO:K00871] [EC:2.7.11.19]
127423393  phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
127449459  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
127425896  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
127451621  phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
127412183  calmodulin-1 [KO:K02183]
127455290  calmodulin-1 [KO:K02183]
127430897  calmodulin-1 [KO:K02183]
127412904  calmodulin-like protein 4 [KO:K02183]
127437620  calmodulin-like protein 4 [KO:K02183]
127413955  calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
127427039  calmodulin-1 [KO:K02183]
127421915  calmodulin-1 [KO:K02183]
127410133  calmodulin-1b [KO:K02183]
127416117  calmodulin-1 [KO:K02183]
127429073  calmodulin-1 [KO:K02183]
127423429  calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
127411559  calmodulin-1 [KO:K02183]
127430037  calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
127442984  calmodulin-like protein 4 [KO:K02183]
127455149  phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
127455565  glycogen phosphorylase, brain form-like [KO:K00688] [EC:2.4.1.1]
127431256  glycogen phosphorylase, muscle form isoform X1 [KO:K00688] [EC:2.4.1.1]
127428484  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
127411386  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
127411642  glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
127451979  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
127410746  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B-like [KO:K13296] [EC:3.1.4.17]
127450164  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127444718  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127426444  protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127451641  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
127428000  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
127440915  cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
127442986  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
127424700  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
127450256  cAMP-dependent protein kinase type I-beta regulatory subunit-like [KO:K04739]
127437652  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
127450850  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
127451756  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
127451878  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
127439146  protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
127414834  protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
127427399  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
127422796  protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b isoform X1 [KO:K04739]
127435290  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
127435802  cAMP-dependent protein kinase type II-beta regulatory subunit-like [KO:K04739]
127425486  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
127421249  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
127452857  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
127453560  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
127424282  protein kinase C zeta type-like isoform X1 [KO:K18952] [EC:2.7.11.13]
127414530  protein kinase C zeta type-like isoform X1 [KO:K18952] [EC:2.7.11.13]
127441280  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
127442457  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
127412455  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
127446667  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
127436544  flotillin-2a [KO:K07192]
127425053  flotillin-1 isoform X1 [KO:K07192]
127421096  flotillin-1-like [KO:K07192]
127427530  flotillin-2a-like isoform X1 [KO:K07192]
127452988  flotillin-1-like [KO:K07192]
127422345  flotillin-2 [KO:K07192]
127453844  flotillin-1-like isoform X1 [KO:K07192]
127429701  flotillin-2-like isoform X1 [KO:K07192]
127421939  SH2B adapter protein 2 [KO:K07193]
127430091  SH2B adapter protein 2-like isoform X1 [KO:K07193]
127414054  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
127411800  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
127421729  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
127429782  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
127432511  E3 ubiquitin-protein ligase CBL-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
127433787  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
127430284  adapter molecule crk-like [KO:K04438]
127430741  crk-like protein [KO:K04438]
127422331  adapter molecule crk [KO:K04438]
127428888  crk-like protein [KO:K04438]
127431146  rap guanine nucleotide exchange factor 1-like [KO:K06277]
127415147  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
127429233  rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
127423918  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
127427278  rho-related GTP-binding protein RhoQ-like [KO:K07194]
127423428  rho-related GTP-binding protein RhoQ [KO:K07194]
127426920  exocyst complex component 7 isoform X1 [KO:K07195]
127422969  exocyst complex component 7 isoform X1 [KO:K07195]
127450624  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
127452100  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
127450786  sterol regulatory element-binding protein 1-like isoform X1 [KO:K07197]
127451151  sterol regulatory element-binding protein 1-like isoform X1 [KO:K07197]
127430727  acetyl-CoA carboxylase isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127437002  LOW QUALITY PROTEIN: acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127418333  acetyl-CoA carboxylase-like isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127438260  acetyl-CoA carboxylase-like isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
127426869  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
127423087  fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
127413868  hexokinase-1-like [KO:K00844] [EC:2.7.1.1]
127413870  hexokinase HKDC1-like isoform X1 [KO:K00844] [EC:2.7.1.1]
127427042  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
127439674  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
127411801  hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
127411803  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
127424638  hexokinase-4-like [KO:K12407] [EC:2.7.1.2]
127415142  hexokinase-4 [KO:K12407] [EC:2.7.1.2]
127425196  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127432092  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
127410385  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
127432779  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
127414777  5'-AMP-activated protein kinase subunit beta-1-like isoform X1 [KO:K07199]
127434020  5'-AMP-activated protein kinase subunit beta-1-like isoform X1 [KO:K07199]
127441359  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
127424155  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
127443049  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
127443512  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127431796  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127445121  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
127445912  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
127434143  5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
127447297  5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
127441655  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
127448685  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
127442651  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
127432728  forkhead box protein O1-B [KO:K07201]
127421890  forkhead box protein O1-A isoform X1 [KO:K07201]
127433996  forkhead box protein O1-B-like [KO:K07201]
127430024  forkhead box protein O1-A-like [KO:K07201]
127450748  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
127442676  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
127450058  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
127451520  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
127426753  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
127426769  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
127422799  glucose-6-phosphatase 3-like [KO:K01084] [EC:3.1.3.9]
127422887  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
127422888  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
127436627  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
127436636  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
127424670  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
127424680  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
127419235  fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
127440188  fructose-1,6-bisphosphatase 1-like isoform X1 [KO:K03841] [EC:3.1.3.11]
127431425  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
127445774  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
127434301  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
127424718  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
127448991  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
127433791  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
127422644  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
127429953  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
127444031  40S ribosomal protein S6 [KO:K02991]
127444893  40S ribosomal protein S6-like [KO:K02991]
127431132  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
127428661  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
127412241  eukaryotic translation initiation factor 4eb [KO:K03259]
127412262  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
127412683  eukaryotic translation initiation factor 4E-1A [KO:K03259]
127437425  eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
127419561  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
127414189  eukaryotic translation initiation factor 4E-like [KO:K03259]
127414275  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
127440274  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
127417642  uncharacterized protein LOC127417642 isoform X1 [KO:K03259]
127443119  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
127431076  hamartin-like isoform X1 [KO:K07206]
127426723  hamartin-like isoform X1 [KO:K07206]
127439107  hamartin-like isoform X1 [KO:K07206]
127428936  TSC complex subunit 1b isoform X1 [KO:K07206]
127443978  tuberin-like isoform X1 [KO:K07207]
127445592  tuberin [KO:K07207]
127449265  GTP-binding protein Rheb-like [KO:K07208]
127431933  GTP-binding protein Rheb isoform X1 [KO:K07208]
127446060  GTP-binding protein Rheb-like [KO:K07208]
127421845  GTP-binding protein Rheb-like [KO:K07208]
127434629  GTP-binding protein Rheb-like [KO:K07208]
127430503  bcl2-associated agonist of cell death [KO:K02158]
127445216  BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
127452900  SHC-transforming protein 1-like isoform X1 [KO:K06279]
127453838  SHC-transforming protein 1-like isoform X1 [KO:K06279]
127438117  SHC-transforming protein 2-like isoform X1 [KO:K17447]
127439285  SHC-transforming protein 2-like isoform X1 [KO:K17447]
127430834  SHC-transforming protein 3-like [KO:K17448]
127429246  SHC-transforming protein 3-like [KO:K17448]
127450046  growth factor receptor-bound protein 2 [KO:K04364]
127452074  growth factor receptor-bound protein 2 [KO:K04364]
127446600  growth factor receptor-bound protein 2-like [KO:K04364]
127449036  growth factor receptor-bound protein 2-like [KO:K04364]
127413882  son of sevenless homolog 2-like [KO:K03099]
127426466  son of sevenless homolog 1-like [KO:K03099]
127428111  son of sevenless homolog 1-like isoform X1 [KO:K03099]
127411634  son of sevenless homolog 2-like [KO:K03099]
127443565  GTPase HRas-like [KO:K02833]
127437085  GTPase HRas-like [KO:K02833]
127452252  GTPase HRas [KO:K02833]
127436084  GTPase HRas-like isoform X1 [KO:K02833]
127437280  GTPase KRas isoform X1 [KO:K07827]
127450507  GTPase HRas-like [KO:K07827]
127451777  GTPase HRas-like [KO:K07827]
127436201  GTPase KRas [KO:K07827]
127415059  GTPase NRas [KO:K07828]
127423940  GTPase NRas [KO:K07828]
127436698  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
127428261  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
127434962  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
127436383  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
127419567  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
127419674  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127425942  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
127456003  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
127417241  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
127438106  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
127439045  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
127441351  dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
127430464  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127450482  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127451450  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127439682  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127424711  MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
127426258  MAP kinase-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K04372] [EC:2.7.11.1]
127415274  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
127428146  MAP kinase-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K04372] [EC:2.7.11.1]
127441304  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
127443206  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
127424615  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
127415035  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
127443518  suppressor of cytokine signaling 1b [KO:K04694]
127450115  suppressor of cytokine signaling 1a [KO:K04694]
127445437  suppressor of cytokine signaling 1-like [KO:K04694]
127452217  suppressor of cytokine signaling 1-like [KO:K04694]
127436864  suppressor of cytokine signaling 2-like isoform X1 [KO:K04695]
127435244  suppressor of cytokine signaling 2 isoform X1 [KO:K04695]
127450412  suppressor of cytokine signaling 3-like [KO:K04696]
127452179  suppressor of cytokine signaling 3-like [KO:K04696]
127427452  suppressor of cytokine signaling 3-like [KO:K04696]
127423057  suppressor of cytokine signaling 3b [KO:K04696]
127455442  suppressor of cytokine signaling 4-like [KO:K04697]
127424255  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
127414928  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
127445891  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
127441395  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
127448656  protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
127442429  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
127412122  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127430781  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127431115  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
127413972  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
127426968  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428642  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127428709  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127423091  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127424113  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
127412866  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like isoform X1 [KO:K15909] [EC:3.1.3.86]
127421813  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A-like isoform X1 [KO:K15909] [EC:3.1.3.86]
127417927  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like isoform X1 [KO:K15909] [EC:3.1.3.86]
127430054  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
127411960  inositol polyphosphate-5-phosphatase A-like [KO:K01106] [EC:3.1.3.56]
127414381  inositol polyphosphate-5-phosphatase A-like [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
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Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
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Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
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Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
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Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
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Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
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Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
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Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
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Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
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Nature 414:799-806 (2001)
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PMID:15624019
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Inoki K, Corradetti MN, Guan KL.
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Dysregulation of the TSC-mTOR pathway in human disease.
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Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
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Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
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Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
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Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
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Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
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Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
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Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
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Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
masi00010  Glycolysis / Gluconeogenesis
masi00061  Fatty acid biosynthesis
masi00500  Starch and sucrose metabolism
masi04010  MAPK signaling pathway
masi04070  Phosphatidylinositol signaling system
masi04210  Apoptosis
KO pathway
ko04910   
LinkDB

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