KEGG   PATHWAY: msam04110
Entry
msam04110                   Pathway                                
Name
Cell cycle - Micropterus salmoides (largemouth bass)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
msam04110  Cell cycle
msam04110

Other DBs
GO: 0000278
Organism
Micropterus salmoides (largemouth bass) [GN:msam]
Gene
119890260  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119894289  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
119918426  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
119894029  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
119908399  ccndx; cyclin Dx [KO:K10151]
119886218  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119886384  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119893229  cdk21; cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
119907205  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119895662  rb1; retinoblastoma-associated protein [KO:K06618]
119886258  rbl1; retinoblastoma-like protein 1 [KO:K04681]
119893339  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119914667  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
119907183  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
119909029  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
119910104  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
119906030  e2f1; transcription factor E2F1 [KO:K17454]
119910174  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
119897875  transcription factor E2F3-like [KO:K06620]
119906856  e2f3; transcription factor E2F3 [KO:K06620]
119890105  transcription factor E2F4-like [KO:K04682]
119893941  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
119901889  e2f5; transcription factor E2F5 [KO:K04682]
119882035  transcription factor Dp-1-like [KO:K04683]
119904272  tfdp1a; transcription factor Dp-1a [KO:K04683]
119904210  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119882881  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
119896887  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119889077  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119910740  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119909133  transforming growth factor beta-3 proprotein-like [KO:K13377]
119891755  mothers against decapentaplegic homolog 2 [KO:K04500]
119890083  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
119893375  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119891427  mothers against decapentaplegic homolog 4-like [KO:K04501]
119898232  mothers against decapentaplegic homolog 4-like [KO:K04501]
119907298  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
119887885  mothers against decapentaplegic homolog 4-like [KO:K04501]
119914352  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
119882023  mych; myelocytomatosis oncogene homolog [KO:K04377]
119911475  myca; transcriptional regulator Myc-A [KO:K04377]
119902666  transcriptional regulator Myc-1-like [KO:K04377]
119905891  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
119898939  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119900727  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
119899190  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
119917913  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
119894302  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
119890429  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
119894165  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
119918434  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
119886232  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
119896935  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119907166  G1/S-specific cyclin-E2-like [KO:K06626]
119889819  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119886002  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
119895680  skp1; S-phase kinase-associated protein 1 [KO:K03094]
119896622  cullin-1 [KO:K03347]
119884920  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
119914397  skp2; S-phase kinase-associated protein 2 [KO:K03875]
119888363  ccna2; cyclin-A2 [KO:K06627]
119895866  ccna1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
119902849  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
119897980  cdc6; LOW QUALITY PROTEIN: cell division control protein 6 homolog [KO:K02213]
119917120  cdt1; DNA replication factor Cdt1 [KO:K10727]
119900209  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
119902455  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
119910397  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
119905270  orc4; origin recognition complex subunit 4 [KO:K02606]
119918471  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
119886261  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
119909106  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
119902010  mcm4; LOW QUALITY PROTEIN: DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
119883540  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
119902445  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
119888562  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
119891693  cdc45; cell division control protein 45 homolog [KO:K06628]
119893461  ticrr; treslin [KO:K26117]
119897858  mdm2-binding protein isoform X1 [KO:K26116]
119900093  cell division cycle 7-related protein kinase-like [KO:K02214] [EC:2.7.11.1]
119902274  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
119897627  dbf4; protein DBF4 homolog A [KO:K06629]
119915764  dbf4b; protein DBF4 homolog B [KO:K06629]
119917593  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119918713  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119914274  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
119889984  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
119890537  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
119882693  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
119911184  G2/mitotic-specific cyclin-B3-like [KO:K21771]
119912588  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
119910142  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
119898082  14-3-3 protein zeta-like [KO:K16197]
119905399  14-3-3 protein beta/alpha-1-like [KO:K16197]
119885827  14-3-3 protein beta/alpha-1-like [KO:K16197]
119907055  14-3-3 protein beta/alpha-like [KO:K16197]
119886893  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
119910277  14-3-3 protein beta/alpha-1-like [KO:K16197]
119883404  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
119895153  14-3-3 protein epsilon isoform X1 [KO:K06630]
119883106  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
119895368  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
119898697  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
119893024  wee2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
119894036  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
119915512  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
119891429  ccnh; cyclin-H [KO:K06634]
119892070  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
119916811  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
119896806  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2-like [KO:K03349]
119895202  anaphase-promoting complex subunit 2-like [KO:K03349]
119896131  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
119901081  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
119892035  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
119904376  cdc16; cell division cycle protein 16 homolog [KO:K03353]
119892429  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
119895572  cdc23; cell division cycle protein 23 homolog [KO:K03355]
119890992  anaphase-promoting complex subunit 10 [KO:K03357]
119913244  anaphase-promoting complex subunit 10 [KO:K03357]
119899748  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
119892827  anaphase-promoting complex subunit CDC26-like [KO:K03359]
119914165  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
119893530  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
119883578  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
119915827  anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
119892294  cell division cycle protein 20 homolog B-like [KO:K03363]
119902106  cdc20; cell division cycle protein 20 homolog [KO:K03363]
119888750  pttg1; securin [KO:K06635]
119886141  espl1; separin [KO:K02365] [EC:3.4.22.49]
119905494  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
119893381  smc1b; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1B [KO:K06636]
119899413  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
119897917  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
119905353  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
119907451  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
119910348  stag1a; cohesin subunit SA-1a [KO:K06671]
119904388  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
119906459  cohesin subunit SA-2-like [KO:K06671]
119894898  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
119888561  cohesin subunit SA-1 isoform X1 [KO:K06671]
119889124  stag2b; cohesin subunit SA-2 [KO:K06671]
119889020  atrx; transcriptional regulator ATRX [KO:K10779]
119895810  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
119893661  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
119891253  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
119914003  nipped-B-like protein isoform X1 [KO:K06672]
119900928  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
119902899  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
119911262  histone deacetylase 8-like isoform X1 [KO:K11405] [EC:3.5.1.98]
119912589  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
119909006  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
119899069  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
119895714  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
119917183  wapla; wings apart-like protein homolog [KO:K25163]
119915530  wings apart-like protein homolog [KO:K25163]
119907377  cdca5; sororin [KO:K17390]
119906668  sgo1; shugoshin 1 isoform X1 [KO:K11580]
119891592  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119888909  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
119895758  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119882311  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119911738  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119884135  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
119887373  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
119908506  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
119908686  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
119910005  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
119910097  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119891255  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
119908919  knl1; kinetochore scaffold 1 [KO:K11542]
119898012  ttk; dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
119898690  mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
119912186  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
119906117  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
119910356  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
119915477  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
119908573  LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1-like [KO:K02178] [EC:2.7.11.1]
119908575  mitotic checkpoint serine/threonine-protein kinase BUB1-like [KO:K02178] [EC:2.7.11.1]
119897719  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
119916925  MAD2L1-binding protein [KO:K26093]
119884433  fizzy-related protein homolog [KO:K03364]
119900710  fizzy-related protein homolog isoform X1 [KO:K03364]
119902390  fzr1b; fizzy-related protein homolog [KO:K03364]
119902911  fizzy-related protein homolog [KO:K03364]
119917582  fbxo5; F-box only protein 5 [KO:K10292]
119891280  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119888641  LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119888646  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119902617  dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119916588  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119884942  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119899431  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119889798  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
119907076  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
119910400  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
119882548  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
119894985  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119911875  tp53; cellular tumor antigen p53 [KO:K04451]
119910438  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119892201  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119901218  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119902265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
119888990  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119915100  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119915101  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
119891324  proliferating cell nuclear antigen [KO:K04802]
119909679  proliferating cell nuclear antigen [KO:K04802]
119895100  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
119891558  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
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Reference
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CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
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Reference
PMID:12809600
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
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Reference
PMID:12925736
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Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Reference
PMID:16212951
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Bond M, Sala-Newby GB, Wu YJ, Newby AC
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Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
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Reference
PMID:15838523
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Harris SL, Levine AJ.
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The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
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Reference
PMID:11099028
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Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
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Nature 408:307-10 (2000)
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Reference
PMID:7973727
  Authors
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  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
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Reference
PMID:9889196
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Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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PMID:17018296
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Sheu YJ, Stillman B
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
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PMID:9029154
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Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
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PMID:15876871
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Lolli G, Johnson LN
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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Cell Cycle 4:572-7 (2005)
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PMID:17426725
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Musacchio A, Salmon ED
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The spindle-assembly checkpoint in space and time.
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Nat Rev Mol Cell Biol 8:379-93 (2007)
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PMID:12573239
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Uhlmann F
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Chromosome cohesion and separation: from men and molecules.
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Curr Biol 13:R104-14 (2003)
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PMID:15568976
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Stegmeier F, Amon A
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
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PMID:9618481
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Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
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PMID:26650195
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de Boer HR, Guerrero Llobet S, van Vugt MA
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Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
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PMID:20935501
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Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
msam03030  DNA replication
msam04010  MAPK signaling pathway
msam04120  Ubiquitin mediated proteolysis
msam04210  Apoptosis
KO pathway
ko04110   
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