Entry Name Mitophagy - animal - Micropterus salmoides (largemouth bass)
Description Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Micropterus salmoides (largemouth bass) [GN:
msam ]
Gene 119893203 ambra1b; activating molecule in BECN1-regulated autophagy protein 1b isoform X1 [KO:K17985 ]
119905159 pink1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688 ] [EC:2.7.11.1 ]
119907066 tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771 ]
119907927 tomm40l; mitochondrial import receptor subunit TOM40B [KO:K11518 ]
119895132 si:dkey-71l1.1; mitochondrial import receptor subunit TOM40B [KO:K11518 ]
119917142 tomm20a; translocase of outer mitochondrial membrane 20 [KO:K17770 ]
119914567 tomm20b; mitochondrial import receptor subunit TOM20 homolog B [KO:K17770 ]
119899239 rhot1b; mitochondrial Rho GTPase 1b isoform X1 [KO:K07870 ] [EC:3.6.5.-]
119888417 rhot1a; mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870 ] [EC:3.6.5.-]
119916020 calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348 ]
119884899 calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348 ]
119918801 LOW QUALITY PROTEIN: next to BRCA1 gene 1 protein-like [KO:K17987 ]
119890309 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
119897470 zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
119894273 gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
119887495 gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
119893191 map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
119886756 map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
119888189 map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
119914571 microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435 ]
119914638 map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435 ]
119914785 zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
119915048 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465 ]
119918282 samm50l; sorting and assembly machinery component 50 homolog B [KO:K07277 ]
119893555 samm50; sorting and assembly machinery component 50 homolog A isoform X1 [KO:K07277 ]
119915332 sorting and assembly machinery component 50 homolog B [KO:K07277 ]
119909531 eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237 ]
119898630 atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374 ]
119915034 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
119882851 hif1al; LOW QUALITY PROTEIN: hypoxia inducible factor 1 subunit alpha, like [KO:K08268 ]
119906062 microphthalmia-associated transcription factor-like isoform X1 [KO:K09455 ]
119883614 rabgef1l; RAB guanine nucleotide exchange factor (GEF) 1, like isoform X1 [KO:K20131 ]
119886441 mon1bb; vacuolar fusion protein MON1 homolog B isoform X1 [KO:K20195 ]
Compound Reference Authors Pickrell AM, Youle RJ
Title The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Journal Reference Authors Durcan TM, Fon EA
Title The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Journal Reference Authors Shirihai OS, Song M, Dorn GW 2nd
Title How mitochondrial dynamism orchestrates mitophagy.
Journal Reference Authors Hamacher-Brady A, Brady NR
Title Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
Journal Reference Authors Yamano K, Matsuda N, Tanaka K
Title The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
Journal Reference Authors Yamaguchi O, Murakawa T, Nishida K, Otsu K
Title Receptor-mediated mitophagy.
Journal Reference Authors Roberts RF, Tang MY, Fon EA, Durcan TM
Title Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
Journal Reference Authors Arena G, Valente EM
Title PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
Journal Related KO pathway LinkDB All DBs
