KEGG   PATHWAY: myb04380
Entry
myb04380                    Pathway                                
Name
Osteoclast differentiation - Myotis brandtii (Brandt's bat)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
myb04380  Osteoclast differentiation
myb04380

Other DBs
GO: 0030316
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102263365  CSF1; colony stimulating factor 1 [KO:K05453]
102256301  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102241832  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102254864  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102254191  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102251050  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102254028  IFNG; interferon gamma [KO:K04687]
102258073  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102260069  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102243651  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102251877  IL1A; interleukin 1 alpha [KO:K04383]
102251576  IL1B; interleukin 1 beta [KO:K04519]
102238676  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
102246703  TNF; tumor necrosis factor [KO:K03156]
102251038  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102262083  TGFB1; transforming growth factor beta 1 [KO:K13375]
102250887  TGFB2; transforming growth factor beta 2 [KO:K13376]
102241353  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102248472  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102260756  TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
102249492  TNFRSF11A; TNF receptor superfamily member 11a [KO:K05147]
102246225  TNFRSF11B; TNF receptor superfamily member 11b [KO:K05148]
102263277  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102250946  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102242493  LCK; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
102242533  FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
102262247  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102261467  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102238857  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
102256944  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102254118  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102239405  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102248925  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102252013  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102261405  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102256580  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102263790  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102255251  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102246844  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
102245976  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102261905  IFNB1; interferon beta 1 [KO:K05415]
102240696  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102246913  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102254628  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102248097  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102254920  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
106723559  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102247950  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102259984  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102263026  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102246292  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102246307  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102254662  FOSB; FosB proto-oncogene, AP-1 transcription factor subunit [KO:K09029]
102255314  FOSL2; FOS like 2, AP-1 transcription factor subunit [KO:K09030]
102238750  FOSL1; FOS like 1, AP-1 transcription factor subunit [KO:K04502]
102260808  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102256360  JUNB; JunB proto-oncogene, AP-1 transcription factor subunit [KO:K09028]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102251611  NOX1; NADPH oxidase 1 [KO:K08008]
102242122  cytochrome b-245 light chain [KO:K08009]
102254652  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
102252724  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
102243613  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
102248642  BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
102254215  TEC; tec protein tyrosine kinase [KO:K07364] [EC:2.7.10.2]
102249097  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
102258466  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
102263862  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102262946  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102251669  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102259518  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102248234  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102259054  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
102258758  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102252948  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102258203  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102248488  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
102261646  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
102247900  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102257412  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102251972  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
102252268  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102248199  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102244423  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102246627  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102259938  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102245021  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102238801  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
106726303  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102249811  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102238779  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102264176  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102254651  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102254947  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
106723658  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102253760  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102255950  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102253455  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
102261679  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102248790  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
102251202  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102261936  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102249386  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
102259680  leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512]
102259096  leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512]
102257159  LILRA6; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
102249630  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
102263991  low affinity immunoglobulin gamma Fc region receptor III [KO:K06472]
102248290  low affinity immunoglobulin gamma Fc region receptor II [KO:K12560]
102247789  FCGR3B; Fc fragment of IgG receptor IIIb [KO:K06463]
102241839  TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378]
102251534  tyrosine-protein phosphatase non-receptor type substrate 1 [KO:K06551]
102249350  SIRPA; signal regulatory protein alpha [KO:K06551]
102250558  signal-regulatory protein beta-1 isoform 3-like [KO:K06551]
102255303  signal-regulatory protein beta-1 isoform 3 [KO:K06551]
102248447  signal-regulatory protein beta-1 [KO:K06551]
102240204  TYROBP; TYRO protein tyrosine kinase binding protein [KO:K07992]
102243247  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102253875  BLNK; B-cell linker [KO:K07371]
102243019  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
102261553  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102262150  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102256216  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102241889  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102242162  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102239308  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102263136  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102264111  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102251300  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102245752  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102250711  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102247129  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102254489  CAMK4; calcium/calmodulin dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
102246867  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102246027  SPI1; Spi-1 proto-oncogene [KO:K09438]
102243162  MITF; melanogenesis associated transcription factor [KO:K09455]
102259503  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102263171  ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
102256117  CALCR; calcitonin receptor [KO:K04576]
102242014  ITGB3; integrin subunit beta 3 [KO:K06493]
102254594  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
102245971  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
102259457  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
102260801  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102244385  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
102240965  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102253544  IRF9; interferon regulatory factor 9 [KO:K04693]
102248245  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
102252296  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102256059  GAB2; GRB2 associated binding protein 2 [KO:K08091]
102249394  FHL2; four and a half LIM domains 2 [KO:K14380]
102247016  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
102258898  SQSTM1; sequestosome 1 [KO:K14381]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
myb04010  MAPK signaling pathway
myb04020  Calcium signaling pathway
myb04064  NF-kappa B signaling pathway
myb04151  PI3K-Akt signaling pathway
myb04630  JAK-STAT signaling pathway
KO pathway
ko04380   
LinkDB

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