KEGG   PATHWAY: nasi05225
Entry
nasi05225                   Pathway                                
Name
Hepatocellular carcinoma - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
nasi05225  Hepatocellular carcinoma
nasi05225

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112407200  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
112412693  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112402368  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112390977  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112398380  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112393390  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
112410312  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112399411  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112397907  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112402600  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
112401764  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112396342  SHC2; SHC-transforming protein 2 [KO:K17447]
112390850  SHC3; SHC-transforming protein 3 [KO:K17448]
112402165  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
112410317  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112405189  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112391586  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112402519  HRAS; GTPase HRas isoform X1 [KO:K02833]
112391643  KRAS; GTPase KRas isoform X1 [KO:K07827]
112413065  NRAS; GTPase NRas [KO:K07828]
112402589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
112398096  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112407243  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112393112  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112400165  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112412232  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112399342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112399575  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112402675  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112402503  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112408022  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112398447  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112397143  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
112406557  RB1; retinoblastoma-associated protein [KO:K06618]
112398484  E2F1; transcription factor E2F1 [KO:K17454]
112414298  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
112396632  E2F3; transcription factor E2F3 [KO:K06620]
112390905  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
112401891  TP53; cellular tumor antigen p53 [KO:K04451]
112414074  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112396403  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112392793  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112390848  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112415661  BAX; apoptosis regulator BAX [KO:K02159]
112414038  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112402084  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112391413  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
112415059  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
112394295  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
112414528  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112402178  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112415266  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
112395811  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112394874  TGFB3; transforming growth factor beta-3 [KO:K13377]
112392633  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112398737  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112407460  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
112393136  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
112407459  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112394416  WNT1; proto-oncogene Wnt-1 [KO:K03209]
112413029  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
112408222  WNT2; protein Wnt-2 [KO:K00182]
112410477  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112413363  WNT3A; protein Wnt-3a [KO:K00312]
112414265  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112400593  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112391774  WNT5B; protein Wnt-5b [KO:K00444]
112411853  WNT6; protein Wnt-6 [KO:K00445]
112411995  WNT7A; protein Wnt-7a [KO:K00572]
112394578  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
112404476  WNT8A; protein Wnt-8a [KO:K00714]
112392982  WNT8B; protein Wnt-8b [KO:K00714]
112410284  WNT9B; protein Wnt-9b [KO:K01064]
112413204  WNT9A; protein Wnt-9a [KO:K01064]
112411902  WNT10A; protein Wnt-10a [KO:K01357]
112394239  WNT10B; protein Wnt-10b [KO:K01357]
112408006  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
112408236  WNT16; protein Wnt-16 [KO:K01558]
112413270  FZD1; frizzled-1 [KO:K02432]
112407859  FZD7; frizzled-7 [KO:K02432]
112410297  FZD2; frizzled-2 [KO:K02235]
112414984  FZD3; frizzled-3 [KO:K02329]
112412116  FZD4; frizzled-4 [KO:K02354]
112413704  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
112395239  FZD5; frizzled-5 [KO:K02375]
112399709  FZD6; frizzled-6 [KO:K02376]
112401141  FZD9; frizzled-9 [KO:K02842]
112408809  FZD10; frizzled-10 [KO:K02842]
112402333  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
112391705  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
112409865  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
112415175  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
112390405  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
112392971  LOW QUALITY PROTEIN: proto-oncogene FRAT1-like [KO:K03069]
112415982  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112409352  AXIN1; axin-1 isoform X1 [KO:K02157]
112410145  AXIN2; axin-2 [KO:K04385]
112396302  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112398645  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112405503  CTNNB1; catenin beta-1 [KO:K02105]
112395213  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
112399678  TCF7; transcription factor 7 isoform X1 [KO:K02620]
112399043  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
112406953  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112397669  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
112400167  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
112391513  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
112398776  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
112411795  NQO1; LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
112397719  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
112397818  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
112412247  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112412315  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
112406852  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
112406855  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
112393799  MGST2; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
112391761  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
112392999  glutathione S-transferase omega-2-like [KO:K00799] [EC:2.5.1.18]
112393047  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
112402342  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
112402344  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
112411953  TXNRD3; thioredoxin reductase 3 isoform X1 [KO:K22182] [EC:1.8.1.9]
112412223  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
112391066  TXNRD1; thioredoxin reductase 1, cytoplasmic [KO:K22182] [EC:1.8.1.9]
112404733  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112408223  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112393782  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
112410217  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112412020  ACTB; actin, cytoplasmic 1 [KO:K05692]
112406361  ACTL6A; actin-like protein 6A [KO:K11340]
112399987  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
112410255  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X1 [KO:K11650]
112403668  LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2-like [KO:K11650]
112405881  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
112394067  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
112399627  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
112394932  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
112392403  DPF1; zinc finger protein neuro-d4 [KO:K22198]
112414342  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
112401566  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
112399695  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
112412225  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
112403791  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
112393971  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
112400115  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
112392487  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
112394104  ARID2; AT-rich interactive domain-containing protein 2 [KO:K11765]
112400539  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
112401230  BRD7; bromodomain-containing protein 7 isoform X1 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
nasi04010  MAPK signaling pathway
nasi04020  Calcium signaling pathway
nasi04110  Cell cycle
nasi04115  p53 signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04310  Wnt signaling pathway
nasi04350  TGF-beta signaling pathway
nasi04932  Non-alcoholic fatty liver disease
nasi04936  Alcoholic liver disease
nasi05160  Hepatitis C
nasi05161  Hepatitis B
KO pathway
ko05225   
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