KEGG   PATHWAY: nnt04060
Entry
nnt04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Nestor notabilis (Kea)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
nnt04060  Cytokine-cytokine receptor interaction
nnt04060

Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104410408  C-C motif chemokine 1-like [KO:K05514]
104409899  CCL19; C-C motif chemokine 19 [KO:K05512]
104409897  CCL21; C-C motif chemokine 21 [KO:K16062]
104407104  C-C motif chemokine 4 homolog [KO:K12964]
104407110  LOW QUALITY PROTEIN: C-C motif chemokine 4-like [KO:K12964]
104407105  CCL5; C-C motif chemokine 5 [KO:K12499]
104408870  CCL20; C-C motif chemokine 20 [KO:K14625]
104407495  interleukin-8-like [KO:K10030]
104407496  interleukin-8-like [KO:K10030]
104407500  interleukin-8-like [KO:K10030]
104411173  C-X-C motif chemokine 13-like [KO:K10032]
104411181  alveolar macrophage chemotactic factor-like [KO:K10032]
104411188  alveolar macrophage chemotactic factor-like [KO:K10032]
104408654  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104401536  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104407051  lymphotactin-like [KO:K05507]
104402097  fractalkine-like [KO:K05508]
104407025  IL4; interleukin-4 [KO:K05430]
104401679  IL15; interleukin-15 [KO:K05433]
104403184  IL21; interleukin-21 [KO:K05434]
104410485  somatotropin [KO:K05438]
104401064  PRL; prolactin [KO:K05439]
104402265  THPO; thrombopoietin [KO:K06854]
104412244  myelomonocytic growth factor-like [KO:K05423]
104411997  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
104412611  IL12A; interleukin-12 subunit alpha [KO:K05406]
104407355  IL12B; interleukin-12 subunit beta [KO:K05425]
104412266  EBI3; LOW QUALITY PROTEIN: interleukin-27 subunit beta [KO:K24476]
104401563  LIF; leukemia inhibitory factor [KO:K05419]
104412614  IL10; interleukin-10 [KO:K05443]
104412615  interleukin-20-like [KO:K22667]
104405136  IL22; interleukin-22 [KO:K05445]
104411022  interferon beta-like [KO:K05414]
104400091  interferon-like [KO:K05415]
104405137  IFNG; interferon gamma [KO:K04687]
104403914  interleukin-1 receptor antagonist protein-like [KO:K04519]
104411799  IL18; interleukin-18 [KO:K05482]
104408968  IL17A; interleukin-17A [KO:K05489]
104408969  interleukin-17F-like [KO:K05494]
104407342  IL17B; interleukin-17B [KO:K05490]
104406896  IL17D; interleukin-17D [KO:K05492]
104401183  IL16; pro-interleukin-16 [KO:K22628]
104404923  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104407830  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104406980  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
104402391  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
104408595  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
104402371  EDA; ectodysplasin-A [KO:K05480]
104402506  NGF; beta-nerve growth factor [KO:K02582]
104411387  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104408492  tumor necrosis factor ligand superfamily member 8-like [KO:K05471]
104405584  CD40LG; CD40 ligand [KO:K03161]
104407862  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104408091  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104411056  TGFB3; transforming growth factor beta-3 [KO:K13377]
104403226  GDF2; growth/differentiation factor 2 [KO:K05503]
104406467  BMP10; bone morphogenetic protein 10 [KO:K22670]
104413040  INHA; inhibin alpha chain [KO:K05500]
104406031  BMP3; bone morphogenetic protein 3 [KO:K05496]
104408909  GDF10; bone morphogenetic protein 3B [KO:K22674]
104406885  growth/differentiation factor 11-like [KO:K22679]
104411511  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
104410225  INHBA; inhibin beta A chain [KO:K04667]
104411480  INHBB; inhibin beta B chain [KO:K22687]
104407938  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
104403613  nodal homolog [KO:K04666]
104399012  GDF9; growth/differentiation factor 9 [KO:K22673]
104401876  INHBC; inhibin beta C chain [KO:K22688]
104410450  inhibin beta C chain-like [KO:K22689]
104403325  bone morphogenetic protein 7-like [KO:K21283]
104405183  BMP2; bone morphogenetic protein 2 [KO:K21283]
104399292  GDF5; growth/differentiation factor 5 [KO:K04664]
104399218  BMP15; bone morphogenetic protein 15 [KO:K05498]
104409245  bone morphogenetic protein 5 [KO:K04663]
104402350  BMP6; bone morphogenetic protein 6 [KO:K16620]
104410928  BMP7; bone morphogenetic protein 7 [KO:K16621]
104412178  LOW QUALITY PROTEIN: C-C chemokine receptor type 8-like [KO:K04183]
104408567  C-C chemokine receptor type 8-like [KO:K04183]
104411567  CCR9; C-C chemokine receptor type 9 [KO:K04184]
104407515  ACKR4; atypical chemokine receptor 4 [KO:K04186]
104413581  LOW QUALITY PROTEIN: C-C chemokine receptor type 7-like [KO:K04182]
104408569  CCR4; LOW QUALITY PROTEIN: C-C chemokine receptor type 4 [KO:K04179]
104400661  C-C chemokine receptor type 5-like [KO:K04180]
104399620  C-C chemokine receptor type 5-like [KO:K04180]
104409326  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104403933  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050]
104412252  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104405428  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104409752  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104407733  XCR1; chemokine XC receptor 1 [KO:K04193]
104408568  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104413181  interleukin-2 receptor subunit alpha-like [KO:K05068]
104409153  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104412205  cytokine receptor common subunit gamma-like [KO:K05070]
104408829  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104406463  interleukin-15 receptor subunit alpha-like [KO:K05074]
104407407  IL21R; interleukin-21 receptor [KO:K05075]
104401469  CRLF2; LOW QUALITY PROTEIN: cytokine receptor-like factor 2 [KO:K05078]
104407404  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
104405511  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104403231  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104403239  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104400932  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104409071  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
104407771  GHR; growth hormone receptor [KO:K05080]
104403711  PRLR; prolactin receptor [KO:K05081]
104403984  prolactin receptor-like [KO:K05081]
104405946  LEPR; leptin receptor [KO:K05062]
104402782  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
104409898  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
104412782  interleukin-12 receptor subunit beta-2-like [KO:K05064]
104409921  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
104412797  ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104413169  LIFR; leukemia inhibitory factor receptor [KO:K05058]
104405757  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
104401843  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
104401062  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104407344  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
104411789  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
104409213  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104407035  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104402682  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
104403388  IFNGR2; interferon gamma receptor 2 [KO:K05133]
104401645  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
104403920  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104408149  LOW QUALITY PROTEIN: interleukin-1 receptor type 2-like [KO:K04387]
104404725  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
104404723  IL18R1; interleukin-18 receptor 1 [KO:K05173]
104404721  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104404724  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
104404290  IL17RA; interleukin-17 receptor A [KO:K05164]
104407045  T-cell surface glycoprotein CD4-like [KO:K06454]
104413058  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104401498  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104399789  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
104401618  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
104413443  FAS; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104407156  tumor necrosis factor receptor superfamily member 21-like [KO:K05157]
104405853  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
104402764  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104409968  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104400389  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
104411857  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104401393  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104401230  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104408034  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
104407629  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
104399601  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
104400863  RELL2; RELT-like protein 2 [KO:K26541]
104400384  RELL1; RELT-like protein 1 [KO:K26541]
104407792  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104404513  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104409828  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104404920  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
104408661  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104408855  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104405537  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104405000  LOW QUALITY PROTEIN: activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
104407191  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
104405131  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
104400200  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
104409964  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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