KEGG   PATHWAY: oke00310
Entry
oke00310                    Pathway                                
Name
Lysine degradation - Oncorhynchus keta (chum salmon)
Class
Metabolism; Amino acid metabolism
Pathway map
oke00310  Lysine degradation
oke00310

Module
oke_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:oke00310]
Other DBs
GO: 0006554
Organism
Oncorhynchus keta (chum salmon) [GN:oke]
Gene
118359306  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
118387278  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118392120  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
118396071  LOW QUALITY PROTEIN: 2-oxoadipate dehydrogenase complex component E1-like [KO:K15791] [EC:1.2.4.-]
118400907  2-oxoadipate dehydrogenase complex component E1 isoform X1 [KO:K15791] [EC:1.2.4.-]
118362484  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
118374099  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
118396470  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
118359304  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
127924930  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
118365540  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
118384625  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
118362866  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
118378687  trifunctional enzyme subunit alpha, mitochondrial-like [KO:K07515] [EC:4.2.1.17 1.1.1.211]
118386454  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
118369454  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
118373434  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
118376780  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
118390117  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
118401587  hykk.2; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
118375781  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase isoform X2 [KO:K18202] [EC:4.2.3.134]
118395853  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
118357703  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
118386248  histone-lysine N-methyltransferase 2A-like isoform X1 [KO:K09186] [EC:2.1.1.354]
118397094  kmt2a; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
118360673  histone-lysine N-methyltransferase 2D-like isoform X2 [KO:K09187] [EC:2.1.1.354]
118360113  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
118402033  histone-lysine N-methyltransferase 2C-like isoform X2 [KO:K09188] [EC:2.1.1.354]
118361750  kmt2ca; histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
118370518  histone-lysine N-methyltransferase 2C-like isoform X1 [KO:K09188] [EC:2.1.1.354]
118395216  histone-lysine N-methyltransferase 2C-like isoform X1 [KO:K09188] [EC:2.1.1.354]
118373824  histone-lysine N-methyltransferase 2A-like isoform X1 [KO:K14959] [EC:2.1.1.354]
118367807  histone-lysine N-methyltransferase 2A-like isoform X1 [KO:K14959] [EC:2.1.1.354]
118398340  histone-lysine N-methyltransferase 2B-like isoform X1 [KO:K14959] [EC:2.1.1.354]
118399190  histone-lysine N-methyltransferase 2B-like isoform X1 [KO:K14959] [EC:2.1.1.354]
118377779  inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
118380705  inactive histone-lysine N-methyltransferase 2E-like isoform X1 [KO:K09189] [EC:2.1.1.354]
118391389  histone-lysine N-methyltransferase SETD1B-A-like isoform X1 [KO:K11422] [EC:2.1.1.354]
118372568  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETD1A [KO:K11422] [EC:2.1.1.354]
118378068  histone-lysine N-methyltransferase SETD1A-like isoform X1 [KO:K11422] [EC:2.1.1.354]
118387666  histone-lysine N-methyltransferase SETD1B-A-like isoform X1 [KO:K11422] [EC:2.1.1.354]
118377847  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
118402879  histone-lysine N-methyltransferase PRDM9-like isoform X1 [KO:K20796] [EC:2.1.1.354]
118374451  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
118370008  histone-lysine N-methyltransferase PRDM9-like [KO:K20796] [EC:2.1.1.354]
118383326  histone-lysine N-methyltransferase ASH1L-like [KO:K06101] [EC:2.1.1.354]
118379684  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase ASH1L-like [KO:K06101] [EC:2.1.1.354]
118398364  histone-lysine N-methyltransferase ASH1L-like isoform X1 [KO:K06101] [EC:2.1.1.354]
118399115  histone-lysine N-methyltransferase ASH1L-like isoform X1 [KO:K06101] [EC:2.1.1.354]
118385266  histone-lysine N-methyltransferase Smyd1-like isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118387015  N-lysine methyltransferase SMYD2-A-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118387563  histone-lysine N-methyltransferase Smyd1-like isoform X2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118382495  LOW QUALITY PROTEIN: N-lysine methyltransferase SMYD2-A-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118373346  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118358536  histone-lysine N-methyltransferase SMYD1 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
118360846  histone-lysine N-methyltransferase SUV39H1 isoform X1 [KO:K11419] [EC:2.1.1.355]
118361267  histone-lysine N-methyltransferase SUV39H1-like isoform X1 [KO:K11419] [EC:2.1.1.355]
118359742  histone-lysine N-methyltransferase SUV39H1-like [KO:K11419] [EC:2.1.1.355]
118385502  ehmt1b; histone-lysine N-methyltransferase EHMT1 isoform X2 [KO:K11420] [EC:2.1.1.355]
118375639  ehmt1a; histone-lysine N-methyltransferase EHMT1a [KO:K11420] [EC:2.1.1.355]
118387461  histone-lysine N-methyltransferase EHMT1-like isoform X1 [KO:K11420] [EC:2.1.1.355]
118398293  histone-lysine N-methyltransferase EHMT2-like isoform X1 [KO:K11420] [EC:2.1.1.355]
118399193  histone-lysine N-methyltransferase EHMT2-like isoform X1 [KO:K11420] [EC:2.1.1.355]
118374768  histone-lysine N-methyltransferase SETDB1-B-like isoform X1 [KO:K11421] [EC:2.1.1.366]
118383196  histone-lysine N-methyltransferase SETDB1-B-like [KO:K11421] [EC:2.1.1.366]
118399124  histone-lysine N-methyltransferase SETDB1-B-like [KO:K11421] [EC:2.1.1.366]
118378285  setdb2; histone-lysine N-methyltransferase SETDB2 [KO:K18494] [EC:2.1.1.355]
118361081  prdm2a; PR domain zinc finger protein 2 isoform X1 [KO:K11432] [EC:2.1.1.355]
118373739  PR domain zinc finger protein 2-like [KO:K11432] [EC:2.1.1.355]
118400029  PR domain zinc finger protein 2-like isoform X1 [KO:K11432] [EC:2.1.1.355]
118370832  histone-lysine N-methyltransferase EZH1-like isoform X1 [KO:K17451] [EC:2.1.1.356]
118365283  histone-lysine N-methyltransferase EZH1-like isoform X1 [KO:K17451] [EC:2.1.1.356]
118361674  ezh2; histone-lysine N-methyltransferase EZH2 isoform X5 [KO:K11430] [EC:2.1.1.356]
118369743  histone-lysine N-methyltransferase EZH2-like isoform X1 [KO:K11430] [EC:2.1.1.356]
118388346  histone-lysine N-methyltransferase SETMAR-like isoform X1 [KO:K11433] [EC:2.1.1.357]
118390692  histone-lysine N-methyltransferase, H3 lysine-36 specific-like [KO:K15588] [EC:2.1.1.357]
118376376  nsd1a; histone-lysine N-methyltransferase, H3 lysine-36 specific [KO:K15588] [EC:2.1.1.357]
118384071  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-36 specific-like [KO:K15588] [EC:2.1.1.357]
118391120  histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K15588] [EC:2.1.1.357]
118368015  histone-lysine N-methyltransferase NSD2-like [KO:K11424] [EC:2.1.1.357]
127917967  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2-like [KO:K11424] [EC:2.1.1.357]
118377970  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
118371621  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD3-like [KO:K11425] [EC:2.1.1.370 2.1.1.371]
118393330  histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
118389810  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
118359228  histone-lysine N-methyltransferase, H3 lysine-79 specific-like isoform X1 [KO:K11427] [EC:2.1.1.360]
118393236  N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
118387821  N-lysine methyltransferase KMT5A-A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
118391486  N-lysine methyltransferase KMT5A-A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
118393619  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
118401244  histone-lysine N-methyltransferase KMT5B-like [KO:K11429] [EC:2.1.1.362]
127929335  histone-lysine N-methyltransferase KMT5B-like [KO:K11429] [EC:2.1.1.362]
118372900  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase KMT5C [KO:K11429] [EC:2.1.1.362]
118396687  histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
127931225  histone-lysine N-methyltransferase MECOM-like isoform X1 [KO:K04462] [EC:2.1.1.367]
118371328  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
118377888  histone-lysine N-methyltransferase PRDM16-like isoform X1 [KO:K22410] [EC:2.1.1.367]
118361104  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
118385155  trimethyllysine dioxygenase, mitochondrial-like isoform X1 [KO:K00474] [EC:1.14.11.8]
118390324  trimethyllysine dioxygenase, mitochondrial-like [KO:K00474] [EC:1.14.11.8]
118372471  aldehyde dehydrogenase, dimeric NADP-preferring-like isoform X1 [KO:K00128] [EC:1.2.1.3]
118363315  aldehyde dehydrogenase, dimeric NADP-preferring-like [KO:K00128] [EC:1.2.1.3]
118384126  aldh16a1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
118365915  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
118381193  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
118377601  aldehyde dehydrogenase family 3 member A2-like isoform X1 [KO:K00128] [EC:1.2.1.3]
118377603  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
118377516  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
118393555  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118401913  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118393663  gamma-butyrobetaine dioxygenase-like [KO:K00471] [EC:1.14.11.1]
118357547  gamma-butyrobetaine dioxygenase-like [KO:K00471] [EC:1.14.11.1]
118361234  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X2 [KO:K00473] [EC:1.14.11.4]
127928967  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like isoform X1 [KO:K13645] [EC:1.14.11.4]
118381823  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2-like isoform X1 [KO:K13645] [EC:1.14.11.4]
118381469  plod3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
118394449  procollagen galactosyltransferase 2-like [KO:K11703] [EC:2.4.1.50]
118391618  procollagen galactosyltransferase 2-like isoform X1 [KO:K11703] [EC:2.4.1.50]
118384132  procollagen galactosyltransferase 1-like [KO:K11703] [EC:2.4.1.50]
118387915  procollagen galactosyltransferase 2 isoform X1 [KO:K11703] [EC:2.4.1.50]
118365092  procollagen galactosyltransferase 1-like [KO:K11703] [EC:2.4.1.50]
118390259  colgalt2b; procollagen galactosyltransferase 2 isoform X1 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
oke00020  Citrate cycle (TCA cycle)
oke00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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