KEGG   PATHWAY: oml04217
Entry
oml04217                    Pathway                                
Name
Necroptosis - Oryzias melastigma (Indian medaka)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
oml04217  Necroptosis
oml04217

Organism
Oryzias melastigma (Indian medaka) [GN:oml]
Gene
112161658  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
112139461  tumor necrosis factor-like [KO:K03156]
112143685  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112161095  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
112162880  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112163300  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112137707  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112157264  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112147068  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112142434  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112153690  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
112144487  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
112151417  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 [KO:K10630] [EC:2.3.2.31]
112151240  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
112144261  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
112151771  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
112147459  sharpin; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
112152506  spata2l; spermatogenesis associated 2-like [KO:K17595]
112159303  spata2; spermatogenesis-associated protein 2 [KO:K17595]
112138748  uncharacterized protein LOC112138748 isoform X1 [KO:K17595]
112161194  cylda; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
112156437  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
112150560  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
112144506  cyldb; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
112160870  fadd; protein FADD [KO:K02373]
112147424  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
112147426  caspase-8 [KO:K04398] [EC:3.4.22.61]
112154781  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
112139809  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
112155945  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
112163261  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
112152644  receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
112151834  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
112151835  receptor-interacting serine/threonine-protein kinase 3 isoform X3 [KO:K08847] [EC:2.7.11.1]
112156765  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
112154180  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
112156501  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
112156983  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
112163512  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112136361  camk2b1; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
112136908  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
118599716  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
112138354  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112141608  si:dkey-251i10.1; ADP/ATP translocase 3 [KO:K05863]
112157442  slc25a4; ADP/ATP translocase 1 [KO:K05863]
112153287  slc25a5; ADP/ATP translocase 2 [KO:K05863]
112139733  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
112142618  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112154172  voltage-dependent anion-selective channel protein 2 [KO:K15040]
112161679  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112148080  vdac3; voltage-dependent anion-selective channel protein 3 isoform X3 [KO:K15041]
112162898  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
112154625  glud1b; glutamate dehydrogenase, mitochondrial [KO:K00261] [EC:1.4.1.3]
112147287  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
112136193  glulc; glutamate-ammonia ligase (glutamine synthase) c [KO:K01915] [EC:6.3.1.2]
112138574  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
112148192  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
112162260  glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
112142987  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
112155919  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
112154188  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112161471  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112163450  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112153234  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
112160516  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
112154619  zgc:56095; ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
112158025  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
112138554  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
112138558  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
112152863  fth1b; ferritin, heavy polypeptide 1b [KO:K00522] [EC:1.16.3.1]
112150852  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
112162007  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
112143352  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112156162  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112150453  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112162134  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112162135  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112143530  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112142590  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
112163185  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
112163186  mixed lineage kinase domain-like protein isoform X2 [KO:K08849] [EC:2.7.11.1]
112148141  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
112148701  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112157867  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112152145  dnm1l; dynamin-1-like protein isoform X2 [KO:K17065] [EC:3.6.5.5]
112140172  putative high mobility group protein B1-like 1 [KO:K12799]
112136506  putative high mobility group protein B1-like 1 [KO:K12799]
112136519  pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112136687  uncharacterized protein LOC112136687 isoform X1 [KO:K12799]
112136702  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
112140709  caspase-1 [KO:K01370] [EC:3.4.22.36]
112149501  caspase-1 [KO:K01370] [EC:3.4.22.36]
112148302  interleukin-1 beta [KO:K04519]
112154592  chmp2a; charged multivesicular body protein 2a [KO:K12191]
112155352  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
112143734  chmp3; charged multivesicular body protein 3 [KO:K12193]
112145623  charged multivesicular body protein 4b [KO:K12194]
112158807  chmp4ba; charged multivesicular body protein 4c [KO:K12194]
112152808  charged multivesicular body protein 4b [KO:K12194]
112151226  chmp4c; charged multivesicular body protein 4c [KO:K24782]
112141861  charged multivesicular body protein 6 [KO:K12195]
112146985  charged multivesicular body protein 6 [KO:K12195]
112147589  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
112136919  vacuolar protein sorting-associated protein 4B [KO:K12196]
112152805  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
112140159  charged multivesicular body protein 1a-like [KO:K12197]
112142596  chmp1b; charged multivesicular body protein 1b [KO:K12197]
112152807  charged multivesicular body protein 1a [KO:K12197]
112147540  chmp5a; charged multivesicular body protein 5 [KO:K12198]
112151024  chmp5b; charged multivesicular body protein 5 [KO:K12198]
112148855  chmp7; charged multivesicular body protein 7 [KO:K15053]
112160646  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
112140333  high mobility group protein B1 [KO:K10802]
112149362  hmgb1b; high mobility group protein B1b [KO:K10802]
112150384  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
112151525  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
112148678  hdr; hematopoietic death receptor [KO:K04722]
112163478  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
112150637  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
112153304  cd40lg; CD40 ligand [KO:K04389]
112161604  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112153944  interferon omega-2 isoform X1 [KO:K05414]
112154525  interferon a3-like [KO:K05414]
112154638  interferon a3-like [KO:K05414]
112155356  interferon alpha/beta receptor 2 [KO:K05131]
112155567  uncharacterized protein LOC112155567 isoform X1 [KO:K05131]
112162119  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
112156998  interferon gamma receptor 1-like [KO:K05132]
112150103  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112148412  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112163270  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
112150124  jak3; tyrosine-protein kinase JAK2 [KO:K11218] [EC:2.7.10.2]
112146551  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112154777  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112156680  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
112144620  stat2; signal transducer and activator of transcription 2 [KO:K11221]
112146943  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112155517  stat4; signal transducer and activator of transcription 4 [KO:K11222]
112162336  signal transducer and activator of transcription 5B [KO:K11224]
112146942  stat5a; signal transducer and activator of transcription 5A isoform X1 [KO:K11224]
112159639  stat6; signal transducer and activator of transcription 6 [KO:K11225]
112151369  irf9; interferon regulatory factor 9 [KO:K04693]
112147833  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
112137631  tlr3; toll-like receptor 3 isoform X2 [KO:K05401]
112159192  usp21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
112141461  sequestosome-1 isoform X1 [KO:K14381]
112141467  sequestosome-1 [KO:K14381]
112157671  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
112137228  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
112137229  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
112161989  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
112158309  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
112158138  apoptosis regulator BAX-like [KO:K02159]
112145947  apoptosis regulator BAX [KO:K02159]
112142638  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
112139927  core histone macro-H2A.1 isoform X1 [KO:K11251]
112148084  histone H2A.V isoform X1 [KO:K11251]
112161901  core histone macro-H2A.2 [KO:K11251]
112142454  histone H2AX [KO:K11251]
112149581  histone H2A [KO:K11251]
112156369  histone H2A.Z [KO:K11251]
112156894  histone H2A [KO:K11251]
112156938  histone H2A [KO:K11251]
112156972  histone H2A-like [KO:K11251]
112156864  histone H2A [KO:K11251]
112157203  histone H2A [KO:K11251]
112157352  histone H2A [KO:K11251]
112138042  histone H2A-like [KO:K11251]
112138076  histone H2A-like [KO:K11251]
112163306  peptidyl-prolyl cis-trans isomerase [KO:K03767] [EC:5.2.1.8]
112138444  ppiaa; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
112147591  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
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