KEGG   PATHWAY: panu04217
Entry
panu04217                   Pathway                                
Name
Necroptosis - Papio anubis (olive baboon)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
panu04217  Necroptosis
panu04217

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101006641  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101017914  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101024624  TRAF5; TNF receptor-associated factor 5 isoform X4 [KO:K09849]
101011511  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
101026503  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
100997299  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100998457  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
101022825  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101001673  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
101015955  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X2 [KO:K11974] [EC:2.3.2.31]
101022832  SHARPIN; sharpin isoform X1 [KO:K20894]
101018689  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
101012636  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
101002814  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X2 [KO:K08601] [EC:3.4.19.12]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101006231  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
101027042  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
101006760  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
116269450  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116269451  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
101008925  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10 [KO:K04515] [EC:2.7.11.17]
101009984  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X37 [KO:K04515] [EC:2.7.11.17]
101011087  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101019885  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18 [KO:K04515] [EC:2.7.11.17]
100998956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101009750  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
101025041  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101000631  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101001746  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
116271990  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101022260  LOW QUALITY PROTEIN: glutamate dehydrogenase 1, mitochondrial-like [KO:K00261] [EC:1.4.1.3]
101026579  glutamate dehydrogenase 1, mitochondrial [KO:K00261] [EC:1.4.1.3]
101015190  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
100998992  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
101008280  PYGL; glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
100137469  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101022614  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
101023625  LOW QUALITY PROTEIN: ferritin light chain-like [KO:K13625]
101026142  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101004198  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
101000142  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101002468  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101007440  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101002819  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101014249  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
101016522  LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase-like [KO:K00460] [EC:1.13.11.33]
101025437  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
101022030  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
101012074  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
101009086  MLKL; mixed lineage kinase domain-like protein isoform X2 [KO:K08849] [EC:2.7.11.1]
101014096  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
101017170  DNM1L; dynamin-1-like protein isoform X4 [KO:K17065] [EC:3.6.5.5]
101007974  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100998153  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
101008696  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
101006831  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
101009375  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
101023446  IL1B; interleukin-1 beta [KO:K04519]
101015580  CHMP2A; charged multivesicular body protein 2a isoform X2 [KO:K12191]
100999632  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101000776  CHMP3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
103875482  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
100997370  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
101017392  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101023361  CHMP6; charged multivesicular body protein 6 isoform X2 [KO:K12195]
116271491  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
100997079  vacuolar protein sorting-associated protein 4B [KO:K12196]
101007665  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
101018904  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101016796  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
101022982  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101005162  CHMP7; charged multivesicular body protein 7 isoform X2 [KO:K15053]
101025161  transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
116268503  transient receptor potential cation channel subfamily M member 7-like isoform X1 [KO:K04982] [EC:2.7.11.1]
101023088  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
100998690  IL33; interleukin-33 [KO:K12967]
100137373  HMGB1; high mobility group protein B1 [KO:K10802]
101016626  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101002483  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
101004108  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101023828  LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
101016516  interferon alpha-1/13 [KO:K05414]
116270026  interferon alpha-1/13 [KO:K05414]
101019008  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101018652  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101017918  interferon alpha-8 [KO:K05414]
101018287  interferon alpha-2 [KO:K05414]
101019380  interferon alpha-6 [KO:K05414]
101021706  interferon alpha-14 [KO:K05414]
101023118  interferon alpha-4 [KO:K05414]
101024523  IFNB1; interferon beta [KO:K05415]
100126724  IFNG; interferon gamma precursor [KO:K04687]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
101000704  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
100137246  IFNGR2; interferon gamma receptor 2 precursor [KO:K05133]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101007171  JAK2; tyrosine-protein kinase JAK2 isoform X4 [KO:K04447] [EC:2.7.10.2]
101014985  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
100998929  STAT3; signal transducer and activator of transcription 3 isoform X9 [KO:K04692]
101007479  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
100998364  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101000002  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101023204  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
101020807  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101011480  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
101009041  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
103885341  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101003041  TLR3; toll-like receptor 3 [KO:K05401]
101014789  ZBP1; Z-DNA-binding protein 1 isoform X3 [KO:K12965]
101001236  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X2 [KO:K21634] [EC:3.4.19.12]
101018581  SQSTM1; sequestosome-1 [KO:K14381]
101000592  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101008161  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100998710  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
101009923  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
101008656  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101004691  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
103875614  histone H2A type 2-C [KO:K11251]
101009919  histone H2A type 2-B [KO:K11251]
101014797  histone H2A.J [KO:K11251]
101020627  histone H2A type 3 [KO:K11251]
101003234  histone H2A.V isoform X2 [KO:K11251]
101015332  histone H2A type 1-B/E [KO:K11251]
101018547  histone H2A type 1-C [KO:K11251]
101011060  histone H2A type 1 [KO:K11251]
101012342  histone H2A type 1-H [KO:K11251]
101021227  histone H2A type 1-D [KO:K11251]
101017105  histone H2A type 1 [KO:K11251]
101017461  histone H2A type 1-J [KO:K11251]
101018889  histone H2A type 1-H-like [KO:K11251]
101019598  histone H2A type 1 [KO:K11251]
101021003  histone H2A type 1 [KO:K11251]
101021735  histone H2A.Z [KO:K11251]
101004146  histone H2A type 2-A [KO:K11251]
100998964  core histone macro-H2A.1 isoform X1 [KO:K11251]
101003762  histone H2A type 2-A [KO:K11251]
103883540  histone H2A type 1-A [KO:K11251]
101019886  core histone macro-H2A.2 [KO:K11251]
101001711  histone H2AX [KO:K11251]
101022644  LOW QUALITY PROTEIN: histone H2A type 1-H [KO:K11251]
101024742  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
103887337  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
101004286  PPIA; peptidyl-prolyl cis-trans isomerase A isoform X1 [KO:K03767] [EC:5.2.1.8]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
panu00250  Alanine, aspartate and glutamate metabolism
panu04210  Apoptosis
panu04668  TNF signaling pathway
panu04922  Glucagon signaling pathway
KO pathway
ko04217   
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