KEGG   PATHWAY: pcoc05168
Entry
pcoc05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Phasianus colchicus (Ring-necked pheasant)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoc05168  Herpes simplex virus 1 infection
pcoc05168

Organism
Phasianus colchicus (Ring-necked pheasant) [GN:pcoc]
Gene
116234112  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
116230246  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
116234507  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116234780  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
116229367  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116238905  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116230614  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
116233119  NECTIN1; nectin-1 isoform X1 [KO:K06081]
116228565  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
116242713  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
116228039  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
116240167  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
116234333  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
116239209  C3; complement C3 [KO:K03990]
116234356  C5; complement C5 [KO:K03994]
116238234  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
116239026  IRF7; interferon regulatory factor 7 [KO:K09447]
116238887  TLR3; toll-like receptor 3 [KO:K05401]
116235677  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
116226644  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
116229116  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
116240737  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116233362  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
116241586  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
116231323  interleukin-1 receptor antagonist protein-like [KO:K04519]
116227847  C-C motif chemokine 5-like isoform X1 [KO:K12499]
116227028  IL6; interleukin-6 [KO:K05405]
116235488  IL12A; interleukin-12 subunit alpha [KO:K05406]
116231896  IL12B; interleukin-12 subunit beta [KO:K05425]
116225955  interleukin-12 subunit beta-like [KO:K05425]
116232915  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
116225681  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
116228830  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
116236999  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
116226617  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
116239796  interferon alpha-2-like [KO:K05414]
116240988  interferon [KO:K05414]
116240629  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
116237731  STING1; stimulator of interferon genes protein [KO:K12654]
116243020  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116228591  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116229780  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116237368  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
116229008  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
116225691  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
116229301  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
116229293  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
116228644  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
116229411  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
116234049  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
116230660  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
116235390  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
116230459  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
116233253  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
116233114  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
116242048  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
116241989  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
116242002  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
116232338  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
116235600  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
116235961  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
116239827  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
116238517  zinc finger protein 282-like isoform X1 [KO:K09228]
116238518  zinc finger protein 777-like [KO:K09228]
116238523  zinc finger protein 282-like [KO:K09228]
116238534  zinc finger protein 777-like [KO:K09228]
116239307  LOW QUALITY PROTEIN: zinc finger protein 660-like [KO:K09228]
116240920  zinc finger protein 501-like isoform X1 [KO:K09228]
116236345  zinc finger protein 420-like isoform X1 [KO:K09228]
116226684  IFNG; interferon gamma [KO:K04687]
116240614  IFNGR1; interferon gamma receptor 1 [KO:K05132]
116242121  IFNGR2; interferon gamma receptor 2 [KO:K05133]
116237171  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116244554  protein PML-like [KO:K10054] [EC:2.3.2.-]
116244555  PML; LOW QUALITY PROTEIN: protein PML [KO:K10054] [EC:2.3.2.-]
116236743  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
116236740  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
116236741  TAPBP; tapasin isoform X1 [KO:K08058]
116225539  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
116243073  CALR; calreticulin [KO:K08057]
116235692  CALR3; calreticulin-3 [KO:K08057]
116236745  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116236755  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
116244504  B2M; beta-2-microglobulin [KO:K08055]
116236744  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
116236746  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
116236747  class II histocompatibility antigen, M alpha chain-like [KO:K06752]
116236748  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
116238844  class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752]
116232149  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
116243400  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116230949  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116242673  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116239922  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116234220  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
116235709  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
116228668  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116228799  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116234278  TSC1; hamartin isoform X1 [KO:K07206]
116237652  TSC2; tuberin isoform X1 [KO:K07207]
116238317  RHEB; GTP-binding protein Rheb [KO:K07208]
116242610  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
116234537  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
116238774  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
116227925  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
116232626  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
116236942  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
116230055  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
116236816  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
116229267  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
116229279  serine/arginine-rich splicing factor 5-like [KO:K12893]
116231287  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
116231296  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
116232560  ALYREF; THO complex subunit 4 [KO:K12881]
116230501  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116238135  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
116242339  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
116243862  TRADD; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116229092  FADD; FAS-associated death domain protein [KO:K02373]
116233978  caspase-8-like [KO:K04398] [EC:3.4.22.61]
116233979  caspase-8-like [KO:K04398] [EC:3.4.22.61]
116226875  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
116236928  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
116226390  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
116226139  BCL2L1; bcl-2-like protein 1 [KO:K04570]
116227051  cytochrome c [KO:K08738]
116233931  LOW QUALITY PROTEIN: cytochrome c, somatic-like [KO:K08738]
116233475  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
116242603  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
116238124  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pcoc03040  Spliceosome
pcoc03050  Proteasome
pcoc04115  p53 signaling pathway
pcoc04210  Apoptosis
pcoc04620  Toll-like receptor signaling pathway
pcoc04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
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