KEGG   PATHWAY: pfor05168
Entry
pfor05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Poecilia formosa (Amazon molly)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pfor05168  Herpes simplex virus 1 infection
pfor05168

Organism
Poecilia formosa (Amazon molly) [GN:pfor]
Gene
103154654  tumor necrosis factor-like [KO:K05468]
103151996  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
103151999  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
103152001  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
103154153  tumor necrosis factor ligand superfamily member 14-like isoform X2 [KO:K05477]
103155328  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
103155324  tumor necrosis factor receptor superfamily member 14-like isoform X2 [KO:K05152]
103150240  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
103150455  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
103154502  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103141905  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
103149802  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
103145827  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103152473  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
103134044  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
103150228  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103154601  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
103149669  NF-kappa-B inhibitor alpha-like [KO:K04734]
103131209  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103140625  transcription factor p65-like isoform X1 [KO:K04735]
103140982  birc2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
103140538  T-cell surface protein tactile-like [KO:K06081]
103141043  nectin-1-like isoform X1 [KO:K06081]
103150352  nectin1; nectin-1 isoform X1 [KO:K06081]
103136823  nectin-2-like [KO:K06531]
103136796  poliovirus receptor-like [KO:K06531]
103153507  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
103155575  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
103144086  integrin alpha-5-like [KO:K06484]
103139150  integrin alpha-5-like [KO:K06484]
103153385  itgb3; integrin beta-3 [KO:K06493]
103142160  integrin beta-3-like [KO:K06493]
103152501  proto-oncogene tyrosine-protein kinase Src-like isoform X2 [KO:K05704] [EC:2.7.10.2]
103134564  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103131402  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
103156846  uncharacterized protein LOC103156846 [KO:K05411]
103137501  tp53; cellular tumor antigen p53 [KO:K04451]
103133105  complement C3-like [KO:K03990]
103154171  complement C3-like isoform X2 [KO:K03990]
103156320  complement C3-like isoform X1 [KO:K03990]
103154176  complement C3-like [KO:K03990]
103154177  complement C3-like isoform X1 [KO:K03990]
103129649  c5; complement C5 isoform X1 [KO:K03994]
103137955  cfp; properdin [KO:K15412]
103155238  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
103149044  tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
103140404  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
103151620  irf7; interferon regulatory factor 7 isoform X2 [KO:K09447]
103136376  tlr3; toll-like receptor 3 [KO:K05401]
103148929  TIR domain-containing adapter molecule 1-like [KO:K05842]
103148932  TIR domain-containing adapter molecule 1-like [KO:K05842]
103134441  interleukin-1 receptor-associated kinase 4-like [KO:K04733] [EC:2.7.11.1]
103134442  interleukin-1 receptor-associated kinase 4-like [KO:K04733] [EC:2.7.11.1]
103131931  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
103153578  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103150840  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103138778  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103156067  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
103140747  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103154418  interleukin-1 beta-like [KO:K04519]
103130698  tumor necrosis factor-like [KO:K03156]
107838033  uncharacterized protein LOC107838033 [KO:K05406]
103148108  interleukin-12 subunit alpha-like [KO:K05406]
103138978  interleukin-12 subunit beta-like [KO:K05425]
103145876  interleukin-12 subunit beta-like isoform X1 [KO:K05425]
103154071  interleukin-12 subunit beta-like [KO:K05425]
103134368  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103150075  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
103153848  traf3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
103144323  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103129555  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
107837727  interferon a3-like [KO:K05414]
107838661  interferon a3-like [KO:K05414]
107833139  interferon a3-like [KO:K05414]
107833145  interferon a3-like [KO:K05414]
107833146  interferon a3-like [KO:K05414]
103143458  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
103137383  mb21d1; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
103139865  tmem173; stimulator of interferon genes protein [KO:K12654]
103144960  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
103152354  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
103152404  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103140626  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103154964  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103142740  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X2 [KO:K16194] [EC:2.7.11.1]
103133060  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
103149415  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
103136120  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
103133672  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103151032  eif2b1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
103138631  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
103148306  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
103138640  eif2b4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
103138386  translation initiation factor eIF-2B subunit epsilon-like isoform X1 [KO:K03240]
103138391  translation initiation factor eIF-2B subunit epsilon-like isoform X1 [KO:K03240]
103130748  host cell factor 1-like isoform X2 [KO:K14966]
103147348  hcfc1; host cell factor 1 [KO:K14966]
103152559  host cell factor 1-like [KO:K27390]
103132203  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
103143434  POU domain, class 2, transcription factor 2-like isoform X1 [KO:K09364]
103140326  pou2f1; POU domain, class 2, transcription factor 1 isoform X9 [KO:K09364]
103136801  pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
103153915  interferon alpha/beta receptor 2-like isoform X2 [KO:K05131]
103153916  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
103145153  suppressor of cytokine signaling 3-like [KO:K04696]
103140953  socs3; suppressor of cytokine signaling 3 [KO:K04696]
103137225  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103143743  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103130104  stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
103130271  signal transducer and activator of transcription 1-like [KO:K11220]
103147660  stat2; signal transducer and activator of transcription 2 [KO:K11221]
103147661  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
103146940  irf9; interferon regulatory factor 9 [KO:K04693]
107833583  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103155043  zinc finger protein OZF-like [KO:K09228]
103156271  zinc finger protein 568-like [KO:K09228]
103130180  zinc finger protein 771-like [KO:K09228]
103151292  zinc finger protein 420-like [KO:K09228]
103130192  zinc finger protein 2-like isoform X1 [KO:K09228]
107834503  zinc finger protein OZF-like [KO:K09228]
107834645  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
103130524  zinc finger protein OZF-like [KO:K09228]
103130526  zinc finger protein OZF-like [KO:K09228]
103130616  zinc finger protein 3-like [KO:K09228]
103130617  zinc finger protein 70-like isoform X2 [KO:K09228]
103130622  zinc finger protein with KRAB and SCAN domains 3-like [KO:K09228]
103138307  znf780a; zinc finger protein 780A isoform X1 [KO:K09228]
103138369  zinc finger protein 420-like [KO:K09228]
103131576  zinc finger protein OZF-like [KO:K09228]
103131770  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103131773  gastrula zinc finger protein XlCGF42.1-like [KO:K09228]
103132001  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
107832878  zinc finger protein OZF-like isoform X1 [KO:K09228]
103132271  zinc finger and SCAN domain-containing protein 12-like isoform X1 [KO:K09228]
103132382  zinc finger protein 501-like isoform X1 [KO:K09228]
103132874  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
107835321  zinc finger protein 239-like [KO:K09228]
103131104  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103131105  znf79; zinc finger protein 79 isoform X1 [KO:K09228]
103131152  zinc finger protein 2-like [KO:K09228]
103131214  zinc finger protein OZF-like [KO:K09228]
103131330  zinc finger protein 136-like isoform X1 [KO:K09228]
103131423  zinc finger protein OZF-like isoform X1 [KO:K09228]
103145444  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103131767  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
103132084  zinc finger protein 436-like [KO:K09228]
103132279  zinc finger protein OZF-like [KO:K09228]
103132280  zinc finger protein 239-like [KO:K09228]
103132283  gastrula zinc finger protein XlCGF7.1-like isoform X2 [KO:K09228]
103132285  oocyte zinc finger protein XlCOF8.4-like isoform X1 [KO:K09228]
103139230  oocyte zinc finger protein XlCOF6 [KO:K09228]
103152492  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
103152569  gastrula zinc finger protein XlCGF57.1-like isoform X3 [KO:K09228]
107836608  zinc finger protein 420-like [KO:K09228]
103140279  zinc finger protein 709-like isoform X1 [KO:K09228]
103132286  zinc finger protein ZFP69-like isoform X1 [KO:K09228]
103152671  gastrula zinc finger protein xFG20-1-like [KO:K09228]
103152724  zinc finger protein 2-like [KO:K09228]
103152747  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103152905  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
103152954  oocyte zinc finger protein XlCOF6-like [KO:K09228]
103152998  zinc finger protein OZF-like isoform X2 [KO:K09228]
107836994  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
103142943  zinc finger protein 37-like [KO:K09228]
103132838  zinc finger protein OZF-like isoform X1 [KO:K09228]
103132948  zinc finger protein OZF-like isoform X1 [KO:K09228]
103133256  DNA ligase 1-like [KO:K09228]
103133263  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103133265  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103133340  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
103146492  zinc finger protein 34-like [KO:K09228]
107837315  zinc finger protein 624-like [KO:K09228]
103144921  zinc finger protein 37-like [KO:K09228]
103147045  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
107837770  zinc finger protein OZF-like [KO:K09228]
103147039  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103147040  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103147042  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103147044  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103147972  zinc finger protein 260-like [KO:K09228]
107837947  zinc finger protein 879-like [KO:K09228]
103147973  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103147935  zinc finger protein OZF-like [KO:K09228]
103150023  zinc finger protein 652-like isoform X1 [KO:K09228]
107838318  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103149975  zinc finger protein 570-like [KO:K09228]
103149981  zinc finger protein OZF-like [KO:K09228]
107838319  zinc finger protein OZF-like [KO:K09228]
103151664  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103147882  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
103147883  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103147888  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103147889  zinc finger protein 624-like [KO:K09228]
103147895  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103147899  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103147922  zinc finger protein 91-like [KO:K09228]
103147924  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
103147925  zinc finger protein OZF-like isoform X1 [KO:K09228]
103147930  zinc finger protein OZF-like [KO:K09228]
103147934  zinc finger protein OZF-like isoform X1 [KO:K09228]
103147939  zinc finger protein 84-like [KO:K09228]
103147942  zinc finger protein 501-like isoform X1 [KO:K09228]
103147943  zinc finger protein OZF-like [KO:K09228]
103148314  zinc finger protein 771-like [KO:K09228]
103154820  zinc finger protein 420-like [KO:K09228]
103155044  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103155049  zinc finger protein 501-like isoform X1 [KO:K09228]
103155050  zinc finger protein 394-like isoform X1 [KO:K09228]
103155060  zinc finger protein 883-like [KO:K09228]
103155062  zinc finger protein OZF-like [KO:K09228]
103156006  zinc finger protein 648-like isoform X1 [KO:K09228]
103142940  zinc finger protein OZF-like isoform X1 [KO:K09228]
103142945  zinc finger protein 583-like isoform X1 [KO:K09228]
103142942  zinc finger protein OZF-like [KO:K09228]
103142947  zinc finger protein 1 homolog [KO:K09228]
103156130  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
103156247  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
103156248  gastrula zinc finger protein XlCGF28.1-like [KO:K09228]
103156249  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103136445  zinc finger protein 91-like [KO:K09228]
103143136  znf221; zinc finger protein 221 isoform X2 [KO:K09228]
103143139  zinc finger protein 425-like [KO:K09228]
103143140  uncharacterized protein LOC103143140 [KO:K09228]
103149977  zinc finger protein 32-like [KO:K09228]
103149978  zinc finger protein 501-like [KO:K09228]
103149980  zinc finger protein 79-like [KO:K09228]
103149983  zinc finger protein 391-like [KO:K09228]
103149984  zinc finger protein 554-like isoform X1 [KO:K09228]
103149987  zinc finger protein OZF-like isoform X1 [KO:K09228]
103149991  zinc finger protein 391-like [KO:K09228]
103149997  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
103153161  zinc finger protein 37-like isoform X1 [KO:K09228]
103152532  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
103130630  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
103142988  zinc finger protein 570-like [KO:K09228]
103152757  zinc finger protein 45-like [KO:K09228]
103155640  uncharacterized protein LOC103155640 [KO:K05132]
103154477  uncharacterized protein LOC103154477 [KO:K05132]
103148019  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103142013  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
103146385  death domain-associated protein 6 [KO:K02308]
103146690  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103152415  antigen peptide transporter 2-like isoform X1 [KO:K05654] [EC:7.4.2.14]
103146402  LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103146386  tapasin isoform X2 [KO:K08058]
103152828  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103147914  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
103138474  calreticulin [KO:K08057]
103146065  calreticulin-like [KO:K08057]
103133221  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
103133238  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
103146387  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
103146389  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103146390  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107832861  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
103146391  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103146392  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X3 [KO:K06751]
103146393  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146409  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146410  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
103146414  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146415  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146462  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146413  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146460  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107837608  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
103146412  zinc-alpha-2-glycoprotein-like [KO:K06751]
103146458  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146459  LOW QUALITY PROTEIN: zinc-alpha-2-glycoprotein-like [KO:K06751]
103149767  uncharacterized protein LOC103149767 [KO:K06751]
103149742  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
103149743  HLA class I histocompatibility antigen, B-38 alpha chain-like isoform X2 [KO:K06751]
103135288  beta-2-microglobulin-like [KO:K08055]
103129860  beta-2-microglobulin-like [KO:K08055]
103144598  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
103144599  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
103132959  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
103131824  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
103131825  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
103140896  H-2 class II histocompatibility antigen, I-E alpha chain-like [KO:K06752]
103140843  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
103140842  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
103132298  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103132958  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
103149099  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
103140841  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
103140897  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
103141693  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X2 [KO:K06752]
103149100  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
103129603  mamu class II histocompatibility antigen, DR alpha chain-like isoform X2 [KO:K06752]
103129604  SLA class II histocompatibility antigen, DQ haplotype D beta chain-like [KO:K06752]
103129620  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
103135523  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103145912  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
103139967  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103140707  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103155249  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
103155589  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103143835  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
103143838  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
103143872  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
103140025  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X2 [KO:K02649]
103153044  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
103154504  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103149961  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X4 [KO:K02649]
103137460  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103150748  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
103145381  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103136096  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103131447  hamartin-like [KO:K07206]
103154408  tsc1; hamartin [KO:K07206]
103150546  tsc2; tuberin isoform X4 [KO:K07207]
103154868  uncharacterized protein LOC103154868 isoform X1 [KO:K07208]
103146337  rheb; GTP-binding protein Rheb [KO:K07208]
103143201  rhebl1; GTPase RhebL1 [KO:K07208]
103142336  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
103151847  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
103145745  eukaryotic translation initiation factor 4E-binding protein 3-like [KO:K07205]
103144354  SRSF protein kinase 1-like isoform X2 [KO:K15409] [EC:2.7.11.1]
103141201  SRSF protein kinase 1-like [KO:K15409] [EC:2.7.11.1]
103129670  SRSF protein kinase 1-like isoform X1 [KO:K15409] [EC:2.7.11.1]
103140933  serine/arginine-rich splicing factor 1B-like [KO:K12890]
103148541  serine/arginine-rich splicing factor 1 isoform X2 [KO:K12890]
103148542  serine/arginine-rich splicing factor 1 isoform X2 [KO:K12890]
103145165  srsf2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
103137614  serine/arginine-rich splicing factor 3-like [KO:K12892]
103150674  serine/arginine-rich splicing factor 3 [KO:K12892]
103130392  serine/arginine-rich splicing factor 4-like isoform X1 [KO:K12893]
103130447  serine/arginine-rich splicing factor 5-like [KO:K12893]
103144742  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
103156038  serine/arginine-rich splicing factor 4 [KO:K12893]
103138330  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
103131944  srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103149198  serine/arginine-rich splicing factor 9-like [KO:K21123]
103136877  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103133395  aly/REF export factor 2-like [KO:K12881]
103153320  alyref; THO complex subunit 4 [KO:K12881]
103140155  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
103137043  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103133531  tumor necrosis factor receptor superfamily member 22-like isoform X1 [KO:K04390]
103138949  tumor necrosis factor receptor superfamily member 10B-like [KO:K03158]
103136739  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103153798  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103150957  fadd; FAS-associated death domain protein isoform X2 [KO:K02373]
103151557  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103134398  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103151574  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103150954  apoptosis regulator BAX-like [KO:K02159]
103142241  apoptosis regulator BAX-like [KO:K02159]
103142242  apoptosis regulator BAX-like [KO:K02159]
103153616  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
103143027  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
103147352  bcl-2-like protein 1 [KO:K04570]
103156114  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
103145274  cytochrome c iso-1/iso-2-like [KO:K08738]
103145277  cytochrome c-like [KO:K08738]
103151902  cytochrome c [KO:K08738]
103134329  cytochrome c-b [KO:K08738]
103134331  cytochrome c-b [KO:K08738]
103146229  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103131123  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103151710  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103151718  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103136385  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
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MacLeod IJ, Minson T
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Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
  Authors
Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
PMID:25798530
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
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Sandri-Goldin RM
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pfor03040  Spliceosome
pfor03050  Proteasome
pfor04115  p53 signaling pathway
pfor04210  Apoptosis
pfor04620  Toll-like receptor signaling pathway
pfor04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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