KEGG   PATHWAY: pgig04714
Entry
pgig04714                   Pathway                                
Name
Thermogenesis - Pteropus giganteus (Indian flying fox)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
pgig04714  Thermogenesis
pgig04714

Other DBs
GO: 1990845
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120595429  ADRB3; beta-3 adrenergic receptor [KO:K04143]
120603881  neuroendocrine secretory protein 55-like [KO:K04632]
120603882  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
120589581  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
120586284  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
120621545  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120608523  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
120586714  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120618216  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120617254  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120588721  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120620331  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120617695  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
120596168  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
120583269  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120618485  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120592160  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
120615385  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120606645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120601151  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120612863  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120602391  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120585894  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
120583944  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
120596321  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
120613229  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
120581350  KDM3B; lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
120594601  KDM3A; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
120610841  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
120621729  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
120606861  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
120582294  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
120604901  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
120618177  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
120600284  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
120601531  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
120611161  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
120615525  ACTB; actin, cytoplasmic 1 [KO:K05692]
120599974  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120597140  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
120591602  ACTL6B; actin-like protein 6B [KO:K11652]
120596166  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
120611407  ARID1B; LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 1B [KO:K11653]
120596599  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
120619466  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
120621474  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
120615779  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120589895  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
120602825  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120602826  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
120597571  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120597692  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120582783  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
120597156  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120615463  SIRT6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
120606965  FGF21; fibroblast growth factor 21 [KO:K22429]
120599418  PLIN1; perilipin-1 [KO:K08768]
120584680  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
120586994  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
120586161  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
120621730  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
120606777  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
120585136  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
120618205  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
120587666  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
120601493  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
120596948  GCG; pro-glucagon isoform X1 [KO:K05259]
120614037  BMP8B; bone morphogenetic protein 8B [KO:K16622]
120593258  BMP8A; bone morphogenetic protein 8A [KO:K16622]
120594916  CNR1; cannabinoid receptor 1 [KO:K04277]
120585723  NPPA; natriuretic peptides A [KO:K12334]
120585722  NPPB; natriuretic peptides B [KO:K12335]
120592268  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120609370  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
120588263  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
120587986  KLB; beta-klotho [KO:K22404]
120595650  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120605054  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
120600272  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120604448  SOS2; son of sevenless homolog 2 [KO:K03099]
120621751  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120594292  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
120595986  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
120618267  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
120608284  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
120602738  TSC1; hamartin isoform X1 [KO:K07206]
120620251  TSC2; tuberin isoform X1 [KO:K07207]
120601454  RHEB; GTP-binding protein Rheb [KO:K07208]
120600162  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
120585826  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120620262  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
120615527  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
120584753  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120620825  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120604299  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120615108  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120595025  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120608272  RPS6; 40S ribosomal protein S6 [KO:K02991]
120616361  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
120616525  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
120618441  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
120597144  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
120609088  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
120587568  NDUFS1; LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
120584202  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
120607415  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
120608171  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
120593298  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
120586301  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
120583687  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
120584743  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
120584746  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
120588577  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
120598742  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
120613848  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
120581414  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
120616482  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
120602254  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
120604950  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
120601258  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
120602938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
120602939  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
120598765  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
120605755  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
120607301  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
120592183  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
120584540  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
120615433  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
120611623  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
120606599  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
120619622  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
120601134  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
120587522  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
120586679  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
120597142  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
120612925  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
120618472  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
120609201  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
120595681  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
120620248  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
120605511  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
120613219  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
120590396  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
120587156  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
120608208  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
120582339  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
120594839  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
120611894  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
120605470  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
120621779  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
120600201  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
120586318  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
120585752  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
120584198  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
120621994  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
120617223  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
120588814  cytochrome c1, heme protein, mitochondrial [KO:K00413]
120582316  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
120584555  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
120620319  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
120605463  cytochrome b-c1 complex subunit 7 [KO:K00417]
120616506  cytochrome b-c1 complex subunit 8 [KO:K00418]
120610685  cytochrome b-c1 complex subunit 8-like [KO:K00418]
120601887  cytochrome b-c1 complex subunit 9 [KO:K00419]
120603514  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
120622928  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
120597795  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
120610239  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
120606788  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
120620534  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
120592433  cytochrome c oxidase subunit 6B1 [KO:K02267]
120598319  cytochrome c oxidase subunit 6B2 [KO:K02267]
120595634  cytochrome c oxidase subunit 6C isoform X1 [KO:K02268]
120592495  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
120594945  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
120609699  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
120621725  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
120591688  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
120588028  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
120588365  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
120589786  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
120620774  cytochrome c oxidase assembly protein COX11, mitochondrial isoform X1 [KO:K02258]
120618179  cytochrome c oxidase assembly protein COX14 [KO:K18181]
120609216  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
120614171  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X1 [KO:K18182]
120586663  cytochrome c oxidase copper chaperone [KO:K02260]
120588189  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
120594291  cytochrome c oxidase assembly protein COX20, mitochondrial-like [KO:K18184]
120619091  cytochrome c oxidase assembly protein COX20, mitochondrial [KO:K18184]
120591759  cytochrome c oxidase assembly factor 1 homolog isoform X1 [KO:K18173]
120611072  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
120590335  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
120610230  cytochrome c oxidase assembly factor 5 [KO:K18178]
120592599  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
120621054  LOW QUALITY PROTEIN: cytochrome c oxidase assembly factor 7 [KO:K18180]
120586049  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
120604925  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
120609017  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
120583693  ATP5F1D; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
120598636  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
120585021  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
120602187  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
120596836  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
120611266  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
120600221  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
120590931  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
120609136  ATP synthase subunit f, mitochondrial-like [KO:K02130]
120598886  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
120618791  LOW QUALITY PROTEIN: ATP synthase subunit g, mitochondrial-like [KO:K02140]
120622053  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
120621294  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
120582324  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
120619693  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
120584729  CPT1A; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
120602813  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
120615532  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
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Related
pathway
pgig00020  Citrate cycle (TCA cycle)
pgig00190  Oxidative phosphorylation
pgig04010  MAPK signaling pathway
pgig04022  cGMP-PKG signaling pathway
pgig04024  cAMP signaling pathway
pgig04150  mTOR signaling pathway
pgig04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
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