KEGG   PATHWAY: pgig04024
Entry
pgig04024                   Pathway                                
Name
cAMP signaling pathway - Pteropus vampyrus (Indian flying fox)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
pgig04024  cAMP signaling pathway
pgig04024

Other DBs
GO: 0019933
Organism
Pteropus vampyrus (Indian flying fox) [GN:pgig]
Gene
120581446  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
120581517  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
120581518  ADRB2; beta-2 adrenergic receptor [KO:K04142]
120581548  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
120581606  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
120581890  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120582159  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
120582346  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
120582355  RHOA; transforming protein RhoA [KO:K04513]
120582379  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120582727  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
120582758  DRD5; D(1B) dopamine receptor [KO:K05840]
120583186  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
120583221  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
120583262  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
120583269  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120583336  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
120583373  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
120583640  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
120583644  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
120583729  AMH; muellerian-inhibiting factor [KO:K04665]
120583821  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120584288  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
120584290  [KO:K01539] [EC:7.2.2.13]
120584763  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120584840  RELA; transcription factor p65 [KO:K04735]
120584959  TSHB; thyrotropin subunit beta [KO:K05251]
120584964  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
120584991  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
120585025  RAP1A; ras-related protein Rap-1A [KO:K04353]
120585084  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
120585454  CRH; corticoliberin [KO:K05256]
120585578  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
120585723  NPPA; natriuretic peptides A [KO:K12334]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120586284  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
120586662  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
120586714  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120587067  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120587763  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120588349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120588366  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
120588721  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120589266  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
120589350  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
120589558  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120589581  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
120589677  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
120590086  ADORA2A; adenosine receptor A2a [KO:K04266]
120590248  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
120590385  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
120590812  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120591507  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120591678  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
120592160  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
120592268  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120592362  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
120592443  FFAR2; free fatty acid receptor 2 [KO:K04328]
120592615  RYR2; ryanodine receptor 2 [KO:K04962]
120592917  SST; somatostatin [KO:K05237]
120593395  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
120593468  [KO:K05264]
120593469  [KO:K05264]
120593470  [KO:K05264]
120593472  [KO:K05264]
120594818  CGA; glycoprotein hormones alpha chain isoform X1 [KO:K08522]
120594849  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
120594888  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595972  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
120596160  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
120596168  [KO:K11265] [EC:4.6.1.1]
120596322  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
120596948  GCG; pro-glucagon isoform X1 [KO:K05259]
120596949  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
120596952  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120597296  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
120597562  GLP1R; glucagon-like peptide 1 receptor isoform X1 [KO:K04581]
120597810  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
120597811  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
120598385  TNNI3; troponin I, cardiac muscle [KO:K12044]
120598497  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
120598569  EDN1; endothelin-1 [KO:K16366]
120598733  SUCNR1; succinate receptor 1 [KO:K10042]
120598929  F2R; proteinase-activated receptor 1 [KO:K03914]
120599657  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
120599777  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
120599886  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
120600011  SOX9; transcription factor SOX-9 [KO:K18435]
120600156  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
120600167  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
120600306  SSTR2; somatostatin receptor type 2 [KO:K04218]
120600327  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120600645  BAD; bcl2-associated agonist of cell death [KO:K02158]
120600688  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
120600782  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120600967  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120601125  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
120601151  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120601203  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120601934  NPY; pro-neuropeptide Y [KO:K05232]
120601955  CRHR2; corticotropin-releasing factor receptor 2 [KO:K04579]
120602391  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120602415  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
120602869  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
120602971  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120603233  RRAS2; ras-related protein R-Ras2 [KO:K07830]
120603240  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
120603307  OXT; oxytocin-neurophysin 1 [KO:K05243]
120603622  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120603762  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
120603881  [KO:K04632]
120603882  [KO:K04632]
120604293  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
120604351  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
120604387  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
120604427  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
120604475  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120604955  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
120605040  RAP1B; ras-related protein Rap-1b [KO:K07836]
120605221  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
120605333  FSHB; follitropin subunit beta [KO:K05250]
120605359  GIPR; LOW QUALITY PROTEIN: gastric inhibitory polypeptide receptor [KO:K04580]
120605880  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
120606299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120606554  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
120606645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120606953  [KO:K08521]
120606995  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
120607278  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
120607351  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120607806  BVES; LOW QUALITY PROTEIN: blood vessel epicardial substance [KO:K21108]
120607814  POPDC3; popeye domain-containing protein 3 [KO:K26207]
120607875  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120608285  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120608298  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
120608523  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
120608993  [KO:K02183]
120609071  ADRB1; beta-1 adrenergic receptor [KO:K04141]
120609283  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
120609540  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120609636  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120610231  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
120610867  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
120611197  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
120611269  [KO:K05258]
120611498  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
120612223  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
120612863  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120613316  EDNRA; endothelin-1 receptor [KO:K04197]
120613331  [KO:K06231]
120613443  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
120613462  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
120613499  DRD1; D(1A) dopamine receptor [KO:K04144]
120613742  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120614034  EDN2; endothelin-2 isoform X1 [KO:K16367]
120614848  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120615120  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
120615146  [KO:K04153]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120615385  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120615458  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
120615540  RRAS; ras-related protein R-Ras [KO:K07829]
120616041  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
120616042  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
120616078  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
120616088  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120616096  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120616613  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120616614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120616899  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
120617254  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120617388  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
120617544  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
120617616  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120617682  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120617695  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
120617844  AFDN; afadin isoform X1 [KO:K05702]
120617886  CALM3; calmodulin-3 [KO:K02183]
120617985  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
120618216  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120618383  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120618485  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120618875  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619299  ADORA1; adenosine receptor A1 [KO:K04265]
120619319  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
120619517  FOS; proto-oncogene c-Fos [KO:K04379]
120619571  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
120619605  CALM1; calmodulin-1 [KO:K02183]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120620145  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
120620206  [KO:K02649]
120620322  [KO:K04498] [EC:2.3.1.48]
120620331  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120620377  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120620539  SSTR5; somatostatin receptor type 5 [KO:K04221]
120620765  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120621089  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
120621427  OXTR; oxytocin receptor [KO:K04229]
120621476  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120621544  POMC; pro-opiomelanocortin [KO:K05228]
120621545  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120621559  [KO:K04145]
120621655  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
120621675  CALM2; calmodulin-2 isoform X1 [KO:K02183]
120621819  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
120621837  JUN; transcription factor AP-1 [KO:K04448]
120621957  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
120622002  [KO:K04145]
120622102  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
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Related
pathway
pgig00071  Fatty acid degradation
pgig04015  Rap1 signaling pathway
pgig04020  Calcium signaling pathway
pgig04151  PI3K-Akt signaling pathway
pgig04210  Apoptosis
pgig04260  Cardiac muscle contraction
pgig04340  Hedgehog signaling pathway
pgig04720  Long-term potentiation
pgig04740  Olfactory transduction
pgig04972  Pancreatic secretion
pgig04976  Bile secretion
KO pathway
ko04024   

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