KEGG   PATHWAY: pspa04068
Entry
pspa04068                   Pathway                                
Name
FoxO signaling pathway - Polyodon spathula (Mississippi paddlefish)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
pspa04068  FoxO signaling pathway
pspa04068

Other DBs
GO: 0009267
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121304906  transforming growth factor beta-1 proprotein-like [KO:K13375]
121306334  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
121315977  transforming growth factor beta-2 proprotein-like [KO:K13376]
121317109  transforming growth factor beta-2 proprotein-like [KO:K13376]
121329880  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
121324804  transforming growth factor beta-3 proprotein-like [KO:K13377]
121314569  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
121313088  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
121314717  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
121322376  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121322837  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
121312913  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121317857  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
121304289  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121294921  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121299241  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121300738  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121301678  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
121299544  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121326929  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121318564  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121331275  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
121297106  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
121299815  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121327017  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121330680  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121321492  5'-AMP-activated protein kinase subunit gamma-3-like [KO:K07200]
121308970  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
121310040  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121314051  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
121306751  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
121308734  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
121317053  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
121318314  S-phase kinase-associated protein 2-like [KO:K03875]
121304766  S-phase kinase-associated protein 2-like [KO:K03875]
121317976  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
121320080  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
121330524  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
121300700  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
121301211  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
121331048  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
121306077  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
121326144  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
121321631  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
121300501  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
121301481  ubiquitin carboxyl-terminal hydrolase 7-like [KO:K11838] [EC:3.4.19.12]
121330826  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
121306488  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
121305717  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
121296957  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121325682  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121301569  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121316125  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121321798  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121324174  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121297674  serine/threonine-protein kinase 4-like [KO:K04411]
121319472  serine/threonine-protein kinase 4-like [KO:K04411]
121300243  uncharacterized protein LOC121300243 [KO:K05459]
121300319  uncharacterized protein LOC121300319 [KO:K05459]
121318433  igf1; insulin-like growth factor I [KO:K05459]
121319666  insulin-like growth factor I [KO:K05459]
121298882  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121294410  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
121295106  insulin-like [KO:K04526]
121330389  insulin-like [KO:K04526]
121305882  insulin-2 [KO:K04526]
121300714  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
121309564  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
121306496  insulin receptor substrate 1-like [KO:K16172]
121327022  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
121322871  insulin receptor substrate 1-B-like [KO:K16172]
121305699  insulin receptor substrate 1-like [KO:K16172]
121295578  insulin receptor substrate 2-B-like [KO:K07187]
121320808  insulin receptor substrate 2-like isoform X1 [KO:K07187]
121327771  insulin receptor substrate 2-like [KO:K07187]
121318669  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
121326758  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121327018  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121328810  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121323116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121323146  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
121329032  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121305638  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121300582  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
121300755  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121326688  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121301490  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121317026  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121330558  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121300983  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121330948  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121321809  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121302294  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
121303214  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
121325727  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121321860  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121316056  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121317179  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121303838  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121324176  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121330210  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121304828  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121315862  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121308260  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
121316985  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
121298292  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
121319369  serine/threonine-protein kinase Sgk2-like isoform X1 [KO:K13303] [EC:2.7.11.1]
121313393  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
121313908  serine/threonine-protein kinase Sgk3-like [KO:K13304] [EC:2.7.11.1]
121321361  foxo1a; forkhead box protein O1-A [KO:K07201]
121320439  forkhead box protein O1-A-like [KO:K09408]
121316298  forkhead box protein O3-like [KO:K09408]
121303292  forkhead box protein O6-like [KO:K09408]
121317417  foxo3a; forkhead box protein O3a isoform X1 [KO:K09408]
121310436  forkhead box protein O1-A-like [KO:K09408]
121295412  forkhead box protein O4-like [KO:K12358]
121318892  foxo4; forkhead box protein O4 [KO:K12358]
121303380  forkhead box protein O6-like [KO:K17847]
121315834  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
121316952  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
121300685  homer protein homolog 3-like isoform X1 [KO:K15010]
121294803  homer protein homolog 2-like [KO:K15010]
121299373  homer protein homolog 2-like isoform X1 [KO:K15010]
121301401  homer protein homolog 3-like isoform X1 [KO:K15010]
121305115  homer protein homolog 1-like isoform X1 [KO:K15010]
121313702  homer protein homolog 1 isoform X1 [KO:K15010]
121308978  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
121306147  casein kinase I [KO:K08960] [EC:2.7.11.1]
121315084  il6; interleukin-6 [KO:K05405]
121300208  interleukin-10-like [KO:K05443]
121304658  il10; interleukin-10 [KO:K05443]
121301776  signal transducer and activator of transcription 3-like isoform X1 [KO:K04692]
121324063  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
121295627  pro-epidermal growth factor-like isoform X1 [KO:K04357]
121322456  pro-epidermal growth factor-like [KO:K04357]
121314598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
121313118  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
121295867  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
121296442  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
121316389  son of sevenless homolog 1-like [KO:K03099]
121316886  son of sevenless homolog 1 isoform X1 [KO:K03099]
121323793  sos2; son of sevenless homolog 2 [KO:K03099]
121294911  GTPase HRas [KO:K02833]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121318385  GTPase KRas isoform X1 [KO:K07827]
121319713  GTPase KRas isoform X1 [KO:K07827]
121300074  GTPase NRas [KO:K07828]
121300091  GTPase NRas [KO:K07828]
121318501  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
121319596  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
121297980  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121328554  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121329240  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121305491  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121301294  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121298255  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121299882  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121299883  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121328667  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
121317948  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121317949  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121304626  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121304667  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
121321977  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
121309065  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
121305987  prmt1; protein arginine N-methyltransferase 1 [KO:K11434] [EC:2.1.1.319]
121316154  foxg1b; forkhead box protein G1b [KO:K09385]
121316563  forkhead box protein G1-like [KO:K09385]
121303742  foxg1c; forkhead box protein G1c [KO:K09385]
121329768  foxg1a; forkhead box protein G1 [KO:K09385]
121324048  forkhead box protein G1-like [KO:K09385]
121300671  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121300682  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121326955  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121317063  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121317073  G2/mitotic-specific cyclin-B1-like [KO:K05868]
121294513  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
121299044  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
121304856  cyclin N-terminal domain-containing protein 2 [KO:K21770]
121295342  G2/mitotic-specific cyclin-B3-like [KO:K21771]
121327212  G2/mitotic-specific cyclin-B3-like [KO:K21771]
121318692  G2/mitotic-specific cyclin-B3-like [KO:K21771]
121295125  G1/S-specific cyclin-D1 [KO:K04503]
121329999  G1/S-specific cyclin-D1-like [KO:K04503]
121305898  ccndx; cyclin Dx [KO:K04503]
121318077  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
121320013  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
121301341  cyclin-G2-like [KO:K10146]
121316345  cyclin-G2-like [KO:K10146]
121296220  cdkn2a/b; cyclin-dependent kinase inhibitor 2A [KO:K04685]
121298958  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
121309160  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
121299757  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
121317833  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
121304756  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
121318617  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
121319555  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
121296603  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
121325214  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
121300783  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
121330472  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
121300868  serine/threonine-protein kinase PLK2-like [KO:K08861] [EC:2.7.11.21]
121316785  serine/threonine-protein kinase PLK2-like [KO:K08861] [EC:2.7.11.21]
121327258  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
121331080  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
121330772  serine/threonine-protein kinase PLK4-like [KO:K08863] [EC:2.7.11.21]
121325413  serine/threonine-protein kinase PLK4-like [KO:K08863] [EC:2.7.11.21]
121301031  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
121294311  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121326375  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
121315739  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121315746  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121315754  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121315761  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121302100  growth arrest and DNA damage-inducible protein GADD45 gamma-like isoform X1 [KO:K04402]
121302121  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121302141  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121309579  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
121317043  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121317116  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
121330907  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
121326429  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121330683  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
121327343  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
121323471  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
121318786  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
121326673  B-cell lymphoma 6 protein homolog isoform X1 [KO:K15618]
121323205  B-cell lymphoma 6 protein homolog isoform X1 [KO:K15618]
121325815  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121307198  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
121322024  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121310799  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121302342  atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
121296099  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121296133  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121296515  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121306598  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121326012  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121305680  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121325389  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121325390  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121294756  catalase-like [KO:K03781] [EC:1.11.1.6]
121329912  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
121317001  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
121302935  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
121298464  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
121305155  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
121319441  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
121301875  g6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
121301985  glucose-6-phosphatase catalytic subunit 1-like isoform X1 [KO:K01084] [EC:3.1.3.9]
121302035  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
121322292  glucose-6-phosphatase 2-like [KO:K01084] [EC:3.1.3.9]
121324720  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
121318266  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
121304728  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
121301565  Krueppel-like factor 2 [KO:K17845]
121309262  Krueppel-like factor 2 [KO:K17845]
121309266  Krueppel-like factor 2 [KO:K17845]
121294094  sphingosine 1-phosphate receptor 1-like [KO:K04288]
121327024  sphingosine 1-phosphate receptor 1-like [KO:K04288]
121300857  sphingosine 1-phosphate receptor 4-like [KO:K04293]
121301259  sphingosine 1-phosphate receptor 4-like [KO:K04293]
121294529  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
121295047  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
121314613  fbxo32; F-box only protein 32 [KO:K10305]
121315922  F-box only protein 25-like isoform X1 [KO:K10305]
121317044  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
pspa00010  Glycolysis / Gluconeogenesis
pspa00020  Citrate cycle (TCA cycle)
pspa00190  Oxidative phosphorylation
pspa04010  MAPK signaling pathway
pspa04110  Cell cycle
pspa04120  Ubiquitin mediated proteolysis
pspa04140  Autophagy - animal
pspa04210  Apoptosis
pspa04350  TGF-beta signaling pathway
pspa04910  Insulin signaling pathway
KO pathway
ko04068   
LinkDB

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