KEGG   PATHWAY: tfn05415
Entry
tfn05415                    Pathway                                
Name
Diabetic cardiomyopathy - Trachypithecus francoisi (Francois's langur)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
tfn05415  Diabetic cardiomyopathy
tfn05415

Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117092745  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
117067797  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
117099784  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
117064807  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
117081990  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117073301  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117065600  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
117085812  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
117091726  TNNI3; troponin I, cardiac muscle [KO:K12044]
117076540  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
117096992  PLN; cardiac phospholamban [KO:K05852]
117087574  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117089420  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
117067902  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
117090035  SP1; transcription factor Sp1 [KO:K04684]
117074039  AGT; angiotensinogen [KO:K09821]
117075586  REN; renin [KO:K01380] [EC:3.4.23.15]
117069890  CMA1; chymase [KO:K01329] [EC:3.4.21.39]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117086989  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
117078537  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
117072588  NCF1; neutrophil cytosol factor 1 [KO:K08011]
117088204  cytochrome b-245 light chain [KO:K08009]
117074547  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
117095969  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117085754  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117070036  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117084057  AGTR1; type-1 angiotensin II receptor [KO:K04166]
117085710  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117081405  RELA; transcription factor p65 [KO:K04735]
117087120  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087121  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096273  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096276  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117087797  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
117068860  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
117073594  COL1A2; collagen alpha-2(I) chain [KO:K06236]
117067210  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
117094747  COL3A1; collagen alpha-1(III) chain [KO:K19720]
117075968  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
117074794  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117069299  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
117072041  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
117096318  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
117096247  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
117072465  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
117074293  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
117067209  PDK2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117082999  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
117072993  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
117080254  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
117089406  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
117062530  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117095609  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
117081391  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
117093432  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117092570  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
117081143  INS; insulin [KO:K04526]
117076717  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117094439  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117086074  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117093322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117090404  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
117091538  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
117063688  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
117096893  MPC1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
117077523  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
117072095  LOW QUALITY PROTEIN: mitochondrial pyruvate carrier 2-like [KO:K22139]
117075927  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
117078518  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
117086397  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
117083059  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
18985085  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
18985073  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
18985079  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
18985081  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
18985080  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
18985082  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
18985083  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
117081005  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
117064141  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
117095835  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
117089611  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117077312  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117096655  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
117065757  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
117087695  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117063629  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117093658  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
117077670  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117089896  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
117072332  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117082326  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117092233  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117095320  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117097361  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117072292  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
117084391  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117076830  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
117096387  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117076742  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
117098726  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
117090671  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
117094305  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117087492  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117093644  LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial-like [KO:K03955]
117075517  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
117075518  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
117075723  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
117089604  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
117076644  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
117071524  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117063948  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117072298  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
117079196  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117071184  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
117095227  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117071291  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117083450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
117084440  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117068009  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117083769  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
117098709  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
117069703  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
117076186  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117069794  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
117068386  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
117079542  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
117097828  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
117078337  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
117086072  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
117094614  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
117076373  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
117080186  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
117065109  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
117065203  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117092829  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
117075209  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117064716  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
117076663  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
117080942  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
117085925  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
117079974  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
117064660  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
117064675  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
117064676  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
117062944  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
117093237  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
117074342  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117092766  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
117074969  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
117073294  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
117092025  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
117092255  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
18985084  CYTB; cytochrome b [KO:K00412]
117079304  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
117080933  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
117087515  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
117092657  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
117079397  cytochrome b-c1 complex subunit 7 [KO:K00417]
117095688  cytochrome b-c1 complex subunit 7-like [KO:K00417]
117065879  cytochrome b-c1 complex subunit 8 [KO:K00418]
117096163  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
117075323  cytochrome b-c1 complex subunit 10 [KO:K00420]
18985078  COX3; cytochrome c oxidase subunit III [KO:K02262]
18985074  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18985075  COX2; cytochrome c oxidase subunit II [KO:K02261]
117068615  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
117088155  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
117073003  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
117070355  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
117096477  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
117099609  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
117085400  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
117087707  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
117089300  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
117081344  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
117091738  cytochrome c oxidase subunit 6B2 [KO:K02267]
117092366  cytochrome c oxidase subunit 6B1 [KO:K02267]
117067730  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117078869  cytochrome c oxidase subunit 6C [KO:K02268]
117078078  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
117087463  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
117062413  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
117095749  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
117078522  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
117085655  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
117076746  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
117068693  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117077892  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117077947  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117088659  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117070928  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117071608  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117080679  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117072476  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117064943  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117065132  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117093179  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117084864  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117093839  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117067104  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117077366  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117095431  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117071500  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
117081060  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
117081585  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
117063944  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117089918  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
117071177  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
117082510  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
117076305  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
117069010  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
18985077  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
117075856  LOW QUALITY PROTEIN: ATP synthase subunit a-like [KO:K02126]
117075878  ATP synthase subunit a-like [KO:K02126]
117070400  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
117074996  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
117076037  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
117062157  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117090028  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
117099787  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117082240  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117075702  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117067177  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117094831  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
117066659  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
117085388  ATP synthase subunit d, mitochondrial [KO:K02138]
117087884  ATP synthase subunit O, mitochondrial-like [KO:K02137]
117095055  ATP synthase subunit O, mitochondrial-like [KO:K02137]
117095725  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
117095627  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
18985076  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
117098307  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117082746  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
117095701  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117077936  ADP/ATP translocase 2-like [KO:K05863]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117082093  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
117091710  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117072600  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
117062271  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117099608  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117090640  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
117065216  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117094935  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117076684  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
117078376  glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
117094508  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
117098928  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
117084287  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
117063928  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117070466  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
117070870  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117080608  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117068469  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117068471  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117067444  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
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  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
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Basic Res Cardiol 114:2 (2018)
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Reference
PMID:24462787
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Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
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Reference
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Related
pathway
tfn00010  Glycolysis / Gluconeogenesis
tfn00020  Citrate cycle (TCA cycle)
tfn00190  Oxidative phosphorylation
tfn00520  Amino sugar and nucleotide sugar metabolism
tfn03320  PPAR signaling pathway
tfn04071  Sphingolipid signaling pathway
tfn04150  mTOR signaling pathway
tfn04210  Apoptosis
tfn04260  Cardiac muscle contraction
tfn04350  TGF-beta signaling pathway
tfn04614  Renin-angiotensin system
tfn04910  Insulin signaling pathway
tfn04930  Type II diabetes mellitus
tfn04931  Insulin resistance
tfn04933  AGE-RAGE signaling pathway in diabetic complications
tfn04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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