KEGG   PATHWAY: vcd03040
Entry
vcd03040                    Pathway                                
Name
Spliceosome - Vanessa cardui (painted lady)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
vcd03040  Spliceosome
vcd03040

Other DBs
GO: 0005681
Organism
Vanessa cardui (painted lady) [GN:vcd]
Gene
124541314  U1 spliceosomal RNA [KO:K14276]
124539482  U1 spliceosomal RNA [KO:K14276]
124534510  U1 spliceosomal RNA [KO:K14276]
124541312  U1 spliceosomal RNA [KO:K14276]
124539484  U1 spliceosomal RNA [KO:K14276]
124534753  U4 spliceosomal RNA [KO:K14278]
124539124  U4 spliceosomal RNA [KO:K14278]
124542943  U4 spliceosomal RNA [KO:K14278]
124535474  U5 spliceosomal RNA [KO:K14279]
124534980  U5 spliceosomal RNA [KO:K14279]
124531477  U5 spliceosomal RNA [KO:K14279]
124541325  U6 spliceosomal RNA [KO:K14280]
124538676  U6 spliceosomal RNA [KO:K14280]
124533303  U6 spliceosomal RNA [KO:K14280]
124536706  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
124532775  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
124531022  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
124536445  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
124532251  pre-mRNA-processing factor 17 [KO:K12816]
124535124  pre-mRNA-splicing factor 18 [KO:K12817]
124533462  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
124543707  pre-mRNA-splicing factor Slu7 [KO:K12819]
124541563  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
124531061  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
124541679  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
124539721  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
124533037  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
124536336  probable small nuclear ribonucleoprotein E [KO:K11097]
124536251  small nuclear ribonucleoprotein F [KO:K11098]
124540541  probable small nuclear ribonucleoprotein G [KO:K11099]
124542150  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
124532310  U1 small nuclear ribonucleoprotein C [KO:K11095]
124532118  pre-mRNA-processing factor 40 homolog B [KO:K12821]
124536523  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
124536200  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
124536375  probable ATP-dependent RNA helicase ddx42 [KO:K12823] [EC:5.6.2.7]
124541733  transcription elongation regulator 1 isoform X1 [KO:K12824]
124533346  RNA-binding protein cabeza [KO:K13098]
124530600  U2 small nuclear ribonucleoprotein A' [KO:K11092]
124536192  U1 small nuclear ribonucleoprotein A [KO:K11094]
124535152  splicing factor 3A subunit 1 [KO:K12825]
124544133  splicing factor 3A subunit 2 [KO:K12826]
124535265  splicing factor 3A subunit 3 [KO:K12827]
124533441  splicing factor 3B subunit 1 [KO:K12828]
124538380  splicing factor 3B subunit 2 [KO:K12829]
124536531  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
124534125  splicing factor 3B subunit 4 [KO:K12831]
124540096  splicing factor 3B subunit 5 [KO:K12832]
124533023  splicing factor 3B subunit 6 [KO:K12833]
124534251  PHD finger-like domain-containing protein 5A [KO:K12834]
124534312  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
124531816  splicing factor U2af 38 kDa subunit [KO:K12836]
124529631  splicing factor U2AF 50 kDa subunit [KO:K12837]
124534674  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
124532931  survival of motor neuron-related-splicing factor 30 [KO:K12839]
124532614  splicing factor 45 [KO:K12840]
124530267  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
124531678  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
124541948  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
124536771  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
124542207  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
124529613  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
124539421  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
124536813  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
124535051  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
124541581  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
124541527  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
124533725  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
124533680  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
124536344  NHP2-like protein 1 [KO:K12845]
124541536  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
124537654  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
124531913  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
124530279  zinc finger matrin-type protein 2 [KO:K12848]
124539412  pre-mRNA-splicing factor 38 [KO:K12849]
124536291  pre-mRNA-splicing factor 38B-like [KO:K12850]
124541979  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
124541396  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
124536826  pre-mRNA-processing factor 6 [KO:K12855]
124534361  pre-mRNA-processing-splicing factor 8 [KO:K12856]
124536830  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
124539404  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
124537851  thioredoxin-like protein 4A [KO:K12859]
124533728  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
124532196  cell division cycle 5-like protein [KO:K12860]
124531995  pre-mRNA-splicing factor SPF27 [KO:K12861]
124543956  pleiotropic regulator 1 [KO:K12862]
124531026  protein CWC15 homolog [KO:K12863]
124539071  beta-catenin-like protein 1 [KO:K12864]
124542362  heat shock protein 68-like [KO:K03283]
124532508  heat shock 70 kDa protein cognate 4 [KO:K03283]
124532918  heat shock protein 68-like [KO:K03283]
124535242  heat shock protein 68-like [KO:K03283]
124540462  heat shock protein 68-like [KO:K03283]
124540465  major heat shock 70 kDa protein Ba-like [KO:K03283]
124540467  major heat shock 70 kDa protein Ba-like [KO:K03283]
124540473  major heat shock 70 kDa protein Ba-like [KO:K03283]
124540509  heat shock protein 68-like [KO:K03283]
124538621  polyglutamine-binding protein 1 [KO:K12865]
124540785  puff-specific protein Bx42 [KO:K06063]
124530797  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
124536928  pre-mRNA-splicing factor Syf2 [KO:K12868]
124535684  protein crooked neck [KO:K12869]
124530489  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
124543030  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
124541950  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
124532551  coiled-coil domain-containing protein 12 [KO:K12871]
124534795  pre-mRNA-splicing factor RBM22 [KO:K12872]
124529774  protein BUD31 homolog [KO:K12873]
124538455  RNA helicase aquarius [KO:K12874]
124538261  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
124541081  RNA-binding protein 8A [KO:K12876]
124537642  protein mago nashi homolog [KO:K12877]
124536297  THO complex subunit 1 [KO:K12878]
124543987  THO complex subunit 2 isoform X1 [KO:K12879]
124539710  THO complex subunit 3 [KO:K12880]
124534214  THO complex subunit 4 isoform X1 [KO:K12881]
124534785  nuclear cap-binding protein subunit 1 [KO:K12882]
124542887  nuclear cap-binding protein subunit 2 [KO:K12883]
124535248  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
124535468  heterogeneous nuclear ribonucleoprotein 87F-like isoform X1 [KO:K12741]
124537161  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
124532730  serine/arginine-rich splicing factor 1B [KO:K12890]
124529674  serine/arginine-rich splicing factor 2 [KO:K12891]
124538700  serine-arginine protein 55 isoform X1 [KO:K12893]
124531941  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
124536777  RNA-binding protein 1 isoform X1 [KO:K12896]
124534276  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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