KEGG   PATHWAY: xco04145
Entry
xco04145                    Pathway                                
Name
Phagosome - Xiphophorus couchianus (Monterrey platyfish)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
xco04145  Phagosome
xco04145

Other DBs
GO: 0045335
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114135728  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
114156463  stx12; syntaxin-12 [KO:K13813]
114158817  stx7; syntaxin-7 [KO:K08488]
114144351  actin, cytoplasmic 2 [KO:K05692]
114159761  actb; actin, cytoplasmic 1 [KO:K05692]
114159976  coronin-1A-like [KO:K13882]
114135495  stx18; syntaxin-18 [KO:K08492]
114151325  sec22b; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
114146549  vesicle-trafficking protein SEC22b-like [KO:K08517]
114156480  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
114156481  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
114156351  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
114156478  major histocompatibility complex class I-related gene protein-like [KO:K06751]
114156479  hereditary hemochromatosis protein-like [KO:K06751]
114140622  SLA class II histocompatibility antigen, DQ haplotype D beta chain-like [KO:K06752]
114140625  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
114140627  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
114140630  LOW QUALITY PROTEIN: mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
114141632  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
114141634  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
114159930  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
114159932  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
114141653  ras-related protein Rab-5A-like [KO:K07887]
114156258  ras-related protein Rab-5A [KO:K07887]
114147998  ras-related protein Rab-5B-like isoform X1 [KO:K07888]
114152177  ras-related protein Rab-5C-like [KO:K07889]
114159736  rab5c; ras-related protein Rab-5C [KO:K07889]
114153153  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
114157271  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
114147191  tfrc; transferrin receptor protein 1 [KO:K06503]
114136987  transferrin receptor protein 1-like isoform X1 [KO:K06503]
114159770  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
114153696  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
114136704  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
114138165  V-type proton ATPase subunit B, brain isoform [KO:K02147]
114149995  V-type proton ATPase subunit B, brain isoform [KO:K02147]
114145317  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
114156244  V-type proton ATPase subunit C 1-A [KO:K02148]
114133886  V-type proton ATPase subunit C 1-B-like [KO:K02148]
114158445  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
114136918  V-type proton ATPase subunit E 1-like [KO:K02150]
114133195  V-type proton ATPase subunit E 1-like isoform X1 [KO:K02150]
114161166  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
114136974  V-type proton ATPase subunit G 1-like [KO:K02152]
114144796  V-type proton ATPase subunit e 2-like [KO:K02153]
114139633  V-type proton ATPase subunit e 2-like [KO:K02153]
114149974  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
114160259  atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114139538  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
114154869  atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
114150880  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
114142797  V-type proton ATPase subunit d 1 [KO:K02146]
114146751  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
114159520  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114156501  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
114146791  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
114140292  atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
114140367  V-type proton ATPase subunit S1-like [KO:K03662]
114135099  ras-related protein rab7-like [KO:K07897]
114135093  ras-related protein rab7-like [KO:K07897]
114136165  ras-related protein rab7 [KO:K07897]
114133396  RILP-like protein 1 [KO:K13883]
114134167  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
114133207  dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
114148039  dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
114156446  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
114146216  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
114142884  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
114156573  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
114140589  tubulin alpha chain-like [KO:K07374]
114140795  tubulin alpha chain-like [KO:K07374]
114141078  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
114141079  tubulin alpha-1A chain [KO:K07374]
114150684  tubulin alpha chain-like isoform X1 [KO:K07374]
114140346  tubulin alpha-8 chain-like [KO:K07374]
114140468  tubulin alpha-1B chain [KO:K07374]
114150188  tubulin alpha-1B chain-like [KO:K07374]
114147943  tubulin alpha chain [KO:K07374]
114147944  tubulin alpha chain-like [KO:K07374]
114147945  tubulin alpha chain-like [KO:K07374]
114150302  tubulin alpha-1C chain-like [KO:K07374]
114150386  tubulin alpha-1 chain-like [KO:K07374]
114144632  tubulin beta-4B chain-like [KO:K07375]
114145912  tubulin beta-4B chain-like isoform X1 [KO:K07375]
114155498  tubulin beta-1 chain-like [KO:K07375]
114141673  tubulin beta chain [KO:K07375]
114160209  tubulin beta-4B chain-like [KO:K07375]
114161889  tubulin beta-4B chain-like isoform X1 [KO:K07375]
114155393  tubulin beta chain-like [KO:K07375]
114146693  tubulin beta chain-like isoform X1 [KO:K07375]
114161588  tubulin beta chain-like isoform X1 [KO:K07375]
114135820  tubulin beta chain-like [KO:K07375]
114135091  tubulin beta-4B chain-like [KO:K07375]
114154726  tubb4b; tubulin beta-4B chain [KO:K07375]
114148546  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
114143297  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
114138879  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
114148411  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
114139365  m6pr; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
114154866  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
114150480  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114154740  ctsl; cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
114134492  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
114156396  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
114142240  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
114135411  protein transport protein Sec61 subunit alpha-like isoform X1 [KO:K10956]
114135412  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
114135845  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
114141941  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
114136807  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
114141733  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
114152292  antigen peptide transporter 2-like isoform X1 [KO:K05654] [EC:7.4.2.14]
114156475  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
114150574  calreticulin-like [KO:K08057]
114146819  calreticulin-like [KO:K08057]
114139000  canx; calnexin isoform X1 [KO:K08054]
114133593  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06498]
114156964  Fc receptor-like B [KO:K06472]
114156970  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06463]
114159462  Ig heavy chain Mem5-like [KO:K06856]
114142160  c1r; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
114161929  integrin alpha-D-like isoform X1 [KO:K06461]
114161936  integrin alpha-D-like [KO:K06461]
114161944  integrin alpha-D-like [KO:K06461]
114148797  integrin beta-2-like [KO:K06464]
114144597  complement C3-like isoform X1 [KO:K03990]
114134699  colec11; collectin-11 [KO:K10066]
114146901  collectin-12-like [KO:K10062]
114136770  colec12; collectin-12 isoform X1 [KO:K10062]
114150409  mannose-binding protein C-like [KO:K03991]
114133569  pulmonary surfactant-associated protein D-like [KO:K10068]
114135020  collectin-43-like isoform X1 [KO:K10068]
114147719  itgav; integrin alpha-V [KO:K06487]
114154747  itga2; integrin alpha-2 [KO:K06481]
114140439  integrin alpha-5-like [KO:K06484]
114135751  integrin alpha-5-like [KO:K06484]
114136672  itgb1; integrin beta-1 isoform X1 [KO:K05719]
114160108  integrin beta-3-like [KO:K06493]
114151891  itgb3; integrin beta-3 [KO:K06493]
114148422  itgb5; integrin beta-5 [KO:K06588]
114158629  thrombospondin-1-like [KO:K16857]
114134229  thrombospondin-1-like [KO:K16857]
114137908  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
114151598  comp; cartilage oligomeric matrix protein [KO:K04659]
114155159  thrombospondin-4-B-like isoform X1 [KO:K04659]
114150055  thrombospondin-4-B-like [KO:K04659]
114141629  thbs3; thrombospondin-3 isoform X1 [KO:K04659]
114151956  thrombospondin-2-like isoform X1 [KO:K04659]
114157991  toll-like receptor 2 type-1 [KO:K10159]
114158033  toll-like receptor 2 type-2 [KO:K10159]
114140250  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
114137189  mrc1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
114146381  macrophage mannose receptor 1-like [KO:K06560]
114146382  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
114149051  macrophage mannose receptor 1-like [KO:K06560]
114143000  pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
114159546  mrc2; C-type mannose receptor 2 [KO:K06560]
114144306  CD209 antigen-like protein E [KO:K06563]
114145311  CD209 antigen-like protein E [KO:K06563]
114148275  marco; macrophage receptor MARCO isoform X1 [KO:K13884]
114149891  scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
114160836  cd36; platelet glycoprotein 4 [KO:K06259]
114142753  cytochrome b-245 light chain [KO:K08009]
114140559  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
114151419  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
114151420  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114151421  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114160398  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114152605  ncf1; neutrophil cytosol factor 1 [KO:K08011]
114137106  ncf2; neutrophil cytosol factor 2 [KO:K08010]
114144445  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
xco04142  Lysosome
xco04144  Endocytosis
xco04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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