KEGG   PATHWAY: pflv04060
Entry
pflv04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Perca flavescens (yellow perch)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pflv04060  Cytokine-cytokine receptor interaction
pflv04060

Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114545237  [KO:K05132]
114545614  rell1; RELT-like protein 1 [KO:K26541]
114545642  epo; erythropoietin isoform X1 [KO:K05437]
114545672  [KO:K05077]
114545698  [KO:K10030]
114545805  [KO:K10030]
114545850  [KO:K10030]
114545959  bmp15; bone morphogenetic protein 15 [KO:K05498]
114546235  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
114546436  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114546643  [KO:K04675] [EC:2.7.11.30]
114546704  bmp4; bone morphogenetic protein 4 [KO:K04662]
114546869  [KO:K04721]
114546930  [KO:K04181]
114547305  [KO:K05060]
114547340  ebi3; interleukin-27 subunit beta [KO:K24476]
114547607  [KO:K21283]
114547911  [KO:K05075]
114548080  [KO:K02583]
114548143  nodal; nodal homolog [KO:K04666]
114548188  [KO:K05414]
114548191  [KO:K05414]
114548200  tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
114548373  [KO:K22674]
114548374  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
114548702  [KO:K05503]
114548823  [KO:K04721]
114548846  bmp6; bone morphogenetic protein 6 [KO:K16620]
114548887  ackr4; atypical chemokine receptor 4 [KO:K04186]
114548898  [KO:K13596] [EC:2.7.11.30]
114548903  [KO:K04667]
114549045  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114549177  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
114549306  [KO:K04184]
114549319  [KO:K14625]
114549426  [KO:K04179]
114550354  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
114550464  il17ra; interleukin-17 receptor A [KO:K05164]
114550554  [KO:K05439]
114550736  [KO:K05497]
114550862  inha; inhibin alpha chain [KO:K05500]
114550865  acvr2a; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
114550953  [KO:K05050]
114550971  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114550998  [KO:K05080]
114551010  [KO:K22687]
114551075  [KO:K04304]
114552233  cxcr5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
114552362  [KO:K13375]
114552498  tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
114552555  [KO:K05438]
114552582  [KO:K21283]
114552639  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
114552704  [KO:K05134]
114553224  [KO:K05406]
114553249  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114553515  [KO:K22667]
114553596  [KO:K13567] [EC:2.7.11.30]
114553710  [KO:K05166]
114553797  [KO:K22679]
114554141  [KO:K16621]
114554280  il10; interleukin-10 [KO:K05443]
114554379  [KO:K05142]
114554420  [KO:K05055]
114554436  [KO:K22687]
114554684  gdf5; growth/differentiation factor 5 [KO:K04664]
114554876  [KO:K05071]
114554921  ngf; beta-nerve growth factor [KO:K02582]
114554940  [KO:K05141]
114555196  cxcl13; C-X-C motif chemokine 13 [KO:K10032]
114555274  [KO:K05080]
114555306  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
114555328  [KO:K22670]
114555607  [KO:K05058]
114555628  il1b; interleukin-1 beta [KO:K04519]
114555836  [KO:K05060]
114555903  [KO:K05491]
114556008  bmp3; bone morphogenetic protein 3 [KO:K05496]
114556107  [KO:K05425]
114556127  [KO:K05513]
114556159  [KO:K04666]
114556380  [KO:K05512]
114556405  [KO:K04722]
114556613  [KO:K04388] [EC:2.7.11.30]
114557046  [KO:K05468]
114557107  [KO:K04179]
114557108  [KO:K04180]
114557129  [KO:K04188]
114557182  [KO:K02583]
114557184  [KO:K05075]
114557291  [KO:K04188]
114557371  [KO:K04179]
114557390  [KO:K20012]
114557393  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
114557411  csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
114557493  [KO:K06454]
114557503  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114557511  [KO:K03160]
114557533  [KO:K05417]
114557568  [KO:K05055]
114557596  [KO:K05494]
114557612  [KO:K05143]
114557679  [KO:K04188]
114557748  tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
114557767  [KO:K04179]
114557790  [KO:K04179]
114557891  [KO:K04179]
114557897  [KO:K22628]
114558320  [KO:K05173]
114558351  [KO:K02582]
114558391  [KO:K05144]
114558456  [KO:K13594] [EC:2.7.11.30]
114558705  [KO:K03160]
114558745  [KO:K05168]
114558805  [KO:K13567] [EC:2.7.11.30]
114558969  [KO:K05166]
114559034  [KO:K16621]
114559122  [KO:K04181]
114559173  [KO:K05152]
114559299  [KO:K05152]
114559301  [KO:K05152]
114559302  [KO:K05152]
114559303  [KO:K05152]
114559304  [KO:K05152]
114559305  [KO:K05152]
114559456  il17rb; interleukin-17 receptor B isoform X1 [KO:K05165]
114559706  [KO:K05439]
114560122  [KO:K05174]
114560517  ccl17; C-C motif chemokine 17 [KO:K12964]
114560546  [KO:K05071]
114560624  [KO:K05164]
114560700  il16; pro-interleukin-16 [KO:K22628]
114560726  il34; interleukin-34 isoform X1 [KO:K22633]
114560768  [KO:K05491]
114560788  [KO:K05491]
114560798  [KO:K05491]
114561014  mpl; LOW QUALITY PROTEIN: thrombopoietin receptor [KO:K05082]
114561120  lepr; leptin receptor [KO:K05062]
114561263  [KO:K21083]
114561273  [KO:K13072]
114561697  amh; muellerian-inhibiting factor [KO:K04665]
114561830  [KO:K05064]
114561835  [KO:K05063]
114561861  [KO:K05064]
114562043  xcr1; chemokine XC receptor 1 [KO:K04193]
114562355  [KO:K05476]
114562478  gdf9; growth/differentiation factor 9 [KO:K22673]
114562717  [KO:K13376]
114562755  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
114562957  eda; ectodysplasin-A isoform X1 [KO:K05480]
114563150  [KO:K04389]
114563165  [KO:K05425]
114563187  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
114563526  [KO:K04388] [EC:2.7.11.30]
114563656  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
114563698  [KO:K05131]
114563754  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K05069]
114563768  [KO:K05069]
114563795  [KO:K04386]
114563797  [KO:K04387]
114563832  [KO:K05171]
114563833  [KO:K05171]
114563841  acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
114563875  [KO:K04670] [EC:2.7.11.30]
114563987  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
114564099  [KO:K04304]
114564182  mstn; growth/differentiation factor 8 [KO:K05497]
114564199  gdf3; growth/differentiation factor 3 [KO:K22672]
114564309  [KO:K22687]
114564409  il17d; interleukin-17D [KO:K05492]
114564415  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
114564416  [KO:K05135]
114564471  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
114564486  [KO:K05050]
114564614  [KO:K05135]
114564645  [KO:K05050]
114564957  [KO:K04186]
114565169  il12a; interleukin-12 subunit alpha [KO:K05406]
114565221  [KO:K04179]
114565452  [KO:K04189]
114565487  il15; interleukin-15 isoform X1 [KO:K05433]
114565658  [KO:K04667]
114565748  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
114565781  [KO:K05504]
114565785  [KO:K14625]
114565790  [KO:K14625]
114565836  [KO:K21283]
114565908  [KO:K13072]
114565937  [KO:K06854]
114565942  ccr7; C-C chemokine receptor type 7 [KO:K04182]
114566231  [KO:K05070]
114566315  [KO:K05425]
114566334  [KO:K05070]
114566378  [KO:K05090] [EC:2.7.10.1]
114566822  [KO:K05077]
114567017  [KO:K22629]
114567738  gdf6; growth/differentiation factor 6 [KO:K20012]
114567910  [KO:K05143]
114568041  bmp8a; bone morphogenetic protein 8A [KO:K16622]
114568194  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114568210  [KO:K03156]
114568216  [KO:K10030]
114568648  [KO:K05405]
114568931  [KO:K05477]
114568956  [KO:K05438]
114569083  [KO:K02583]
114569629  [KO:K05439]
114569734  [KO:K05060]
114569849  [KO:K05079]
114569858  [KO:K04738]
114570115  [KO:K04188]
114570150  [KO:K10031]
114570267  [KO:K05414]
114570269  [KO:K05414]
114570378  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
114570622  [KO:K05056]
114570789  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
114570890  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
114570926  [KO:K13578] [EC:2.7.11.30]
114571107  [KO:K05058]
114571142  prlr; prolactin receptor [KO:K05081]
114571241  [KO:K04722]
114571286  [KO:K05478]
114571320  [KO:K04666]
114571503  [KO:K05080]
114571561  [KO:K22670]
114571580  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
114571590  [KO:K05058]
114571691  [KO:K05416]
114571908  [KO:K05132]
114571963  [KO:K10031]
114572005  bmp5; bone morphogenetic protein 5 [KO:K04663]
114572155  [KO:K04390]
114572242  bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
114572538  [KO:K22674]
114572770  bmp2; bone morphogenetic protein 2 [KO:K21283]
114573007  [KO:K13377]
114573092  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
114573145  [KO:K05477]
114573255  [KO:K05136]
114573534  [KO:K04181]
114573652  [KO:K05494]
114573764  [KO:K22630]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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