KEGG   PATHWAY: pleu04210
Entry
pleu04210                   Pathway                                
Name
Apoptosis - Peromyscus leucopus (white-footed mouse)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
pleu04210  Apoptosis
pleu04210

Other DBs
GO: 0006915
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680598  Actg1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114681069  Nol3; nucleolar protein 3 [KO:K28177]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114681446  Bbc3; bcl-2-binding component 3 isoform X1 [KO:K10132]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114682019  Ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
114682091  Capn1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
114682099  Rela; transcription factor p65 [KO:K04735]
114682383  Mcl1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
114682396  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
114682409  Ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682740  Casp6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683361  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114683786  [KO:K01353] [EC:3.4.21.79]
114683791  Parp4; protein mono-ADP-ribosyltransferase PARP4 [KO:K10798] [EC:2.4.2.-]
114683802  [KO:K01353] [EC:3.4.21.79]
114683803  [KO:K01353] [EC:3.4.21.79]
114683804  [KO:K01353] [EC:3.4.21.79]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684256  [KO:K05692]
114684418  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114684877  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114685127  [KO:K02833]
114685615  Dffb; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
114685740  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X1 [KO:K10131]
114686266  [KO:K07374]
114686852  [KO:K04741] [EC:3.4.22.-]
114687417  [KO:K01365] [EC:3.4.22.15]
114687991  [KO:K04374]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688301  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114688304  Lmnb2; lamin-B2 isoform X1 [KO:K07611]
114688488  [KO:K02833]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689300  [KO:K01353] [EC:3.4.21.79]
114689301  [KO:K01353] [EC:3.4.21.79]
114689482  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689745  [KO:K08738]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690277  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114690416  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114690631  Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690937  Bcl2a1; bcl-2-related protein A1 [KO:K02162]
114690943  Ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691778  Ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X2 [KO:K02374]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692456  [KO:K01353] [EC:3.4.21.79]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693493  [KO:K02833]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693765  Pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693805  [KO:K01363] [EC:3.4.22.1]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114694043  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
114694223  Csf2rb; cytokine receptor common subunit beta isoform X3 [KO:K04738]
114694224  [KO:K04738]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694427  Htra2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695408  [KO:K08738]
114696016  Parp2; poly [ADP-ribose] polymerase 2 [KO:K28005]
114696553  [KO:K02833]
114696902  [KO:K04727] [EC:1.-.-.-]
114697063  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114697551  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
114697766  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114697928  [KO:K08738]
114698017  Casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698577  Ngf; beta-nerve growth factor [KO:K02582]
114698582  Nras; GTPase NRas [KO:K07828]
114699266  Septin4; septin-4 isoform X3 [KO:K16943]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699646  Hrk; activator of apoptosis harakiri [KO:K02512]
114700430  [KO:K04736]
114700492  Ctso; cathepsin O isoform X2 [KO:K01374] [EC:3.4.22.42]
114700550  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114700731  Tuba8; tubulin alpha-8 chain isoform X2 [KO:K07374]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114700813  [KO:K08738]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700921  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114701254  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
114701517  [KO:K04725] [EC:2.3.2.27]
114702264  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
114702690  [KO:K04722]
114702740  Endog; endonuclease G, mitochondrial [KO:K01173]
114702748  Sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703364  [KO:K01363] [EC:3.4.22.1]
114703574  [KO:K08738]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704457  Cflar; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
114704539  Diablo; diablo homolog, mitochondrial isoform X1 [KO:K10522]
114704682  Traf1; TNF receptor-associated factor 1 [KO:K03172]
114704709  [KO:K19901]
114704726  Prf1; perforin-1 [KO:K07818]
114704800  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114705473  Aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
114705499  Actb; actin, cytoplasmic 1 [KO:K05692]
114705602  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
114705701  [KO:K01366] [EC:3.4.22.16]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114706145  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114708003  [KO:K16060]
114708004  [KO:K16060]
114708371  Lmnb1; LOW QUALITY PROTEIN: lamin-B1 [KO:K07611]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114708419  [KO:K01365] [EC:3.4.22.15]
114708475  [KO:K07374]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708557  [KO:K07374]
114708577  [KO:K07374]
114708578  Tuba1b; tubulin alpha-1B chain [KO:K07374]
114708739  [KO:K01353] [EC:3.4.21.79]
114708754  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
114708759  [KO:K01353] [EC:3.4.21.79]
114708762  [KO:K01353] [EC:3.4.21.79]
114708763  [KO:K01353] [EC:3.4.21.79]
114708793  [KO:K07374]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708968  Birc5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
114709020  [KO:K08738]
114709151  Ctsf; cathepsin F isoform X2 [KO:K01373] [EC:3.4.22.41]
114709171  Ctsw; LOW QUALITY PROTEIN: cathepsin W [KO:K08569] [EC:3.4.22.-]
114709335  Tuba4a; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
114709516  Bcl2l11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
114709660  Dffa; DNA fragmentation factor subunit alpha [KO:K02310]
114710287  [KO:K08738]
114710523  [KO:K04371] [EC:2.7.11.24]
114710707  Ctsc; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
114710984  Parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.-]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Reference
PMID:36652128
  Authors
Liu K, Lan D, Li C, Liu S, Dai X, Song T, Wang X, Kong Q, He Z, Tan J, Zhang J
  Title
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.
  Journal
Apoptosis 28:313-325 (2023)
DOI:10.1007/s10495-022-01802-4
Related
pathway
pleu04010  MAPK signaling pathway
pleu04020  Calcium signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04115  p53 signaling pathway
pleu04141  Protein processing in endoplasmic reticulum
pleu04151  PI3K-Akt signaling pathway
pleu04650  Natural killer cell mediated cytotoxicity
pleu04668  TNF signaling pathway
KO pathway
ko04210   

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