Entry Name ECM-receptor interaction - Perognathus longimembris pacificus (Pacific pocket mouse)
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Other DBs Organism Perognathus longimembris pacificus (Pacific pocket mouse) [GN:
plop ]
Gene 125341854 Hmmr; hyaluronan mediated motility receptor isoform X1 [KO:K06267 ]
125348107 Col4a2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237 ]
125349378 Gp1bb; LOW QUALITY PROTEIN: platelet glycoprotein Ib beta chain [KO:K06262 ]
125350154 Col6a3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238 ]
125351377 Col6a2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238 ]
125351379 Col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238 ]
125354688 Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255 ]
125355265 Frem1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380 ]
125364482 Fras1; extracellular matrix organizing protein FRAS1 isoform X1 [KO:K23379 ]
125365631 Col1a1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236 ]
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related KO pathway
