KEGG   PATHWAY: ppam04714
Entry
ppam04714                   Pathway                                
Name
Thermogenesis - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
ppam04714  Thermogenesis
ppam04714

Other DBs
GO: 1990845
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061437  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
129061505  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129061573  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
129061679  GCG; pro-glucagon [KO:K05259]
129061773  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
129061960  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
129062087  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
129062202  [KO:K03959]
129062244  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
129062304  [KO:K02130]
129062388  CREB3L4; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
129062810  [KO:K03948]
129062851  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
129062895  [KO:K03948]
129062966  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
129063038  [KO:K11351]
129063111  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
129063220  [KO:K00417]
129063334  [KO:K18173]
129063444  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
129063510  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
129063885  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
129063946  NRAS; GTPase NRas [KO:K07828]
129064042  [KO:K02140]
129064050  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
129064134  [KO:K03099]
129064191  [KO:K02140]
129064218  [KO:K02264]
129064682  ADRB3; beta-3 adrenergic receptor [KO:K04143]
129064807  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
129064888  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
129065047  [KO:K18183]
129065242  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
129065327  [KO:K02140]
129065331  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129065349  [KO:K02271]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129065821  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
129065908  [KO:K02270]
129065920  DPF3; zinc finger protein DPF3 [KO:K22198]
129065927  [KO:K18182]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129066147  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
129066202  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
129066208  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
129066439  [KO:K00418]
129066622  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
129066653  KDM3B; lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
129066700  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
129067027  [KO:K11265] [EC:4.6.1.1]
129067112  [KO:K02270]
129067273  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129067621  CNR1; cannabinoid receptor 1 [KO:K04277]
129067648  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129067870  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
129068161  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
129068180  [KO:K00411] [EC:7.1.1.8]
129068255  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129068306  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
129068340  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
129068527  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
129068534  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
129068535  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
129068626  [KO:K02273]
129068738  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129068792  [KO:K02257] [EC:2.5.1.141]
129068928  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129069068  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
129069069  [KO:K16622]
129069071  [KO:K16622]
129069129  ACTB; actin, cytoplasmic 1 [KO:K05692]
129069159  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
129069204  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129069206  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
129069210  [KO:K02267]
129069416  [KO:K00416]
129069629  [KO:K02260]
129069732  [KO:K18180]
129069924  [KO:K02132]
129069979  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
129070176  [KO:K02267]
129070203  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
129070312  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
129070485  [KO:K02263]
129070595  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
129070597  [KO:K04632]
129070681  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
129070881  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
129071413  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
129071519  [KO:K02267]
129071563  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129071827  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129071855  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
129071966  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
129072246  [KO:K02267]
129072628  [KO:K18177]
129072781  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
129072830  [KO:K02140]
129073026  [KO:K18184]
129073075  [KO:K18179]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129073133  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
129073752  [KO:K02134]
129073755  [KO:K02134]
129073794  [KO:K03947]
129073888  PLIN1; perilipin-1 [KO:K08768]
129073965  [KO:K03962]
129073975  KDM3A; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
129074168  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
129074234  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
129074314  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
129074346  [KO:K02271]
129074405  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
129074539  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
129074559  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
129074565  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
129074665  [KO:K02272]
129074723  [KO:K02267]
129074799  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
129075001  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
129075499  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
129075595  NPPA; natriuretic peptides A [KO:K12334]
129075618  NPPB; natriuretic peptides B [KO:K12335]
129075622  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
129075656  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129075768  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
129075788  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
129075808  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
129075876  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
129075999  [KO:K03951]
129076111  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
129076184  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
129076708  [KO:K11340]
129076717  ACTL6A; actin-like protein 6A [KO:K11340]
129076733  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
129076737  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
129076751  [KO:K00415]
129076934  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129077103  [KO:K02259] [EC:1.17.99.9]
129077119  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
129077179  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
129077553  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
129077583  KLB; beta-klotho [KO:K22404]
129077657  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
129077717  [KO:K02271]
129077877  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
129077881  [KO:K02267]
129077999  [KO:K02266]
129078156  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
129078157  SIRT6; NAD-dependent protein deacylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
129078219  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
129078285  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
129078347  RPS6; 40S ribosomal protein S6 [KO:K02991]
129078572  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
129078685  [KO:K00415]
129078697  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
129078780  ZNF516; zinc finger protein 516 [KO:K22411]
129079006  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129079019  PRDM16; histone-lysine N-methyltransferase PRDM16 [KO:K22410] [EC:2.1.1.367]
129079187  TSC1; hamartin isoform X1 [KO:K07206]
129079300  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
129079431  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129080072  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
129080120  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
129080157  [KO:K02258]
129080311  ACSL3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
129080341  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
129080390  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129080402  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
129080430  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
129080483  [KO:K03960]
129080578  [KO:K02265]
129080666  [KO:K02136]
129080715  [KO:K18178]
129081111  [KO:K11651]
129081425  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
129081516  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129081580  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
129081642  [KO:K00420]
129081681  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
129081814  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
129081909  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
129082086  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
129082090  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
129082512  [KO:K02267]
129082796  FGF21; fibroblast growth factor 21 [KO:K22429]
129082808  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
129082947  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
129083115  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
129083132  [KO:K02263]
129083194  [KO:K02267]
129083211  [KO:K02270]
129083456  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
129083505  [KO:K02138]
129083592  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
129083598  TSC2; tuberin isoform X1 [KO:K07207]
129083602  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
129083643  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129083852  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
129084082  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129084129  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
129084215  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
129084220  [KO:K00417]
129084233  [KO:K02140]
129084242  [KO:K02268]
129084321  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
129084412  [KO:K00413]
129084652  [KO:K18181]
129084810  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
129084859  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
129084869  [KO:K02271]
129084876  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
129084881  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129085073  [KO:K17797]
129085977  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
129086072  [KO:K02271]
129086199  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
129086489  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
129086550  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129086631  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
129086703  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
129086754  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
129086755  RHEB; GTP-binding protein Rheb [KO:K07208]
129086760  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
129086885  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
129087071  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
129087076  [KO:K18175]
129087246  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
129087380  [KO:K00419]
129087477  [KO:K02266]
129087578  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
129087602  [KO:K00414]
129087684  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
129087752  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
129087868  [KO:K02270]
129088189  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
129088213  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
129088401  [KO:K02272]
129088538  [KO:K02128]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
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Related
pathway
ppam00020  Citrate cycle (TCA cycle)
ppam00190  Oxidative phosphorylation
ppam04010  MAPK signaling pathway
ppam04022  cGMP-PKG signaling pathway
ppam04024  cAMP signaling pathway
ppam04150  mTOR signaling pathway
ppam04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   

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