KEGG   PATHWAY: spul04060
Entry
spul04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Semicossyphus pulcher (California sheephead)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
spul04060  Cytokine-cytokine receptor interaction
spul04060

Organism
Semicossyphus pulcher (California sheephead) [GN:spul]
Gene
138583322  [KO:K22630]
138583568  [KO:K03160]
138583573  ifnlr1; interferon lambda receptor 1 [KO:K05136]
138583661  [KO:K22628]
138583679  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
138583728  [KO:K05143]
138583816  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
138583880  cd4-1; CD4-1 molecule [KO:K06454]
138583937  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
138584001  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
138584056  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
138584091  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
138584097  [KO:K04188]
138584132  gdf6a; growth/differentiation factor 6-A [KO:K20012]
138584337  cabz01093075.1; C-C chemokine receptor type 5 [KO:K04179]
138584361  [KO:K04388] [EC:2.7.11.30]
138584375  [KO:K04179]
138584409  [KO:K04180]
138584424  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
138584425  nradd; death domain-containing membrane protein NRADD [KO:K02583]
138584502  il21r.1; interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
138584584  [KO:K05148]
138584669  il11a; uncharacterized protein il11a [KO:K05417]
138584670  [KO:K05073]
138584718  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
138585171  [KO:K04181]
138585172  [KO:K04181]
138585455  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
138588149  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
138588306  bmp5; bone morphogenetic protein 5 [KO:K04663]
138588395  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
138588538  gdf10b; growth/differentiation factor 10b [KO:K05132]
138588563  gdf10a; growth/differentiation factor 10 [KO:K22674]
138588632  [KO:K05416]
138588966  bmpr1aa; bone morphogenetic protein receptor, type IAa [KO:K04673] [EC:2.7.11.30]
138589186  [KO:K05168]
138589340  [KO:K05173]
138589419  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
138589476  [KO:K05152]
138589477  acvrl1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
138589538  [KO:K03158]
138589597  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a [KO:K05146]
138589728  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
138589757  bmp7b; bone morphogenetic protein 7b [KO:K16621]
138589827  [KO:K05152]
138589845  [KO:K05165]
138589873  [KO:K05166]
138589940  [KO:K05152]
138590138  ngfa; neurotrophin-7 [KO:K02582]
138590290  [KO:K05174]
138590304  [KO:K05152]
138590349  [KO:K05152]
138590361  [KO:K05152]
138590371  [KO:K05152]
138590373  [KO:K05152]
138590378  [KO:K05152]
138590381  [KO:K05152]
138590815  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
138590884  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
138591007  il16; pro-interleukin-16 [KO:K22628]
138591096  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
138591187  [KO:K05060]
138591336  bmp4; bone morphogenetic protein 4 [KO:K04662]
138591559  [KO:K04721]
138591705  ebi3; interleukin-27 subunit beta [KO:K24476]
138591788  il17a/f1; interleukin 17a/f1 [KO:K05494]
138591998  [KO:K04671] [EC:2.7.11.30]
138592022  mstnb; growth/differentiation factor 8 [KO:K05497]
138592064  [KO:K13568] [EC:2.7.11.30]
138592081  [KO:K04675] [EC:2.7.11.30]
138592273  [KO:K04304]
138592275  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
138592284  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
138592312  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
138592355  [KO:K04388] [EC:2.7.11.30]
138592399  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
138592441  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
138592443  il17d; interleukin-17D [KO:K05492]
138592478  [KO:K05050]
138592487  inhbb; inhibin beta B chain [KO:K22687]
138592513  [KO:K05171]
138592535  il1rl2; interleukin-1 receptor type 1 [KO:K04386]
138592699  [KO:K04387]
138592852  gdf3; protein DVR-1 [KO:K22672]
138592961  [KO:K05173]
138593028  [KO:K21283]
138593079  [KO:K05414]
138593293  [KO:K05071]
138593575  [KO:K22674]
138593704  [KO:K05414]
138593730  [KO:K05075]
138593733  [KO:K05149]
138593851  ngfrb; nerve growth factor receptor b [KO:K02583]
138593958  ndr2; nodal-related 2 [KO:K04666]
138593976  gdf2; growth/differentiation factor 2 [KO:K22670]
138594149  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
138594307  [KO:K10030]
138594692  ifngr1; interferon gamma receptor 1 [KO:K05132]
138594729  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
138594737  [KO:K05069]
138594845  [KO:K05477]
138594984  il15; interleukin-15 [KO:K05433]
138595473  [KO:K22629]
138595568  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
138595640  ccl20b; C-C motif chemokine 20b [KO:K14625]
138595645  ackr4b; atypical chemokine receptor 4b [KO:K04186]
138595651  bmp6; bone morphogenetic protein 6 [KO:K16620]
138595669  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
138595709  inhbaa; inhibin subunit beta Aa [KO:K04667]
138595851  [KO:K04184]
138595881  ccr12b.2; C-C chemokine receptor type 3 [KO:K04179]
138596018  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
138596152  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
138596905  [KO:K04190]
138596989  smtla; somatolactin alpha [KO:K05438]
138597035  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
138597043  [KO:K05155]
138597101  il15l; interleukin 15, like isoform X1 [KO:K05433]
138597152  bmp16; bone morphogenetic protein 16 [KO:K21283]
138597223  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
138597224  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
138597273  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
138597490  il12a; interleukin-12 subunit alpha [KO:K05406]
138597766  gdf9; growth/differentiatio [KO:K22673]
138597794  clcf1; uncharacterized protein clcf1 [KO:K05421]
138597850  rell2; RELT-like protein 2 [KO:K26541]
138597875  [KO:K05090] [EC:2.7.10.1]
138598070  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
138598372  eda; ectodysplasin-A isoform X1 [KO:K05480]
138598577  il12ba; interleukin 12Ba precursor [KO:K05425]
138598578  cd40lg; CD40 ligand [KO:K04389]
138598702  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
138598720  il21; interleukin-21 [KO:K05434]
138599470  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
138599622  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
138599700  il22; interleukin-22 [KO:K05445]
138599758  prl2; prolactin 2 [KO:K05439]
138599772  [KO:K05424]
138600353  [KO:K10030]
138600354  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
138600720  epoa; erythropoietin isoform X1 [KO:K05437]
138600830  il13ra1; interleukin-13 receptor subunit alpha-1 [KO:K05077]
138600864  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
138601052  bmp15; bone morphogenetic protein 15 [KO:K05498]
138601059  rell1; RELT-like protein 1 [KO:K26541]
138601940  prlra; prolactin receptor a [KO:K05081]
138602155  [KO:K05072]
138602300  [KO:K22670]
138602348  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
138602367  ndr1; nodal-related 1 [KO:K04666]
138602433  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
138602645  prl; prolactin [KO:K05439]
138602818  epor; erythropoietin receptor [KO:K05079]
138603030  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
138603049  il12bb; interleukin-12 subunit beta [KO:K05425]
138603154  il12rb2l; interleukin 12 receptor, beta 2a, like [KO:K05060]
138603329  [KO:K05497]
138603334  [KO:K22687]
138603379  [KO:K04670] [EC:2.7.11.30]
138603509  [KO:K04671] [EC:2.7.11.30]
138603557  [KO:K05080]
138603622  [KO:K05050]
138603709  [KO:K04304]
138603745  inha; inhibin alpha chain [KO:K05500]
138603972  [KO:K05414]
138604000  gh1; somatotropin [KO:K05438]
138604264  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K04738]
138604411  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
138604436  [KO:K05414]
138604493  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
138604962  ccr7; C-C chemokine receptor type 7 [KO:K04182]
138605089  ghrb; growth hormone receptor b [KO:K05080]
138605130  [KO:K05058]
138605148  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
138605237  il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
138605539  [KO:K16621]
138605547  [KO:K05070]
138605548  gdf11; growth/differentiation factor 11 [KO:K22679]
138605570  il10; interleukin-10 isoform X1 [KO:K05443]
138605973  gdf5; growth/differentiation factor 5 [KO:K04664]
138606080  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
138606081  [KO:K05142]
138606140  [KO:K13567] [EC:2.7.11.30]
138606475  il19l; interleukin 19 like [KO:K22667]
138606481  [KO:K22687]
138606564  ngfb; nerve growth factor [KO:K02582]
138606598  il17rc; interleukin-17 receptor C [KO:K05166]
138606832  [KO:K05491]
138606839  [KO:K12499]
138606850  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
138606895  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 [KO:K04193]
138607041  [KO:K21083]
138607071  amh; muellerian-inhibiting factor [KO:K04665]
138607165  lepr; leptin receptor [KO:K05062]
138607340  ccl25b; C-C motif chemokine 25b [KO:K13072]
138607401  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
138607587  il23r; interleukin-23 receptor [KO:K05064]
138607628  il12rb1; oncostatin-M-specific receptor subunit beta [KO:K05063]
138607909  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
138608238  [KO:K05131]
138608247  [KO:K05135]
138608250  il10rb; interleukin-10 receptor subunit beta [KO:K05135]
138608800  bmp8a; bone morphogenetic protein 8A [KO:K16622]
138608885  tnfrsf11b; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
138609114  [KO:K04388] [EC:2.7.11.30]
138609173  gdf6b; growth/differentiation factor 6-B [KO:K20012]
138609407  [KO:K05405]
138609597  il6st; interleukin-6 receptor subunit beta [KO:K05060]
138609616  [KO:K03156]
138609906  ghra; growth hormone receptor a [KO:K05080]
138610247  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
138610286  bmpr1ba; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
138610325  bmp3; bone morphogenetic protein 3 [KO:K05496]
138610350  [KO:K04519]
138610521  bmp10; bone morphogenetic protein 10 [KO:K22670]
138610572  lifra; LIF receptor subunit alpha a [KO:K05058]
138610734  ccl27a; C-C motif chemokine 27a [KO:K05513]
138610785  il12b2; interleukin-12 subunit beta [KO:K05425]
138610843  spaw; southpaw [KO:K04666]
138610930  [KO:K05060]
138611452  [KO:K04189]
138611542  ackr4a; atypical chemokine receptor 4 [KO:K04186]
138611562  [KO:K04193]
138611615  crfb16; interleukin-20 receptor subunit beta [KO:K05137]
138611646  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
138611806  [KO:K13596] [EC:2.7.11.30]
138611877  ccl25a; C-C motif chemokine 4 homolog [KO:K13072]
138611951  inhbab; inhibin subunit beta Ab [KO:K04667]
138611981  xcr1b.2; chemokine XC receptor 1 [KO:K04193]
138611988  [KO:K14625]
138612004  [KO:K14625]
138612081  thpo; thrombopoietin isoform X1 [KO:K06854]
138612096  gdf15; inhibin beta C chain [KO:K05504]
138612099  [KO:K05406]
138612123  [KO:K14625]
138612229  admp; anti-dorsalizing morphogenic protein [KO:K21283]
138612596  il17a/f3; interleukin 17a/f3 [KO:K05494]
138612602  [KO:K05164]
138612661  [KO:K05439]
138612717  bmp2b; bone morphogenetic protein 2b [KO:K21283]
138612851  [KO:K13377]
138613005  il34; interleukin-34 [KO:K22633]
138613072  [KO:K12964]
138613117  [KO:K12964]
138613503  [KO:K05408]
138613526  il17c; interleukin-17C [KO:K05491]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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