KEGG   PATHWAY: xhe04530
Entry
xhe04530                    Pathway                                
Name
Tight junction - Xiphophorus hellerii (green swordtail)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
xhe04530  Tight junction
xhe04530

Other DBs
GO: 0005923
Organism
Xiphophorus hellerii (green swordtail) [GN:xhe]
Gene
116707478  [KO:K05631]
116707561  [KO:K06087]
116707567  [KO:K06087]
116707578  [KO:K06087]
116707581  [KO:K06087]
116707582  [KO:K06087]
116707583  [KO:K06087]
116707584  [KO:K06087]
116707587  [KO:K06087]
116707588  [KO:K06087]
116707590  [KO:K06087]
116707594  [KO:K06087]
116707792  rab8b; ras-related protein Rab-8B [KO:K07902]
116707847  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
116707982  [KO:K06786]
116708006  [KO:K06087]
116708213  [KO:K06087]
116708236  [KO:K06087]
116708243  jam3; junctional adhesion molecule C [KO:K06785]
116708696  [KO:K06091]
116708718  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
116708856  [KO:K06087]
116708859  [KO:K06093]
116708898  cldn11; claudin-11 [KO:K06087]
116709004  cldn20; claudin-20 [KO:K06087]
116709245  [KO:K05702]
116709457  cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
116709485  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
116709576  [KO:K08007]
116709730  [KO:K10351]
116710023  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
116710084  [KO:K12755]
116710147  [KO:K05704] [EC:2.7.10.2]
116710156  [KO:K12751]
116710170  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
116710174  cldn19; claudin-19 isoform X1 [KO:K06087]
116710265  [KO:K04851]
116710286  [KO:K04393]
116710292  [KO:K04513]
116710773  rap1a; ras-related protein Rap-1A [KO:K04353]
116710995  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
116711144  [KO:K05755]
116711184  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
116711589  [KO:K07200]
116711593  [KO:K18584]
116711626  scrib; protein scribble homolog isoform X1 [KO:K16175]
116711638  itgb1; integrin beta-1 isoform X1 [KO:K05719]
116711717  [KO:K04237]
116711940  [KO:K12757]
116712138  [KO:K04353]
116712171  [KO:K06087]
116712628  [KO:K07374]
116712736  [KO:K04440] [EC:2.7.11.24]
116712859  [KO:K18050] [EC:2.7.11.13]
116712905  tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
116713334  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
116713843  actr2; actin-related protein 2 [KO:K17260]
116714002  [KO:K09489]
116714047  [KO:K04354]
116714255  [KO:K05763]
116714287  [KO:K04354]
116714288  rap2c; ras-related protein Rap-2c [KO:K07839]
116714334  synpo; synaptopodin isoform X1 [KO:K21112]
116714406  [KO:K04440] [EC:2.7.11.24]
116714445  [KO:K04440] [EC:2.7.11.24]
116714469  dlg3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
116714879  [KO:K04382] [EC:3.1.3.16]
116714923  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116715516  [KO:K07374]
116715551  [KO:K06087]
116715612  mpp4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
116715615  [KO:K06087]
116715616  [KO:K06087]
116715855  [KO:K08367]
116715863  [KO:K07374]
116715891  [KO:K07200]
116716062  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
116716078  [KO:K06735]
116716089  [KO:K18584]
116716126  [KO:K05762]
116716140  [KO:K06087]
116716460  [KO:K12076]
116716538  [KO:K06785]
116716669  [KO:K07902]
116716778  cldn12; claudin-12 [KO:K06087]
116716982  [KO:K07374]
116717242  [KO:K04426] [EC:2.7.11.25]
116717398  [KO:K05704] [EC:2.7.10.2]
116717493  arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
116717509  cgn; cingulin [KO:K06102]
116717598  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
116717619  rab13; ras-related protein Rab-13 [KO:K06109]
116717672  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
116717718  [KO:K04393]
116718091  [KO:K05701]
116718151  whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
116718175  [KO:K07374]
116718187  [KO:K07374]
116718236  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
116718455  cgnl1; cingulin-like protein 1 [KO:K21110]
116718507  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
116718893  cttn; src substrate cortactin isoform X1 [KO:K06106]
116719094  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
116719223  [KO:K07902]
116719583  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
116719658  [KO:K05757]
116719659  [KO:K05757]
116719700  [KO:K05692]
116719711  [KO:K10352]
116719831  myh11; myosin-11 isoform X1 [KO:K10352]
116719884  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116719978  [KO:K10352]
116720145  [KO:K06087]
116720168  [KO:K06095]
116720335  [KO:K04354]
116720408  [KO:K21068]
116720928  [KO:K12076]
116721026  [KO:K06087]
116721085  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
116721147  jun; transcription factor AP-1 [KO:K04448]
116721172  [KO:K21066]
116721299  [KO:K07200]
116721365  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
116721370  [KO:K07901]
116721454  pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116721484  [KO:K04513]
116721543  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
116721626  [KO:K06087]
116721661  [KO:K04513]
116721705  [KO:K07199]
116721832  [KO:K12757]
116721939  [KO:K17291]
116721940  [KO:K06088]
116721951  [KO:K06104]
116722099  [KO:K05754]
116722100  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
116722123  [KO:K04513]
116722128  [KO:K04513]
116722574  [KO:K21109]
116722581  [KO:K06087]
116722582  [KO:K06087]
116722583  cldn10; claudin-10 isoform X1 [KO:K06087]
116722629  [KO:K06735]
116722832  [KO:K05762]
116722864  [KO:K07374]
116722866  [KO:K07374]
116722867  [KO:K07374]
116723131  [KO:K18584]
116723196  sympk; symplekin isoform X1 [KO:K06100]
116723671  cldn14; claudin-14 [KO:K06087]
116723734  [KO:K07200]
116723818  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116723909  pard6b; partitioning defective 6 homolog beta [KO:K06093]
116724071  [KO:K04448]
116724220  [KO:K07374]
116724248  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
116724284  marveld2; MARVEL domain-containing protein 2 [KO:K17291]
116724395  [KO:K06088]
116724400  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
116724439  tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
116724556  [KO:K04354]
116724763  [KO:K06087]
116724810  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
116724992  [KO:K06087]
116725090  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
116725097  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
116725206  [KO:K07374]
116725234  [KO:K07374]
116725300  [KO:K06087]
116725313  [KO:K06087]
116725349  arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
116725369  [KO:K07374]
116725370  [KO:K07374]
116725526  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
116725566  [KO:K21099]
116725598  cldn34; claudin-34 [KO:K06087]
116725606  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116725678  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
116725739  patj; inaD-like protein isoform X1 [KO:K06092]
116725863  [KO:K12076]
116725965  [KO:K04448]
116726121  rab8a; ras-related protein Rab-8A [KO:K07901]
116726145  amotl2; angiomotin-like protein 2 [KO:K06104]
116726359  [KO:K06088]
116726487  [KO:K06097]
116726619  slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
116726742  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116726861  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
116726889  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
116726919  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116727083  arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
116727110  [KO:K12751]
116727627  [KO:K04392]
116727628  [KO:K04392]
116727629  [KO:K04392]
116727630  [KO:K04392]
116727818  [KO:K06087]
116727880  rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
116727897  [KO:K04345] [EC:2.7.11.11]
116727920  [KO:K09489]
116727971  [KO:K06087]
116728039  [KO:K16819]
116728045  [KO:K06087]
116728054  [KO:K06087]
116728109  [KO:K05731]
116728114  [KO:K06786]
116728194  [KO:K06274]
116728285  [KO:K06089]
116728368  msn; moesin isoform X1 [KO:K05763]
116728537  [KO:K16684]
116728705  [KO:K12075]
116728739  [KO:K06087]
116728773  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
116728783  [KO:K06087]
116728813  [KO:K06785]
116728856  [KO:K06087]
116728860  [KO:K06087]
116728932  [KO:K06087]
116728957  [KO:K06087]
116728971  [KO:K06087]
116728972  [KO:K06087]
116729368  [KO:K10351]
116729406  [KO:K04354]
116729470  [KO:K17291]
116729472  [KO:K06088]
116729511  pcna; proliferating cell nuclear antigen [KO:K04802]
116729721  nf2; merlin [KO:K16684]
116729847  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
116730197  [KO:K05692]
116730218  cldn5; claudin-5 [KO:K06087]
116730273  [KO:K07199]
116730280  [KO:K06087]
116730630  [KO:K06087]
116731340  [KO:K04393]
116731418  [KO:K06102]
116731792  pard6g; partitioning defective 6 homolog gamma [KO:K06093]
116731862  [KO:K05701]
116732059  [KO:K06087]
116732550  [KO:K17260]
116732846  mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
116732862  cldn15; claudin-15 [KO:K06087]
116732863  [KO:K06087]
116733671  [KO:K06087]
116733788  mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
116733855  [KO:K04393]
116734003  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116734072  ezr; ezrin [KO:K08007]
116734123  [KO:K17388] [EC:2.7.11.39]
116734354  afdn; afadin isoform X1 [KO:K05702]
116734699  gata4; transcription factor GATA-4 [KO:K09183]
116734805  [KO:K04393]
116734814  micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
116735010  [KO:K20638]
116735166  [KO:K06087]
116735167  [KO:K06087]
116735168  [KO:K06087]
116735169  [KO:K06087]
116735170  [KO:K06087]
116735171  [KO:K06087]
116735266  actb; actin, cytoplasmic 1 [KO:K05692]
116735310  [KO:K04392]
116735424  [KO:K05757]
116735550  llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
116735818  [KO:K06087]
116735879  [KO:K10352]
116736050  [KO:K13365]
116736135  [KO:K10352]
116736298  [KO:K04345] [EC:2.7.11.11]
116736300  crb3; protein crumbs homolog 3 [KO:K06090]
116736853  was; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
116736917  [KO:K06106]
116737365  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
116737601  tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116737644  [KO:K05699]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
xhe04520  Adherens junction
xhe04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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