KEGG ORTHOLOGY: K09063

ORTHOLOGY: K09063

Entry

K09063                      KO

Symbol

TCF3, E2A

Name

transcription factor E2-alpha

Pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map05166

Human T-cell leukemia virus 1 infection

map05202

Transcriptional misregulation in cancer

Disease

H00001

B-cell acute lymphoblastic leukemia

H00085

Agammaglobulinemias

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K09063  TCF3, E2A; transcription factor E2-alpha
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09063  TCF3, E2A; transcription factor E2-alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09063  TCF3, E2A; transcription factor E2-alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09063  TCF3, E2A; transcription factor E2-alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Ubiquitous (class A) factors
    K09063  TCF3, E2A; transcription factor E2-alpha

Genes

HSA:	6929(TCF3)

PTR:	468650(TCF3)

PPS:	100969894(TCF3)

GGO:	101132300(TCF3)

PON:	100439917(TCF3)

PPYG:

129020695(TCF3)

NLE:	100606515(TCF3)

HMH:	116484011(TCF3)

SSYN:

129465411(TCF3)

MCC:	721325(TCF3)

MCF:	102129537(TCF3)

MTHB:

126942554

MNI:	105486025(TCF3)

CSAB:

103233616(TCF3)

CATY:

105591727(TCF3)

PANU:

110741428(TCF3)

TGE:	112612625(TCF3)

MLEU:

105534402 105551994(TCF3)

RRO:	104671408(TCF3)

RBB:	108530243(TCF3)

TFN:	117075320(TCF3)

PTEH:

111520667(TCF3)

CANG:

105527628(TCF3)

CJC:	100400856(TCF3)

SBQ:	101028931(TCF3)

CIMI:

108293140(TCF3)

ANAN:

105706133(TCF3)

MMUR:

105860775(TCF3)

LCAT:

123632552(TCF3)

PCOQ:

105811283(TCF3)

OGA:	100966976(TCF3)

MMU:	21423(Tcf3)

MCAL:

110302901(Tcf3)

MPAH:

110326192(Tcf3)

RNO:	171046(Tcf3)

MCOC:

116075738(Tcf3)

ANU:	117696269(Tcf3)

ASYL:

127670362(Tcf3)

MUN:	110551338(Tcf3)

CGE:	100768423(Tcf3)

MAUA:

101840411(Tcf3)

PROB:

127216617(Tcf3)

PLEU:

114686516(Tcf3)

MORG:

121459425(Tcf3)

MFOT:

126489250

AAMP:

119815508(Tcf3)

NGI:	103737314(Tcf3)

HGL:	101725133(Tcf3)

CPOC:

100733634(Tcf3)

CCAN:

109699485(Tcf3)

DORD:

105990450(Tcf3)

DSP:	122122778(Tcf3)

PLOP:

125348488(Tcf3)

NCAR:

124968988

MMMA:

107157410(Tcf3)

ITI:	101955406(Tcf3)

OCU:

127485528

OPI:	101533529(TCF3)

TUP:	102473035(TCF3)

GVR:	103606025(TCF3)

CFA:	485079(TCF3)

CLUD:

112666201(TCF3)

VVP:	112935526(TCF3)

VLG:	121495597(TCF3)

NPO:	129521636(TCF3)

AML:	100479681(TCF3)

UMR:	103681791(TCF3)

UAH:	113242743(TCF3)

UAR:	123794009(TCF3)

ELK:

111161705

LLV:

125088838

MPUF:

101691224(TCF3)

MNP:	132010725(TCF3)

MLK:	131823215(TCF3)

NVS:	122909940(TCF3)

ORO:	101370667(TCF3)

EJU:	114226168(TCF3)

ZCA:	113916651(TCF3)

MLX:	118005998(TCF3)

NSU:	110593725(TCF3)

LWW:	102732215(TCF3)

FCA:	101098930(TCF3)

PYU:	121021427(TCF3)

PBG:	122488608(TCF3)

PVIV:

125159727(TCF3)

LRUF:

124527674

LGF:	123605018(TCF3)

AJU:

106983705

PTG:	102968224(TCF3)

PPAD:

109257652(TCF3)

PUC:

125928807

PLEZ:

122213680(TCF3)

HHV:	120242381(TCF3)

BTA:	530616(TCF3)

BOM:	102273101(TCF3)

BIU:	109561995(TCF3)

BBUB:

102415632(TCF3)

BBIS:

104991883(TCF3)

CHX:	102168820(TCF3)

OAS:	101116477(TCF3)

BTAX:

128050287(TCF3)

CSUM:

138085186(TCF3)

ODA:	120863687(TCF3)

CCAD:

122439946(TCF3)

MREE:

136156091(TCF3)

OVR:	110122568(TCF3)

MBEZ:

129558200(TCF3)

SSC:	100524070(TCF3)

CFR:	102506168(TCF3)

CBAI:

105078145(TCF3)

CDK:	105106537(TCF3)

VPC:	102545720(TCF3)

BACU:

103010761(TCF3)

BMUS:

118891851(TCF3)

LVE:	103083785(TCF3)

OOR:	101277248(TCF3)

LALB:

132517794(TCF3)

DLE:	111165939(TCF3)

PCAD:

102991267(TCF3)

PSIU:

116750713(TCF3)

NASI:

112396280(TCF3)

ECB:	100147220(TCF3)

EPZ:	103544311(TCF3)

EAI:	106834175(TCF3)

MYB:	102247067(TCF3)

MYD:	102771545(TCF3)

MMYO:

118658114(TCF3)

MLF:	102417648(TCF3)

MDT:	132235256(TCF3)

MYUM:

139010786(TCF3)

PKL:	118710897(TCF3)

EFUS:

103294286(TCF3) 103300161

MNA:	107534587(TCF3)

DRO:	112312212(TCF3)

SHON:

118984424(TCF3)

AJM:	119043919(TCF3)

PDIC:

114502666(TCF3)

PHAS:

123813765(TCF3)

MMF:	118643732(TCF3)

PPAM:

129081561(TCF3)

HAI:	109390608(TCF3)

RFQ:	117037572(TCF3)

PALE:

102882010(TCF3)

PGIG:

120583708(TCF3)

PVP:	105302256(TCF3)

RAY:	107500893(TCF3)

MJV:	108392067(TCF3)

TOD:	119240516(TCF3)

SARA:

101540234(TCF3)

SFUM:

130022053(TCF3)

SETR:

126029617(TCF3)

LAV:	100654844(TCF3)

TMU:

101352541

ETF:	101640028(TCF3)

DNM:

101444066

MDO:	100017411(TCF3)

GAS:	123243970(TCF3)

SHR:	100931290(TCF3)

AFZ:

127545170

PCW:	110223537(TCF3)

TVP:	118844559(TCF3)

PBRV:

138147785(TCF3)

OAA:	100091463(TCF3)

TACU:

119949212(TCF3)

GGA:	395146(TCF3)

PCOC:

116235848(TCF3)

MGP:

100549543

CJO:	107325535(TCF3)

TPAI:

128090433(TCF3)

LMUT:

125684856(TCF3)

NMEL:

110388794(TCF3)

APLA:

101799513(TCF3)

ACYG:

106045671(TCF3)

CATA:

118259845(TCF3)

AFUL:

116499050(TCF3)

TGU:	100221318(TCF3)

LSR:	110469462(TCF3)

SCAN:

103821899(TCF3)

PMOA:

120496344(TCF3)

OTC:	121346165(TCF3)

PRUF:

121353349(TCF3)

ATRC:

139602354(TCF3)

GFR:	102038247(TCF3)

FAB:	101821763(TCF3)

OMA:	130264406(TCF3)

PHI:	102109920(TCF3)

PMAJ:

107215580(TCF3)

CCAE:

111940316(TCF3)

CCW:	104696950(TCF3)

CBRC:

103620495(TCF3)

ACOE:

138099851(TCF3)

ETL:	114070845(TCF3)

ZAB:	102071436(TCF3)

ZLE:	135459020(TCF3)

ACHL:

103808553(TCF3)

SVG:	106858004(TCF3)

MMEA:

130586293

HRT:	120763507(TCF3)

SATI:

136371827(TCF3)

CCIC:

134054348(TCF3)

FPG:	101918749(TCF3)

FCH:	102052079(TCF3)

CCRI:

104168473(TCF3)

NNT:	104402610(TCF3)

SHAB:

115618155(TCF3)

ACUN:

113489441(TCF3)

TALA:

116964727(TCF3)

ACHC:

115348789(TCF3)

HLE:	104831190(TCF3)

AGEN:

126041992

HHAR:

128148557(TCF3)

GCL:

127025503

LDI:

104353438

DPUB:

104308205(TCF3)

PPUS:

135192299(TCF3)

BRHI:

104498309(TCF3)

EGZ:	104126319(TCF3)

NNI:	104009635(TCF3)

PADL:

103921154(TCF3)

AFOR:

103903638(TCF3)

CLV:	102089930(TCF3)

MUI:	104540527(TCF3)

PLET:

104625952(TCF3)

EHS:	104508933(TCF3)

CMAC:

104482695(TCF3)

CUCA:

104067722(TCF3)

TEO:	104383493(TCF3)

ACAR:

104532621(TCF3)

CPEA:

104393889(TCF3)

CVF:	104289040(TCF3)

RTD:	128900826(TCF3)

CRID:

134526467(TCF3)

AAM:

106486643

AROW:

112969409(TCF3)

NPD:	112943905(TCF3)

TGT:	104564523(TCF3)

DNE:	112989821(TCF3)

SCAM:

104150719(TCF3)

ASN:	102374574(TCF3)

AMJ:	102575017(TCF3)

CPOO:

109324902(TCF3)

GGN:	109294809(TCF3)

PSS:	102460048(TCF3)

CMY:	102940112(TCF3)

CCAY:

125627165(TCF3)

DCC:	119848463(TCF3)

CPIC:

101941246(TCF3)

TST:	117868815(TCF3)

CABI:

116835822(TCF3)

MRV:	120391533(TCF3)

ACS:

103282379

ASAO:

132781087(TCF3)

PVT:	110072455(TCF3)

SUND:

121937061(TCF3)

PBI:	103061134(TCF3)

PMUR:

107282185(TCF3)

CTIG:

120301344(TCF3)

PGUT:

117677489(TCF3)

APRI:

131188250(TCF3)

PTEX:

113435262(TCF3)

NSS:	113420944(TCF3)

VKO:	123035395(TCF3)

PMUA:

114588488(TCF3)

PRAF:

128405873(TCF3)

ZVI:	118087025(TCF3)

HCG:	128344910(TCF3)

GJA:	107106803(TCF3)

STOW:

125432527(TCF3)

EMC:	129329638(TCF3)

XLA:	379355(tcf3.L) 380101(tcf3.S)

XTR:	100101779(tcf3)

NPR:	108792860(TCF3)

RTEM:

120912645(TCF3)

BBUF:

120990941

BGAR:

122946610(TCF3)

PWL:	138267337(TCF3)

MUO:	115479620(TCF3)

GSH:	117364749(TCF3)

DRE:	30310(tcf3a) 664768(tcf3b)

SRX:	107713412 107719584 107724980 107729684(tcf3)

SANH:

107655210 107671808 107676964 107696481

SGH:	107552693 107574311 107586385 107596874

CCAR:

109046729(tcf3b) 109089308 109105782(tcf3a)

CAUA:

113039640(tcf3) 113045152 113045215 113065228 113082033 113093749 113112071

CGIB:

127938545 127942745 127950659 127987903

PTET:

122327716(tcf3b) 122362705(tcf3a)

LROH:

127153478(tcf3b) 127180190(tcf3a)

OMC:	131530273(tcf3b) 131552240(tcf3a)

PPRM:

120471307(tcf3a) 120495428(tcf3b)

RKG:	130089197(tcf3b) 130106522(tcf3a)

MAMB:

125250361(tcf3a) 125263782(tcf3b)

CIDE:

127502237 127520439

CERY:

137003504(tcf3a) 137027742(tcf3b)

MASI:

127438234 127438962 127441335 127443028

TROS:

130548519(tcf3b) 130553852(tcf3a)

TDW:	130417384(tcf3a) 130430065(tcf3b)

MANU:

129443285(tcf3a) 129454105(tcf3b)

PDAB:

135728686(tcf3b) 135757825(tcf3a)

IPU:	100304646(tcf3a) 100305065(tcf3b)

IFU:	128613650(tcf3b) 128624078(tcf3a)

PHYP:

113527386 113533377

SMEO:

124390781(tcf3b) 124403347(tcf3a)

TFD:	113645229(tcf3a) 113657780(tcf3b)

TVC:	132845579(tcf3a) 132853021(tcf3b)

CGAR:

128512899(tcf3a) 128542878(tcf3b)

NGRA:

132871781(tcf3a) 132899506(tcf3b)

TRN:	134302496(tcf3a) 134331104(tcf3b)

AMEX:

103028498(tcf3a) 125782208(tcf3b)

CMAO:

118796836(tcf3a) 118818780(tcf3b)

EEE:	113584673 113588941

CHAR:

105905897 116219514 122130575(tcf3b)

SPIL:

134063559 134101700(tcf3b)

TRU:	101070613(tcf3) 101079401

TFS:	130528685(tcf3b) 130539035(tcf3a)

TNG:	GSTEN00007529G001 GSTEN00028519G001

LCO:	104929652 109140959

NCC:	104940952 104965130(tcf3)

TBEN:

117488650(tcf3a) 117495602(tcf3b)

CGOB:

115006843 115022024

PGEO:

117445208(tcf3b) 117461879(tcf3a)

GACU:

117532646(tcf3a) 117546143(tcf3b)

EMAC:

134866182(tcf3a) 134869565(tcf3b)

ELY:	117253844(tcf3b) 117271830(tcf3a)

EFO:	125896357(tcf3b) 125902379(tcf3a)

PLEP:

121938949(tcf3b) 121951027(tcf3a)

SLUC:

116037258(tcf3a) 116063343(tcf3b)

ECRA:

117950714(tcf3b) 117954050(tcf3a)

ESP:	116695833 116698686 116698695

PFLV:

114561081(tcf3) 114565258

GAT:	120815740(tcf3a) 120823673(tcf3b)

PPUG:

119209099(tcf3a) 119216390

AFB:	129094398(tcf3b) 129115270(tcf3a)

CLUM:

117729148(tcf3b) 117747034(tcf3a)

PSWI:

130193905(tcf3b) 130197721(tcf3a)

CANA:

137794617(tcf3b) 137802035(tcf3a)

CVE:	137884292(tcf3b) 137892495(tcf3a)

MSAM:

119884627(tcf3b) 119902920(tcf3a)

SCHU:

122878194(tcf3b) 122886275(tcf3a)

CUD:	121512124(tcf3b) 121520154(tcf3a)

SPUL:

138607125(tcf3b) 138611929(tcf3a)

LMIX:

132961671(tcf3b) 132979025(tcf3a)

ALAT:

119010793(tcf3a) 119028358(tcf3b)

ASTR:

137598595(tcf3b) 137612006(tcf3a)

MZE:	101479723 101487799

ONL:	100707414 100708816(tcf3)

OAU:	116310016(tcf3b) 116319027(tcf3a)

OLA:	100820722 100820723(tcf3)

OML:	112141904 112146242(tcf3b) 112147757(tcf3a)

CSAI:

133452628(tcf3a) 133458125(tcf3b)

XMA:	102217582 102225512

XCO:	114146516 114150617

XHE:	116721680 116725373

PRET:

103463652 103479462

PFOR:

103149824 103151249 103153557

PLAI:

106942726 106943138 106959275

PMEI:

106915819 106923039

GAF:	122839028(tcf3b) 122841549(tcf3a)

PPRL:

129361875(tcf3a) 129371739(tcf3b)

CVG:	107096961 107098382

CTUL:

119773379(tcf3a) 119792541(tcf3b)

GMU:	124869950(tcf3a) 124873718(tcf3b)

NFU:	107384145 107393296

KMR:	108230787(tcf3b) 108239464(tcf3a)

ALIM:

106515021 106526468(tcf3)

NWH:	119414616(tcf3a) 119430710(tcf3b)

AOCE:

111567903(tcf3b) 111572320(tcf3a)

EJA:	138198667(tcf3b) 138202833(tcf3a)

BFRE:

138618884(tcf3b) 138625303(tcf3a)

MCEP:

125009256(tcf3b) 125010069(tcf3a)

CSEM:

103376623 103395943(tcf3)

POV:	109642828 109643989

SSEN:

122770981(tcf3a) 122780665(tcf3b)

SSOE:

131456327(tcf3a) 131466101(tcf3b)

HHIP:

117759672(tcf3b) 117778124(tcf3a)

HSP:	118118109(tcf3a) 124854731(tcf3b)

PPLT:

128447715(tcf3b) 128454654(tcf3a)

SMAU:

118311425(tcf3a) 118317884(tcf3b)

LCF:	108877284(tcf3b) 108883593(tcf3a)

SDU:	111228963 111232104

SLAL:

111652593 111656347

XGL:	120790918(tcf3b) 120798621(tcf3a)

HCQ:	109507402 109532234

SSCV:

125967266(tcf3b) 125984442(tcf3a)

SBIA:

133503415(tcf3b) 133510438(tcf3a)

PEE:	133406235(tcf3b) 133411224(tcf3a)

PTAO:

133480504(tcf3b) 133488475

BPEC:

110158012 110173997(tcf3)

ENY:	140353547(tcf3b) 140356408(tcf3a)

MALB:

109969320 109974177

BSPL:

114845207(tcf3a) 114853406(tcf3b)

SJO:	128361715(tcf3b) 128368876(tcf3a)

SSCO:

133984335(tcf3b) 133990375

GMH:	115549432 115556315(tcf3)

SASA:

106569532(tcf3) 106599996 106613772

STRU:

115157408 115158250 115169412 115192628

OTW:	112226599 112230859 112237788(tcf3a) 112250871

OMY:	110508414 110521434 110524290 110530695(tcf3a)

OGO:	123997086 124010008(tcf3a) 124037662 124041523

ONE:	115102718 115108305 115114727 115144886

OKI:	109872186 109874955 109897849 109902500

OKE:	118359234 118389684 118395056 118401817(tcf3a)

OMM:	135512778 135556527 135558926

OCLA:

139376303 139386497 139406522 139409178

SALP:

111956823 111972093 111975991 111979391

SNH:	120020166 120052437 120054776 120056022

CCLU:

121533528 121535505(tcf3a) 121540362 121581199

ELS:	105011555 105020565

OEP:	134013129(tcf3b) 134036865

SFM:	108919866(tcf3) 108921499

PKI:	111836660 111860412

AANG:

118225810(tcf3b) 118229940(tcf3a)

AROT:

135251278(tcf3a) 135252331(tcf3b)

CCOG:

133126326(tcf3b) 133129249(tcf3a)

LOC:	102687105(tcf3)

PSPA:

121301007 121301185 121301277

ARUT:

117401202 117966159(tcf3b)

PSEX:

120537763(tcf3b)

LCM:	102354843(TCF3)

RTP:

CPLA:

HOC:

LERI:

SCLV:

DFR:

Reference

PMID:8756721

Authors

Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destree O, Clevers H

Title

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.

Journal

Cell 86:391-9 (1996)
DOI:10.1016/S0092-8674(00)80112-9

Sequence

[xla:379355]

LinkDB

DBGET integrated database retrieval system