KEGG   PATHWAY: achc04060
Entry
achc04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Aquila chrysaetos chrysaetos (golden eagle)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
achc04060  Cytokine-cytokine receptor interaction
achc04060

Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115333433  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
115333600  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
115333618  [KO:K05077]
115333705  BMP15; bone morphogenetic protein 15 [KO:K05498]
115333810  EDA; ectodysplasin-A isoform X1 [KO:K05480]
115333840  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
115333857  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076]
115333939  CD40LG; CD40 ligand isoform X1 [KO:K03161]
115334108  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
115334159  GDF9; growth/differentiation factor 9 [KO:K22673]
115334184  IL17B; interleukin-17B [KO:K05490]
115334313  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
115334326  IL4; interleukin-4 [KO:K05430]
115334331  [KO:K05432]
115334335  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
115334435  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
115334468  [KO:K05428]
115334517  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
115334518  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
115334641  [KO:K05066]
115334642  [KO:K05066]
115334650  [KO:K05174]
115334690  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
115334695  IL18R1; interleukin-18 receptor 1 [KO:K05173]
115334704  [KO:K05172]
115334721  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
115334738  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
115334762  NGF; beta-nerve growth factor [KO:K02582]
115335148  [KO:K05471]
115335166  [KO:K22667]
115335407  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
115335409  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
115335475  IL10; interleukin-10 [KO:K05443]
115335529  [KO:K05073]
115335694  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
115335706  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
115335707  IL21R; interleukin-21 receptor isoform X3 [KO:K05075]
115335950  TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153]
115336044  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
115336132  IL26; interleukin-26 [KO:K05446]
115336243  IL22; interleukin-22 [KO:K05445]
115336262  IFNG; interferon gamma [KO:K04687]
115336342  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
115336480  [KO:K05414]
115336487  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
115336770  PRLR; prolactin receptor isoform X1 [KO:K05081]
115336970  [KO:K05512]
115337094  [KO:K05415]
115337096  [KO:K05415]
115337097  [KO:K05415]
115337271  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
115337289  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
115337293  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
115337297  IL31RA; interleukin-31 receptor subunit alpha isoform X2 [KO:K22630]
115337346  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
115337355  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
115337454  LIFR; leukemia inhibitory factor receptor [KO:K05058]
115337474  GHR; growth hormone receptor [KO:K05080]
115337485  [KO:K16062]
115337974  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
115338037  BMP3; bone morphogenetic protein 3 isoform X1 [KO:K05496]
115338579  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
115338768  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
115338998  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
115339016  BMP7; bone morphogenetic protein 7 [KO:K16621]
115339326  GDF5; growth/differentiation factor 5 isoform X1 [KO:K04664]
115339500  XCR1; chemokine XC receptor 1 [KO:K04193]
115339536  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
115339541  ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186]
115339556  CCR9; C-C chemokine receptor type 9 [KO:K04184]
115339661  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
115339707  [KO:K04180]
115339708  [KO:K04180]
115339728  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
115339729  CCR4; C-C chemokine receptor type 4 [KO:K04179]
115339734  INHBA; inhibin beta A chain [KO:K04667]
115339802  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
115339881  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143]
115339927  [KO:K04183]
115339986  [KO:K04183]
115340258  [KO:K10030]
115340259  [KO:K10030]
115340262  [KO:K10030]
115340268  [KO:K10030]
115340437  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
115340710  GDF6; growth/differentiation factor 6 [KO:K20012]
115340800  IL7; interleukin-7 isoform X1 [KO:K05431]
115341381  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
115341457  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
115341694  [KO:K05439]
115342260  [KO:K05068]
115342465  [KO:K04388] [EC:2.7.11.30]
115342468  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
115342563  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
115342594  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
115342661  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
115342667  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
115342765  [KO:K22669]
115342805  [KO:K10032]
115342869  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
115342870  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
115342992  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
115343032  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
115343124  INHA; inhibin alpha chain [KO:K05500]
115343134  IL15; interleukin-15 isoform X1 [KO:K05433]
115343150  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
115343172  ACKR3; atypical chemokine receptor 3 [KO:K04304]
115343176  INHBB; inhibin beta B chain [KO:K22687]
115343350  [KO:K05050]
115343357  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
115343425  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
115343515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
115343634  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
115343635  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
115343793  [KO:K05507]
115343830  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
115343845  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
115344046  [KO:K10032]
115344140  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
115344249  RELL1; RELT-like protein 1 [KO:K26541]
115344285  [KO:K05438]
115344366  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
115344435  CCR7; C-C chemokine receptor type 7 [KO:K04182]
115344457  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
115344535  CSF3; granulocyte colony-stimulating factor [KO:K05423]
115344623  CCR10; C-C chemokine receptor type 10 [KO:K04185]
115344649  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
115344729  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
115344735  CCR6; C-C chemokine receptor type 6 [KO:K04181]
115344821  IFNGR1; interferon gamma receptor 1 [KO:K05132]
115345010  IL18; interleukin-18 [KO:K05482]
115345016  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
115345170  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
115345830  IL17C; interleukin-17C [KO:K05491]
115345866  [KO:K10032]
115346083  [KO:K21083]
115346218  LIF; leukemia inhibitory factor [KO:K05419]
115346289  [KO:K21083]
115346428  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
115346499  IL34; interleukin-34 isoform X1 [KO:K22633]
115346586  CX3CL1; fractalkine [KO:K05508]
115347215  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
115347263  [KO:K05514]
115347274  [KO:K12499]
115347275  [KO:K12964]
115347304  [KO:K12964]
115347329  CCL20; C-C motif chemokine 20 [KO:K14625]
115347332  [KO:K04723]
115347472  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
115347807  THPO; thrombopoietin [KO:K06854]
115347943  [KO:K05477]
115348274  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
115348327  [KO:K21283]
115348399  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
115348477  GDF10; growth/differentiation factor 10 [KO:K22674]
115348478  GDF2; growth/differentiation factor 2 [KO:K05503]
115348644  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
115348676  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
115348915  LEPR; leptin receptor isoform X1 [KO:K05062]
115349026  GDF15; LOW QUALITY PROTEIN: growth/differentiation factor 15 [KO:K05504]
115349144  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115349216  [KO:K21283]
115349279  AMH; muellerian-inhibiting factor isoform X2 [KO:K04665]
115349306  EBI3; interleukin-27 subunit beta [KO:K24476]
115349515  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
115349596  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
115349635  MPL; thrombopoietin receptor isoform X4 [KO:K05082]
115349686  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
115349857  [KO:K05481]
115349859  [KO:K05483]
115350083  [KO:K04666]
115350114  [KO:K04519]
115350118  [KO:K04722]
115350306  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
115350336  BMP10; bone morphogenetic protein 10 [KO:K22670]
115350597  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
115350784  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
115350957  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
115350958  GDF11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679]
115350991  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
115350993  ACVR1B; LOW QUALITY PROTEIN: activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
115351155  GDF7; growth/differentiation factor 7 [KO:K20013]
115351158  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
115351166  IL17A; interleukin-17A [KO:K05489]
115351206  [KO:K05494]
115351336  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
115351340  [KO:K22688]
115351347  [KO:K22689]
115351361  IL23A; interleukin-23 subunit alpha isoform X1 [KO:K05426]
115351446  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
115351503  [KO:K16622]
115352180  CNTF; ciliary neurotrophic factor [KO:K05420]
115352202  IFNLR1; interferon lambda receptor 1 [KO:K05140]
115352215  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
115352317  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
115352694  [KO:K04738]
115352701  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151]
115352724  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
115352756  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
115352951  PRL; prolactin [KO:K05439]
115352961  BMP6; bone morphogenetic protein 6 [KO:K16620]
115352971  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
115353144  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
115353253  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
115353515  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
115353541  IL17D; interleukin-17D [KO:K05492]
115353667  IL17RE; interleukin-17 receptor E [KO:K05168]
115353675  IL17RC; interleukin-17 receptor C [KO:K05166]
121232759  [KO:K05080]
121233533  [KO:K05434]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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