KEGG   PATHWAY: bbis04540
Entry
bbis04540                   Pathway                                
Name
Gap junction - Bison bison bison (American bison)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bbis04540  Gap junction
bbis04540

Other DBs
GO: 0005921
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104979885  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
104979900  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104979917  TUBB4A; tubulin beta-4A chain [KO:K07375]
104980414  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104980465  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104981322  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
104981582  NRAS; GTPase NRas [KO:K07828]
104981671  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
104982045  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104982774  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
104983318  [KO:K07375]
104983319  [KO:K07375]
104984484  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104984486  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104984593  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104984667  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104984835  [KO:K07374]
104984854  [KO:K07374]
104985522  [KO:K12319] [EC:4.6.1.2]
104985766  PDGFC; platelet-derived growth factor C [KO:K05450]
104986157  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
104986422  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
104986737  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104987189  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
104987448  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104987815  PDGFD; platelet-derived growth factor D [KO:K05450]
104988909  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104989034  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104989926  [KO:K07375]
104989972  [KO:K04632]
104989974  [KO:K04632]
104989979  TUBB1; tubulin beta-1 chain [KO:K07375]
104990172  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104990277  SOS2; son of sevenless homolog 2 [KO:K03099]
104990859  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
104990931  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
104991117  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
104991173  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104991455  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
104991589  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
104991630  GJD2; gap junction delta-2 protein [KO:K07373]
104991731  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104992261  TUBA8; tubulin alpha-8 chain [KO:K07374]
104992296  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104992909  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
104993381  TUBA3E; tubulin alpha-3E chain [KO:K07374]
104993807  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
104994462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104994506  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
104994526  [KO:K07375]
104994750  [KO:K07374]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104995620  [KO:K04371] [EC:2.7.11.24]
104996312  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
104996774  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
104997048  [KO:K04603]
104997186  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
104997621  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
104997622  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
104998531  [KO:K07374]
104999154  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
104999563  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104999887  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104999941  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
105000232  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105000236  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105000455  CSNK1D; casein kinase I isoform delta isoform X1 [KO:K08959] [EC:2.7.11.1]
105000525  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105001032  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105001247  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105001471  TUBA1B; tubulin alpha-1B chain [KO:K07374]
105001472  TUBA1A; tubulin alpha-1A chain [KO:K07374]
105001683  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105002073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105002478  TUBB6; tubulin beta-6 chain [KO:K07375]
105002777  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
105002851  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105003252  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105003692  HRAS; GTPase HRas [KO:K02833]
105003795  [KO:K07374]
105003796  [KO:K07374]
105004241  GJA1; gap junction alpha-1 protein [KO:K07372]
105004479  DRD1; D(1A) dopamine receptor [KO:K04144]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105004836  [KO:K04603]
105005036  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
bbis04010  MAPK signaling pathway
bbis04020  Calcium signaling pathway
bbis04060  Cytokine-cytokine receptor interaction
bbis04070  Phosphatidylinositol signaling system
bbis04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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