KEGG   PATHWAY: breg04810
Entry
breg04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Balearica regulorum gibbericeps (East African grey crowned-crane)
Class
Cellular Processes; Cell motility
Pathway map
breg04810  Regulation of actin cytoskeleton
breg04810

Other DBs
GO: 0030036
Organism
Balearica regulorum gibbericeps (East African grey crowned-crane) [GN:breg]
Gene
104628991  FGF6; fibroblast growth factor 6 [KO:K04358]
104629471  [KO:K04369] [EC:2.7.12.2]
104629609  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104629631  ITGA2; integrin alpha-2 [KO:K06481]
104629708  [KO:K12329]
104629719  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
104630326  [KO:K13710]
104630434  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104630578  [KO:K12756]
104630597  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104630650  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104630694  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104630818  PFN4; profilin-4 [KO:K05759]
104630829  C9; complement component C9 [KO:K04000]
104630864  ACTB; actin, cytoplasmic 1 [KO:K05692]
104631064  HRAS; GTPase HRas [KO:K02833]
104631092  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104631160  [KO:K05741]
104631198  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104631202  [KO:K05093] [EC:2.7.10.1]
104631241  [KO:K05692]
104631307  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104631449  FGF3; fibroblast growth factor 3 [KO:K04358]
104631451  [KO:K12757]
104631634  FGF16; fibroblast growth factor 16 [KO:K04358]
104631681  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104631759  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
104631809  [KO:K05725] [EC:2.7.10.2]
104632256  PXN; paxillin [KO:K05760]
104632433  NCKAP1; nck-associated protein 1 [KO:K05750]
104632441  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104632555  [KO:K04456] [EC:2.7.11.1]
104632578  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
104632611  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
104632677  ITGA1; integrin alpha-1 [KO:K06480]
104632729  [KO:K04366] [EC:2.7.11.1]
104632918  [KO:K05692]
104632924  PFN3; profilin-3 [KO:K05759]
104633205  [KO:K12329]
104633353  [KO:K05753]
104633398  FN1; fibronectin [KO:K05717]
104633630  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104633738  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104633850  EGF; pro-epidermal growth factor [KO:K04357]
104633933  ITGAE; integrin alpha-E [KO:K06524]
104633980  [KO:K04358]
104634174  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104634246  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104634270  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104634276  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
104634279  KRAS; GTPase KRas isoform X1 [KO:K07827]
104634286  ITGB6; integrin beta-6 [KO:K06589]
104634297  [KO:K04289]
104634336  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
104634362  [KO:K02649]
104634486  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104634577  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104634774  ITGB1; integrin beta-1 [KO:K05719]
104634798  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104634830  GSN; gelsolin [KO:K05768]
104634908  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104634926  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104634929  [KO:K05767]
104635027  [KO:K07828]
104635099  ENAH; protein enabled homolog isoform X1 [KO:K05746]
104635111  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104635433  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
104635437  FGF9; fibroblast growth factor 9 [KO:K04358]
104635449  [KO:K12757]
104635541  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104635922  FGF2; fibroblast growth factor 2 [KO:K18497]
104636125  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104636219  C5; complement C5 [KO:K03994]
104636258  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
104636316  [KO:K06269] [EC:3.1.3.16]
104636319  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
104636404  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104636413  FGF8; fibroblast growth factor 8 [KO:K04358]
104636471  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104636492  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
104636493  C8B; complement component C8 beta chain [KO:K03998]
104636529  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104636632  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104636734  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104636741  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104636756  ITGB3; integrin beta-3 [KO:K06493]
104636844  FAM49A; protein FAM49A isoform X1 [KO:K27976]
104637047  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104637064  ITGAV; integrin alpha-V [KO:K06487]
104637129  ACTR3B; actin-related protein 3B [KO:K18584]
104637160  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
104637219  [KO:K05749]
104637233  MYH11; myosin-11 isoform X1 [KO:K10352]
104637340  PDGFC; LOW QUALITY PROTEIN: platelet-derived growth factor C [KO:K05450]
104637383  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104637393  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104637486  DOCK2; dedicator of cytokinesis protein 2 [KO:K13708]
104637598  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
104637631  ITGA6; integrin alpha-6 [KO:K06485]
104637641  EZR; ezrin isoform X1 [KO:K08007]
104637652  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104637663  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104637781  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
104637782  BDKRB2; B2 bradykinin receptor [KO:K03916]
104637786  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104637989  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104638008  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
104638010  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104638047  [KO:K12755]
104638134  RGCC; regulator of cell cycle RGCC [KO:K26108]
104638183  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104638194  [KO:K22428]
104638423  ITGA4; integrin alpha-4 [KO:K06483]
104638444  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104638509  [KO:K18584]
104638679  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104638783  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
104638931  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104638935  FGF7; fibroblast growth factor 7 [KO:K04358]
104639304  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
104639315  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104639335  MYH9; myosin-9 [KO:K10352]
104639414  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104639441  [KO:K05749]
104639471  INS; insulin [KO:K04526]
104639474  CRKL; crk-like protein [KO:K04438]
104639488  F2R; proteinase-activated receptor 1 [KO:K03914]
104639535  [KO:K05699]
104639747  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104639949  [KO:K04368] [EC:2.7.12.2]
104640028  [KO:K10352]
104640043  PFN2; profilin-2 [KO:K05759]
104640250  [KO:K04456] [EC:2.7.11.1]
104640348  ITGB2; integrin beta-2 [KO:K06464]
104640411  C7; complement component C7 [KO:K03996]
104640412  C6; complement component C6 [KO:K03995]
104640759  APC; adenomatous polyposis coli protein [KO:K02085]
104641031  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104641052  MSN; moesin [KO:K05763]
104641105  ACTR2; actin-related protein 2 [KO:K17260]
104641266  [KO:K04371] [EC:2.7.11.24]
104641270  [KO:K06587]
104641328  RHOA; transforming protein RhoA [KO:K04513]
104641341  [KO:K05762]
104641405  PDGFD; platelet-derived growth factor D [KO:K05450]
104641498  VCL; vinculin [KO:K05700]
104641558  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104641625  [KO:K04358]
104641774  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104641797  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104641862  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104641925  FAM49B; protein FAM49B [KO:K27976]
104641989  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
104642045  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
104642082  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104642137  FGF18; fibroblast growth factor 18 [KO:K04358]
104642163  [KO:K00907] [EC:2.7.11.18]
104642252  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104642312  [KO:K00907] [EC:2.7.11.18]
104642363  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
104642385  ABI2; abl interactor 2 [KO:K05751]
104642611  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104642816  [KO:K04358]
104643080  [KO:K00907] [EC:2.7.11.18]
104643187  ITGA8; integrin alpha-8 [KO:K06584]
104643218  KNG1; kininogen-1 [KO:K03898]
104643225  TMSB4X; thymosin beta-4 [KO:K05764]
104643242  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
104643354  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104643460  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104643585  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104643636  MRAS; ras-related protein M-Ras [KO:K07831]
104643786  SOS1; son of sevenless homolog 1 [KO:K03099]
104643797  [KO:K02649]
104643806  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104643811  FGF19; fibroblast growth factor 19 [KO:K22603]
104643921  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104643950  CFL2; cofilin-2 [KO:K05765]
104644146  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104644171  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
breg04010  MAPK signaling pathway
breg04510  Focal adhesion
breg04520  Adherens junction
KO pathway
ko04810   

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