KEGG   PATHWAY: ccae04060
Entry
ccae04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Cyanistes caeruleus (blue tit)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ccae04060  Cytokine-cytokine receptor interaction
ccae04060

Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111941108  CCL19; C-C motif chemokine 19 [KO:K05512]
111941042  C-C motif chemokine 21-like [KO:K16062]
111928230  C-C motif chemokine 3-like [KO:K05408]
111937615  C-C motif chemokine 4 homolog [KO:K12964]
111937616  C-C motif chemokine 4 homolog [KO:K12964]
111941351  CCL28; C-C motif chemokine 28 [KO:K05513]
111933534  CCL20; C-C motif chemokine 20 [KO:K14625]
111929440  growth-regulated alpha protein-like [KO:K05505]
111929439  interleukin-8-like [KO:K10030]
111929465  interleukin-8-like [KO:K10030]
111929466  interleukin-8 [KO:K10030]
111929498  alveolar macrophage chemotactic factor-like [KO:K10032]
111929499  C-X-C motif chemokine 5-like isoform X1 [KO:K10032]
111929500  LOW QUALITY PROTEIN: C-X-C motif chemokine 2-like [KO:K10032]
111931155  CXCL12; stromal cell-derived factor 1 [KO:K10031]
111935593  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
111939662  lymphotactin-like [KO:K05507]
111934503  fractalkine-like [KO:K05508]
111928898  IL15; interleukin-15 isoform X1 [KO:K05433]
111944001  somatotropin-like [KO:K05438]
111940061  somatotropin [KO:K05438]
111932116  prolactin-like [KO:K05439]
111923970  PRL; prolactin [KO:K05439]
111933391  THPO; thrombopoietin isoform X1 [KO:K06854]
111940009  CSF3; granulocyte colony-stimulating factor [KO:K05423]
111924309  IL6; interleukin-6 [KO:K05405]
111935760  IL12B; interleukin-12 subunit beta [KO:K05425]
111936773  LIF; leukemia inhibitory factor [KO:K05419]
111939675  IL10; interleukin-10 [KO:K05443]
111939863  interleukin-20-like [KO:K22667]
111937221  IL22; interleukin-22 [KO:K05445]
111937211  IL26; interleukin-26 [KO:K05446]
111931691  interferon lambda-3-like [KO:K22669]
111940613  interferon kappa-like [KO:K05414]
111941171  interferon-like [KO:K05414]
111941173  interferon-like [KO:K05414]
111945250  interferon-like [KO:K05414]
111937200  IFNG; interferon gamma [KO:K04687]
111938925  interleukin-1 receptor antagonist protein-like [KO:K04519]
111939282  interleukin-18-like [KO:K05482]
111927489  IL17A; interleukin-17A [KO:K05489]
111927503  interleukin-17F-like [KO:K05494]
111942477  IL17B; interleukin-17B [KO:K05490]
111923768  IL17D; interleukin-17D [KO:K05492]
111934064  IL16; pro-interleukin-16 [KO:K22628]
111934533  IL34; interleukin-34 [KO:K22633]
111939755  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
111932669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111936935  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
111933337  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
111928736  EDA; ectodysplasin-A [KO:K05480]
111939656  NGF; beta-nerve growth factor [KO:K02582]
111935210  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
111936936  tumor necrosis factor ligand superfamily member 8-like [KO:K05471]
111928529  CD40LG; CD40 ligand [KO:K03161]
111945510  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
111942551  transforming growth factor beta-1-like [KO:K13375]
111926211  TGFB2; transforming growth factor beta-2 [KO:K13376]
111929961  TGFB3; transforming growth factor beta-3 [KO:K13377]
111940273  GDF15; growth/differentiation factor 15 [KO:K05504]
111931135  GDF2; growth/differentiation factor 2 [KO:K05503]
111938928  BMP10; bone morphogenetic protein 10 [KO:K22670]
111932167  INHA; inhibin alpha chain [KO:K05500]
111942299  BMP3; bone morphogenetic protein 3 [KO:K05496]
111931136  GDF10; growth/differentiation factor 10 [KO:K22674]
111931925  MSTN; growth/differentiation factor 8 [KO:K05497]
111923669  INHBA; inhibin beta A chain [KO:K04667]
111931751  INHBB; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
111940455  LOW QUALITY PROTEIN: uncharacterized protein LOC111940455 [KO:K05495]
111935788  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
111940530  inhibin beta C chain-like [KO:K22688]
111940221  AMH; muellerian-inhibiting factor [KO:K04665]
111926633  BMP2; bone morphogenetic protein 2 [KO:K21283]
111931148  bone morphogenetic protein 5-like [KO:K21283]
111940378  bone morphogenetic protein 2-like [KO:K21283]
111929526  BMP4; bone morphogenetic protein 4 [KO:K04662]
111938374  GDF5; growth/differentiation factor 5 [KO:K04664]
111926059  GDF7; growth/differentiation factor 7 [KO:K20013]
111929291  LOW QUALITY PROTEIN: bone morphogenetic protein 15-like [KO:K05498]
111925868  BMP5; bone morphogenetic protein 5 [KO:K04663]
111923936  BMP6; bone morphogenetic protein 6 [KO:K16620]
111938012  BMP7; bone morphogenetic protein 7 [KO:K16621]
111938967  bone morphogenetic protein 8A-like [KO:K16622]
111923561  C-C chemokine receptor type 8-like [KO:K04183]
111923565  CCR9; C-C chemokine receptor type 9 [KO:K04184]
111923878  ACKR4; atypical chemokine receptor 4 [KO:K04186]
111939960  CCR7; C-C chemokine receptor type 7 [KO:K04182]
111923569  CCR4; C-C chemokine receptor type 4 [KO:K04179]
111923559  C-C chemokine receptor type 5-like [KO:K04180]
111923560  C-C chemokine receptor type 5-like [KO:K04180]
111926925  CCR6; C-C chemokine receptor type 6 [KO:K04181]
111932197  C-X-C chemokine receptor type 2-like [KO:K05050]
111939208  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
111931764  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111931854  ACKR3; atypical chemokine receptor 3 [KO:K04304]
111923562  XCR1; chemokine XC receptor 1 [KO:K04193]
111923570  CX3C chemokine receptor 1-like isoform X1 [KO:K04192]
111923146  interleukin-2 receptor subunit alpha-like isoform X1 [KO:K05068]
111935345  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
111929372  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
111936216  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
111940971  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
111936218  interleukin-9 receptor-like isoform X1 [KO:K05073]
111923220  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
111936217  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
111944543  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
111935466  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
111934940  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
111944534  interleukin-5 receptor subunit alpha-like [KO:K05067]
111945764  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
111945781  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
111945793  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
111928746  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
111929358  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
111941452  GHR; growth hormone receptor [KO:K05080]
111932908  MPL; thrombopoietin receptor [KO:K05082]
111938933  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
111922067  LOW QUALITY PROTEIN: leptin receptor-like [KO:K05062]
111939461  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
111941441  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
111941168  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
111940322  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
111945019  interleukin-12 receptor subunit beta-2-like [KO:K05064]
111945126  interleukin-12 receptor subunit beta-2-like [KO:K05064]
111932956  IL23R; interleukin-23 receptor [KO:K05065]
111941538  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
111941155  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
111941018  LIFR; leukemia inhibitory factor receptor [KO:K05058]
111941103  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
111943508  interleukin-10 receptor subunit alpha-like [KO:K05134]
111928928  interleukin-10 receptor subunit beta-like isoform X1 [KO:K05135]
111926797  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
111935914  interleukin-20 receptor subunit beta-like [KO:K05137]
111939114  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
111939113  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
111928918  interferon alpha/beta receptor 1-like [KO:K05130]
111928947  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111926795  IFNGR1; interferon gamma receptor 1 [KO:K05132]
111929263  interferon alpha/beta receptor 1-like [KO:K05133]
111942272  interleukin-1 receptor type 1-like [KO:K04386]
111933457  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
111922338  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
111922347  interleukin-1 receptor type 1-like isoform X1 [KO:K05172]
111922407  IL18R1; interleukin-18 receptor 1 [KO:K05173]
111922760  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
111922423  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
111927994  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
111945610  IL17RC; interleukin-17 receptor C [KO:K05166]
111935300  IL17RE; interleukin-17 receptor E [KO:K05168]
111938276  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
111935546  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111938725  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111938704  tumor necrosis factor receptor superfamily member 1B-like [KO:K05141]
111938116  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
111930915  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111942927  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
111930789  tumor necrosis factor receptor superfamily member 26-like isoform X1 [KO:K04722]
111938818  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
111927427  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
111922695  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
111928608  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
111925071  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
111923866  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
111938722  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
111945133  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
111938469  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
111938666  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
111938483  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
111935965  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
111936132  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
111934422  uncharacterized protein LOC111934422 isoform X1 [KO:K05151]
111923585  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
111931017  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
111945196  RELL2; RELT-like protein 2 [KO:K26541]
111928111  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
111923709  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111932269  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111923501  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111940463  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
111932342  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
111931997  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
111925449  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
111940581  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
111932400  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
111932401  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
111931579  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
111929421  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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