KEGG   PATHWAY: cmac04810
Entry
cmac04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Chlamydotis macqueenii (Macqueen's bustard)
Class
Cellular Processes; Cell motility
Pathway map
cmac04810  Regulation of actin cytoskeleton
cmac04810

Other DBs
GO: 0030036
Organism
Chlamydotis macqueenii (Macqueen's bustard) [GN:cmac]
Gene
104472916  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104472979  FGF6; fibroblast growth factor 6 [KO:K04358]
104473180  [KO:K05753]
104473420  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104473425  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
104473432  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104473639  ITGAV; integrin alpha-V [KO:K06487]
104473654  FGF23; fibroblast growth factor 23 [KO:K22428]
104473996  [KO:K06589]
104474285  C8B; complement component C8 beta chain [KO:K03998]
104474423  FAM49A; protein FAM49A isoform X1 [KO:K27976]
104474485  APC; adenomatous polyposis coli protein [KO:K02085]
104474672  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104474713  FAM49B; protein FAM49B isoform X1 [KO:K27976]
104475026  ITGB8; integrin beta-8 [KO:K06591]
104475106  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104475145  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104475226  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104475253  [KO:K04358]
104475393  KRAS; GTPase KRas isoform X1 [KO:K07827]
104475716  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
104475831  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104475876  [KO:K00907] [EC:2.7.11.18]
104475944  [KO:K04438]
104475947  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104476028  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104476137  ENAH; protein enabled homolog isoform X1 [KO:K05746]
104476232  ITGA2; integrin alpha-2 [KO:K06481]
104476302  FN1; fibronectin [KO:K05717]
104476656  ITGB3; integrin beta-3 [KO:K06493]
104476682  GSN; gelsolin [KO:K05768]
104476698  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
104476702  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
104476880  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104476901  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104476979  BDKRB1; B1 bradykinin receptor [KO:K03915]
104476982  BDKRB2; B2 bradykinin receptor [KO:K03916]
104477028  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104477102  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104477163  [KO:K05762]
104477214  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104477512  C5; complement C5 [KO:K03994]
104477576  [KO:K04358]
104477662  [KO:K04359]
104477672  ACTR3B; actin-related protein 3B [KO:K18584]
104477734  ITGAE; integrin alpha-E [KO:K06524]
104477878  MRAS; ras-related protein M-Ras [KO:K07831]
104477891  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
104478090  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
104478194  [KO:K00907] [EC:2.7.11.18]
104478206  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104478341  VCL; vinculin [KO:K05700]
104478394  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104478428  EZR; ezrin isoform X1 [KO:K08007]
104478567  [KO:K04513]
104478573  ACTR2; actin-related protein 2 [KO:K17260]
104478657  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104478734  [KO:K04392]
104478743  [KO:K10352]
104478819  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104478932  [KO:K12756]
104478936  FGF18; fibroblast growth factor 18 [KO:K04358]
104478939  PFN3; profilin-3 [KO:K05759]
104478974  [KO:K05699]
104479325  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104479333  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104479348  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
104479360  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104479437  [KO:K03898]
104479527  C7; complement component C7 [KO:K03996]
104479793  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
104479936  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104479956  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
104479986  [KO:K04358]
104480013  LIMK2; LOW QUALITY PROTEIN: LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
104480033  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104480072  CRKL; crk-like protein [KO:K04438]
104480086  [KO:K07828]
104480126  FGF19; fibroblast growth factor 19 [KO:K22603]
104480187  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
104480229  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
104480317  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104480324  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
104480440  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104480529  FGF2; fibroblast growth factor 2 [KO:K18497]
104480565  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
104480634  [KO:K04358]
104480722  [KO:K05692]
104480771  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104480799  ITGB2; integrin beta-2 [KO:K06464]
104480820  [KO:K05757]
104480999  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
104481171  FGF7; fibroblast growth factor 7 [KO:K04358]
104481206  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104481214  PDGFC; platelet-derived growth factor C [KO:K05450]
104481307  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
104481361  ITGA6; integrin alpha-6 [KO:K06485]
104481649  [KO:K04358]
104481650  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104481673  [KO:K13708]
104481707  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104481790  SOS2; son of sevenless homolog 2 [KO:K03099]
104481813  ITGA8; integrin alpha-8 [KO:K06584]
104481855  FGF3; fibroblast growth factor 3 [KO:K04358]
104481981  ITGA1; integrin alpha-1 [KO:K06480]
104482073  CFL2; cofilin-2 [KO:K05765]
104482122  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104482128  [KO:K10351]
104482198  [KO:K06269] [EC:3.1.3.16]
104482397  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
104482426  TMSB4X; thymosin beta-4 [KO:K05764]
104482446  FGF8; fibroblast growth factor 8 [KO:K04358]
104482529  [KO:K05749]
104482643  [KO:K18584]
104482652  [KO:K05095] [EC:2.7.10.1]
104482790  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104482794  MSN; moesin [KO:K05763]
104482796  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104482918  F2R; proteinase-activated receptor 1 [KO:K03914]
104483008  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104483049  ABI2; abl interactor 2 [KO:K05751]
104483265  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104483381  [KO:K12757]
104483409  [KO:K12329]
104483456  ITGA4; integrin alpha-4 [KO:K06483]
104483543  [KO:K00907] [EC:2.7.11.18]
104483597  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
104483602  LPAR4; lysophosphatidic acid receptor 4 isoform X1 [KO:K04275]
104483607  [KO:K12757]
104483622  [KO:K10352]
104483634  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
104484007  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104484067  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
104484091  [KO:K12755]
104484233  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
104484244  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104484307  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
104484433  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104484528  C9; complement component C9 [KO:K04000]
104484558  INS; insulin [KO:K04526]
104484562  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104484801  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104484802  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104484893  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104485128  ITGB1; integrin beta-1 [KO:K05719]
104485177  PXN; paxillin [KO:K05760]
104485330  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
104485376  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104485389  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104485540  [KO:K05759]
104485542  [KO:K05759]
104485553  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104485657  [KO:K05692]
104485761  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104485793  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104486016  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104486063  NCKAP1; nck-associated protein 1 [KO:K05750]
104486073  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104486314  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104486438  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104486513  [KO:K06587]
104486514  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104486553  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104486585  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104486612  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
104486990  [KO:K13708]
104487010  C6; complement component C6 [KO:K03995]
104487224  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104487232  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104487373  HRAS; GTPase HRas [KO:K02833]
104487804  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cmac04010  MAPK signaling pathway
cmac04510  Focal adhesion
cmac04520  Adherens junction
KO pathway
ko04810   

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