KEGG   PATHWAY: csab04380
Entry
csab04380                   Pathway                                
Name
Osteoclast differentiation - Chlorocebus sabaeus (green monkey)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
csab04380  Osteoclast differentiation
csab04380

Other DBs
GO: 0030316
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214344  TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
103215459  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103215732  SIRPA; signal regulatory protein alpha [KO:K06551]
103215767  [KO:K06551]
103215791  [KO:K06551]
103215800  [KO:K06551]
103215816  [KO:K06551]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103215997  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103216327  BLNK; B-cell linker [KO:K07371]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103216431  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
103216867  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103216875  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103216889  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103217529  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103218776  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103219106  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
103219139  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
103219383  IFNB1; interferon beta 1 [KO:K05415]
103219736  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103220127  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103220575  FOSL2; FOS like 2, AP-1 transcription factor subunit [KO:K09030]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103221524  TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378]
103221595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103221596  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103221654  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103223257  NCF4; neutrophil cytosolic factor 4 [KO:K08012]
103223342  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103223551  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103223553  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103223672  FCGR2B; Fc fragment of IgG receptor IIb [KO:K12560]
103223675  [KO:K06463]
103223676  FCGR2A; Fc fragment of IgG receptor IIa [KO:K06472]
103224269  CSF1; colony stimulating factor 1 [KO:K05453]
103224682  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103224726  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103225555  FOSL1; FOS like 1, AP-1 transcription factor subunit [KO:K04502]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103225952  LCK; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
103226547  CALCR; calcitonin receptor [KO:K04576]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103227882  MITF; melanogenesis associated transcription factor [KO:K09455]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103228027  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
103228298  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
103228710  IRF9; interferon regulatory factor 9 [KO:K04693]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103229352  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103230082  TGFB2; transforming growth factor beta 2 [KO:K13376]
103230269  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
103230452  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103232344  NOX1; NADPH oxidase 1 [KO:K08008]
103232359  BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
103232722  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103233371  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103233451  [KO:K08009]
103233823  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103233941  ACP5; acid phosphatase 5, tartrate resistant [KO:K14379] [EC:3.1.3.2]
103233990  JUNB; JunB proto-oncogene, AP-1 transcription factor subunit [KO:K09028]
103234174  JUND; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
103234360  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234547  TYROBP; TYRO protein tyrosine kinase binding protein [KO:K07992]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103234729  TGFB1; transforming growth factor beta 1 [KO:K13375]
103234846  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
103234863  FOSB; FosB proto-oncogene, AP-1 transcription factor subunit [KO:K09029]
103235238  OSCAR; osteoclast associated, immunoglobulin-like receptor [KO:K14377]
103235247  LILRA5; leukocyte immunoglobulin like receptor A5 [KO:K06512]
103235248  [KO:K06512]
103235252  LILRB5; leukocyte immunoglobulin like receptor B5 [KO:K06512]
103235254  [KO:K06512]
103235257  [KO:K06512]
103235264  LILRA4; leukocyte immunoglobulin like receptor A4 [KO:K06512]
103235273  [KO:K06512]
103235274  [KO:K06512]
103235275  [KO:K06512]
103235477  [KO:K06512]
103235563  [KO:K06512]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103236040  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103236117  SPI1; Spi-1 proto-oncogene [KO:K09438]
103237106  TMEM64; transmembrane protein 64 [KO:K26770]
103237340  TNFRSF11B; TNF receptor superfamily member 11b [KO:K05148]
103237554  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103238525  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103238673  IFNG; interferon gamma [KO:K04687]
103239106  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
103239600  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103240115  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103240159  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103240303  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103240563  FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
103241149  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
103241187  FHL2; four and a half LIM domains 2 [KO:K14380]
103241278  IL1B; interleukin 1 beta [KO:K04519]
103241279  IL1A; interleukin 1 alpha [KO:K04383]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103241808  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
103242172  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
103243048  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103243132  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103243277  ITGB3; integrin subunit beta 3 [KO:K06493]
103243289  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103243658  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103244028  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
103244174  TNFRSF11A; TNF receptor superfamily member 11a [KO:K05147]
103244215  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
103244326  CAMK4; calcium/calmodulin dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
103244788  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103244954  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
103245112  SQSTM1; sequestosome 1 [KO:K14381]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103246131  TEC; tec protein tyrosine kinase [KO:K07364] [EC:2.7.10.2]
103246614  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103247163  [KO:K06498]
103247207  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
103247837  [KO:K06512]
103248110  GAB2; GRB2 associated binding protein 2 [KO:K08091]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
csab04010  MAPK signaling pathway
csab04020  Calcium signaling pathway
csab04064  NF-kappa B signaling pathway
csab04151  PI3K-Akt signaling pathway
csab04630  JAK-STAT signaling pathway
KO pathway
ko04380   

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