KEGG   PATHWAY: cuca04060
Entry
cuca04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Cuculus canorus (common cuckoo)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cuca04060  Cytokine-cytokine receptor interaction
cuca04060

Organism
Cuculus canorus (common cuckoo) [GN:cuca]
Gene
104054331  EDA; ectodysplasin-A isoform X1 [KO:K05480]
104054338  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
104054426  CCR7; C-C chemokine receptor type 7 [KO:K04182]
104054469  CCR10; C-C chemokine receptor type 10 [KO:K04185]
104054514  INHA; inhibin alpha chain [KO:K05500]
104054784  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
104054806  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
104055320  IL17D; interleukin-17D [KO:K05492]
104055437  BMP2; bone morphogenetic protein 2 [KO:K21283]
104055532  [KO:K05151]
104055586  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
104055618  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104055683  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
104055753  [KO:K04674] [EC:2.7.11.30]
104055837  [KO:K05507]
104055867  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104055883  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
104055884  [KO:K05471]
104055900  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
104056146  LIF; leukemia inhibitory factor isoform X1 [KO:K05419]
104056184  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
104056185  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
104056246  [KO:K05050]
104056254  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
104056256  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104056493  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104056514  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104056546  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104056547  CCL21; C-C motif chemokine 21 [KO:K16062]
104056575  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
104056576  CCL19; C-C motif chemokine 19 [KO:K05512]
104056627  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X3 [KO:K05162]
104056638  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104056639  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
104056640  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
104056641  [KO:K05172]
104056642  [KO:K04386]
104056690  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
104056779  GDF6; growth/differentiation factor 6 [KO:K20012]
104056984  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104057114  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
104057118  GDF7; growth/differentiation factor 7 [KO:K20013]
104057334  [KO:K12964]
104057336  [KO:K12964]
104057337  [KO:K12499]
104057425  BMP4; bone morphogenetic protein 4 [KO:K04662]
104057544  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
104057563  MPL; thrombopoietin receptor [KO:K05082]
104057873  THPO; thrombopoietin [KO:K06854]
104057926  [KO:K04519]
104057933  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
104057934  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104058315  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104058331  MSTN; growth/differentiation factor 8 [KO:K05497]
104058367  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104058775  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
104059003  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
104059117  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104059455  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104059667  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
104059668  [KO:K05058]
104059792  [KO:K05432]
104059995  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
104060112  [KO:K16622]
104060523  BMP15; bone morphogenetic protein 15 [KO:K05498]
104060562  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
104060586  GDF9; growth/differentiation factor 9 [KO:K22673]
104060604  [KO:K05141]
104060677  CD40LG; CD40 ligand isoform X1 [KO:K03161]
104060818  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
104060873  [KO:K05428]
104060908  BMPR1B; bone morphogenetic protein receptor type-1B isoform X3 [KO:K13578] [EC:2.7.11.30]
104060922  AMH; muellerian-inhibiting factor [KO:K04665]
104060991  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
104061306  IL17C; interleukin-17C isoform X1 [KO:K05491]
104061358  IL22; interleukin-22 [KO:K05445]
104061369  IFNG; interferon gamma [KO:K04687]
104061860  IL10; interleukin-10 [KO:K05443]
104061881  [KO:K22667]
104062067  CNTF; ciliary neurotrophic factor [KO:K05420]
104062070  [KO:K21283]
104062135  PRL; prolactin [KO:K05439]
104062146  BMP6; bone morphogenetic protein 6 [KO:K16620]
104062502  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
104062812  GHR; growth hormone receptor isoform X1 [KO:K05080]
104062908  IL12B; interleukin-12 subunit beta isoform X2 [KO:K05425]
104062978  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104063167  [KO:K05414]
104063216  GDF5; growth/differentiation factor 5 [KO:K04664]
104063347  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
104063357  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
104063466  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
104063622  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
104063685  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104063719  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
104063742  [KO:K05066]
104063743  [KO:K05066]
104063839  PRLR; prolactin receptor isoform X1 [KO:K05081]
104063845  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
104063897  [KO:K10032]
104063898  [KO:K10032]
104063985  INHBC; inhibin beta C chain [KO:K22688]
104063987  [KO:K22689]
104064152  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
104064210  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
104064271  RELL1; RELT-like protein 1 [KO:K26541]
104064368  [KO:K06454]
104064759  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104064760  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104064789  IFNGR2; interferon gamma receptor 2 [KO:K05133]
104064790  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104064807  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
104064889  [KO:K05438]
104065023  [KO:K05068]
104065041  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
104065050  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
104065077  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
104065224  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104065317  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
104065363  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
104065404  BMP10; bone morphogenetic protein 10 [KO:K22670]
104065688  [KO:K05494]
104065696  [KO:K05489]
104065771  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
104065832  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
104065840  GDF15; growth/differentiation factor 15 [KO:K05504]
104065861  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104065901  [KO:K04738]
104065902  [KO:K04738]
104065942  INHBA; inhibin beta A chain [KO:K04667]
104065979  BMP7; bone morphogenetic protein 7 [KO:K16621]
104066076  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104066188  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X2 [KO:K05148]
104066405  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
104066451  IL15; interleukin-15 isoform X1 [KO:K05433]
104066564  LEPR; leptin receptor isoform X1 [KO:K05062]
104066593  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
104066954  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
104067075  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
104067218  IL18; interleukin-18 [KO:K05482]
104067376  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104067396  [KO:K22669]
104067474  [KO:K10030]
104067483  [KO:K10030]
104067611  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104067618  XCR1; chemokine XC receptor 1 [KO:K04193]
104067619  [KO:K04180]
104067620  [KO:K04180]
104067627  ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186]
104067644  CCR9; C-C chemokine receptor type 9 [KO:K04184]
104067646  [KO:K04183]
104067711  INHBB; inhibin beta B chain [KO:K22687]
104067887  GDF2; growth/differentiation factor 2 [KO:K05503]
104067905  CSF3; granulocyte colony-stimulating factor [KO:K05423]
104067957  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
104067960  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
104067961  [KO:K21283]
104067970  GDF10; growth/differentiation factor 10 [KO:K22674]
104068044  IL6; interleukin-6 [KO:K05405]
104068116  IL7; interleukin-7 isoform X1 [KO:K05431]
104068265  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104068572  [KO:K04666]
104068597  [KO:K04722]
104068632  GDF11; growth/differentiation factor 11 [KO:K22679]
104068637  [KO:K04388] [EC:2.7.11.30]
104068746  IL17B; interleukin-17B [KO:K05490]
104068809  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
104068845  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
104068846  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104068856  [KO:K04183]
104069038  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
128850512  [KO:K05415]
128852008  [KO:K10030]
128852014  [KO:K10032]
128853706  [KO:K05073]
128853733  [KO:K05439]
128854165  IL26; interleukin-26 [KO:K05446]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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