KEGG   PATHWAY: cvf04082
Entry
cvf04082                    Pathway                                
Name
Neuroactive ligand signaling - Charadrius vociferus (killdeer)
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cvf04082  Neuroactive ligand signaling
cvf04082

Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281594  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
104281595  [KO:K05034]
104281596  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
104281751  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
104281752  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
104281753  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
104281762  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
104281765  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 [KO:K05186]
104281767  TACR1; substance-P receptor [KO:K04222]
104281821  GRIK3; glutamate receptor ionotropic, kainate 3 [KO:K05203]
104281862  DRD3; D(3) dopamine receptor [KO:K04146]
104281955  [KO:K04819]
104282006  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
104282114  [KO:K15015]
104282140  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
104282261  P2RX4; P2X purinoceptor 4 [KO:K05218]
104282380  [KO:K05189]
104282448  DRD5; D(1B) dopamine receptor [KO:K05840]
104282492  [KO:K05617]
104282499  [KO:K05618]
104282620  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
104282791  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
104282884  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104282970  GRM2; LOW QUALITY PROTEIN: metabotropic glutamate receptor 2 [KO:K04605]
104283045  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
104283090  [KO:K14387]
104283158  ADORA1; adenosine receptor A1 [KO:K04265]
104283336  SLC1A2; excitatory amino acid transporter 2 [KO:K05613]
104283392  ADRA2A; alpha-2A adrenergic receptor [KO:K04138]
104283411  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
104283463  ADRB1; beta-1 adrenergic receptor [KO:K04141]
104283539  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
104283560  P2RY4; P2Y purinoceptor 4 [KO:K04271]
104283743  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104283793  GLRA3; glycine receptor subunit alpha-3 [KO:K05195]
104283846  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
104283856  ADRB2; beta-2 adrenergic receptor [KO:K04142]
104283878  [KO:K05186]
104283893  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104284165  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
104284196  [KO:K04163]
104284204  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
104284251  [KO:K04150]
104284272  SLC17A8; LOW QUALITY PROTEIN: vesicular glutamate transporter 3 [KO:K12302]
104284360  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104284382  P2RX5; P2X purinoceptor 5 [KO:K05219]
104284387  ADORA2B; adenosine receptor A2b [KO:K04267]
104284540  GRM7; LOW QUALITY PROTEIN: metabotropic glutamate receptor 7 [KO:K04609]
104284557  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
104284574  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104284583  GRM3; metabotropic glutamate receptor 3 [KO:K04606]
104284698  SLC5A7; high affinity choline transporter 1 [KO:K14387]
104284734  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
104284735  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
104284823  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
104284868  AGRP; agouti-related protein [KO:K05231]
104284920  CHRNA6; neuronal acetylcholine receptor subunit alpha-6 [KO:K04808]
104284960  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
104285057  ADRA2B; alpha-2B adrenergic receptor [KO:K04139]
104285165  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
104285231  GRM8; metabotropic glutamate receptor 8 [KO:K04610]
104285350  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
104285362  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
104285482  MC4R; melanocortin receptor 4 [KO:K04202]
104285500  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104285648  [KO:K05840]
104285661  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
104285819  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
104285864  SLC18A1; chromaffin granule amine transporter [KO:K08155]
104285886  P2RY1; P2Y purinoceptor 1 [KO:K04270]
104286069  SLC1A7; excitatory amino acid transporter 5 [KO:K05618]
104286144  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104286286  SLC6A9; sodium- and chloride-dependent glycine transporter 1 [KO:K05038]
104286302  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104286379  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
104286380  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
104286417  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
104286418  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
104286482  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104286511  P2RX1; P2X purinoceptor 1 [KO:K05215]
104286858  TACR3; neuromedin-K receptor [KO:K04224]
104286903  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104287087  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
104287100  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104287244  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
104287253  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
104287337  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104287385  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104287540  SLC17A6; vesicular glutamate transporter 2 isoform X1 [KO:K12302]
104287581  SLC6A5; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
104287754  [KO:K05035]
104287901  [KO:K04151]
104287928  [KO:K04151]
104287943  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
104287979  CHRNA3; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
104288045  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
104288285  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104288441  [KO:K04161]
104288498  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104288651  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
104288662  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190]
104288663  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
104288671  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
104288751  OPRM1; mu-type opioid receptor [KO:K04215]
104288861  [KO:K04153]
104288878  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
104288889  OPRD1; delta-type opioid receptor [KO:K04213]
104289380  GRM4; metabotropic glutamate receptor 4 [KO:K04607]
104289509  [KO:K04268]
104289510  [KO:K04268]
104289582  GNG13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104289786  [KO:K05840]
104289793  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
104289836  OGFRL1; opioid growth factor receptor-like protein 1 [KO:K27951]
104289948  [KO:K04634]
104289949  GABBR1; LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
104290021  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
104290111  [KO:K05037]
104290119  OPRK1; kappa-type opioid receptor [KO:K04214]
104290181  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
104290182  GABRQ; gamma-aminobutyric acid receptor subunit theta isoform X1 [KO:K05192]
104290239  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
104290266  GRIA3; glutamate receptor 3 [KO:K05199]
104290288  [KO:K04270]
104290377  [KO:K05614]
104290451  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
104290505  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104290506  GABRD; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
104290780  HRH1; histamine H1 receptor [KO:K04149]
104290781  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
104290782  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
104290808  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104290844  [KO:K04813]
104290901  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
104290919  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
104291117  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
104291328  ADRA2C; alpha-2C adrenergic receptor [KO:K04140]
104291656  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
104291718  P2RY2; P2Y purinoceptor 2 [KO:K04269]
104291719  P2RY6; P2Y purinoceptor 6 [KO:K04272]
104292779  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104292946  [KO:K04630]
104292993  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104292995  DRD4; D(4) dopamine receptor [KO:K04147]
104292999  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
104293131  GLRA1; glycine receptor subunit alpha-1 isoform X1 [KO:K05193]
104293134  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
104293298  PENK; proenkephalin-A [KO:K18832]
104293486  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
104293536  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
104293537  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
104293701  ADORA2A; adenosine receptor A2a [KO:K04266]
104293801  P2RX6; P2X purinoceptor 6 [KO:K05221]
104293833  MC3R; melanocortin receptor 3 [KO:K04201]
104293862  DRD1; D(1A) dopamine receptor [KO:K04144]
104293874  PDYN; LOW QUALITY PROTEIN: proenkephalin-B [KO:K15840]
104293888  OPRL1; nociceptin receptor [KO:K04216]
104293895  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
104293905  OGFR; opioid growth factor receptor [KO:K27951]
104293921  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
104293947  HRH2; histamine H2 receptor [KO:K04150]
104294024  SLC17A9; solute carrier family 17 member 9 [KO:K12303]
104294033  HRH3; histamine H3 receptor [KO:K04151]
104294075  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
104294138  GLRB; glycine receptor subunit beta isoform X1 [KO:K05196]
104294191  GRIA2; glutamate receptor 2 [KO:K05198]
104294270  GRIK2; glutamate receptor ionotropic, kainate 2 [KO:K05202]
104294304  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
104294373  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
104294410  TACR2; substance-K receptor [KO:K04223]
104294482  [KO:K04151]
104294983  SLC1A3; LOW QUALITY PROTEIN: excitatory amino acid transporter 1 [KO:K05614]
104295097  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104295210  GRIK1; glutamate receptor ionotropic, kainate 1 [KO:K05201]
104295315  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104295330  [KO:K04809]
104295377  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104295392  GRIK4; glutamate receptor ionotropic, kainate 4 [KO:K05204]
104295466  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
104295545  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
104295590  TAC1; protachykinin-1 [KO:K05239]
104295601  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104295676  POMC; pro-opiomelanocortin [KO:K05228]
104295685  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104295746  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
104295864  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
104296106  [KO:K04819]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00029  UDP-glucose
C00037  Glycine
C00075  UTP
C00076  Calcium cation
C00114  Choline
C00165  Diacylglycerol
C00212  Adenosine
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01330  Sodium cation
C01996  Acetylcholine
C02210  beta-Endorphin
C02758  alpha-Melanotropin
C03758  Dopamine
C11684  MET-enkephalin
C15871  Nocistatin
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C16041  Leu-enkephalin
C16044  Nociceptin
C16094  Substance P
C16095  Neuropeptide K
C16096  Neuropeptide gamma
C16097  Neurokinin A
C16098  Neurokinin B
C16099  Endokinin A/B
C16100  Endokinin C
C16101  Endokinin D
C16103  Agouti related protein (87-132)
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
PMID:37385351
  Authors
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
  Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
  Journal
Ageing Res Rev 89:101994 (2023)
DOI:10.1016/j.arr.2023.101994
Reference
PMID:31726793
  Authors
Malik AR, Willnow TE
  Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
  Journal
Int J Mol Sci 20:ijms20225671 (2019)
DOI:10.3390/ijms20225671
Reference
PMID:25116141
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:35055019
  Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
  Journal
Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
PMID:33924731
  Authors
Wang Y, Tan B, Wang Y, Chen Z
  Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
  Journal
Molecules 26:molecules26082258 (2021)
DOI:10.3390/molecules26082258
Reference
PMID:36757901
  Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
  Title
Dopamine, Immunity, and Disease.
  Journal
Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
PMID:25037203
  Authors
Savica R, Benarroch EE
  Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
  Journal
Neurology 83:758-67 (2014)
DOI:10.1212/WNL.0000000000000719
Reference
PMID:33651238
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
  Journal
Cell Mol Neurobiol 42:1671-1692 (2022)
DOI:10.1007/s10571-021-01064-9
Reference
PMID:35492402
  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
  Journal
Curr Res Immunol 2:202-217 (2021)
DOI:10.1016/j.crimmu.2021.11.001
Reference
PMID:39337347
  Authors
Szukiewicz D
  Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
  Journal
Int J Mol Sci 25:ijms25189859 (2024)
DOI:10.3390/ijms25189859
Reference
PMID:33907179
  Authors
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
  Title
From purines to purinergic signalling: molecular functions and human diseases.
  Journal
Signal Transduct Target Ther 6:162 (2021)
DOI:10.1038/s41392-021-00553-z
Reference
PMID:16715052
  Authors
Fields RD, Burnstock G
  Title
Purinergic signalling in neuron-glia interactions.
  Journal
Nat Rev Neurosci 7:423-36 (2006)
DOI:10.1038/nrn1928
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:28360832
  Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
  Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
  Journal
Front Neurosci 11:128 (2017)
DOI:10.3389/fnins.2017.00128
Reference
PMID:26956246
  Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
  Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
  Journal
Pharmacol Rev 68:419-57 (2016)
DOI:10.1124/pr.114.009209
Reference
PMID:36589829
  Authors
Campo A, Dufour S, Rousseau K
  Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
  Journal
Front Endocrinol (Lausanne) 13:1056939 (2022)
DOI:10.3389/fendo.2022.1056939
Related
pathway
cvf04080  Neuroactive ligand-receptor interaction
KO pathway
ko04082   

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