KEGG   PATHWAY: eja04621
Entry
eja04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Embiotoca jacksoni (black perch)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
eja04621  NOD-like receptor signaling pathway
eja04621

Organism
Embiotoca jacksoni (black perch) [GN:eja]
Gene
138191896  [KO:K17065] [EC:3.6.5.5]
138192069  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
138192186  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
138192217  [KO:K08846] [EC:2.7.11.1]
138192226  pkn2a; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
138192485  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
138192629  [KO:K04513]
138192631  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
138192746  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
138192827  [KO:K04513]
138193355  [KO:K04441] [EC:2.7.11.24]
138193538  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
138193901  [KO:K11974] [EC:2.3.2.31]
138193906  nampt2; nicotinamide phosphoribosyltransferase 2 [KO:K03462] [EC:2.4.2.12]
138194096  [KO:K08341]
138194117  atg12; ubiquitin-like protein ATG12 [KO:K08336]
138194126  [KO:K04513]
138194582  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
138194643  [KO:K04427] [EC:2.7.11.25]
138194706  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
138194914  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
138195106  [KO:K05858] [EC:3.1.4.11]
138195206  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
138195389  antxr1d; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
138195395  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
138195412  [KO:K04467] [EC:2.7.11.10]
138195491  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
138195946  casr; extracellular calcium-sensing receptor [KO:K04612]
138196115  [KO:K06630]
138196401  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
138196693  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
138196994  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
138197128  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
138197400  [KO:K01370] [EC:3.4.22.36]
138197453  [KO:K03443]
138197458  rhoca; ras homolog family member Ca [KO:K04513]
138197852  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
138198150  [KO:K06068] [EC:2.7.11.13]
138198151  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
138198157  txn2; thioredoxin, mitochondrial [KO:K03671]
138198379  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
138198569  mfn1b; mitofusin-1b [KO:K21356] [EC:3.6.5.-]
138198574  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
138198584  jun; transcription factor Jun isoform X1 [KO:K04448]
138199478  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
138199782  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
138200460  jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
138200515  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
138200820  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
138200896  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
138201173  [KO:K05131]
138201204  prkcda; protein kinase C, delta a isoform X1 [KO:K06068] [EC:2.7.11.13]
138201281  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
138201408  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
138201418  [KO:K11220]
138201725  [KO:K04958]
138201890  [KO:K15040]
138202030  irf3; interferon regulatory factor 3 [KO:K05411]
138202246  antxr1c; anthrax toxin receptor 1 [KO:K20909]
138202248  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
138202541  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
138202611  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
138202645  [KO:K17065] [EC:3.6.5.5]
138202650  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
138202700  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
138202870  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
138202976  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
138202980  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
138203000  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
138203009  sharpin; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K20894]
138203549  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
138203550  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
138203577  [KO:K04570]
138203578  [KO:K05858] [EC:3.1.4.11]
138203580  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
138203631  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
138203929  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
138204028  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
138204130  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
138204240  [KO:K11974] [EC:2.3.2.31]
138204241  irf9; interferon regulatory factor 9 [KO:K04693]
138204297  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
138204511  [KO:K05414]
138204651  [KO:K04467] [EC:2.7.11.10]
138204826  [KO:K03173] [EC:2.3.2.27]
138204877  [KO:K05414]
138204917  [KO:K04622]
138205004  brcc3; lys-63-specific deubiquitinase [KO:K11864] [EC:3.4.19.-]
138205094  traf3; TNF receptor-associated factor 3 [KO:K03174]
138205110  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
138205519  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
138205583  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
138205736  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
138205866  itpr1b; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
138205935  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
138205945  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
138206006  itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
138206084  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
138206128  [KO:K20909]
138206285  [KO:K08847] [EC:2.7.11.1]
138206596  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a [KO:K12804]
138206726  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
138206927  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
138206991  cybb; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
138207327  sugt1; protein SGT1 homolog [KO:K12795]
138207359  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
138207360  [KO:K04398] [EC:3.4.22.61]
138207363  [KO:K20909]
138207467  [KO:K04448]
138207730  ifnphi1; interferon phi 1 [KO:K05414]
138208093  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
138208199  [KO:K15041]
138208244  [KO:K03443]
138208307  [KO:K03173] [EC:2.3.2.27]
138208540  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
138208779  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
138208956  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
138209022  tab1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
138209342  [KO:K10030]
138209444  erbin; LOW QUALITY PROTEIN: erbin [KO:K12796]
138210089  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
138210148  bcl2l1; bcl-2-like protein 1 [KO:K04570]
138210232  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
138210294  antxr2a; LOW QUALITY PROTEIN: anthrax toxin receptor 2 [KO:K20909]
138210309  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
138210489  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
138210550  txnb; thioredoxin b [KO:K03671]
138210567  [KO:K08341]
138210631  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
138210882  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
138211006  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
138211231  sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]
138211332  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
138211467  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
138211824  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
138211829  gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622]
138211980  [KO:K10030]
138212377  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
138212562  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
138212642  atg16l1; LOW QUALITY PROTEIN: autophagy-related protein 16-1 [KO:K17890]
138212732  rnf31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
138212801  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
138212985  [KO:K12804]
138212996  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
138213238  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
138213244  cyba; cytochrome b-245 light chain [KO:K08009]
138213268  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
138213609  vdac1; non-selective voltage-gated ion channel VDAC1 [KO:K05862]
138213684  atg5; autophagy protein 5 isoform X1 [KO:K08339]
138213875  [KO:K08341]
138213892  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
138214005  [KO:K12799]
138214584  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
138214684  txnipa; thioredoxin interacting protein a [KO:K20910]
138214706  il6; interleukin-6 [KO:K05405]
138214988  [KO:K20910]
138215452  [KO:K02161]
138215540  itpr3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1 [KO:K04960]
138215666  fadd; FAS-associated death domain protein [KO:K02373]
138215739  [KO:K20909]
138215742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
138215773  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
138215774  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
138215964  [KO:K04519]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
eja04010  MAPK signaling pathway
eja04140  Autophagy - animal
eja04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

DBGET integrated database retrieval system