KEGG   PATHWAY: lmix04060
Entry
lmix04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Labrus mixtus (cuckoo wrasse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
lmix04060  Cytokine-cytokine receptor interaction
lmix04060

Organism
Labrus mixtus (cuckoo wrasse) [GN:lmix]
Gene
132954115  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
132954349  [KO:K05069]
132954434  csf2rb; cytokine receptor common subunit beta [KO:K04738]
132954463  ifnphi1; interferon phi 1 [KO:K05414]
132954464  [KO:K05414]
132954516  il12rb2l; interleukin 12 receptor, beta 2a, like [KO:K05060]
132954538  prl; prolactin isoform X1 [KO:K05439]
132955037  [KO:K05152]
132955038  [KO:K05152]
132955234  ngfrb; nerve growth factor receptor b [KO:K02583]
132955315  [KO:K05152]
132955386  [KO:K22670]
132955406  ndr2; nodal-related 2 [KO:K04666]
132955585  [KO:K21283]
132955604  [KO:K05414]
132955646  [KO:K05075]
132955652  si:rp71-1c10.7; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
132955692  [KO:K22674]
132955696  [KO:K22674]
132955709  [KO:K22674]
132955837  [KO:K05414]
132955929  [KO:K22670]
132955930  [KO:K22670]
132955933  [KO:K22670]
132956131  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
132956400  [KO:K05439]
132956474  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
132956618  [KO:K05445]
132956701  [KO:K05424]
132958250  rell1; RELT-like protein 1 isoform X1 [KO:K26541]
132958295  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
132958336  [KO:K05077]
132958556  epoa; erythropoietin isoform X1 [KO:K05437]
132958717  bmp15; bone morphogenetic protein 15 [KO:K05498]
132958829  [KO:K12672]
132958830  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
132959266  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132959285  [KO:K04671] [EC:2.7.11.30]
132959352  [KO:K05080]
132959485  [KO:K22687]
132959556  inha; inhibin alpha chain [KO:K05500]
132959765  [KO:K05497]
132959781  [KO:K05050]
132959800  [KO:K04670] [EC:2.7.11.30]
132960340  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 [KO:K04193]
132961470  amh; muellerian-inhibiting factor [KO:K04665]
132962894  ccl25b; C-C motif chemokine 25b [KO:K13072]
132962926  ccl44; chemokine (C-C motif) ligand 44 [KO:K21083]
132967151  [KO:K10032]
132970282  mpl; thrombopoietin receptor [KO:K05082]
132970498  [KO:K05131]
132971388  lepr; leptin receptor [KO:K05062]
132971842  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
132971979  il12rb1; interleukin-12 receptor subunit beta-2 [KO:K05063]
132972014  il23r; interleukin-23 receptor isoform X1 [KO:K05064]
132972051  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
132972278  [KO:K05174]
132972292  [KO:K05173]
132972297  [KO:K05173]
132972723  [KO:K05164]
132973088  ccl35.1; chemokine (C-C motif) ligand 35, duplicate 1 [KO:K12964]
132973133  il17c; interleukin-17C [KO:K05491]
132973347  [KO:K05152]
132973456  il34; interleukin-34 [KO:K22633]
132973484  [KO:K05439]
132973714  bmp10; bone morphogenetic protein 10 [KO:K22670]
132973755  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
132974324  [KO:K04519]
132974546  lifra; LIF receptor subunit alpha a [KO:K05058]
132974594  ghra; growth hormone receptor a [KO:K05080]
132974670  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
132974715  spaw; southpaw [KO:K04666]
132974722  bmp3; bone morphogenetic protein 3 isoform X1 [KO:K05496]
132974762  [KO:K05060]
132974985  [KO:K05420]
132974994  il12b2; LOW QUALITY PROTEIN: interleukin-12 subunit beta [KO:K05425]
132975005  [KO:K10032]
132975210  bmp5; bone morphogenetic protein 5 [KO:K04663]
132975249  [KO:K05416]
132975254  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
132975266  gdf10a; growth/differentiation factor 10 [KO:K22674]
132975397  fas; tumor necrosis factor receptor superfamily member 26 [KO:K04390]
132975492  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
132975696  bmpr1aa; bone morphogenetic protein receptor, type IAa [KO:K04673] [EC:2.7.11.30]
132975716  [KO:K05491]
132976219  [KO:K05071]
132977144  gdf5; growth/differentiation factor 5 [KO:K04664]
132977425  il10; interleukin-10 [KO:K05443]
132977428  il19l; interleukin 19 like [KO:K22667]
132977653  [KO:K16621]
132977757  [KO:K13567] [EC:2.7.11.30]
132977843  [KO:K22679]
132977948  il17rc; interleukin-17 receptor C isoform X1 [KO:K05166]
132978041  si:ch73-361p23.3; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
132978087  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
132978094  il16; pro-interleukin-16 isoform X1 [KO:K22628]
132978161  [KO:K22687]
132978237  ngfb; nerve growth factor [KO:K02582]
132978479  admp; anti-dorsalizing morphogenic protein [KO:K21283]
132978492  inhbab; inhibin subunit beta Ab [KO:K04667]
132978562  ccr12a; chemokine (C-C motif) receptor 12a [KO:K04179]
132978582  il17a/f1; interleukin 17a/f1 [KO:K05494]
132978785  [KO:K04189]
132978961  [KO:K05504]
132978999  [KO:K14625]
132979066  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
132979116  [KO:K05406]
132979145  thpo; thrombopoietin [KO:K06854]
132979318  [KO:K04193]
132979319  [KO:K04193]
132979360  ackr4a; atypical chemokine receptor 4 [KO:K04186]
132979431  [KO:K13596] [EC:2.7.11.30]
132979451  ccl25a; C-C motif chemokine 25 [KO:K13072]
132979578  crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137]
132979643  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
132979951  il12a; interleukin-12 subunit alpha [KO:K05406]
132980039  smtla; somatolactin alpha [KO:K05438]
132980335  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
132980423  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
132980642  bmp16; bone morphogenetic protein 16 [KO:K21283]
132980760  [KO:K04190]
132980791  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
132980890  il15l; interleukin 15, like isoform X1 [KO:K05433]
132980923  [KO:K04723]
132981605  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
132981686  il21; interleukin-21 [KO:K05434]
132981711  eda; ectodysplasin-A isoform X1 [KO:K05480]
132981715  ccr7; C-C chemokine receptor type 7 [KO:K04182]
132981766  gdf9; growth/differentiation factor 9 [KO:K22673]
132981828  [KO:K05090] [EC:2.7.10.1]
132981890  clcf1; uncharacterized protein clcf1 [KO:K05421]
132982055  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
132982115  cd40lg; CD40 ligand [KO:K04389]
132982366  rell2; RELT-like protein 2 [KO:K26541]
132982467  il12ba; interleukin 12Ba isoform X1 [KO:K05425]
132982598  ifngr1; interferon gamma receptor 1 [KO:K05132]
132983047  cd4-1; CD4-1 molecule isoform X1 [KO:K06454]
132983060  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132983067  [KO:K03160]
132983186  il11a; uncharacterized protein il11a [KO:K05417]
132983301  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
132983328  [KO:K04388] [EC:2.7.11.30]
132983563  il21r.1; interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
132983564  [KO:K05073]
132983605  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
132983692  ifnlr1; interferon lambda receptor 1 [KO:K05136]
132983727  csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
132983792  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
132983794  [KO:K04188]
132983795  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
132983939  nradd; death domain-containing membrane protein NRADD [KO:K02583]
132984030  si:dkey-92i15.4; uncharacterized protein si:dkey-92i15.4 [KO:K22628]
132984043  il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
132984230  [KO:K05148]
132984231  [KO:K05143]
132984260  [KO:K04179]
132984262  cabz01093075.1; C-C chemokine receptor type 5 [KO:K04179]
132984263  si:cabz01093077.1; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
132984264  [KO:K04180]
132984367  gdf6a; growth/differentiation factor 6-A [KO:K20012]
132984455  tnfrsf21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
132984567  [KO:K04179]
132984814  [KO:K22630]
132985024  [KO:K13377]
132985044  [KO:K05477]
132985121  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
132985198  bmp2b; bone morphogenetic protein 2b [KO:K21283]
132985285  il17a/f3; interleukin 17a/f3 [KO:K05494]
132985459  ccr6a; C-C chemokine receptor type 6a isoform X1 [KO:K04181]
132986580  ackr3a; atypical chemokine receptor 3a [KO:K04304]
132986585  [KO:K04387]
132986624  gdf3; protein DVR-1 [KO:K22672]
132986799  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
132986841  il1rl1; interleukin-1 receptor type 1 [KO:K05171]
132986857  il17d; interleukin-17D [KO:K05492]
132986875  [KO:K05135]
132986876  il10rb; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
132987047  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
132987057  [KO:K05050]
132987093  mstnb; growth/differentiation factor 8 [KO:K05497]
132987135  inhbb; inhibin beta B chain [KO:K22687]
132987173  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132987193  [KO:K04671] [EC:2.7.11.30]
132987204  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
132987218  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
132987252  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
132987336  [KO:K13568] [EC:2.7.11.30]
132987337  [KO:K04675] [EC:2.7.11.30]
132987538  [KO:K04386]
132987805  il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
132988084  [KO:K05070]
132988104  il12bb; interleukin-12 subunit beta [KO:K05425]
132988233  [KO:K22629]
132988389  csf1rb; macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
132989225  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
132989366  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
132989400  [KO:K05168]
132989439  acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
132989443  wu:fl23c11; uncharacterized protein wu:fl23c11 [KO:K05166]
132989521  [KO:K05165]
132989539  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132989815  [KO:K05146]
132990001  ngfa; neurotrophin-7 [KO:K02582]
132990009  [KO:K05152]
132990015  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
132990397  [KO:K05152]
132990403  [KO:K05152]
132990405  [KO:K05152]
132990408  [KO:K05152]
132990545  [KO:K04388] [EC:2.7.11.30]
132991052  [KO:K05405]
132991247  bmp8a; bone morphogenetic protein 8A [KO:K16622]
132991377  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
132991398  [KO:K05143]
132991561  gdf6b; growth/differentiation factor 6-B [KO:K20012]
132991925  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
132991964  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
132991993  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
132992009  ghrb; growth hormone receptor b isoform X1 [KO:K05080]
132992120  [KO:K05058]
132992253  prlra; prolactin receptor a [KO:K05081]
132992314  [KO:K22670]
132992432  [KO:K05478]
132992666  ndr1; nodal-related 1 [KO:K04666]
132992711  il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
132992712  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
132992900  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
132993144  bmp4; bone morphogenetic protein 4 [KO:K04662]
132993204  ebi3; interleukin-27 subunit beta [KO:K24476]
132993363  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
132993456  [KO:K04721]
132993510  [KO:K05060]
132993525  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
132993935  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
132994054  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
132994133  [KO:K13596] [EC:2.7.11.30]
132994149  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
132994151  inhbaa; inhibin subunit beta Aa [KO:K04667]
132994204  [KO:K04179]
132994416  bmp6; bone morphogenetic protein 6 [KO:K16620]
132994423  ccl20b; C-C motif chemokine 20b [KO:K14625]
132994539  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
132994551  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
132994612  ackr4b; atypical chemokine receptor 4b [KO:K04186]
132995481  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132995535  [KO:K10030]
132995542  [KO:K10030]
132995681  epor; erythropoietin receptor [KO:K05079]
132995737  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
132995755  gh1; somatotropin [KO:K05438]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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